KR102053487B1 - 혈액 샘플에서의 입자 분석을 위한 시스 유체 시스템 및 방법 - Google Patents
혈액 샘플에서의 입자 분석을 위한 시스 유체 시스템 및 방법 Download PDFInfo
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- KR102053487B1 KR102053487B1 KR1020157024436A KR20157024436A KR102053487B1 KR 102053487 B1 KR102053487 B1 KR 102053487B1 KR 1020157024436 A KR1020157024436 A KR 1020157024436A KR 20157024436 A KR20157024436 A KR 20157024436A KR 102053487 B1 KR102053487 B1 KR 102053487B1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1404—Handling flow, e.g. hydrodynamic focusing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1429—Signal processing
- G01N15/1433—Signal processing using image recognition
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1434—Optical arrangements
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1434—Optical arrangements
- G01N15/1436—Optical arrangements the optical arrangement forming an integrated apparatus with the sample container, e.g. a flow cell
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
- G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
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- G01N15/1463—
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
- G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
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- G01N15/1475—
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/05—Flow-through cuvettes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4915—Blood using flow cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1404—Handling flow, e.g. hydrodynamic focusing
- G01N15/1409—Handling samples, e.g. injecting samples
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
- G01N2015/012—Red blood cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
- G01N2015/016—White blood cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
- G01N2015/018—Platelets
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1019—Associating Coulter-counter and optical flow cytometer [OFC]
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1404—Handling flow, e.g. hydrodynamic focusing
- G01N15/1409—Handling samples, e.g. injecting samples
- G01N2015/1411—Features of sheath fluids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1404—Handling flow, e.g. hydrodynamic focusing
- G01N2015/1413—Hydrodynamic focussing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1434—Optical arrangements
- G01N2015/1452—Adjustment of focus; Alignment
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1486—Counting the particles
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/05—Flow-through cuvettes
- G01N2021/058—Flat flow cell
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/12—Circuits of general importance; Signal processing
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Ecology (AREA)
- Biophysics (AREA)
- Signal Processing (AREA)
- Cell Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Physiology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Optical Measuring Cells (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361799152P | 2013-03-15 | 2013-03-15 | |
| US61/799,152 | 2013-03-15 | ||
| PCT/US2014/030850 WO2014145983A1 (en) | 2013-03-15 | 2014-03-17 | Sheath fluid systems and methods for particle analysis in blood samples |
| US14/215,834 | 2014-03-17 | ||
| US14/215,834 US9316635B2 (en) | 2013-03-15 | 2014-03-17 | Sheath fluid systems and methods for particle analysis in blood samples |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20150129706A KR20150129706A (ko) | 2015-11-20 |
| KR102053487B1 true KR102053487B1 (ko) | 2019-12-06 |
Family
ID=50694017
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020157024436A Active KR102053487B1 (ko) | 2013-03-15 | 2014-03-17 | 혈액 샘플에서의 입자 분석을 위한 시스 유체 시스템 및 방법 |
| KR1020157024441A Active KR102044593B1 (ko) | 2013-03-15 | 2014-03-18 | 혈액학 시스템 및 방법 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020157024441A Active KR102044593B1 (ko) | 2013-03-15 | 2014-03-18 | 혈액학 시스템 및 방법 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US9316635B2 (https=) |
| EP (1) | EP2972200B1 (https=) |
| JP (2) | JP6523245B2 (https=) |
| KR (2) | KR102053487B1 (https=) |
| CN (3) | CN113484200B (https=) |
| BR (2) | BR112015021902B1 (https=) |
| WO (2) | WO2014145983A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11525766B2 (en) | 2013-03-15 | 2022-12-13 | Iris International, Inc. | Dynamic range extension systems and methods for particle analysis in blood samples |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9857361B2 (en) | 2013-03-15 | 2018-01-02 | Iris International, Inc. | Flowcell, sheath fluid, and autofocus systems and methods for particle analysis in urine samples |
| JP6523245B2 (ja) | 2013-03-15 | 2019-05-29 | アイリス インターナショナル, インコーポレイテッド | 血液試料における粒子分析のためのシース液システム及び方法 |
| WO2015013605A1 (en) * | 2013-07-26 | 2015-01-29 | Abbott Point Of Care, Inc. | Method and apparatus for producing an image of undiluted whole blood sample having wright stain coloration |
| WO2015029032A1 (en) | 2013-08-26 | 2015-03-05 | Parasight Ltd. | Digital microscopy systems, methods and computer program products |
| JP6616407B2 (ja) * | 2014-09-29 | 2019-12-04 | バイオサーフィット、 ソシエダッド アノニマ | フォーカシング方法 |
| WO2016050837A1 (en) * | 2014-09-30 | 2016-04-07 | Foss Analytical A/S | Method, device and system for hydrodynamic flow focusing |
| BR112017007654B1 (pt) | 2014-10-17 | 2020-12-01 | Iris International, Inc | método para imageamento de uma pluralidade de porções de fluido sanguíneo, e sistema para imageamento de uma pluralidade de porções de fluido sanguíneo |
| US9366606B1 (en) | 2015-08-27 | 2016-06-14 | Ativa Medical Corporation | Fluid processing micro-feature devices and methods |
| US11071982B2 (en) | 2015-08-27 | 2021-07-27 | Ativa Medical Corporation | Fluid holding and dispensing micro-feature |
| US20170059590A1 (en) | 2015-08-27 | 2017-03-02 | Ativa Medical Corporation | Fluid holding and dispensing micro-feature |
| US20170059459A1 (en) * | 2015-08-27 | 2017-03-02 | Ativa Medical Corporation | Fluid processing micro-feature devices and methods |
| HUE061715T2 (hu) * | 2015-12-23 | 2023-08-28 | Siemens Healthcare Gmbh | Áramlási cella részecskék elemzéséhez egy vizsgálni kívánt folyadékban, eljárás és alkalmazás |
| JP6688089B2 (ja) * | 2016-01-22 | 2020-04-28 | 日本光電工業株式会社 | フローセルおよび粒子分析装置 |
| CA3018536A1 (en) | 2016-03-30 | 2017-10-05 | S.D. Sight Diagnostics Ltd | Distinguishing between blood sample components |
| US10656070B2 (en) * | 2016-03-30 | 2020-05-19 | Siemens Healthcare Gmbh | Aligning a non-spherical biological entity in a sample flow using ambient viscoelastic fluid flows |
| WO2017174652A1 (en) * | 2016-04-06 | 2017-10-12 | Biosurfit, S.A. | Method and system for capturing images of a liquid sample |
| EP3455626B1 (en) | 2016-05-11 | 2025-08-06 | S.D. Sight Diagnostics Ltd. | Performing optical measurements on a sample |
| BE1023760B1 (fr) * | 2016-06-24 | 2017-07-13 | Occhio | Dispositif optique de mesure d'une charge en particules d'un echantillon |
| JP6347353B2 (ja) * | 2016-08-30 | 2018-06-27 | 静岡製機株式会社 | 穀粒の品質測定装置 |
| KR101967820B1 (ko) * | 2017-01-09 | 2019-04-10 | 동아대학교 산학협력단 | 차압 점도계용 미세 흐름 장치 및 이의 설계방법 |
| USD852979S1 (en) * | 2017-01-24 | 2019-07-02 | Life Technologies Corporation | Capillary electrophoresis cartridge |
| EP3602003B1 (en) | 2017-03-31 | 2026-04-22 | Life Technologies Corporation | Apparatuses, systems and methods for imaging flow cytometry |
| ES2919343T3 (es) * | 2017-05-25 | 2022-07-26 | Abbott Lab | Métodos y sistemas para el análisis de muestras |
| JP6875944B2 (ja) * | 2017-06-27 | 2021-05-26 | アークレイ株式会社 | フローセル及び測定装置 |
| KR20240059633A (ko) * | 2017-06-28 | 2024-05-07 | 벡톤 디킨슨 앤드 컴퍼니 | 고농도의 분석물을 포함한 분석물을 측정하기 위한 용량 반응 곡선의 신호 부분을 감소시키는 단계를 사용하는 샌드위치-유형 분석법 |
| US12433843B2 (en) * | 2017-07-28 | 2025-10-07 | National University Of Singapore | Biomolecular composites comprising modified cell ghosts |
| DE102017008946A1 (de) * | 2017-09-23 | 2019-03-28 | Universität Greifswald | Verfahren zum Verformen von deformierbaren Körpern und Vorrichtungen dazu |
| WO2019090126A1 (en) * | 2017-11-03 | 2019-05-09 | Streck, Inc. | Linearity control materials |
| CN111788471B (zh) | 2017-11-14 | 2023-12-12 | 思迪赛特诊断有限公司 | 用于光学测量的样品载体 |
| CN108226015A (zh) * | 2018-01-04 | 2018-06-29 | 江苏苏净集团有限公司 | 一种新型液体颗粒计数方法及系统 |
| WO2019150997A1 (ja) * | 2018-02-01 | 2019-08-08 | 東レ株式会社 | 液中粒子の評価装置及びその運転方法 |
| CN111684264B (zh) * | 2018-04-28 | 2023-05-23 | 深圳迈瑞生物医疗电子股份有限公司 | 血液分析方法、血液分析系统及存储介质 |
| WO2019221913A1 (en) * | 2018-05-15 | 2019-11-21 | Illumina, Inc. | Flow cell with flexible connection |
| JP7269692B2 (ja) * | 2018-09-26 | 2023-05-09 | シスメックス株式会社 | 検体測定システム及び検体測定方法 |
| CN109374608B (zh) * | 2018-10-18 | 2021-05-28 | 东北大学 | 一种分光光度法检测胺类捕收剂的方法 |
| JP7175158B2 (ja) * | 2018-10-29 | 2022-11-18 | アークレイ株式会社 | 情報処理装置、測定システム、及びプログラム |
| US20220081671A1 (en) * | 2018-12-21 | 2022-03-17 | Global Life Sciences Solutions Usa Llc | In-Process Device and Method for Cell Culture Monitoring |
| JP7292643B2 (ja) * | 2019-06-04 | 2023-06-19 | 出光興産株式会社 | 観察装置、観察システム、及び観察方法 |
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| WO2021041205A1 (en) * | 2019-08-23 | 2021-03-04 | The Penn State Research Foundation | Methods and systems for estimating proportion of filled virus capsids using cryo-em |
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| EP4042134B1 (en) * | 2019-10-11 | 2024-12-18 | Beckman Coulter, Inc. | Method and composition for staining and sample processing |
| AU2020370212B2 (en) | 2019-10-22 | 2025-09-25 | S.D. Sight Diagnostics Ltd | Accounting for errors in optical measurements |
| JP7677972B2 (ja) | 2019-12-12 | 2025-05-15 | エス.ディー.サイト ダイアグノスティックス リミテッド | カラー血液スミア画像の人工的な生成 |
| CN114787625B (zh) | 2019-12-12 | 2026-01-13 | 思迪赛特诊断有限公司 | 检测血液样品中的血小板 |
| BR112022011312A2 (pt) | 2019-12-12 | 2022-08-23 | S D Sight Diagnostics Ltd | Análise de um analito disposto dentro de um meio |
| CN113390867A (zh) * | 2020-03-12 | 2021-09-14 | 平湖莱顿光学仪器制造有限公司 | 一种黏滞性相关的智能二维视频播放方法及其视频装置 |
| CN111721950A (zh) * | 2020-05-29 | 2020-09-29 | 迪瑞医疗科技股份有限公司 | 一种稳定的有形成分分析聚焦液及其制备方法 |
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| BR112015021577B1 (pt) | 2021-06-22 |
| US20170003273A1 (en) | 2017-01-05 |
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| BR112015021577A2 (pt) | 2017-07-18 |
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| EP2972200A2 (en) | 2016-01-20 |
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| KR102044593B1 (ko) | 2019-11-13 |
| KR20150129709A (ko) | 2015-11-20 |
| BR112015021902B1 (pt) | 2021-06-15 |
| CN113484200B (zh) | 2024-04-26 |
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