KR101366414B1 - 헤지호그 신호전달에 대한 피리딜 억제제 - Google Patents

헤지호그 신호전달에 대한 피리딜 억제제 Download PDF

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KR101366414B1
KR101366414B1 KR1020127029702A KR20127029702A KR101366414B1 KR 101366414 B1 KR101366414 B1 KR 101366414B1 KR 1020127029702 A KR1020127029702 A KR 1020127029702A KR 20127029702 A KR20127029702 A KR 20127029702A KR 101366414 B1 KR101366414 B1 KR 101366414B1
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chloro
pyridin
phenyl
methyl
benzimid
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KR20120139846A (ko
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자넷 건츠너
대니얼 서덜린
마크 스탠리
량 바오
게오르게트 카스타네도
레베카 랄론드
슈메이 왕
마크 레이놀즈
스코트 새비지
킴벌리 말레스키
마이클 디나
마이클 에프. 티. 코울러
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쿠리스 인코퍼레이션
제넨테크, 인크.
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    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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