KR102191353B1 - 히알루론산의 c6-c18-아실화된 유도체, 이의 제조 방법, 이를 기재로 하는 나노미쉘형 조성물, 이의 제조 방법, 및 안정화된 나노미쉘형 조성물의 제조 방법, 및 이의 용도 - Google Patents

히알루론산의 c6-c18-아실화된 유도체, 이의 제조 방법, 이를 기재로 하는 나노미쉘형 조성물, 이의 제조 방법, 및 안정화된 나노미쉘형 조성물의 제조 방법, 및 이의 용도 Download PDF

Info

Publication number
KR102191353B1
KR102191353B1 KR1020157016788A KR20157016788A KR102191353B1 KR 102191353 B1 KR102191353 B1 KR 102191353B1 KR 1020157016788 A KR1020157016788 A KR 1020157016788A KR 20157016788 A KR20157016788 A KR 20157016788A KR 102191353 B1 KR102191353 B1 KR 102191353B1
Authority
KR
South Korea
Prior art keywords
acid
nano
hyaluronan
hyaluronic acid
delete delete
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020157016788A
Other languages
English (en)
Korean (ko)
Other versions
KR20150088848A (ko
Inventor
다니엘라 스메즈카로바
글로리아 후에르타-앤젤레스
마틴 보벡
마르티나 헤르마노바
루시 비스테즈노바
야로슬라브 노보트니
에바 프리코포바
크리스티나 네스포로바
미로슬라바 넴코바
클라라 슬레진저로바
자로미르 쿨하넥
다그마르 코지코바
자나 소고르코바
얀 쿠체라
파벨 클레인
블라디미르 벨레브니
Original Assignee
콘티프로 에이.에스.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 콘티프로 에이.에스. filed Critical 콘티프로 에이.에스.
Publication of KR20150088848A publication Critical patent/KR20150088848A/ko
Application granted granted Critical
Publication of KR102191353B1 publication Critical patent/KR102191353B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6907—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a microemulsion, nanoemulsion or micelle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0291—Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/30—Sulfur-, selenium- or tellurium-containing compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/10—General cosmetic use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/30—Sulfur-, selenium- or tellurium-containing compounds
    • C08K2003/3045—Sulfates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Birds (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Nanotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Cosmetics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
KR1020157016788A 2012-11-27 2013-11-26 히알루론산의 c6-c18-아실화된 유도체, 이의 제조 방법, 이를 기재로 하는 나노미쉘형 조성물, 이의 제조 방법, 및 안정화된 나노미쉘형 조성물의 제조 방법, 및 이의 용도 Active KR102191353B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CZ2012-842A CZ304654B6 (cs) 2012-11-27 2012-11-27 Nanomicelární kompozice na bázi C6-C18-acylovaného hyaluronanu, způsob přípravy C6-C18-acylovaného hyaluronanu, způsob přípravy nanomicelární kompozice a stabilizované nanomicelární kompozice a použití
CZPV2012-842 2012-11-27
PCT/CZ2013/000156 WO2014082609A1 (en) 2012-11-27 2013-11-26 C6-c18-acylated derivative of hyaluronic acid, method of preparation thereof, nanomicellar composition on its basis, method of preparation thereof and method of preparation stabilized nanomicellar composition, and use thereof

Publications (2)

Publication Number Publication Date
KR20150088848A KR20150088848A (ko) 2015-08-03
KR102191353B1 true KR102191353B1 (ko) 2020-12-16

Family

ID=50097520

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020157016788A Active KR102191353B1 (ko) 2012-11-27 2013-11-26 히알루론산의 c6-c18-아실화된 유도체, 이의 제조 방법, 이를 기재로 하는 나노미쉘형 조성물, 이의 제조 방법, 및 안정화된 나노미쉘형 조성물의 제조 방법, 및 이의 용도

Country Status (12)

Country Link
US (1) US9999678B2 (enExample)
EP (1) EP2934592B1 (enExample)
JP (1) JP2016500130A (enExample)
KR (1) KR102191353B1 (enExample)
BR (1) BR112015012191A8 (enExample)
CZ (1) CZ304654B6 (enExample)
DK (1) DK2934592T3 (enExample)
ES (1) ES2683993T3 (enExample)
HU (1) HUE038664T2 (enExample)
PL (1) PL2934592T3 (enExample)
RU (1) RU2640287C2 (enExample)
WO (1) WO2014082609A1 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ304654B6 (cs) 2012-11-27 2014-08-20 Contipro Biotech S.R.O. Nanomicelární kompozice na bázi C6-C18-acylovaného hyaluronanu, způsob přípravy C6-C18-acylovaného hyaluronanu, způsob přípravy nanomicelární kompozice a stabilizované nanomicelární kompozice a použití
CZ305153B6 (cs) 2014-03-11 2015-05-20 Contipro Biotech S.R.O. Konjugáty oligomeru kyseliny hyaluronové nebo její soli, způsob jejich přípravy a použití
CZ2014451A3 (cs) 2014-06-30 2016-01-13 Contipro Pharma A.S. Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití
CZ309295B6 (cs) 2015-03-09 2022-08-10 Contipro A.S. Samonosný, biodegradabilní film na bázi hydrofobizované kyseliny hyaluronové, způsob jeho přípravy a použití
CN113786489A (zh) * 2015-05-29 2021-12-14 生化学工业株式会社 包含糖胺聚糖衍生物和趋化因子受体活性调节材料的组合物
CZ2015398A3 (cs) 2015-06-15 2017-02-08 Contipro A.S. Způsob síťování polysacharidů s využitím fotolabilních chránicích skupin
CZ306662B6 (cs) 2015-06-26 2017-04-26 Contipro A.S. Deriváty sulfatovaných polysacharidů, způsob jejich přípravy, způsob jejich modifikace a použití
PL229276B1 (pl) * 2015-07-17 2018-06-29 Univ Jagiellonski Nanokapsuła do przenoszenia związku lipofilowego i sposób jej wytwarzania
CZ307511B6 (cs) 2015-12-23 2018-10-31 Contipro A.S. Fluorescenční konjugát kyseliny hyaluronové nebo jeho sůl, hydrofobizovaný konjugát, způsoby jejich přípravy a použití
CZ308106B6 (cs) 2016-06-27 2020-01-08 Contipro A.S. Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití
CZ2016826A3 (cs) 2016-12-22 2018-07-04 Contipro A.S. Léčivý prostředek s nosičem na bázi hyaluronanu a/nebo jeho derivátů, způsob výroby a použití
CZ2016827A3 (cs) * 2016-12-23 2018-02-07 Contipro A.S. Oftalmologický prostředek
US12324789B2 (en) * 2017-08-28 2025-06-10 Apirx Pharmaceutical Usa, Llc Method to treat psoriasis
WO2020002597A1 (en) 2018-06-29 2020-01-02 Merz Pharma Gmbh & Co. Kgaa Fatty acid-grafted hyaluronic acid, dermal filler formulations comprising same, process for preparation and use thereof
FR3105922B1 (fr) 2020-01-08 2022-12-02 Le Rouge Francais Composition cosmétique pour le traitement des lèvres sous forme de solide compact contenant au moins un agent probiotique et au moins un composé choisi parmi l'acide hyaluronique et ses dérivés.
TWI834948B (zh) * 2020-02-05 2024-03-11 日商旭化成股份有限公司 玻尿酸衍生物組合物、醫藥組合物及玻尿酸衍生物－藥物結合體組合物
EP4101860A4 (en) * 2020-02-07 2023-07-19 Asahi Kasei Kabushiki Kaisha HYALURONIC ACID DERIVATIVE, PHARMACEUTICAL COMPOSITION AND MEDICINE CONJUGATE - HYALURONIC ACID DERIVATIVE -
KR102547183B1 (ko) * 2020-10-19 2023-06-26 주식회사 메피온 필러 및 필러 제조 방법
CN112159527B (zh) * 2020-10-29 2023-06-06 绍兴文理学院 一种含有透明质酸基团的聚甘油脂肪酸酯ha-pg及其合成方法和其在制备药物制剂中的应用
CN113476426B (zh) * 2021-06-29 2023-11-24 大连工业大学 一种基于透明质酸的双靶向功能因子递送体系的制备及其在炎症性肠病中的应用
CN114561827B (zh) * 2022-02-25 2023-04-21 华南理工大学 一种全生物质基蜡乳液防水涂料及其制备方法与应用
CN116444695B (zh) * 2022-12-27 2024-09-06 山东丰金美业科技有限公司 一种低成本、低分子量乙酰化透明质酸钠的制备方法
CN116459213A (zh) * 2023-02-20 2023-07-21 莫佳杰 一种具有过氧化氢响应性胶束及制备方法和应用
FR3148720A1 (fr) 2023-05-18 2024-11-22 Le Rouge Francais Composition cosmétique aqueuse contenant un agent probiotique, un composé choisi parmi l'acide hyaluronique et ses dérivés, un colorant particulier et une huile végétale.
FR3151215A1 (fr) 2023-07-23 2025-01-24 Le Rouge Francais Composition cosmétique topique anhydre pulvérulente comprenant un agent probiotique, de l'acide hyaluronique ou un de ses dérivés, un colorant particulier et une poudre minérale particulière.
CN116874640B (zh) * 2023-07-24 2025-08-08 江南大学 一种长驻留的用于头发修护的透明质酸钠衍生物及其制备方法
WO2025029805A2 (en) * 2023-08-03 2025-02-06 Pmidg, Llc Hemostatic compositions and methods

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004123785A (ja) * 2002-09-30 2004-04-22 Chisso Corp ｎ−アルカノイル化ヒアルロン酸もしくはその塩およびその製造法
WO2007033677A1 (en) * 2005-09-26 2007-03-29 Novozymes Biopolymer A/S Aryl/alkyl succinic anhydride hyaluronan derivatives

Family Cites Families (155)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3720662A (en) 1971-09-13 1973-03-13 Nat Starch Chem Corp Preparation of starch esters
US3728223A (en) 1971-10-08 1973-04-17 Amano Pharma Co Ltd Production of hyaluronidase from a strain of streptomyces
GB1527592A (en) 1974-08-05 1978-10-04 Ici Ltd Wound dressing
CH628088A5 (en) 1975-09-17 1982-02-15 Dresden Arzneimittel Process for obtaining streptococcal metabolic products
US4205025A (en) 1975-12-22 1980-05-27 Champion International Corporation Synthetic polymeric fibrids, fibrid products and process for their production
JPS6033474B2 (ja) 1978-05-11 1985-08-02 藤沢薬品工業株式会社 新規なヒアルロニダ−ゼｂｍｐ−８２３１およびその製造法
US4716224A (en) 1984-05-04 1987-12-29 Seikagaku Kogyo Co. Ltd. Crosslinked hyaluronic acid and its use
US4713448A (en) 1985-03-12 1987-12-15 Biomatrix, Inc. Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues
US4851521A (en) 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
GB8519416D0 (en) 1985-08-01 1985-09-04 Unilever Plc Oligosaccharides
JPS62104579A (ja) 1985-10-30 1987-05-15 Kyowa Hakko Kogyo Co Ltd ヒアルロニダ−ゼの製造法
JPH0751064B2 (ja) 1986-08-13 1995-06-05 生化学工業株式会社 新規なヒアルロニダ−ゼｓｄ−６７８およびその製造法
IT1219587B (it) 1988-05-13 1990-05-18 Fidia Farmaceutici Polisaccaridi carbossiilici autoreticolati
JPH0214019A (ja) 1988-06-30 1990-01-18 Tonen Corp 繊維状成形物及びその製造方法
JPH0755961B2 (ja) * 1989-04-18 1995-06-14 工業技術院長 新規なヒアルロン酸誘導体及びその製造方法
US5522879A (en) 1991-11-12 1996-06-04 Ethicon, Inc. Piezoelectric biomedical device
US5824335A (en) 1991-12-18 1998-10-20 Dorigatti; Franco Non-woven fabric material comprising auto-crosslinked hyaluronic acid derivatives
IT1254704B (it) 1991-12-18 1995-10-09 Mini Ricerca Scient Tecnolog Tessuto non tessuto essenzialmente costituito da derivati dell'acido ialuronico
JP2855307B2 (ja) 1992-02-05 1999-02-10 生化学工業株式会社 光反応性グリコサミノグリカン、架橋グリコサミノグリカン及びそれらの製造方法
FR2689131B1 (fr) 1992-03-30 1994-05-20 Oreal Procede de preparation de monoesters majoritairement en position 6' du d-maltose et leur utilisation dans les domaines cosmetique, bucco-dentaire, pharmaceutique et alimentaire.
JPH0625306A (ja) 1992-04-21 1994-02-01 Shiseido Co Ltd 溶媒不溶化ヒアルロン酸及びその製造方法
IT1263316B (it) 1993-02-12 1996-08-05 Fidia Advanced Biopolymers Srl Tessuto non tessuto multistrato in cui uno degli strati e' costituito essenzialmente da esteri dell'acido ialuronico
NL9700003A (nl) 1993-09-28 1997-07-01 House Foods Corp Werkwijze voor het inoculeren van Fistulina hepatica.
US5616568A (en) 1993-11-30 1997-04-01 The Research Foundation Of State University Of New York Functionalized derivatives of hyaluronic acid
EP0701704B1 (en) 1994-03-14 1999-12-15 Seikagaku Corporation Material to be worn on the eyeball
US5455349A (en) 1994-05-13 1995-10-03 Polaroid Corporation Vinylbenzyl thymine monomers
RU2147243C1 (ru) 1994-09-27 2000-04-10 Нюкомед Имагинг А/С Контрастное средство
JP3308742B2 (ja) 1994-11-17 2002-07-29 生化学工業株式会社 光架橋性ヒアルロン酸誘導体とその架橋体およびそれらの製造方法
US6025444A (en) 1994-11-17 2000-02-15 Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) Cinnamic acid derivative
US5690961A (en) 1994-12-22 1997-11-25 Hercules Incorporated Acidic polysaccharides crosslinked with polycarboxylic acids and their uses
CZ278797A3 (en) 1995-03-07 1997-11-12 Ciba Geigy Ag Photochemically cross-linked polysaccharide derivatives, process of their preparation and their use as carriers for chromatographic separation of enantiomers
IT1281877B1 (it) 1995-05-10 1998-03-03 Fidia Advanced Biopolymers Srl Sali di metalli pesanti di succinil derivati dell'acido ialuronico e loro impiego come potenziali agenti terapeutici
EP0850074B1 (en) 1995-08-29 2005-06-08 Fidia Advanced Biopolymers S.R.L. Biomaterials for preventing post-surgical adhesions comprised of hyaluronic acid derivatives
US5789462A (en) 1995-09-13 1998-08-04 Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) Photocured crosslinked-hyaluronic acid contact lens
DE19604706A1 (de) 1996-02-09 1997-08-14 Merck Patent Gmbh Vernetzungsprodukte von Aminogruppen-haltigen Biopolymeren
DE19616010C2 (de) 1996-04-23 1998-07-09 Seitz Filter Werke Verfahren und Vorrichtung zur Herstellung von Fibrets (Fibriden) aus Zellulosederivaten
IT1287698B1 (it) 1996-08-29 1998-08-18 Fidia Advanced Biopolymers Srl Fili da sutura essenzialmente costituiti da derivati esterei dello acido ialuronico
US6632802B2 (en) 1996-08-29 2003-10-14 Fidia Advanced Biopolymers S.R.L. Hyaluronic acid esters, threads and biomaterials containing them, and their use in surgery
IT1286510B1 (it) 1996-11-29 1998-07-15 Cooperativa Centro Ricerche Po Esteri butirrici ad attivita' antiproliferativa e composizioni farmaceutiche che li contengono
JP4247846B2 (ja) 1997-07-03 2009-04-02 デュピュイ・スパイン・インコーポレーテッド 架橋ポリサッカリド薬物キャリア
US5977348A (en) 1997-07-25 1999-11-02 National Starch And Chemical Investment Holding Corporation Polysaccharide modification in densified fluid
RU2218922C2 (ru) 1998-04-30 2003-12-20 Маруха Корпорейшн Соединения, имеющие в своей структуре фрагмент производного глюкуроновой кислоты и фрагмент производного глюкозамина, способы получения этих соединений и применение этих соединений
ES2174605T3 (es) 1998-05-07 2002-11-01 Tno Procedimiento para la oxidacion selectiva de alcoholes primarios.
US6630457B1 (en) 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
IT1302534B1 (it) 1998-12-21 2000-09-05 Fidia Advanced Biopolymers Srl Composizioni iniettabili, biocompatibili e biodegradabili comprendentialmeno un derivato dell'acido ialuronico, cellule condrogeniche, per
DE59906392D1 (de) 1998-12-23 2003-08-28 Esparma Gmbh Hyaluronatlyase als penetrationsförderer in topischen mitteln
DE19917614C2 (de) 1999-04-19 2001-07-05 Thueringisches Inst Textil Verfahren zur Herstellung von cellulosischen Formkörpern mit hohem Adsorptionsvermögen
US6288043B1 (en) 1999-06-18 2001-09-11 Orquest, Inc. Injectable hyaluronate-sulfated polysaccharide conjugates
US6592794B1 (en) 1999-09-28 2003-07-15 Organogenesis Inc. Process of making bioengineered collagen fibrils
CO5231217A1 (es) 1999-11-08 2002-12-27 Sca Hygiene Prod Zeist Bv Procedimiento de oxidacion de alcoholes primarios
DE10003397A1 (de) 2000-01-27 2001-08-09 Hartmann Paul Ag Polyelektrolyt-Feststoffsystem, Verfahren zur Herstellung desselben sowie Wundverband
DE10009996B4 (de) * 2000-03-02 2005-10-13 Cognis Ip Management Gmbh Feststoffgranulate mit monodisperser Korngrößenverteilung, ein Verfahren zu ihrer Herstellung sowie ihre Verwendung
IT1317358B1 (it) 2000-08-31 2003-06-16 Fidia Advanced Biopolymers Srl Derivati cross-linkati dell'acido ialuronico.
IT1317359B1 (it) 2000-08-31 2003-06-16 Fidia Advanced Biopolymers Srl Polisaccaridi percarbossilati, quali l'acido ialuronico, processo perla loro preparazione e loro impiego in campo farmaceutico e
US6498269B1 (en) 2000-10-17 2002-12-24 The University Of Connecticut Method for the oxidation of aldehydes, hemiacetals and primary alcohols
AU2002219718A1 (en) 2000-12-13 2002-06-24 Sca Hygiene Products Zeist B.V. Process for oxidising primary alcohols
EP1217008B1 (en) 2000-12-19 2006-03-01 Seikagaku Corporation Photocurable hyaluronic acid derivative and process for producing the same, and photocured crosslinked hyaluronic acid derivative and medical material using the same
FR2819808B1 (fr) 2001-01-19 2003-04-18 Simafex Compositions stabilisees d'acide o-iodoxybenzoique et leur procede de preparation
EP1369441A4 (en) 2001-01-31 2004-12-08 Seikagaku Kogyo Co Ltd NETWORKED POLYSACCHARIDE SPONGE
US6902548B1 (en) 2001-03-19 2005-06-07 Ed Schuler Use of Streptomyces hyalurolyticus enzyme in ophthalmic treatments
US6673919B2 (en) 2001-03-30 2004-01-06 Chisso Cororation Chemically modified hyaluronic acid or salts thereof, and a process for producing thereof
US6946284B2 (en) 2001-11-16 2005-09-20 University Of Massachusetts Solubilizing cross-linked polymers with photolyase
US20060189516A1 (en) 2002-02-19 2006-08-24 Industrial Technology Research Institute Method for producing cross-linked hyaluronic acid-protein bio-composites
ITPD20020064A1 (it) 2002-03-12 2003-09-12 Fidia Advanced Biopolymers Srl Derivati esterei dell'acido ialuronico per la preparazione di idrogelda utilizzare in campo biomedico, sanitario e chirurgico e come sistem
JP3975267B2 (ja) 2002-06-03 2007-09-12 独立行政法人産業技術総合研究所 多糖物質のアシル化方法
US20040101546A1 (en) 2002-11-26 2004-05-27 Gorman Anne Jessica Hemostatic wound dressing containing aldehyde-modified polysaccharide and hemostatic agents
US7550136B2 (en) 2002-12-20 2009-06-23 University Of Massachusetts Photo-reactive polymers and devices for use in hair treatments
ITMI20022745A1 (it) 2002-12-23 2004-06-24 Coimex Scrl United Companies Esteri misti dell'acido ialuronico ad attivita' citostatica e prodifferenziante e procedimento per la loro produzione.
US7465766B2 (en) 2004-01-08 2008-12-16 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US6982298B2 (en) 2003-01-10 2006-01-03 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US20050126338A1 (en) * 2003-02-24 2005-06-16 Nanoproducts Corporation Zinc comprising nanoparticles and related nanotechnology
FR2852012B1 (fr) 2003-03-04 2006-06-23 Oreal Procede de preparation de derives o-acyles du glucose
DE602004032525D1 (de) 2003-03-11 2011-06-16 Seikagaku Kogyo Co Ltd Rstellungsverfahren dafür
ES2226567B1 (es) * 2003-06-20 2006-07-01 Universidad De Santiago De Compostela Nanoparticulas de acido hialuronico.
DE10331342B4 (de) 2003-07-11 2009-03-12 Thüringisches Institut für Textil- und Kunststoff-Forschung e.V. Thermostabile Form- oder Spinnmasse
WO2005014655A2 (en) 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
JP4755496B2 (ja) 2003-09-08 2011-08-24 中外製薬株式会社 ヒアルロン酸修飾物、及びそれを用いた薬物担体
WO2005025630A1 (en) 2003-09-10 2005-03-24 Cato T Laurencin Polymeric nanofibers for tissue engineering and drug delivery
WO2005028632A2 (en) * 2003-09-19 2005-03-31 Colorado State University Research Foundation (Csurf) Hyaluronan (ha) esterification via acylation technique for moldable devices
GB2408741B (en) 2003-12-04 2008-06-18 Ind Tech Res Inst Hyaluronic acid derivative with urethane linkage
US20100330143A1 (en) 2003-12-04 2010-12-30 University Of Utah Research Foundation Modified macromolecules and methods of making and using thereof
US8313765B2 (en) 2003-12-04 2012-11-20 Industrial Technology Research Institute Biodegradable hyaluronic acid derivative, biodegradable polymeric micelle composition and pharmaceutical or bioactive composition
ITMI20040605A1 (it) 2004-03-29 2004-06-29 Coimex S C R L United Companie Esteri butirrici dell'acido ialuronico a basso grado di sostituzione procedimento per la loro preparazione ed uso
JP2008505716A (ja) 2004-07-09 2008-02-28 ザ クリーヴランド クリニック ファウンデーション ヒドロキシフェニル架橋高分子ネットワーク及びその用途
US7323425B2 (en) 2004-08-27 2008-01-29 Stony Brook Technology And Applied Research Crosslinking of hyaluronan solutions and nanofiberous membranes made therefrom
CN101107270B (zh) * 2004-11-24 2011-11-23 诺维信生物制药丹麦公司 用二乙烯基砜交联透明质酸的方法
US7214759B2 (en) 2004-11-24 2007-05-08 Advanced Cardiovascular Systems, Inc. Biologically absorbable coatings for implantable devices based on polyesters and methods for fabricating the same
US7680038B1 (en) 2005-04-25 2010-03-16 Electronic Arts, Inc. Dynamic bandwidth detection and response for online games
GB0513552D0 (en) 2005-07-01 2005-08-10 Bristol Myers Squibb Co Bandage
CA2614312C (en) 2005-07-06 2014-02-18 Seikagaku Corporation Drug-introduced photo-crosslinked hyaluronic acid derived gel
ITPD20050206A1 (it) 2005-07-07 2007-01-08 Fidia Advanced Biopolymers Srl Biomateriali in forma di fibra da impiegarsi come dispositivi medici nel trattamento delle ferite e loro processi di produzione
ITMI20051415A1 (it) 2005-07-22 2007-01-23 Fidia Advanced Biopolymers Srl Biomateriali a base di corbossimetilcellulosa salificata con zinco associata a derivati dell'acido ialuronico da impiegarsi come dispositivi medici con attivita' antimicrobica ed antifungina e loro processo di produzione
EP1926742B1 (en) 2005-09-21 2016-12-28 Kode Biotech Limited Cell surface coating with hyaluronic acid oligomer derivative
WO2007070617A1 (en) 2005-12-14 2007-06-21 Anika Therapeutics, Inc. Bioabsorbable implant of hyaluronic acid derivative for treatment of osteochondral and chondral defects
US20070202570A1 (en) 2006-02-24 2007-08-30 Kikkoman Corporation Enzyme composition, low molecular weight hyaluronan and process for preparing the same
JP2009528438A (ja) 2006-02-28 2009-08-06 ノボザイムス バイオポリマー アクティーゼルスカブ ヒアルロン酸誘導体
EP1994062B1 (en) * 2006-03-02 2009-07-15 Novozymes Biopolymer A/S Aryl/alkyl vinyl sulfone hyaluronic acid derivatives
JP4892679B2 (ja) 2006-03-27 2012-03-07 国立大学法人弘前大学 ゲル紡糸によるヒアルロン酸繊維およびその製造方法
KR20070118730A (ko) 2006-06-13 2007-12-18 주식회사 코오롱 보습성이 우수한 창상피복재 및 그의 제조방법
US20080124395A1 (en) 2006-06-22 2008-05-29 Weiliam Chen Formulations and devices for treatment or prevention of neural ischemic damage
WO2008014787A1 (en) 2006-08-04 2008-02-07 Novozymes Biopolymer A/S Branched hyaluronic acid and method of manufacture
US20080063617A1 (en) 2006-09-07 2008-03-13 Abrahams John M Cosmetics formulations
ITMI20061726A1 (it) 2006-09-11 2008-03-12 Fidia Farmaceutici Derivati crosslinkati a base di acido ialuronico reticolato via click chemistry
CZ302856B6 (cs) * 2006-09-27 2011-12-14 Cpn Spol. S R. O. Zpusob prípravy derivátu polysacharidu
US9597277B2 (en) 2006-12-22 2017-03-21 Croma-Pharma Gesellschaft M.B.H. Use of polymers
EP1942117A1 (en) 2006-12-29 2008-07-09 Sigea S.R.L. Derivatives of acid polysaccharides
KR20080062092A (ko) 2006-12-29 2008-07-03 주식회사 핸슨바이오텍 세포전달체로서의 히알루론산 유도체 및 이의 제조 방법
JP5329767B2 (ja) 2007-02-26 2013-10-30 帝人株式会社 芳香族コポリアミド繊維の製造装置
WO2008115799A1 (en) 2007-03-21 2008-09-25 William Marsh Rice University Novel gene delivery vectors for human mesenchymal stem cells
CZ2007299A3 (cs) 2007-04-24 2009-02-04 Cpn Spol. S R. O. Príprava nanovláken z polysacharidu a jejich smesí s polyvinylalkoholem
JP5165281B2 (ja) 2007-06-01 2013-03-21 株式会社バイオベルデ ２反応剤型の医療用含水ゲル形成剤、及び、これより得られるヒアルロン酸ゲル
WO2009037566A2 (en) 2007-06-19 2009-03-26 Uvarkina Tamara P Hyaluronidase and method of use thereof
US8709809B2 (en) 2007-06-22 2014-04-29 Innovative Surface Technologies, Inc. Nanofibers containing latent reactive groups
WO2009012372A1 (en) 2007-07-18 2009-01-22 Advantageous Systems, Llc Methods and apparatuses for detecting analytes in biological fluid of an animal
FR2921675B1 (fr) 2007-09-28 2010-03-19 Univ Claude Bernard Lyon Filament a base d'acide hyaluronique et son procede d'obtention.
US7976825B2 (en) 2007-12-06 2011-07-12 Janos Borbely Cancer cell diagnosis by targeting delivery of nanodevices
US8999211B2 (en) 2008-02-11 2015-04-07 Basf Se Method for producing porous structures from synthetic polymers
WO2009108100A1 (en) 2008-02-29 2009-09-03 Ipr-Systems Sweden Ab Composition for the formation of gels
JP5563563B2 (ja) 2008-06-05 2014-07-30 エージェンシー フォー サイエンス， テクノロジー アンド リサーチ ペルオキシダーゼおよび低濃度の過酸化水素の存在下でのヒドロゲルの形成方法
JP2010014784A (ja) 2008-07-01 2010-01-21 Fuji Xerox Co Ltd 光書込型表示装置、書込装置、及び光書き込み方法
FR2934999B1 (fr) 2008-08-13 2011-07-29 Adocia Polysaccharides fonctionnalises par des derives du tryptophane
ES2658609T3 (es) 2008-09-02 2018-03-12 Tautona Group Lp Hilos de ácido hialurónico y/o derivados de los mismos, métodos para fabricar los mismos, y usos de los mismos
CZ301555B6 (cs) 2008-11-06 2010-04-14 Cpn S. R. O. Zpusob prípravy DTPA sítovaných derivátu kyseliny hyaluronové a jejich modifikace
ITRM20080636A1 (it) 2008-11-28 2010-05-29 Univ Palermo Procedimento per la produzione di derivati funzionalizzati dell acido ialuronico e relativi idrogeli.
JP2010138276A (ja) 2008-12-11 2010-06-24 Nipro Corp ヒアルロン酸単糸の製造方法
WO2010095049A1 (en) 2009-02-21 2010-08-26 Sofradim Production Crosslinked fibers and method of making same by extrusion
CA2753165A1 (en) 2009-02-21 2010-08-26 Sofradim Production Compounds and medical devices activated with solvophobic linkers
EP2398850B1 (en) 2009-02-21 2018-08-22 Sofradim Production Medical devices with an activated coating
CZ301899B6 (cs) 2009-03-17 2010-07-21 Contipro C, A.S. Zpusob prípravy derivátu kyseliny hyaluronové pomocí O-acyl-O´-alkylkarbonátu v prítomnosti substituovaného pyridinu
US8551378B2 (en) 2009-03-24 2013-10-08 North Carolina State University Nanospinning of polymer fibers from sheared solutions
IT1396003B1 (it) 2009-05-14 2012-11-09 Fidia Farmaceutici Ialuronidasi extracellulare da streptomyces koganeiensis
DE102009022805B4 (de) 2009-05-27 2013-04-25 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Herstellung von Polysaccharidestern oder Polysaccharidmischestern
WO2010138074A1 (en) 2009-05-29 2010-12-02 Hilborn Joens Hyaluronic acid based delivery systems
AU2010259184B2 (en) * 2009-06-09 2015-08-13 Aurinia Pharmaceuticals Inc. Topical drug delivery systems for ophthalmic use
JP5683587B2 (ja) 2009-07-30 2015-03-11 カービラン バイオサージェリー， インコーポレイテッド 修飾ヒアルロン酸ポリマー組成物および関連する方法
KR101103423B1 (ko) 2009-09-04 2012-01-06 아주대학교산학협력단 생체 주입형 조직 접착성 하이드로젤 및 이의 생의학적 용도
WO2011059326A2 (en) 2009-11-11 2011-05-19 University Of Twente, Institute For Biomedical Technology And Technical Medicine (Mira) Hydrogels based on polymers of dextran tyramine and tyramine conjugates of natural polymers
WO2011059325A2 (en) 2009-11-11 2011-05-19 University Of Twente, Institute For Biomedical Technology And Technical Medicine (Mira) Dextran-hyaluronic acid based hydrogels
US20110111012A1 (en) 2009-11-12 2011-05-12 Hemcon Medical Technologies, Inc. Nanomaterial wound dressing assembly
CZ302504B6 (cs) 2009-12-11 2011-06-22 Contipro C A.S. Derivát kyseliny hyaluronové oxidovaný v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd, zpusob jeho prípravy a zpusob jeho modifikace
CZ2009835A3 (cs) 2009-12-11 2011-06-22 Contipro C A.S. Zpusob prípravy derivátu kyseliny hyaluronové oxidovaného v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd a zpusob jeho modifikace
US8197849B2 (en) 2010-02-12 2012-06-12 National Health Research Institutes Cross-linked oxidated hyaluronic acid for use as a vitreous substitute
CN101897976A (zh) * 2010-07-16 2010-12-01 沈阳药科大学 一种药物增溶载体及其制备方法和应用
CZ20101001A3 (cs) 2010-12-31 2012-02-08 Cpn S.R.O. Hyaluronová vlákna, zpusob jejich prípravy a použití
CZ304072B6 (cs) 2011-04-26 2013-09-25 Contipro Biotech S.R.O. Amfoterní materiál na bázi sítované kyseliny hyaluronové, zpusob jeho prípravy, materiály obsahující aktivní cinidla uzavrené v síti hyaluronanu, zpusob jejich prípravy a jejich pouzití
CN102154738B (zh) 2011-05-10 2012-08-01 青岛大学 一种红藻琼胶纤维的制备方法
ITTO20110428A1 (it) 2011-05-13 2012-11-14 Rottapharm Spa Esteri dell'acido ialuronico, loro preparazione ed uso in dermatologia
ES2657756T3 (es) 2011-10-18 2018-03-06 Heiq Pty Ltd Proceso de formación de fibra y fibras producidas por medio del proceso
CZ2012282A3 (cs) 2012-04-25 2013-11-06 Contipro Biotech S.R.O. Zesítovaný derivát hyaluronanu, zpusob jeho prípravy, hydrogel a mikrovlákna na jeho bázi
CZ304512B6 (cs) 2012-08-08 2014-06-11 Contipro Biotech S.R.O. Derivát kyseliny hyaluronové, způsob jeho přípravy, způsob jeho modifikace a použití
CZ304654B6 (cs) 2012-11-27 2014-08-20 Contipro Biotech S.R.O. Nanomicelární kompozice na bázi C6-C18-acylovaného hyaluronanu, způsob přípravy C6-C18-acylovaného hyaluronanu, způsob přípravy nanomicelární kompozice a stabilizované nanomicelární kompozice a použití
CZ2012841A3 (cs) 2012-11-27 2014-02-19 Contipro Biotech S.R.O. Vlákna založená na hydrofobizovaném hyaluronanu, způsob jejich přípravy a použití, textilie na jejich bázi a použití
CZ304267B6 (cs) 2012-11-27 2014-02-05 Contipro Biotech S.R.O. Fotoreaktivní derivát kyseliny hyaluronové, způsob jeho přípravy, 3D síťovaný derivát kyseliny hyaluronové, způsob jeho přípravy a použití
CN103505736A (zh) 2013-09-23 2014-01-15 天津大学 基于改性透明质酸的高分子脂质体及其制备方法
CZ305153B6 (cs) 2014-03-11 2015-05-20 Contipro Biotech S.R.O. Konjugáty oligomeru kyseliny hyaluronové nebo její soli, způsob jejich přípravy a použití

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004123785A (ja) * 2002-09-30 2004-04-22 Chisso Corp ｎ−アルカノイル化ヒアルロン酸もしくはその塩およびその製造法
WO2007033677A1 (en) * 2005-09-26 2007-03-29 Novozymes Biopolymer A/S Aryl/alkyl succinic anhydride hyaluronan derivatives

Also Published As

Publication number Publication date
CZ2012842A3 (cs) 2014-08-20
RU2640287C2 (ru) 2017-12-27
HUE038664T2 (hu) 2018-11-28
US20150320873A1 (en) 2015-11-12
WO2014082609A1 (en) 2014-06-05
CZ304654B6 (cs) 2014-08-20
BR112015012191A2 (pt) 2017-07-11
US9999678B2 (en) 2018-06-19
EP2934592B1 (en) 2018-05-16
KR20150088848A (ko) 2015-08-03
JP2016500130A (ja) 2016-01-07
EP2934592A1 (en) 2015-10-28
BR112015012191A8 (pt) 2018-01-23
DK2934592T3 (en) 2018-07-02
PL2934592T3 (pl) 2018-12-31
RU2015125076A (ru) 2017-01-13
ES2683993T3 (es) 2018-10-01

Similar Documents

Publication Publication Date Title
KR102191353B1 (ko) 히알루론산의 c6-c18-아실화된 유도체, 이의 제조 방법, 이를 기재로 하는 나노미쉘형 조성물, 이의 제조 방법, 및 안정화된 나노미쉘형 조성물의 제조 방법, 및 이의 용도
Li et al. Redox-sensitive micelles self-assembled from amphiphilic hyaluronic acid-deoxycholic acid conjugates for targeted intracellular delivery of paclitaxel
Zhang et al. A facile approach for dual-responsive prodrug nanogels based on dendritic polyglycerols with minimal leaching
Sun et al. Temperature-sensitive gold nanoparticle-coated pluronic-PLL nanoparticles for drug delivery and chemo-photothermal therapy
Lee et al. Inflammation-responsive drug-conjugated dextran nanoparticles enhance anti-inflammatory drug efficacy
Li et al. Redox-sensitive and intrinsically fluorescent photoclick hyaluronic acid nanogels for traceable and targeted delivery of cytochrome c to breast tumor in mice
Gu et al. Acetal-linked paclitaxel prodrug micellar nanoparticles as a versatile and potent platform for cancer therapy
Jia et al. Multi-functionalized hyaluronic acid nanogels crosslinked with carbon dots as dual receptor-mediated targeting tumor theranostics
Yoon et al. Photo-crosslinked hyaluronic acid nanoparticles with improved stability for in vivo tumor-targeted drug delivery
Luan et al. Hyaluronic-acid-based pH-sensitive nanogels for tumor-targeted drug delivery
Tian et al. The effect of the molecular weight of hyaluronic acid on the physicochemical characterization of hyaluronic acid-curcumin conjugates and in vitro evaluation in glioma cells
Chen et al. Tunable conjugation densities of camptothecin on hyaluronic acid for tumor targeting and reduction-triggered release
Cao et al. Folate-conjugated polyphosphoester with reversible cross-linkage and reduction sensitivity for drug delivery
Huang et al. Hyaluronic acid nanoparticles based on a conjugated oligomer photosensitizer: Target-specific two-photon imaging, redox-sensitive drug delivery, and synergistic chemo-photodynamic therapy
Yin et al. Redox-sensitive hyaluronic acid–paclitaxel conjugate micelles with high physical drug loading for efficient tumor therapy
Huang et al. Amphiphilic prodrug-decorated graphene oxide as a multi-functional drug delivery system for efficient cancer therapy
Sun et al. Robust, active tumor-targeting and fast bioresponsive anticancer nanotherapeutics based on natural endogenous materials
Wang et al. Diselenide-crosslinked carboxymethyl chitosan nanoparticles for doxorubicin delivery: Preparation and in vivo evaluation
Sun et al. Dual-responsive core-crosslinked polyphosphoester-based nanoparticles for pH/redox-triggered anticancer drug delivery
Shirani et al. Redox responsive polymeric micelles of gellan gum/abietic acid for targeted delivery of ribociclib
Razi et al. Self-assembled reduced albumin and glycol chitosan nanoparticles for paclitaxel delivery
Liu et al. A ROS-stimulus-responsive nanocarrier loading with guanidine-modified hydroxycamptothecin prodrug for enhanced anti-tumor efficacy
Zhou et al. Lactosylated PLGA nanoparticles containing ϵ-polylysine for the sustained release and liver-targeted delivery of the negatively charged proteins
Huerta-Ángeles et al. Grafting of steroids to hyaluronan towards the design of delivery systems for antioxidants: The role of hydrophobic core
Liu et al. pH-sensitive dextran-based micelles from copper-free click reaction for antitumor drug delivery

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20150623

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PN2301 Change of applicant

Patent event date: 20170210

Comment text: Notification of Change of Applicant

Patent event code: PN23011R01D

A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20181122

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20200401

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20200915

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20201209

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20201209

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
PR1001 Payment of annual fee

Payment date: 20231102

Start annual number: 4

End annual number: 4