KR102162138B1 - 췌장 내분비 세포에서 mafa 발현을 향상시키기 위한 소분자의 용도 - Google Patents
췌장 내분비 세포에서 mafa 발현을 향상시키기 위한 소분자의 용도 Download PDFInfo
- Publication number
- KR102162138B1 KR102162138B1 KR1020167034809A KR20167034809A KR102162138B1 KR 102162138 B1 KR102162138 B1 KR 102162138B1 KR 1020167034809 A KR1020167034809 A KR 1020167034809A KR 20167034809 A KR20167034809 A KR 20167034809A KR 102162138 B1 KR102162138 B1 KR 102162138B1
- Authority
- KR
- South Korea
- Prior art keywords
- cells
- inhibitor
- stage
- medium
- pancreatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/375—Thyroid stimulating hormone [TSH]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases [EC 2.]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases [EC 2.]
- C12N2501/727—Kinases (EC 2.7.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/22—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from pancreatic cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461994259P | 2014-05-16 | 2014-05-16 | |
| US61/994,259 | 2014-05-16 | ||
| PCT/US2015/029636 WO2015175307A1 (en) | 2014-05-16 | 2015-05-07 | Use of small molecules to enhance mafa expression in pancreatic endocrine cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20170002630A KR20170002630A (ko) | 2017-01-06 |
| KR102162138B1 true KR102162138B1 (ko) | 2020-10-06 |
Family
ID=53264778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020167034809A Active KR102162138B1 (ko) | 2014-05-16 | 2015-05-07 | 췌장 내분비 세포에서 mafa 발현을 향상시키기 위한 소분자의 용도 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US10006006B2 (enExample) |
| EP (2) | EP3143127B1 (enExample) |
| JP (1) | JP6588969B2 (enExample) |
| KR (1) | KR102162138B1 (enExample) |
| CN (2) | CN106414720A (enExample) |
| AR (1) | AR100446A1 (enExample) |
| AU (2) | AU2015259573B2 (enExample) |
| BR (1) | BR112016026626A2 (enExample) |
| CA (1) | CA2949056C (enExample) |
| DK (1) | DK3143127T3 (enExample) |
| MX (1) | MX2016015004A (enExample) |
| PH (1) | PH12016502274A1 (enExample) |
| RU (1) | RU2694311C2 (enExample) |
| SG (2) | SG11201609473XA (enExample) |
| SV (1) | SV2016005319A (enExample) |
| WO (1) | WO2015175307A1 (enExample) |
| ZA (1) | ZA201608681B (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE112014002780B4 (de) | 2013-06-11 | 2025-05-22 | President And Fellows Of Harvard College | SC-ß-Zellen und Zusammensetzungen und Verfahren zur Erzeugung der Zellen |
| JP6588969B2 (ja) * | 2014-05-16 | 2019-10-09 | ヤンセン バイオテツク,インコーポレーテツド | 膵内分泌細胞内のmafa発現を強化するための小分子の使用 |
| WO2016100925A1 (en) * | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | METHODS FOR GENERATING AUGMENTED STEM CELL-DERIVED β CELLS AND USES THEREOF |
| WO2016100909A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | METHODS FOR GENERATING STEM CELL-DERIVED β CELLS AND USES THEREOF |
| WO2016100921A1 (en) * | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | METHODS FOR GENERATING STEM CELL-DERIVED β CELLS AND USES THEREOF |
| CN107614678B (zh) | 2014-12-18 | 2021-04-30 | 哈佛学院校长同事会 | 干细胞来源的β细胞的产生方法及其使用方法 |
| WO2016100898A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived b cells and uses thereof |
| IL293289B2 (en) * | 2015-11-30 | 2024-04-01 | Kadimastem Ltd | Methods for differentiating and purifying pancreatic endocrine cells |
| GB2562406B (en) | 2016-01-12 | 2020-09-02 | Cedars Sinai Medical Center | A method of non destructive monitoring of biological processes in microfluidic tissue culture systems |
| US11473061B2 (en) | 2016-02-01 | 2022-10-18 | Cedars-Sinai Medical Center | Systems and methods for growth of intestinal cells in microfluidic devices |
| MA45747A (fr) | 2016-02-24 | 2019-01-02 | Novo Nordisk As | Génération de cellules bêta fonctionnelles à partir de progéniteurs endocrines dérivés de cellules souhes pluripotentes humaines |
| MA45329A (fr) * | 2016-04-08 | 2019-02-13 | Univ California | Production de cellules bêta matures pleinement fonctionnelles à partir de progénitrices pancréatiques humaines |
| MA45479A (fr) * | 2016-04-14 | 2019-02-20 | Janssen Biotech Inc | Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen |
| MA45502A (fr) * | 2016-06-21 | 2019-04-24 | Janssen Biotech Inc | Génération de cellules bêta fonctionnelles dérivées de cellules souches pluripotentes humaines ayant une respiration mitochondriale glucose-dépendante et une réponse en sécrétion d'insuline en deux phases |
| WO2018002290A1 (en) * | 2016-07-01 | 2018-01-04 | Centre National De La Recherche Scientifique (Cnrs) | Amplifying beta cell differentiation with small molecules bet (bromodomain and extraterminal family of bromodomain-containing proteins) inhibitors |
| AU2016429418B2 (en) | 2016-11-10 | 2023-07-20 | Viacyte, Inc. | PDX1 pancreatic endoderm cells in cell delivery devices and methods thereof |
| US11913022B2 (en) | 2017-01-25 | 2024-02-27 | Cedars-Sinai Medical Center | In vitro induction of mammary-like differentiation from human pluripotent stem cells |
| US11767513B2 (en) | 2017-03-14 | 2023-09-26 | Cedars-Sinai Medical Center | Neuromuscular junction |
| US11414648B2 (en) | 2017-03-24 | 2022-08-16 | Cedars-Sinai Medical Center | Methods and compositions for production of fallopian tube epithelium |
| US10391156B2 (en) | 2017-07-12 | 2019-08-27 | Viacyte, Inc. | University donor cells and related methods |
| WO2019053727A1 (en) * | 2017-09-18 | 2019-03-21 | Ramot At Tel-Aviv University Ltd. | REDIFFERENCING IN VITRO DEVELOPED CELLS FROM HUMAN PANCREATIC ISLAND BEA CELLS ADULPTED BY SMALL MOLECULE INHIBITORS OF THE SIGNALING PATH |
| AU2018370029B2 (en) | 2017-11-15 | 2024-11-07 | Vertex Pharmaceuticals Incorporated | Islet cell manufacturing compositions and methods of use |
| CA3088968C (en) | 2018-01-18 | 2023-10-17 | Daiichi Sankyo Company, Limited | Dihydroindolizinone derivative |
| CN110218696A (zh) * | 2018-03-01 | 2019-09-10 | 中国科学院广州生物医药与健康研究院 | 一种用于化学诱导多能性干细胞生成的培养体系以及使用该培养体系的化学重编程方法 |
| IL277025B2 (en) * | 2018-03-02 | 2024-04-01 | Vertex Pharma | Methods of enhancing stem cell differentiation into beta cells |
| WO2019183597A1 (en) | 2018-03-23 | 2019-09-26 | Cedars-Sinai Medical Center | Methods of use of islet cells |
| US11981918B2 (en) | 2018-04-06 | 2024-05-14 | Cedars-Sinai Medical Center | Differentiation technique to generate dopaminergic neurons from induced pluripotent stem cells |
| WO2019195798A1 (en) | 2018-04-06 | 2019-10-10 | Cedars-Sinai Medical Center | Human pluripotent stem cell derived neurodegenerative disease models on a microfluidic chip |
| AU2019320072A1 (en) | 2018-08-10 | 2021-02-25 | Vertex Pharmaceuticals Incorporated | Stem cell derived islet differentiation |
| US12378572B2 (en) | 2018-09-07 | 2025-08-05 | Crispr Therapeutics Ag | Universal donor cells |
| CN111154711B (zh) * | 2018-11-07 | 2022-08-05 | 杭州瑞普晨创科技有限公司 | JAK2抑制剂在胰岛β细胞诱导分化中的应用 |
| US20220025336A1 (en) * | 2018-11-14 | 2022-01-27 | Kataoka Corporation | Method for producing insulin-producing cells, and composition |
| CN109468277A (zh) * | 2018-12-28 | 2019-03-15 | 诺未科技(北京)有限公司 | 扩增造血干细胞的培养体系、方法及其用途 |
| CN109749986B (zh) * | 2019-03-13 | 2021-04-02 | 武汉大学 | 一种由人多能干细胞分化获得胰腺前体细胞及胰岛β细胞的方法 |
| CA3139292C (en) | 2019-05-31 | 2025-06-10 | Viacyte, Inc. | CELL ENCAPSULATION DEVICES WITH REGULATED OXYGEN DIFFUSION DISTANCES |
| CA3139585C (en) | 2019-05-31 | 2024-01-23 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
| AU2020283056B2 (en) | 2019-05-31 | 2023-06-08 | Viacyte, Inc. | A biocompatible membrane composite |
| US20220234006A1 (en) | 2019-05-31 | 2022-07-28 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
| CN114375300A (zh) | 2019-09-05 | 2022-04-19 | 克里斯珀医疗股份公司 | 通用供体细胞 |
| CA3150233A1 (en) | 2019-09-05 | 2021-03-11 | Alireza Rezania | Universal donor cells |
| WO2021118924A2 (en) | 2019-12-12 | 2021-06-17 | Ting Therapeutics Llc | Compositions and methods for the prevention and treatment of hearing loss |
| EP4189067A4 (en) | 2020-07-31 | 2024-10-23 | Vertex Pharmaceuticals Incorporated | DIFFERENTIATION OF PANCREATIC ENDOCRINE CELLS |
| EP4271399A4 (en) * | 2020-12-29 | 2024-12-18 | Vertex Pharmaceuticals Incorporated | ENHANCED DIFFERENTIATION OF BETA CELLS |
| AU2021414405A1 (en) | 2020-12-31 | 2023-08-10 | Crispr Therapeutics Ag | Universal donor cells |
| WO2023076554A1 (en) * | 2021-10-28 | 2023-05-04 | Memorial Sloan-Kettering Cancer Center | Compositions and methods for promoting in vitro maturation of cells |
| CN114317401B (zh) * | 2021-12-07 | 2022-10-04 | 浙江大学 | 一种促进胰岛前体细胞长期稳定传代的方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010051223A1 (en) * | 2008-10-31 | 2010-05-06 | Centocor Ortho Biotech Inc. | Differentiation of human embryonic stem cells to the pancreatic endocrine lineage |
Family Cites Families (250)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3209652A (en) | 1961-03-30 | 1965-10-05 | Burgsmueller Karl | Thread whirling method |
| AT326803B (de) | 1968-08-26 | 1975-12-29 | Binder Fa G | Maschenware sowie verfahren zur herstellung derselben |
| US3935067A (en) | 1974-11-22 | 1976-01-27 | Wyo-Ben Products, Inc. | Inorganic support for culture media |
| CA1201400A (en) | 1982-04-16 | 1986-03-04 | Joel L. Williams | Chemically specific surfaces for influencing cell activity during culture |
| US4499802A (en) | 1982-09-29 | 1985-02-19 | Container Graphics Corporation | Rotary cutting die with scrap ejection |
| US4537773A (en) | 1983-12-05 | 1985-08-27 | E. I. Du Pont De Nemours And Company | α-Aminoboronic acid derivatives |
| US4557264A (en) | 1984-04-09 | 1985-12-10 | Ethicon Inc. | Surgical filament from polypropylene blended with polyethylene |
| US5215893A (en) | 1985-10-03 | 1993-06-01 | Genentech, Inc. | Nucleic acid encoding the ba chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid |
| US5089396A (en) | 1985-10-03 | 1992-02-18 | Genentech, Inc. | Nucleic acid encoding β chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid |
| US4737578A (en) | 1986-02-10 | 1988-04-12 | The Salk Institute For Biological Studies | Human inhibin |
| US5863531A (en) | 1986-04-18 | 1999-01-26 | Advanced Tissue Sciences, Inc. | In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework |
| CA1340581C (en) | 1986-11-20 | 1999-06-08 | Joseph P. Vacanti | Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices |
| US5567612A (en) | 1986-11-20 | 1996-10-22 | Massachusetts Institute Of Technology | Genitourinary cell-matrix structure for implantation into a human and a method of making |
| US5759830A (en) | 1986-11-20 | 1998-06-02 | Massachusetts Institute Of Technology | Three-dimensional fibrous scaffold containing attached cells for producing vascularized tissue in vivo |
| NZ229354A (en) | 1988-07-01 | 1990-09-26 | Becton Dickinson Co | Treating polymer surfaces with a gas plasma and then applying a layer of endothelial cells to the surface |
| EP0363125A3 (en) | 1988-10-03 | 1990-08-16 | Hana Biologics Inc. | Proliferated pancreatic endocrine cell product and process |
| US5837539A (en) | 1990-11-16 | 1998-11-17 | Osiris Therapeutics, Inc. | Monoclonal antibodies for human mesenchymal stem cells |
| ATE181575T1 (de) | 1991-04-25 | 1999-07-15 | Chugai Pharmaceutical Co Ltd | Rekombinierte humane antikörper gegen den humanen interleukin 6-rezeptor |
| US5449383A (en) | 1992-03-18 | 1995-09-12 | Chatelier; Ronald C. | Cell growth substrates |
| GB9206861D0 (en) | 1992-03-28 | 1992-05-13 | Univ Manchester | Wound healing and treatment of fibrotic disorders |
| CA2114282A1 (en) | 1993-01-28 | 1994-07-29 | Lothar Schilder | Multi-layered implant |
| JP3525221B2 (ja) | 1993-02-17 | 2004-05-10 | 味の素株式会社 | 免疫抑制剤 |
| JP2813467B2 (ja) | 1993-04-08 | 1998-10-22 | ヒューマン・セル・カルチャーズ・インコーポレーテッド | 細胞培養法および培地 |
| US5523226A (en) | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
| GB9310557D0 (en) | 1993-05-21 | 1993-07-07 | Smithkline Beecham Plc | Novel process and apparatus |
| TW257671B (enExample) | 1993-11-19 | 1995-09-21 | Ciba Geigy | |
| US5834308A (en) | 1994-04-28 | 1998-11-10 | University Of Florida Research Foundation, Inc. | In vitro growth of functional islets of Langerhans |
| US6703017B1 (en) | 1994-04-28 | 2004-03-09 | Ixion Biotechnology, Inc. | Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures |
| US6001647A (en) | 1994-04-28 | 1999-12-14 | Ixion Biotechnology, Inc. | In vitro growth of functional islets of Langerhans and in vivo uses thereof |
| US6083903A (en) | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
| US6086874A (en) | 1994-12-29 | 2000-07-11 | Chugai Seiyaku Kabushiki Kaisha | Antitumor agent effect enhancer containing IL-6 antagonist |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5718922A (en) | 1995-05-31 | 1998-02-17 | Schepens Eye Research Institute, Inc. | Intravitreal microsphere drug delivery and method of preparation |
| US5908782A (en) | 1995-06-05 | 1999-06-01 | Osiris Therapeutics, Inc. | Chemically defined medium for human mesenchymal stem cells |
| NZ500447A (en) | 1997-04-24 | 2001-09-28 | Ortho Mcneil Pharm Inc | Substituted imidazoles that inhibit cytokine production and are useful in the treatment of inflammatory disease |
| DE69837491T2 (de) | 1997-07-03 | 2008-01-17 | Osiris Therapeutics, Inc. | Menschliche mesenchymale stammzellen aus peripherem blut |
| PT1538206E (pt) | 1997-09-16 | 2010-04-12 | Centocor Ortho Biotech Inc | Método para a síntese química e construção completa de genes e genomas |
| US6670127B2 (en) | 1997-09-16 | 2003-12-30 | Egea Biosciences, Inc. | Method for assembly of a polynucleotide encoding a target polypeptide |
| AU729377B2 (en) | 1997-10-23 | 2001-02-01 | Asterias Biotherapeutics, Inc. | Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture |
| CO4980885A1 (es) | 1997-12-29 | 2000-11-27 | Ortho Mcneil Pharm Inc | Compuestos de trifenilpropanamida utiles en el tratamiento de inflamaciones y metodos para preparar dicho compuesto |
| PT1066052E (pt) | 1998-03-18 | 2006-06-30 | Osiris Therapeutics Inc | Celulas estaminais mesenquimatosas para a prevencao e tratamento |
| MY132496A (en) | 1998-05-11 | 2007-10-31 | Vertex Pharma | Inhibitors of p38 |
| US6413773B1 (en) | 1998-06-01 | 2002-07-02 | The Regents Of The University Of California | Phosphatidylinositol 3-kinase inhibitors as stimulators of endocrine differentiation |
| US6667176B1 (en) | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
| US7410798B2 (en) | 2001-01-10 | 2008-08-12 | Geron Corporation | Culture system for rapid expansion of human embryonic stem cells |
| US6610540B1 (en) | 1998-11-18 | 2003-08-26 | California Institute Of Technology | Low oxygen culturing of central nervous system progenitor cells |
| US6413556B1 (en) | 1999-01-08 | 2002-07-02 | Sky High, Llc | Aqueous anti-apoptotic compositions |
| CA2359159A1 (en) | 1999-01-21 | 2000-07-27 | Vitro Diagnostics, Inc. | Immortalized cell lines and methods of making the same |
| US6815203B1 (en) | 1999-06-23 | 2004-11-09 | Joslin Diabetes Center, Inc. | Methods of making pancreatic islet cells |
| US6306424B1 (en) | 1999-06-30 | 2001-10-23 | Ethicon, Inc. | Foam composite for the repair or regeneration of tissue |
| US6333029B1 (en) | 1999-06-30 | 2001-12-25 | Ethicon, Inc. | Porous tissue scaffoldings for the repair of regeneration of tissue |
| CA2385628A1 (en) | 1999-09-27 | 2001-04-05 | Ammon B. Peck | Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures |
| US6685936B2 (en) | 1999-10-12 | 2004-02-03 | Osiris Therapeutics, Inc. | Suppressor cells induced by culture with mesenchymal stem cells for treatment of immune responses in transplantation |
| US20030082155A1 (en) | 1999-12-06 | 2003-05-01 | Habener Joel F. | Stem cells of the islets of langerhans and their use in treating diabetes mellitus |
| US6753153B2 (en) | 1999-12-13 | 2004-06-22 | The Scripps Research Institute | Markers for identification and isolation of pancreatic islet α and β progenitors |
| US7439064B2 (en) | 2000-03-09 | 2008-10-21 | Wicell Research Institute, Inc. | Cultivation of human embryonic stem cells in the absence of feeder cells or without conditioned medium |
| US7005252B1 (en) | 2000-03-09 | 2006-02-28 | Wisconsin Alumni Research Foundation | Serum free cultivation of primate embryonic stem cells |
| US6436704B1 (en) | 2000-04-10 | 2002-08-20 | Raven Biotechnologies, Inc. | Human pancreatic epithelial progenitor cells and methods of isolation and use thereof |
| US6458589B1 (en) | 2000-04-27 | 2002-10-01 | Geron Corporation | Hepatocyte lineage cells derived from pluripotent stem cells |
| EP2295539A1 (en) | 2000-06-26 | 2011-03-16 | Nc Medical Research Inc. | Cell fractions containing cells capable of differentiating into neural cells |
| NZ524806A (en) | 2000-10-23 | 2006-03-31 | Smithkline Beecham Corp | Tri-substituted 8H-pyrido[2,3-d]pyrimidin-7-one compounds |
| AU2737102A (en) | 2000-12-08 | 2002-06-18 | Ortho Mcneil Pharm Inc | Macroheterocylic compounds useful as kinase inhibitors |
| MXPA03005140A (es) | 2000-12-08 | 2004-10-15 | Johnson & Johnson | Compuestos de pirrolina sustituidos con indazolilo como inhibidores de cinasa. |
| US6599323B2 (en) | 2000-12-21 | 2003-07-29 | Ethicon, Inc. | Reinforced tissue implants and methods of manufacture and use |
| CA2435826A1 (en) | 2001-01-24 | 2002-08-01 | The Government Of The United States Of America | Differentiation of stem cells to pancreatic endocrine cells |
| TR201819416T4 (tr) | 2001-01-25 | 2019-01-21 | The United States Of America Represented By The Sec Dep Of Health And Human Services | Boronik asit bileşiklerinin formülasyonu. |
| US6656488B2 (en) | 2001-04-11 | 2003-12-02 | Ethicon Endo-Surgery, Inc. | Bioabsorbable bag containing bioabsorbable materials of different bioabsorption rates for tissue engineering |
| EP1379626A2 (en) | 2001-04-19 | 2004-01-14 | DeveloGen Aktiengesellschaft für entwicklungsbiologische Forschung | A method for differentiating stem cells into insulin-producing cells |
| EP1391505B1 (en) | 2001-04-24 | 2009-01-28 | Ajinomoto Co., Inc. | Stem cells and method of separating the same |
| JP2004531262A (ja) | 2001-05-15 | 2004-10-14 | ラッパポート ファミリー インスチチュート フォア リサーチ イン ザ メディカル サイエンシズ | ヒト胚性幹細胞由来インスリン産生細胞 |
| US6626950B2 (en) | 2001-06-28 | 2003-09-30 | Ethicon, Inc. | Composite scaffold with post anchor for the repair and regeneration of tissue |
| KR100418195B1 (ko) | 2001-07-05 | 2004-02-11 | 주식회사 우리기술 | 전력케이블의 다중절연진단장치 및 그 방법 |
| GB0117583D0 (en) | 2001-07-19 | 2001-09-12 | Astrazeneca Ab | Novel compounds |
| CA2456981C (en) | 2001-08-06 | 2012-02-28 | Bresagen, Inc. | Alternative compositions and methods for the culture of stem cells |
| US6617152B2 (en) | 2001-09-04 | 2003-09-09 | Corning Inc | Method for creating a cell growth surface on a polymeric substrate |
| EP1298201A1 (en) | 2001-09-27 | 2003-04-02 | Cardion AG | Process for the production of cells exhibiting an islet-beta-cell-like state |
| JP2005506074A (ja) | 2001-10-18 | 2005-03-03 | イクシオン・バイオテクノロジー・インコーポレーテッド | 肝臓の幹細胞および前駆細胞の膵臓機能細胞への転換 |
| US8021876B2 (en) | 2001-11-15 | 2011-09-20 | Children's Medical Center Corporation | Methods of isolation, expansion and differentiation of fetal stem cells from chorionic villus, amniotic fluid, and placenta and therapeutic uses thereof |
| CN1602351B (zh) | 2001-12-07 | 2011-03-30 | 杰龙公司 | 源自人胚胎干细胞的胰岛细胞 |
| BR0214772A (pt) | 2001-12-07 | 2007-01-09 | Macropore Biosurgery Inc | sistemas e métodos para o tratamento de pacientes com células lipoaspiradas processadas |
| AU2002218893A1 (en) | 2001-12-21 | 2003-07-09 | Thromb-X Nv | Compositions for the in vitro derivation and culture of embryonic stem (es) cell lines with germline transmission capability |
| CN1671835A (zh) | 2001-12-28 | 2005-09-21 | 塞拉提斯股份公司 | 一种建立多能人胚泡衍生的干细胞的方法 |
| US20030162290A1 (en) | 2002-01-25 | 2003-08-28 | Kazutomo Inoue | Method for inducing differentiation of embryonic stem cells into functioning cells |
| JPWO2003087349A1 (ja) | 2002-04-17 | 2005-08-18 | 大塚製薬株式会社 | 間葉系細胞から膵β細胞を形成する方法 |
| US20040161419A1 (en) | 2002-04-19 | 2004-08-19 | Strom Stephen C. | Placental stem cells and uses thereof |
| AU2003225295A1 (en) | 2002-05-08 | 2003-11-11 | Janssen Pharmaceutica N.V. | Substituted pyrroline kinase inhibitors |
| US20060003446A1 (en) | 2002-05-17 | 2006-01-05 | Gordon Keller | Mesoderm and definitive endoderm cell populations |
| WO2003102134A2 (en) | 2002-05-28 | 2003-12-11 | Becton, Dickinson And Company | Pancreatic acinar cells into insulin producing cells |
| US6987110B2 (en) | 2002-06-05 | 2006-01-17 | Janssen Pharmaceutica N.V. | Substituted pyrrolines as kinase inhibitors |
| GB0212976D0 (en) | 2002-06-06 | 2002-07-17 | Tonejet Corp Pty Ltd | Ejection method and apparatus |
| CN1171991C (zh) | 2002-07-08 | 2004-10-20 | 徐如祥 | 人神经干细胞的培养方法 |
| US6877147B2 (en) | 2002-07-22 | 2005-04-05 | Broadcom Corporation | Technique to assess timing delay by use of layout quality analyzer comparison |
| US7838290B2 (en) | 2002-07-25 | 2010-11-23 | The Scripps Research Institute | Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith |
| JP2005534345A (ja) | 2002-07-29 | 2005-11-17 | エス セル インターナショナル ピーティーイー リミテッド | インスリン陽性、グルコース応答性細胞の分化のための多段階方法 |
| AU2003262628A1 (en) | 2002-08-14 | 2004-03-03 | University Of Florida | Bone marrow cell differentiation |
| US7371576B2 (en) | 2002-09-06 | 2008-05-13 | Reneuron, Inc. | CD56 positive human adult pancreatic endocrine progenitor cells |
| US9969977B2 (en) | 2002-09-20 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
| US20040062753A1 (en) | 2002-09-27 | 2004-04-01 | Alireza Rezania | Composite scaffolds seeded with mammalian cells |
| AU2003285172A1 (en) | 2002-11-08 | 2004-06-03 | The Johns Hopkins University | Human embryonic stem cell cultures, and compositions and methods for growing same |
| US7144999B2 (en) | 2002-11-23 | 2006-12-05 | Isis Pharmaceuticals, Inc. | Modulation of hypoxia-inducible factor 1 alpha expression |
| EP1567639A4 (en) | 2002-12-05 | 2005-12-21 | Technion Res & Dev Foundation | CULTURE OF HUMAN PANCREATIC ISLANDS AND USES THEREOF |
| PT2457999T (pt) | 2002-12-16 | 2019-01-28 | Technion Res & Dev Foundation | Sistema de cultura para células estaminais pluripotentes |
| RU2359671C2 (ru) | 2003-01-29 | 2009-06-27 | Такеда Фармасьютикал Компани Лимитед | Способ получения препарата с покрытием |
| CA2514539C (en) | 2003-01-29 | 2012-03-06 | Takeda Pharmaceutical Company Limited | Process for producing coated preparation |
| US20070155661A1 (en) | 2003-02-14 | 2007-07-05 | The Board Of Trustees Of The Leland Standord Junior University | Methods and compositions for modulating the development of stem cells |
| US20070154981A1 (en) | 2003-02-14 | 2007-07-05 | The Board Of Trustees Of The Leland Stanford Junior University | Insulin-producing cells derived from stem cells |
| US20070020242A1 (en) | 2003-03-27 | 2007-01-25 | Ixion Biotechnology, Inc. | Method for transdifferentiation of non-pancreatic stem cells to the pancreatic pathway |
| WO2004090110A2 (en) | 2003-03-31 | 2004-10-21 | Bresagen Inc. | Compositions and methods for the control, differentiation and/or manipulation of pluripotent cells through a gamma-secretase signaling pathway |
| US20090203141A1 (en) | 2003-05-15 | 2009-08-13 | Shi-Lung Lin | Generation of tumor-free embryonic stem-like pluripotent cells using inducible recombinant RNA agents |
| PL1641916T3 (pl) | 2003-06-27 | 2016-08-31 | Depuy Synthes Products Inc | Regeneracja i naprawa tkanki nerwowej z wykorzystaniem komórek poporodowych |
| IL161903A0 (en) | 2003-07-17 | 2005-11-20 | Gamida Cell Ltd | Ex vivo progenitor and stem cell expansion for usein the treatment of disease of endodermally- deri ved organs |
| ITRM20030395A1 (it) | 2003-08-12 | 2005-02-13 | Istituto Naz Per Le Malattie Infettive Lazz | Terreno di coltura per il mantenimento, la proliferazione e il differenziamento di cellule di mammifero. |
| US7569385B2 (en) | 2003-08-14 | 2009-08-04 | The Regents Of The University Of California | Multipotent amniotic fetal stem cells |
| US7157275B2 (en) | 2003-08-15 | 2007-01-02 | Becton, Dickinson And Company | Peptides for enhanced cell attachment and growth |
| WO2005021728A2 (en) | 2003-08-27 | 2005-03-10 | Stemcells California, Inc. | Enriched pancreatic stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for these populations |
| US7468391B2 (en) | 2003-12-17 | 2008-12-23 | Allergan, Inc. | Methods for treating retinoid responsive disorders using selective inhibitors of CYP26A and CYP26B |
| US20060030042A1 (en) | 2003-12-19 | 2006-02-09 | Ali Brivanlou | Maintenance of embryonic stem cells by the GSK-3 inhibitor 6-bromoindirubin-3'-oxime |
| US20050266554A1 (en) | 2004-04-27 | 2005-12-01 | D Amour Kevin A | PDX1 expressing endoderm |
| US7625753B2 (en) | 2003-12-23 | 2009-12-01 | Cythera, Inc. | Expansion of definitive endoderm cells |
| SG149061A1 (en) | 2003-12-23 | 2009-01-29 | Cythera Inc | Definitive endoderm |
| CN112813019A (zh) | 2003-12-23 | 2021-05-18 | 维亚希特公司 | 定形内胚层 |
| TWI334443B (en) | 2003-12-31 | 2010-12-11 | Ind Tech Res Inst | Method of single cell culture of undifferentiated human embryonic stem cells |
| US20050233446A1 (en) | 2003-12-31 | 2005-10-20 | Parsons Xuejun H | Defined media for stem cell culture |
| US7794704B2 (en) | 2004-01-23 | 2010-09-14 | Advanced Cell Technology, Inc. | Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration |
| WO2005071066A1 (en) | 2004-01-23 | 2005-08-04 | Board Of Regents, The University Of Texas System | Methods and compositions for preparing pancreatic insulin secreting cells |
| WO2005080551A2 (en) | 2004-02-12 | 2005-09-01 | University Of Newcastle Upon Tyne | Stem cells |
| JP4901471B2 (ja) | 2004-02-19 | 2012-03-21 | 国立大学法人京都大学 | 体細胞核初期化物質のスクリーニング方法 |
| WO2005086860A2 (en) | 2004-03-09 | 2005-09-22 | Gang Xu | Methods for generating insulin-producing cells |
| EP1730261A4 (en) | 2004-03-10 | 2007-11-28 | Univ California | COMPOSITIONS AND METHODS FOR GROWING EMBRYONIC STEM CELLS |
| CA2560581C (en) | 2004-03-23 | 2013-06-11 | Toshihiro Akaike | Pluripotent stem cell growing method |
| WO2005097980A2 (en) | 2004-03-26 | 2005-10-20 | Geron Corporation | New protocols for making hepatocytes from embryonic stem cells |
| JP4491014B2 (ja) | 2004-04-01 | 2010-06-30 | ウイスコンシン アラムニ リサーチ ファンデーション | 幹細胞の内胚葉および膵臓系統への分化 |
| DK1740612T3 (da) | 2004-04-27 | 2019-10-07 | Viacyte Inc | Pdx1 udtrykkende endoderm |
| WO2006016999A1 (en) | 2004-07-09 | 2006-02-16 | Cythera, Inc. | Methods for identifying factors for differentiating definitive endoderm |
| CA2576872C (en) | 2004-08-13 | 2013-11-12 | University Of Georgia Research Foundation, Inc. | Compositions and methods for self-renewal and differentiation in human embryonic stem cells |
| WO2006026473A2 (en) | 2004-08-25 | 2006-03-09 | University Of Georgia Research Foundation, Inc. | METHODS AND COMPOSITIONS UTILIZING MYC AND GSK3ß TO MANIPULATE THE PLURIPOTENCY OF EMBRYONIC STEM CELLS |
| DE102004043256B4 (de) | 2004-09-07 | 2013-09-19 | Rheinische Friedrich-Wilhelms-Universität Bonn | Skalierbarer Prozess zur Kultivierung undifferenzierter Stammzellen in Suspension |
| GB2432846B (en) | 2004-09-08 | 2009-12-30 | Wisconsin Alumni Res Found | Medium and culture of embryonic stem cells |
| US7442548B2 (en) | 2004-09-08 | 2008-10-28 | Wisconsin Alumni Research Foundation | Culturing human embryonic stem cells in medium containing pipecholic acid and gamma amino butyric acid |
| GB2437689B (en) | 2005-01-28 | 2009-10-28 | Novathera Ltd | Culture and screening methods |
| US20060194321A1 (en) | 2005-01-31 | 2006-08-31 | Alan Colman | Directed differentiation of embryonic stem cells and uses thereof |
| ES2627419T3 (es) | 2005-03-04 | 2017-07-28 | Lifescan, Inc. | Células estromales adultas derivadas del páncreas |
| GB0505970D0 (en) | 2005-03-23 | 2005-04-27 | Univ Edinburgh | Culture medium containing kinase inhibitor, and uses thereof |
| CN101589137B (zh) | 2005-03-31 | 2013-06-05 | 斯丹姆涅恩有限公司 | 羊膜来源的细胞组合物及其制备方法和用途 |
| WO2006113470A2 (en) | 2005-04-15 | 2006-10-26 | Geron Corporation | Cancer treatment by combined inhibition of proteasome and telomerase activities |
| CN100425694C (zh) | 2005-04-15 | 2008-10-15 | 北京大学 | 诱导胚胎干细胞向胰腺细胞分化的方法 |
| WO2006114097A2 (en) | 2005-04-26 | 2006-11-02 | Aarhus Universitet | Biosurface structure array |
| AU2006202209B2 (en) | 2005-05-27 | 2011-04-14 | Lifescan, Inc. | Amniotic fluid derived cells |
| CN101238129A (zh) | 2005-06-10 | 2008-08-06 | Irm责任有限公司 | 维持胚胎干细胞多能性的化合物 |
| WO2006138433A2 (en) | 2005-06-14 | 2006-12-28 | The Regents Of The University Of California | Induction of cell differentiation by class i bhlh polypeptides |
| EP1931764A1 (en) | 2005-06-21 | 2008-06-18 | GE Healthcare Bio-Sciences AB | Method for cell culture |
| KR20130100221A (ko) | 2005-06-22 | 2013-09-09 | 제론 코포레이션 | 인간 배아 줄기 세포의 현탁 배양 |
| BRPI0612888B8 (pt) | 2005-06-30 | 2022-12-27 | Janssen Pharmaceutica Nv | anilino-piridinotriazinas cíclicas como inibidoras de gsk-3, seus usos e composição farmacêutica, intermediário, seu uso e composição farmacêutica |
| WO2007012144A1 (en) | 2005-07-29 | 2007-02-01 | Australian Stem Cell Centre Limited | Compositions and methods for growth of pluripotent cells |
| US20080194021A1 (en) | 2005-07-29 | 2008-08-14 | Mays Robert W | Use of a Gsk-3 Inhibitor to Maintain Potency of Culture Cells |
| WO2007025234A2 (en) | 2005-08-26 | 2007-03-01 | The Trustees Of Columbia University In The City Of New York | Generation of pancreatic endocrine cells from primary duct cell cultures and methods of use for treatment of diabetes |
| EP3354723B1 (en) | 2005-08-29 | 2023-12-13 | Technion Research & Development Foundation Ltd. | Media for culturing stem cells |
| KR20080056181A (ko) | 2005-09-02 | 2008-06-20 | 에이전시 포 사이언스, 테크놀로지 앤드 리서치 | 전구세포주의 유도 방법 |
| AU2006292021B2 (en) | 2005-09-12 | 2012-05-31 | Es Cell International Pte Ltd. | Cardiomyocyte production |
| EP1941032A2 (en) | 2005-10-14 | 2008-07-09 | Regents Of The University Of Minnesota | Differentiation of non-embryonic stem cells to cells having a pancreatic phenotype |
| ES2743202T3 (es) | 2005-10-27 | 2020-02-18 | Viacyte Inc | Endodermo de intestino proximal dorsal y ventral que expresa PDX1 |
| CN101864392B (zh) | 2005-12-13 | 2016-03-23 | 国立大学法人京都大学 | 核重新编程因子 |
| WO2007082963A1 (es) | 2006-01-18 | 2007-07-26 | Fundación Instituto Valenciano De Infertilidad | Líneas de células madre embrionarias humanas y métodos para usar las mismas |
| CA2643478C (en) | 2006-02-23 | 2019-06-18 | Novocell, Inc. | Compositions and methods useful for culturing differentiable cells |
| US7695965B2 (en) | 2006-03-02 | 2010-04-13 | Cythera, Inc. | Methods of producing pancreatic hormones |
| EP4112718A1 (en) | 2006-03-02 | 2023-01-04 | ViaCyte, Inc. | Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production |
| US8741643B2 (en) | 2006-04-28 | 2014-06-03 | Lifescan, Inc. | Differentiation of pluripotent stem cells to definitive endoderm lineage |
| EP2021462B1 (en) | 2006-04-28 | 2019-01-09 | Lifescan, Inc. | Differentiation of human embryonic stem cells |
| SE534150C2 (sv) | 2006-05-02 | 2011-05-10 | Wisconsin Alumni Res Found | Förfarande för differentiering av stamceller till celler av den endodermala och pankreatiska utvecklingslinjen |
| US8685730B2 (en) | 2006-05-02 | 2014-04-01 | Wisconsin Alumni Research Foundation | Methods and devices for differentiating pluripotent stem cells into cells of the pancreatic lineage |
| WO2007139929A2 (en) | 2006-05-25 | 2007-12-06 | The Burnham Institute For Medical Research | Methods for culture and production of single cell populations of human embryonic stem cells |
| CA2654196A1 (en) | 2006-06-02 | 2007-12-13 | University Of Georgia Research Foundation, Inc. | Pancreatic and liver endoderm cells and tissue by differentiation of definitive endoderm cells obtained from human embryonic stems |
| CN101541953A (zh) | 2006-06-02 | 2009-09-23 | 佐治亚大学研究基金会 | 通过从人胚胎干细胞获得的定形内胚层细胞的分化得到胰和肝内胚层细胞及组织 |
| US8415153B2 (en) | 2006-06-19 | 2013-04-09 | Geron Corporation | Differentiation and enrichment of islet-like cells from human pluripotent stem cells |
| CN100494359C (zh) | 2006-06-23 | 2009-06-03 | 中日友好医院 | 神经干细胞三维立体培养体外扩增的方法 |
| CA2893679C (en) | 2006-06-26 | 2018-10-30 | Lifescan, Inc. | Conditioned medium for pluripotent stem cell culture |
| US20080003676A1 (en) | 2006-06-26 | 2008-01-03 | Millipore Corporation | Growth of embryonic stem cells |
| GB2454386B (en) | 2006-07-06 | 2011-07-06 | Es Cell Int Pte Ltd | Method for embryonic stem cell culture on a positively charged support surface |
| AU2007277364B2 (en) | 2006-07-26 | 2010-08-12 | Viacyte, Inc. | Methods of producing pancreatic hormones |
| EP2733203B1 (en) | 2006-08-02 | 2018-10-10 | Technion Research & Development Foundation Ltd. | Methods of expanding embryonic stem cells in a suspension culture |
| KR101331510B1 (ko) | 2006-08-30 | 2013-11-20 | 재단법인서울대학교산학협력재단 | 저농도의 포도당을 함유하는 인간 배아줄기세포용 배지조성물 및 이를 이용한 인간 배아 줄기세포로부터 인슐린생산 세포 또는 세포괴로 분화시키는 방법, 그리고그로부터 유도된 인슐린 생산 세포 또는 세포괴 |
| JP2008099662A (ja) | 2006-09-22 | 2008-05-01 | Institute Of Physical & Chemical Research | 幹細胞の培養方法 |
| US20080091234A1 (en) | 2006-09-26 | 2008-04-17 | Kladakis Stephanie M | Method for modifying a medical implant surface for promoting tissue growth |
| WO2008048647A1 (en) | 2006-10-17 | 2008-04-24 | Cythera, Inc. | Modulation of the phosphatidylinositol-3-kinase pathway in the differentiation of human embryonic stem cells |
| AU2007311026B2 (en) | 2006-10-17 | 2012-05-17 | Stiefel Laboratories, Inc. | Talarazole metabolites |
| CA2666789C (en) | 2006-10-18 | 2016-11-22 | Yong Zhao | Embryonic-like stem cells derived from adult human peripheral blood and methods of use |
| JP5067949B2 (ja) | 2006-11-09 | 2012-11-07 | 独立行政法人国立国際医療研究センター | 霊長類動物胚性幹細胞の培養及び継代方法、並びにその分化誘導方法 |
| WO2008086005A1 (en) | 2007-01-09 | 2008-07-17 | University Of South Florida | Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof |
| CN101641436A (zh) | 2007-01-30 | 2010-02-03 | 佐治亚大学研究基金会 | 用于产生内胚层和中胚层细胞系及多能游走细胞(mmc)的早期中胚层细胞即稳定的中内胚层细胞群 |
| GB0703188D0 (en) | 2007-02-19 | 2007-03-28 | Roger Land Building | Large scale production of stem cells |
| US20090053182A1 (en) | 2007-05-25 | 2009-02-26 | Medistem Laboratories, Inc. | Endometrial stem cells and methods of making and using same |
| DK2173863T3 (en) | 2007-06-29 | 2019-01-21 | Fujifilm Cellular Dynamics Inc | Automated method and apparatus for embryonic stem cell culture |
| EP3957716A1 (en) | 2007-07-18 | 2022-02-23 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| PL2185691T3 (pl) | 2007-07-31 | 2018-08-31 | Lifescan, Inc. | Różnicowanie pluripotencjalnych komórek macierzystych poprzez zastosowanie ludzkich komórek odżywczych |
| CA2695225C (en) | 2007-07-31 | 2021-06-01 | Lifescan, Inc. | Differentiation of human embryonic stem cells to pancreatic endocrine |
| CA2696622C (en) | 2007-08-24 | 2016-07-19 | Stichting Het Nederlands Kanker Instituut | Compositions for the treatment of neoplastic diseases |
| WO2009061442A1 (en) | 2007-11-06 | 2009-05-14 | Children's Medical Center Corporation | Method to produce induced pluripotent stem (ips) cells form non-embryonic human cells |
| CA2954431C (en) | 2007-11-27 | 2021-08-24 | Lifescan, Inc. | Differentiation of human embryonic stem cells to pancreatic cells |
| SG154367A1 (en) | 2008-01-31 | 2009-08-28 | Es Cell Int Pte Ltd | Method of differentiating stem cells |
| WO2009096049A1 (ja) | 2008-02-01 | 2009-08-06 | Kyoto University | 人工多能性幹細胞由来分化細胞 |
| EP2250252A2 (en) | 2008-02-11 | 2010-11-17 | Cambridge Enterprise Limited | Improved reprogramming of mammalian cells, and the cells obtained |
| CN102046779A (zh) | 2008-02-21 | 2011-05-04 | 森托科尔奥索生物科技公司 | 用于细胞粘附、培养和分离的方法、表面改性培养板和组合物 |
| WO2009110215A1 (ja) | 2008-03-03 | 2009-09-11 | 独立行政法人 科学技術振興機構 | 繊毛細胞の分化誘導方法 |
| WO2009116951A2 (en) | 2008-03-17 | 2009-09-24 | Agency For Science, Technology And Research | Microcarriers for stem cell culture |
| EP2727998B1 (en) | 2008-04-21 | 2019-06-12 | Viacyte, Inc. | Methods for purifying pancreatic endoderm cells derived from human embryonic stem cells |
| US8338170B2 (en) | 2008-04-21 | 2012-12-25 | Viacyte, Inc. | Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells |
| WO2009132083A2 (en) | 2008-04-22 | 2009-10-29 | President And Fellows Of Harvard College | Compositions and methods for promoting the generation of pdx1+ pancreatic cells |
| US7939322B2 (en) | 2008-04-24 | 2011-05-10 | Centocor Ortho Biotech Inc. | Cells expressing pluripotency markers and expressing markers characteristic of the definitive endoderm |
| US8623648B2 (en) | 2008-04-24 | 2014-01-07 | Janssen Biotech, Inc. | Treatment of pluripotent cells |
| US20090298178A1 (en) | 2008-06-03 | 2009-12-03 | D Amour Kevin Allen | Growth factors for production of definitive endoderm |
| WO2009154606A1 (en) | 2008-06-03 | 2009-12-23 | Cythera, Inc. | Growth factors for production of definitive endoderm |
| EP2942392B1 (en) | 2008-06-30 | 2018-10-03 | Janssen Biotech, Inc. | Differentiation of pluripotent stem cells |
| RU2011103183A (ru) | 2008-06-30 | 2012-08-10 | Сентокор Орто Байотек Инк. (Us) | Дифференцирование плюрипотентных стволовых клеток |
| DE102008032236A1 (de) | 2008-06-30 | 2010-04-01 | Eberhard-Karls-Universität Tübingen | Isolierung und/oder Identifizierung von Stammzellen mit adipozytärem, chondrozytärem und pankreatischem Differenzierungspotential |
| US20100028307A1 (en) | 2008-07-31 | 2010-02-04 | O'neil John J | Pluripotent stem cell differentiation |
| ES2727950T3 (es) | 2008-10-31 | 2019-10-21 | Janssen Biotech Inc | Diferenciación de células madre embrionarias humanas en linaje endocrino pancreático |
| IL320421A (en) | 2008-11-04 | 2025-06-01 | Viacyte Inc | Stem cell aggregate suspension compositions and methods for differentiation thereof |
| US8008075B2 (en) | 2008-11-04 | 2011-08-30 | Viacyte, Inc. | Stem cell aggregate suspension compositions and methods of differentiation thereof |
| AU2009313870B2 (en) | 2008-11-14 | 2013-07-11 | Viacyte, Inc. | Encapsulation of pancreatic cells derived from human pluripotent stem cells |
| KR101774546B1 (ko) | 2008-11-20 | 2017-09-04 | 얀센 바이오테크 인코포레이티드 | 마이크로-캐리어 상의 만능 줄기 세포 배양 |
| JP5604766B2 (ja) | 2008-12-05 | 2014-10-15 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 多能性細胞の神経分化のための方法および培地 |
| CN103952372B (zh) | 2009-07-20 | 2016-10-05 | 詹森生物科技公司 | 人胚胎干细胞的分化 |
| BR112012001480A2 (pt) | 2009-07-20 | 2015-09-01 | Janssen Biotech Inc | Diferenciação de células-tronco embriônicas humanas |
| PL2494035T3 (pl) | 2009-10-29 | 2018-07-31 | Janssen Biotech, Inc. | Pluripotencjalne komórki macierzyste |
| FI20096288A0 (fi) | 2009-12-04 | 2009-12-04 | Kristiina Rajala | Formulations and methods for culturing stem cells |
| ES2633648T3 (es) * | 2009-12-23 | 2017-09-22 | Janssen Biotech, Inc. | Diferenciación de células madre embrionarias humanas |
| MX343786B (es) | 2009-12-23 | 2016-11-22 | Janssen Biotech Inc | Diferenciacion de celulas madre embrionarias humanas. |
| EP2505639B1 (en) | 2009-12-29 | 2018-09-19 | Takeda Pharmaceutical Company Limited | Method for manufacturing pancreatic-hormone-producing cells |
| CA2791846A1 (en) | 2010-03-02 | 2011-09-09 | National University Of Singapore | Culture additives to boost stem cell proliferation and differentiation response |
| ES2624780T3 (es) | 2010-03-31 | 2017-07-17 | The Scripps Research Institute | Reprogramación de células |
| CN103068970A (zh) | 2010-04-25 | 2013-04-24 | 西奈山医学院 | 来自多能细胞的前部前肠内胚层的形成 |
| EP3498825A1 (en) | 2010-05-12 | 2019-06-19 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| US9085757B2 (en) | 2010-06-17 | 2015-07-21 | Regents Of The University Of Minnesota | Production of insulin producing cells |
| CN108531444A (zh) | 2010-08-05 | 2018-09-14 | 威斯康星校友研究基金会 | 用于人多能细胞培养的简化基础培养基 |
| NZ607608A (en) | 2010-08-09 | 2014-03-28 | Takeda Pharmaceuticals Co | Method of producing pancreatic hormone-producing cells |
| ES2585028T3 (es) | 2010-08-31 | 2016-10-03 | Janssen Biotech, Inc. | Diferenciación de células madre pluripotentes |
| MY177150A (en) | 2011-02-28 | 2020-09-08 | Stempeutics Res Malaysia Sdn Bhd | Isolation and expansion of adult stem cells, their therapeutic composition and uses thereof |
| US20130274184A1 (en) | 2011-10-11 | 2013-10-17 | The Trustees Of Columbia University In The City Of New York | Er stress relievers in beta cell protection |
| WO2013055397A1 (en) * | 2011-10-14 | 2013-04-18 | Children's Medical Center Corporation | Inhibition and enhancement of reprogramming by chromatin modifying enzymes |
| MX2014007744A (es) * | 2011-12-22 | 2015-01-12 | Janssen Biotech Inc | Diferenciacion de celulas madre embrionicas humanas en celulas individuales positivas de insulina hormonal. |
| US10519422B2 (en) | 2012-02-29 | 2019-12-31 | Riken | Method of producing human retinal pigment epithelial cells |
| DK3450542T3 (da) | 2012-06-08 | 2021-11-01 | Janssen Biotech Inc | Differentiering af humane embryonale stamceller til endokrine pancreatiske celler |
| WO2014033322A1 (en) * | 2012-09-03 | 2014-03-06 | Novo Nordisk A/S | Generation of pancreatic endoderm from pluripotent stem cells using small molecules |
| US10344264B2 (en) | 2012-12-31 | 2019-07-09 | Janssen Biotech, Inc. | Culturing of human embryonic stem cells at the air-liquid interface for differentiation into pancreatic endocrine cells |
| ES2942484T3 (es) | 2012-12-31 | 2023-06-01 | Janssen Biotech Inc | Diferenciación de células madre embrionarias humanas en células endocrinas pancreáticas usando reguladores de HB9 |
| US8859286B2 (en) | 2013-03-14 | 2014-10-14 | Viacyte, Inc. | In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells |
| EP2970892A1 (en) | 2013-03-15 | 2016-01-20 | The Jackson Laboratory | Isolation of non-embryonic stem cells and uses thereof |
| DE112014002780B4 (de) | 2013-06-11 | 2025-05-22 | President And Fellows Of Harvard College | SC-ß-Zellen und Zusammensetzungen und Verfahren zur Erzeugung der Zellen |
| JP6588969B2 (ja) * | 2014-05-16 | 2019-10-09 | ヤンセン バイオテツク,インコーポレーテツド | 膵内分泌細胞内のmafa発現を強化するための小分子の使用 |
| MA45747A (fr) | 2016-02-24 | 2019-01-02 | Novo Nordisk As | Génération de cellules bêta fonctionnelles à partir de progéniteurs endocrines dérivés de cellules souhes pluripotentes humaines |
-
2015
- 2015-05-07 JP JP2017512643A patent/JP6588969B2/ja active Active
- 2015-05-07 AU AU2015259573A patent/AU2015259573B2/en active Active
- 2015-05-07 CN CN201580026042.5A patent/CN106414720A/zh active Pending
- 2015-05-07 DK DK15724442.7T patent/DK3143127T3/da active
- 2015-05-07 EP EP15724442.7A patent/EP3143127B1/en active Active
- 2015-05-07 BR BR112016026626A patent/BR112016026626A2/pt not_active IP Right Cessation
- 2015-05-07 WO PCT/US2015/029636 patent/WO2015175307A1/en not_active Ceased
- 2015-05-07 SG SG11201609473XA patent/SG11201609473XA/en unknown
- 2015-05-07 RU RU2016149126A patent/RU2694311C2/ru active
- 2015-05-07 US US14/706,310 patent/US10006006B2/en active Active
- 2015-05-07 KR KR1020167034809A patent/KR102162138B1/ko active Active
- 2015-05-07 SG SG10201810739VA patent/SG10201810739VA/en unknown
- 2015-05-07 EP EP21184754.6A patent/EP3954759A1/en active Pending
- 2015-05-07 CA CA2949056A patent/CA2949056C/en active Active
- 2015-05-07 MX MX2016015004A patent/MX2016015004A/es unknown
- 2015-05-07 CN CN202311485003.4A patent/CN117821369A/zh active Pending
- 2015-05-14 AR ARP150101504A patent/AR100446A1/es unknown
-
2016
- 2016-11-15 PH PH12016502274A patent/PH12016502274A1/en unknown
- 2016-11-16 SV SV2016005319A patent/SV2016005319A/es unknown
- 2016-12-15 ZA ZA2016/08681A patent/ZA201608681B/en unknown
-
2018
- 2018-06-13 US US16/007,600 patent/US10870832B2/en active Active
-
2020
- 2020-11-17 US US16/950,244 patent/US11981929B2/en active Active
-
2021
- 2021-06-16 AU AU2021203995A patent/AU2021203995B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010051223A1 (en) * | 2008-10-31 | 2010-05-06 | Centocor Ortho Biotech Inc. | Differentiation of human embryonic stem cells to the pancreatic endocrine lineage |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR102162138B1 (ko) | 췌장 내분비 세포에서 mafa 발현을 향상시키기 위한 소분자의 용도 | |
| JP7278990B2 (ja) | Hb9調節物を用いたヒト胚性幹細胞の膵臓内分泌細胞への分化 | |
| KR102084561B1 (ko) | 췌장 내분비 세포로의 분화를 위한 공기-액체 계면에서의 인간 배아 줄기세포의 배양 | |
| CN103154237B (zh) | 多能干细胞的分化 | |
| US20170081634A1 (en) | Differentiation of human embryonic stem cells | |
| CA3253251A1 (en) | Use of small molecules to enhance mafa expression in pancreatic endocrine cells |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
St.27 status event code: A-0-1-A10-A15-nap-PA0105 |
|
| PG1501 | Laying open of application |
St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
|
| A201 | Request for examination | ||
| A302 | Request for accelerated examination | ||
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| PA0201 | Request for examination |
St.27 status event code: A-1-2-D10-D11-exm-PA0201 |
|
| PA0302 | Request for accelerated examination |
St.27 status event code: A-1-2-D10-D17-exm-PA0302 St.27 status event code: A-1-2-D10-D16-exm-PA0302 |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
St.27 status event code: A-1-2-D10-D21-exm-PE0902 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
St.27 status event code: A-1-2-D10-D22-exm-PE0701 |
|
| GRNT | Written decision to grant | ||
| PR0701 | Registration of establishment |
St.27 status event code: A-2-4-F10-F11-exm-PR0701 |
|
| PR1002 | Payment of registration fee |
St.27 status event code: A-2-2-U10-U12-oth-PR1002 Fee payment year number: 1 |
|
| PG1601 | Publication of registration |
St.27 status event code: A-4-4-Q10-Q13-nap-PG1601 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 4 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 5 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 6 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-OTH-PR1001 (AS PROVIDED BY THE NATIONAL OFFICE) Year of fee payment: 6 |