KR100971850B1 - 모노아민 재흡수 저해제로서 유용한 ｎ,ｎ-치환3-아미노피롤리딘 화합물 - Google Patents

모노아민 재흡수 저해제로서 유용한 ｎ,ｎ-치환3-아미노피롤리딘 화합물 Download PDF

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KR100971850B1
KR100971850B1 KR1020077029022A KR20077029022A KR100971850B1 KR 100971850 B1 KR100971850 B1 KR 100971850B1 KR 1020077029022 A KR1020077029022 A KR 1020077029022A KR 20077029022 A KR20077029022 A KR 20077029022A KR 100971850 B1 KR100971850 B1 KR 100971850B1
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South Korea
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alkyl group
pyrrolidin
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Expired - Fee Related
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Korean (ko)
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KR20080008423A (ko
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무네아끼 구리무라
신이찌 다이라
다까히로 도모야스
노부아끼 이또
구니노리 다이
노리아끼 다께무라
다까유끼 마쯔자끼
야스히로 멘조
신 미야무라
요지 사꾸라이
아끼히또 와따나베
야스요 사까따
다꾸미 마스모또
고헤이 아까자와
하루히꼬 스기노
나오끼 아마다
사또시 오하시
도모이찌 시노하라
히로후미 사사끼
찌사꼬 모리따
준꼬 야마시따
사또꼬 나까지마
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오츠카 세이야쿠 가부시키가이샤
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KR1020077029022A 2005-05-13 2006-05-12 모노아민 재흡수 저해제로서 유용한 ｎ,ｎ-치환3-아미노피롤리딘 화합물 Expired - Fee Related KR100971850B1 (ko)

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JP2005141230 2005-05-13
JPJP-P-2005-00141230 2005-05-13

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KR1020107004207A Division KR20100038453A (ko) 2005-05-13 2006-05-12 모노아민 재흡수 저해제로서 유용한 ｎ,ｎ-치환 3-아미노피롤리딘 화합물

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KR20080008423A KR20080008423A (ko) 2008-01-23
KR100971850B1 true KR100971850B1 (ko) 2010-07-22

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Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05005660A (es) 2002-11-27 2005-10-18 Incyte Corp Derivados de 3-aminopirrolidina como moduladores de receptores de quimocina.
TWI410406B (zh) 2005-05-13 2013-10-01 Otsuka Pharma Co Ltd 吡咯烷化合物
JP2009517430A (ja) * 2005-11-30 2009-04-30 エフ．ホフマン−ラ ロシュ アーゲー ３−アミノ−１−アリールプロピルインドール類及びアザ置換インドール類
US20100216813A1 (en) * 2005-11-30 2010-08-26 Smithkline Beecham Corporation Pyrrolidineanilines
JP5219465B2 (ja) * 2006-11-10 2013-06-26 大塚製薬株式会社 医薬
WO2009115427A1 (en) * 2008-03-20 2009-09-24 F. Hoffmann-La Roche Ag Pyrrolidinyl derivatives and uses thereof
CN102596200A (zh) 2009-11-07 2012-07-18 默克专利有限公司 作为TGF-β受体激酶抑制剂的杂芳基氨基喹啉类
WO2011131748A2 (en) * 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
CN102766079B (zh) * 2011-05-06 2015-04-08 上海医药工业研究院 一类吡咯烷衍生物、其制备方法及应用
WO2015050984A1 (en) 2013-10-01 2015-04-09 New York University Amino, amido, and heterocyclic compounds as modulators of rage activity and uses thereof
KR20160148871A (ko) 2015-06-17 2016-12-27 양순구 일방향 클러치 제동장치
WO2017070796A1 (en) * 2015-10-30 2017-05-04 Trillium Therapeutics Inc. Heterocycle derivatives and their use for the treatment of cns disorders
US12030875B2 (en) 2018-09-07 2024-07-09 PIC Therapeutics, Inc. EIF4E inhibitors and uses thereof
RU2698400C1 (ru) * 2018-12-17 2019-08-26 Георгий Сергеевич Немов Способ лечения депрессии у собак и кошек
CN113024517A (zh) * 2019-12-09 2021-06-25 武汉九州钰民医药科技有限公司 一种制备厄达替尼的方法
CN113024518A (zh) * 2019-12-09 2021-06-25 武汉九州钰民医药科技有限公司 一种厄达替尼的制备方法
AU2021230289A1 (en) 2020-03-03 2022-09-29 PIC Therapeutics, Inc. eIF4E inhibitors and uses thereof
JP2024534127A (ja) 2021-08-25 2024-09-18 ピク セラピューティクス， インコーポレイテッド ｅＩＦ４Ｅ阻害剤及びその使用
US12157732B2 (en) 2021-08-25 2024-12-03 PIC Therapeutics, Inc. eIF4E inhibitors and uses thereof
EP4665718A1 (en) * 2023-02-13 2025-12-24 Apogee Pharmaceuticals, Inc. Small molecules as monoacylglycerol lipase (magl) inhibitors, compositions and use thereof
WO2025030117A1 (en) * 2023-08-02 2025-02-06 Arpeggio Biosciences, Inc. Ferroptosis inducers

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2295387A (en) 1994-11-23 1996-05-29 Glaxo Inc Quinazoline antagonists of alpha 1c adrenergic receptors
WO2005000811A1 (en) * 2003-06-11 2005-01-06 Eli Lilly And Company 3-aminopyrrolidines as inhibitors of monoamine uptake

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1164828A (en) 1965-10-23 1969-09-24 Robins Co Inc A H 3-(2-Substituted Ethyl)Indoles and their Manufacture and Use
SE308721B (https=) 1966-03-22 1969-02-24 Robbins A Co Inc
US3509171A (en) * 1967-09-14 1970-04-28 Robins Co Inc A H 3-amino-1-carbamyl and thiocarbamyl pyrrolidines
US3433802A (en) * 1968-06-25 1969-03-18 Robins Co Inc A H 3-(n-lower-alkylanilino)pyrrolidines
US3577440A (en) * 1968-12-23 1971-05-04 Robins Co Inc A H 1-substituted-3-amido-pyrrolidines
GB1523631A (en) 1975-07-08 1978-09-06 Leo Pharm Prod Ltd Sulphonamide derivatives
US4254135A (en) * 1979-10-16 1981-03-03 A. H. Robins Company, Inc. 3-Amino-4-hydroxypyrrolidines
SE9604786D0 (sv) * 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
EP1138672A1 (en) 1998-01-12 2001-10-04 Basilea Pharmaceutica AG Process for the preparation of 3-amino-pyrrolidine derivatives
NZ506465A (en) * 1998-02-26 2003-08-29 Akzo Nobel Nv Derivatives of azetidine and pyrrolidine
US7271176B2 (en) * 1998-09-04 2007-09-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
CN100374416C (zh) * 2000-04-28 2008-03-12 霍夫曼-拉罗奇有限公司 对(磺酰基)芳基和杂芳基类化合物
DK1395567T3 (da) 2001-05-18 2009-04-06 Astrazeneca Ab 4-(phenylpiperazinylmethyl)-benzamidderivater og deres anvendelse til behandling af smerte, angst eller mavetarmslidelser
SI1638933T1 (sl) 2003-06-17 2008-10-31 Pfizer Derivati N-pirolidin-3-il-amida kot inhibitorji ponovnega privzema serotonina in noradrenalina
GB0314054D0 (en) 2003-06-17 2003-07-23 Pfizer Ltd Amide derivatives as selective serotonin re-uptake inhibitors
EP1638560A1 (en) 2003-06-20 2006-03-29 Eli Lilly And Company 3-aminopiperidines and 3-aminoquinuclidines as inhibitors of monoamine uptake
US7989634B2 (en) 2003-11-12 2011-08-02 Lg Life Sciences Ltd. Melanocortin receptor agonists
EP1729754B1 (en) 2003-12-12 2008-07-02 Eli Lilly And Company Selective norepinephrine reuptake inhibitors for the treatment of hot flashes
CA2606288A1 (en) 2005-04-18 2006-10-26 Neurogen Corporation Subtituted heteroaryl cb1 antagonists
TWI410406B (zh) * 2005-05-13 2013-10-01 Otsuka Pharma Co Ltd 吡咯烷化合物
WO2008000811A1 (en) * 2006-06-30 2008-01-03 Arcelik Anonim Sirketi A cooling device

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2295387A (en) 1994-11-23 1996-05-29 Glaxo Inc Quinazoline antagonists of alpha 1c adrenergic receptors
WO2005000811A1 (en) * 2003-06-11 2005-01-06 Eli Lilly And Company 3-aminopyrrolidines as inhibitors of monoamine uptake

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