DK1165126T3 - Fremgangsmåde til fremstilling af en humant papillomvirus-vaccine med demonterede og remonterede viruslignende partikler - Google Patents

Fremgangsmåde til fremstilling af en humant papillomvirus-vaccine med demonterede og remonterede viruslignende partikler

Info

Publication number
DK1165126T3
DK1165126T3 DK00918248T DK00918248T DK1165126T3 DK 1165126 T3 DK1165126 T3 DK 1165126T3 DK 00918248 T DK00918248 T DK 00918248T DK 00918248 T DK00918248 T DK 00918248T DK 1165126 T3 DK1165126 T3 DK 1165126T3
Authority
DK
Denmark
Prior art keywords
remounted
disassembled
virus
particles
preparation
Prior art date
Application number
DK00918248T
Other languages
Danish (da)
English (en)
Inventor
David B Volkin
Li Shi
Henryk Mach
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26824774&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1165126(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of DK1165126T3 publication Critical patent/DK1165126T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK00918248T 1999-03-26 2000-03-22 Fremgangsmåde til fremstilling af en humant papillomvirus-vaccine med demonterede og remonterede viruslignende partikler DK1165126T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12652899P 1999-03-26 1999-03-26
US09/524,624 US6245568B1 (en) 1999-03-26 2000-03-13 Human papilloma virus vaccine with disassembled and reassembled virus-like particles

Publications (1)

Publication Number Publication Date
DK1165126T3 true DK1165126T3 (da) 2007-01-08

Family

ID=26824774

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00918248T DK1165126T3 (da) 1999-03-26 2000-03-22 Fremgangsmåde til fremstilling af en humant papillomvirus-vaccine med demonterede og remonterede viruslignende partikler

Country Status (19)

Country Link
US (2) US6245568B1 (enExample)
EP (1) EP1165126B1 (enExample)
JP (1) JP4594534B2 (enExample)
KR (1) KR20020013516A (enExample)
AR (1) AR023166A1 (enExample)
AT (1) ATE339222T1 (enExample)
AU (1) AU778937B2 (enExample)
CA (1) CA2368391C (enExample)
CY (4) CY1105779T1 (enExample)
DE (4) DE60030698T2 (enExample)
DK (1) DK1165126T3 (enExample)
ES (1) ES2270822T3 (enExample)
FR (1) FR07C0026I2 (enExample)
LT (1) LTC1165126I2 (enExample)
LU (3) LU91327I2 (enExample)
NL (3) NL300270I1 (enExample)
PT (1) PT1165126E (enExample)
SI (1) SI1165126T1 (enExample)
WO (1) WO2000057906A1 (enExample)

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US6962777B1 (en) * 1997-09-05 2005-11-08 Medimmune, Inc. In vitro method for disassembly/reassembly of papillomavirus virus-like particles (vlps), homogeneous vlp and capsomere compositions produced by said methods; use thereof as vehicle for improved purification, and delivery of active agents
ATE426803T1 (de) * 1999-12-09 2009-04-15 Medimmune Inc In-vitro-methode zur zerlegung und zum wiederzusammenfugen von papillomavirusartigen partikeln
GB0118249D0 (en) 2001-07-26 2001-09-19 Chiron Spa Histidine vaccines
WO2003009869A1 (en) * 2001-07-26 2003-02-06 Chiron Srl. Vaccines comprising aluminium adjuvants and histidine
DE10137102A1 (de) * 2001-07-30 2003-02-27 Deutsches Krebsforsch Polyvalente Vakzine gegen durch Papillomaviren verursachte Erkrankungen, Verfahren zu deren Herstellung und deren Verwendung
US20060073530A1 (en) * 2001-08-15 2006-04-06 Olaf Schneewind Methods and compositions involving sortase B
MX339524B (es) 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
WO2003068163A2 (en) * 2002-02-14 2003-08-21 Novavax, Inc. Optimization of gene sequences of chimeric virus-like particles for expression in insect cells
GB0206359D0 (en) * 2002-03-18 2002-05-01 Glaxosmithkline Biolog Sa Viral antigens
GB0206360D0 (en) * 2002-03-18 2002-05-01 Glaxosmithkline Biolog Sa Viral antigens
DE10237639A1 (de) * 2002-08-13 2004-02-26 Martin-Luther-Universität Halle-Wittenberg Verfahren zur Herstellung von virusanalogen Partikeln durch in vitro-Assemblierung von Kapsomeren oder von Kapsomeren, an die biologisch aktive Makromoleküle gebunden sind, bei gleichzeitiger Verpackung der Makromoleküle
GB0220194D0 (en) * 2002-08-30 2002-10-09 Chiron Spa Improved vesicles
HUE034801T2 (en) 2002-11-01 2018-02-28 Glaxosmithkline Biologicals Sa Drying procedure
JP5475939B2 (ja) 2002-12-20 2014-04-16 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム Ｈｐｖ−１６およびｈｐｖ−１８ｌ１ｖｌｐワクチン
US7858098B2 (en) * 2002-12-20 2010-12-28 Glaxosmithkline Biologicals, S.A. Vaccine
CA2572129A1 (en) * 2004-07-01 2006-01-12 The Circle For The Promotion Of Science And Engineering Viral particle-like construct and method of forming the same under physiological conditions
MX2007008777A (es) * 2005-01-25 2007-10-23 Wyeth Res Ireland Ltd Metodo para diafiltracion.
CA2614322A1 (en) * 2005-07-14 2007-01-25 Mayo Foundation For Medical Education And Research Paramyxoviridae virus preparations
US20090105130A1 (en) * 2005-08-12 2009-04-23 Astellas Pharma Inc. Depsipeptide-containing injection solution
BRPI0520505B1 (pt) * 2005-09-01 2015-03-31 José Luis Nuño Ayalá Fórmula estabilizadora de vacinas com antígenos vivos para uso em sistemas de vacinação em massa
TWI457133B (zh) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
CA2652118C (en) * 2006-05-11 2015-07-07 Becton, Dickinson And Company Method of protein extraction from cells
US9207240B2 (en) * 2007-11-14 2015-12-08 Arbor Vita Corporation Method of efficient extraction of protein from cells
EP2258380B1 (en) * 2008-03-31 2013-03-13 Morinaga Milk Industry Co., Ltd. Nucleic acid for imparting heat resistance to lactoferrin
DK2473596T3 (en) * 2009-09-03 2018-01-22 Becton Dickinson Co METHODS AND COMPOSITIONS FOR DIRECT CHEMICAL LYSIS
PT3246044T (pt) 2010-08-23 2021-02-15 Wyeth Llc Formulações estáveis de antigénios de rlp2086 de neisseria meningitidis
AU2011300409B2 (en) 2010-09-10 2015-03-26 Wyeth Llc Non-lipidated variants of Neisseria meningitidis ORF2086 antigens
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
US8986710B2 (en) 2012-03-09 2015-03-24 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
CN104203270A (zh) 2012-03-18 2014-12-10 葛兰素史密丝克莱恩生物有限公司 针对人乳头状瘤病毒的接种方法
KR101559622B1 (ko) * 2012-07-30 2015-10-13 중앙대학교 산학협력단 인유두종바이러스 바이러스 유사입자의 고효율 정제방법
WO2014136064A2 (en) 2013-03-08 2014-09-12 Pfizer Inc. Immunogenic fusion polypeptides
MX369534B (es) 2013-09-08 2019-11-11 Pfizer Composiciones de neisseria meningitidis y sus metodos.
RU2723045C2 (ru) 2015-02-19 2020-06-08 Пфайзер Инк. Композиции neisseria meningitidis и способы их получения
SG10202111092UA (en) 2017-01-31 2021-11-29 Pfizer Neisseria meningitidis compositions and methods thereof
WO2018152505A1 (en) 2017-02-17 2018-08-23 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Efficient cell free production of papillomavirus gene transfer vectors
CA3080656A1 (en) 2017-10-30 2019-05-09 Baxalta GmbH Environmentally compatible detergents for inactivation of lipid-enveloped viruses
CA3155669A1 (en) 2019-09-27 2021-04-01 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
CN110987571A (zh) * 2019-12-31 2020-04-10 广州金域医学检验中心有限公司 一种单克隆多聚体m蛋白解聚方法
CN111812313B (zh) * 2020-06-22 2021-10-08 北京生物制品研究所有限责任公司 铝佐剂吸附型新型冠状病毒灭活疫苗中抗原的解离方法

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JP4598201B2 (ja) 1997-04-08 2010-12-15 メルク・シャープ・エンド・ドーム・コーポレイション 安定化ヒトパピローマウイルス製剤
CA2295316C (en) 1997-07-03 2007-06-26 University Of Colorado, University Technology Corporation Homogeneous human papilloma virus capsomere containing compositions, methods for manufacture, and the use thereof as diagnostic, prophylactic or therapy

Also Published As

Publication number Publication date
US6245568B1 (en) 2001-06-12
WO2000057906A1 (en) 2000-10-05
JP2002540167A (ja) 2002-11-26
NL300268I1 (nl) 2007-05-01
CY2007009I1 (el) 2010-07-28
JP4594534B2 (ja) 2010-12-08
AU778937B2 (en) 2004-12-23
LU91327I9 (enExample) 2019-03-01
CY1105779T1 (el) 2010-07-28
PT1165126E (pt) 2006-12-29
LU91327I2 (fr) 2007-05-14
CY2007010I1 (el) 2009-11-04
US20010021385A1 (en) 2001-09-13
SI1165126T1 (sl) 2006-12-31
NL300269I2 (nl) 2008-07-01
AU3909300A (en) 2000-10-16
ATE339222T1 (de) 2006-10-15
LU91328I9 (enExample) 2019-03-01
LTPA2007002I1 (lt) 2020-03-25
DE60030698T2 (de) 2007-07-19
AR023166A1 (es) 2002-09-04
LU91326I2 (fr) 2007-05-14
DE122007000033I1 (de) 2007-08-09
CY2007008I2 (el) 2009-11-04
DE60030698D1 (de) 2006-10-26
CA2368391A1 (en) 2000-10-05
DE122007000032I1 (de) 2007-08-09
CA2368391C (en) 2011-06-07
KR20020013516A (ko) 2002-02-20
ES2270822T3 (es) 2007-04-16
LU91326I9 (enExample) 2018-12-31
EP1165126A1 (en) 2002-01-02
FR07C0026I1 (enExample) 2007-04-27
DE122007000034I1 (de) 2007-08-09
FR07C0026I2 (fr) 2012-08-03
CY2007009I2 (el) 2010-07-28
LU91328I2 (fr) 2007-05-14
NL300270I1 (nl) 2007-05-01
CY2007008I1 (el) 2009-11-04
LTC1165126I2 (lt) 2020-04-27
EP1165126B1 (en) 2006-09-13
NL300269I1 (nl) 2007-05-01
CY2007010I2 (el) 2009-11-04

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