MXPA05005660A - Derivados de 3-aminopirrolidina como moduladores de receptores de quimocina. - Google Patents

Derivados de 3-aminopirrolidina como moduladores de receptores de quimocina.

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Publication number
MXPA05005660A
MXPA05005660A MXPA05005660A MXPA05005660A MXPA05005660A MX PA05005660 A MXPA05005660 A MX PA05005660A MX PA05005660 A MXPA05005660 A MX PA05005660A MX PA05005660 A MXPA05005660 A MX PA05005660A MX PA05005660 A MXPA05005660 A MX PA05005660A
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MX
Mexico
Prior art keywords
modulators
chemokine receptors
chemokine
ccr2
useful
Prior art date
Application number
MXPA05005660A
Other languages
English (en)
Inventor
Feng Hao
Original Assignee
Incyte Corp
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Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of MXPA05005660A publication Critical patent/MXPA05005660A/es

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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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Abstract

La presente invencion se refiere a derivados de 3-aminopirrolidina de la formula I, (en donde R1, R2, R3, R4, R5, R6, R7, R8, X Y y Z son como se definen en este documento), los cuales son empleados como moduladores de la actividad del receptor de quimocina, en particular, estos compuestos son empleados como moduladores de los receptores de quimocina y mas especificamente, como moduladores del receptor CCR2 y/o CCR5. los compuestos y composiciones de la invencion pueden unirse a receptores de quimocinas, por ejemplo, los receptores de quimocina CCR2 y/o CCR5, y son utiles para tratar enfermedades asociadas con la quimocina, por ejemplo, actividad CCR2 y/o CCR5, tal como aterosclerosis, restenosis, lupus, rechazo al transplante y artritis reumatoide.
MXPA05005660A 2002-11-27 2003-11-26 Derivados de 3-aminopirrolidina como moduladores de receptores de quimocina. MXPA05005660A (es)

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CN102153539B (zh) 2016-01-13
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