CN107954936B - 一种制备氘代咪唑二酮类化合物的方法 - Google Patents
一种制备氘代咪唑二酮类化合物的方法 Download PDFInfo
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- CN107954936B CN107954936B CN201610901502.0A CN201610901502A CN107954936B CN 107954936 B CN107954936 B CN 107954936B CN 201610901502 A CN201610901502 A CN 201610901502A CN 107954936 B CN107954936 B CN 107954936B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
DMSO | 二甲基亚砜 |
IPAc | 乙酸异丙酯 |
DMF | N,N-二甲基甲酰胺 |
EA | 乙酸乙酯 |
THF | 四氢呋喃 |
DMAA | N,N-二甲基甘氨酸 |
HATU | 2-(7-氧化苯并三氮唑)-N,N,N',N'-四甲基脲六氟磷酸酯 |
CDI | N,N’-羰基二咪唑 |
Claims (13)
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610901502.0A CN107954936B (zh) | 2016-10-17 | 2016-10-17 | 一种制备氘代咪唑二酮类化合物的方法 |
DK16919556.7T DK3527556T3 (da) | 2016-10-17 | 2016-12-20 | Fremgangsmåde til fremstilling af deutereret imidazoldiketonforbindelse |
PT169195567T PT3527556T (pt) | 2016-10-17 | 2016-12-20 | Método para a preparação de composto de imidazol dicetona deuterado |
ES16919556T ES2943011T3 (es) | 2016-10-17 | 2016-12-20 | Procedimiento de preparación del compuesto imidazol dicetona deuterado |
PCT/CN2016/110978 WO2018072300A1 (zh) | 2016-10-17 | 2016-12-20 | 一种制备氘代咪唑二酮类化合物的方法 |
EP16919556.7A EP3527556B1 (en) | 2016-10-17 | 2016-12-20 | Method for preparing deuterated imidazole diketone compound |
AU2016426847A AU2016426847B2 (en) | 2016-10-17 | 2016-12-20 | Method for preparing deuterated imidazole diketone compound |
HUE16919556A HUE061557T2 (hu) | 2016-10-17 | 2016-12-20 | Eljárás deuterizált imidazol-diketon vegyület elõállítására |
PL16919556.7T PL3527556T3 (pl) | 2016-10-17 | 2016-12-20 | Sposób wytwarzania deuterowanych związków imidazolodiketonowych |
US16/342,912 US20200087261A1 (en) | 2016-10-17 | 2016-12-20 | Method for preparing deuterated imidazole diketone compound |
FIEP16919556.7T FI3527556T3 (fi) | 2016-10-17 | 2016-12-20 | Menetelmä deuteroidun imidatsolidiketoniyhdisteen valmistamiseksi |
JP2019520547A JP7241682B2 (ja) | 2016-10-17 | 2016-12-20 | 重水素化イミダゾリジンジオン系化合物を調製する方法 |
CA3040785A CA3040785C (en) | 2016-10-17 | 2016-12-20 | A method for the preparation of deuterated imidazole diketone compounds |
TW106109895A TWI728077B (zh) | 2016-10-17 | 2017-03-24 | 氘代咪唑二酮類化合物的製備方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610901502.0A CN107954936B (zh) | 2016-10-17 | 2016-10-17 | 一种制备氘代咪唑二酮类化合物的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN107954936A CN107954936A (zh) | 2018-04-24 |
CN107954936B true CN107954936B (zh) | 2021-03-19 |
Family
ID=61954120
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610901502.0A Active CN107954936B (zh) | 2016-10-17 | 2016-10-17 | 一种制备氘代咪唑二酮类化合物的方法 |
Country Status (14)
Country | Link |
---|---|
US (1) | US20200087261A1 (zh) |
EP (1) | EP3527556B1 (zh) |
JP (1) | JP7241682B2 (zh) |
CN (1) | CN107954936B (zh) |
AU (1) | AU2016426847B2 (zh) |
CA (1) | CA3040785C (zh) |
DK (1) | DK3527556T3 (zh) |
ES (1) | ES2943011T3 (zh) |
FI (1) | FI3527556T3 (zh) |
HU (1) | HUE061557T2 (zh) |
PL (1) | PL3527556T3 (zh) |
PT (1) | PT3527556T (zh) |
TW (1) | TWI728077B (zh) |
WO (1) | WO2018072300A1 (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109180511A (zh) * | 2018-08-22 | 2019-01-11 | 辽宁东科药业有限公司 | 一种盐酸丁卡因的制备方法 |
CN113698310B (zh) * | 2021-08-20 | 2023-03-17 | 江西金丰药业有限公司 | 一种恩杂鲁胺双酯中间体的制备方法 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102421291A (zh) * | 2009-02-24 | 2012-04-18 | 梅迪维新前列腺医疗股份有限公司 | 具体的二芳基乙内酰脲和二芳基乙内酰硫脲化合物 |
CN103108549A (zh) * | 2010-02-24 | 2013-05-15 | 梅迪维新前列腺医疗股份有限公司 | 合成二芳基乙内酰硫脲和二芳基乙内酰脲化合物的方法 |
CN104016924A (zh) * | 2014-06-16 | 2014-09-03 | 上海鼎雅药物化学科技有限公司 | 一种“一锅法”合成恩杂鲁胺的方法 |
CN104211683A (zh) * | 2013-05-29 | 2014-12-17 | 成都海创药业有限公司 | 咪唑二酮类化合物及其用途 |
CN104024228B (zh) * | 2011-12-14 | 2015-07-08 | 成都海创药业有限公司 | 咪唑二酮类化合物及其用途 |
CN104803918A (zh) * | 2014-01-26 | 2015-07-29 | 上海医药工业研究院 | 恩杂鲁胺的制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL3100727T3 (pl) * | 2006-03-27 | 2019-01-31 | The Regents Of The University Of California | Modulator receptora androgenowego do leczenia raka gruczołu krokowego i chorób związanych z receptorem androgenowym |
CN101817787B (zh) * | 2009-02-26 | 2013-07-24 | 童友之 | 抗前列腺癌的雄性激素受体拮抗剂 |
CN104341352A (zh) * | 2013-08-09 | 2015-02-11 | 南京衡杰生物科技有限公司 | 作为雄激素受体拮抗剂的二芳基乙内酰脲化合物及其应用 |
RU2557235C1 (ru) * | 2014-07-08 | 2015-07-20 | Александр Васильевич Иващенко | Замещенные 2-тиоксо-имидазолидин-4-оны и их спироаналоги, противораковый активный компонент, фармацевтическая композиция, лекарственный препарат, способ лечения рака простаты |
-
2016
- 2016-10-17 CN CN201610901502.0A patent/CN107954936B/zh active Active
- 2016-12-20 EP EP16919556.7A patent/EP3527556B1/en active Active
- 2016-12-20 PL PL16919556.7T patent/PL3527556T3/pl unknown
- 2016-12-20 ES ES16919556T patent/ES2943011T3/es active Active
- 2016-12-20 CA CA3040785A patent/CA3040785C/en active Active
- 2016-12-20 JP JP2019520547A patent/JP7241682B2/ja active Active
- 2016-12-20 PT PT169195567T patent/PT3527556T/pt unknown
- 2016-12-20 DK DK16919556.7T patent/DK3527556T3/da active
- 2016-12-20 HU HUE16919556A patent/HUE061557T2/hu unknown
- 2016-12-20 US US16/342,912 patent/US20200087261A1/en not_active Abandoned
- 2016-12-20 WO PCT/CN2016/110978 patent/WO2018072300A1/zh unknown
- 2016-12-20 FI FIEP16919556.7T patent/FI3527556T3/fi active
- 2016-12-20 AU AU2016426847A patent/AU2016426847B2/en active Active
-
2017
- 2017-03-24 TW TW106109895A patent/TWI728077B/zh active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102421291A (zh) * | 2009-02-24 | 2012-04-18 | 梅迪维新前列腺医疗股份有限公司 | 具体的二芳基乙内酰脲和二芳基乙内酰硫脲化合物 |
CN103108549A (zh) * | 2010-02-24 | 2013-05-15 | 梅迪维新前列腺医疗股份有限公司 | 合成二芳基乙内酰硫脲和二芳基乙内酰脲化合物的方法 |
CN104024228B (zh) * | 2011-12-14 | 2015-07-08 | 成都海创药业有限公司 | 咪唑二酮类化合物及其用途 |
CN104211683A (zh) * | 2013-05-29 | 2014-12-17 | 成都海创药业有限公司 | 咪唑二酮类化合物及其用途 |
CN104803918A (zh) * | 2014-01-26 | 2015-07-29 | 上海医药工业研究院 | 恩杂鲁胺的制备方法 |
CN104016924A (zh) * | 2014-06-16 | 2014-09-03 | 上海鼎雅药物化学科技有限公司 | 一种“一锅法”合成恩杂鲁胺的方法 |
Non-Patent Citations (1)
Title |
---|
"An improved and practical route for the synthesis of enzalutamide and potential impurities study";Zhou, Ai-Nan, et al.;《Chinese Chemical Letters》;20160921;第28卷(第2期);第426-430页,supporting information * |
Also Published As
Publication number | Publication date |
---|---|
ES2943011T3 (es) | 2023-06-08 |
CA3040785A1 (en) | 2018-04-26 |
EP3527556B1 (en) | 2023-01-25 |
CN107954936A (zh) | 2018-04-24 |
EP3527556A1 (en) | 2019-08-21 |
FI3527556T3 (fi) | 2023-04-25 |
PL3527556T3 (pl) | 2023-08-14 |
TWI728077B (zh) | 2021-05-21 |
WO2018072300A1 (zh) | 2018-04-26 |
CA3040785C (en) | 2021-06-15 |
TW201815768A (zh) | 2018-05-01 |
HUE061557T2 (hu) | 2023-07-28 |
AU2016426847B2 (en) | 2020-11-26 |
JP7241682B2 (ja) | 2023-03-17 |
DK3527556T3 (da) | 2023-05-01 |
JP2019532075A (ja) | 2019-11-07 |
AU2016426847A1 (en) | 2019-06-06 |
PT3527556T (pt) | 2023-05-02 |
US20200087261A1 (en) | 2020-03-19 |
EP3527556A4 (en) | 2020-04-29 |
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EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20180424 Assignee: SICHUAN HAISCO PHARMACEUTICAL Co.,Ltd. Assignor: Chengdu Haichuang Pharmaceutical Co.,Ltd. Contract record no.: X2020510000020 Denomination of invention: Method for preparing deuterated imidazole diketone compounds License type: Exclusive License Record date: 20200727 |
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EE01 | Entry into force of recordation of patent licensing contract | ||
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Address after: No.2 and No.3, floor 4, building 1, Rongyao building, No.5 Keyuan South Road, high tech Zone, Chengdu, Sichuan 610000 Applicant after: Haichuang Pharmaceutical Co., Ltd Address before: Room 801, C1 incubation building, Tianfu Life Science Park, 88 Keyuan South Road, high tech Zone, Chengdu, Sichuan 610000 Applicant before: Chengdu Haichuang Pharmaceutical Co.,Ltd. |
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EC01 | Cancellation of recordation of patent licensing contract |
Assignee: SICHUAN HAISCO PHARMACEUTICAL Co.,Ltd. Assignor: Chengdu Haichuang Pharmaceutical Co.,Ltd. Contract record no.: X2020510000020 Date of cancellation: 20210312 |
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EC01 | Cancellation of recordation of patent licensing contract |