KR101514659B1 - 디아릴티오히단토인 및 디아릴히단토인 화합물의 합성 방법 - Google Patents

디아릴티오히단토인 및 디아릴히단토인 화합물의 합성 방법 Download PDF

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KR101514659B1
KR101514659B1 KR1020127024687A KR20127024687A KR101514659B1 KR 101514659 B1 KR101514659 B1 KR 101514659B1 KR 1020127024687 A KR1020127024687 A KR 1020127024687A KR 20127024687 A KR20127024687 A KR 20127024687A KR 101514659 B1 KR101514659 B1 KR 101514659B1
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KR20130027468A (ko
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앤드류 톰슨
캐롤 램버슨
스캇 그린필드
라젠드라 파라스말 자인
레미 앙즈러드
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메디베이션 프로스테이트 테라퓨틱스 인코퍼레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020127024687A 2010-02-24 2011-02-24 디아릴티오히단토인 및 디아릴히단토인 화합물의 합성 방법 Active KR101514659B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30779610P 2010-02-24 2010-02-24
US61/307,796 2010-02-24
PCT/US2011/026135 WO2011106570A1 (en) 2010-02-24 2011-02-24 Processes for the synthesis of diarylthiohydantoin and diarylhydantoin compounds

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KR20130027468A KR20130027468A (ko) 2013-03-15
KR101514659B1 true KR101514659B1 (ko) 2015-04-23

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US (1) US9174943B2 (https=)
EP (2) EP2538785B1 (https=)
JP (1) JP5718372B2 (https=)
KR (1) KR101514659B1 (https=)
CN (1) CN103108549B (https=)
BR (1) BR112012021406B1 (https=)
CA (1) CA2790924C (https=)
CY (2) CY1120207T1 (https=)
DK (2) DK2538785T3 (https=)
ES (2) ES2671343T3 (https=)
HU (2) HUE038637T2 (https=)
MX (1) MX2012009782A (https=)
PL (2) PL2538785T3 (https=)
PT (2) PT2538785T (https=)
RU (1) RU2554081C2 (https=)
SI (2) SI2538785T1 (https=)
WO (1) WO2011106570A1 (https=)

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CN113698310B (zh) * 2021-08-20 2023-03-17 江西金丰药业有限公司 一种恩杂鲁胺双酯中间体的制备方法
CN114591246A (zh) * 2022-03-25 2022-06-07 重庆华邦制药有限公司 一种恩扎卢胺的纯化方法
CN114907439B (zh) * 2022-06-29 2023-07-21 云南中医药大学 一种抗癌化合物及其制药用途
CN115181043B (zh) * 2022-07-27 2024-05-07 爱斯特（成都）生物制药股份有限公司 一种连续流制备4-异硫氰基-2-(三氟甲基)苯甲腈的方法
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HUE038637T2 (hu) 2018-12-28
DK2538785T3 (en) 2018-05-22
CN103108549B (zh) 2015-09-09
EP3329775B1 (en) 2021-04-21
EP2538785B1 (en) 2018-03-21
CA2790924A1 (en) 2011-09-01
CY1120207T1 (el) 2018-12-12
BR112012021406A8 (pt) 2018-07-31
CY1124334T1 (el) 2022-07-22
EP3329775A1 (en) 2018-06-06
SI2538785T1 (en) 2018-05-31
WO2011106570A1 (en) 2011-09-01
US20130190507A1 (en) 2013-07-25
MX2012009782A (es) 2012-11-29
EP2538785A4 (en) 2013-10-30
DK3329775T3 (da) 2021-07-26
PL2538785T3 (pl) 2018-08-31
CN103108549A (zh) 2013-05-15
PL3329775T3 (pl) 2021-11-08
EP2538785A1 (en) 2013-01-02
JP2013520519A (ja) 2013-06-06
ES2880354T3 (es) 2021-11-24
HUE055051T2 (hu) 2021-10-28
KR20130027468A (ko) 2013-03-15
PT2538785T (pt) 2018-05-09
RU2554081C2 (ru) 2015-06-27
US9174943B2 (en) 2015-11-03
JP5718372B2 (ja) 2015-05-13
BR112012021406A2 (pt) 2018-06-05
SI3329775T1 (sl) 2021-09-30
BR112012021406B1 (pt) 2021-08-10
PT3329775T (pt) 2021-07-19
ES2671343T3 (es) 2018-06-06
CA2790924C (en) 2016-08-02
RU2012140454A (ru) 2014-03-27

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