NO20052543L - 3-aminopyrrolidinderivater som modulatorer av kjemokinreseptorer. - Google Patents

3-aminopyrrolidinderivater som modulatorer av kjemokinreseptorer.

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Publication number
NO20052543L
NO20052543L NO20052543A NO20052543A NO20052543L NO 20052543 L NO20052543 L NO 20052543L NO 20052543 A NO20052543 A NO 20052543A NO 20052543 A NO20052543 A NO 20052543A NO 20052543 L NO20052543 L NO 20052543L
Authority
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Norway
Prior art keywords
modulators
chemokine receptors
chemokine
ccr2
useful
Prior art date
Application number
NO20052543A
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English (en)
Other versions
NO20052543D0 (no
NO330860B1 (no
Inventor
Chu-Biao Xue
Hao Feng
Brian Metcalf
Ganfeng Cao
Tuishing Huang
Chungsheng Zheng
Darius J Robinson
Amy Qi Han
Original Assignee
Incyte Corp
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Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of NO20052543D0 publication Critical patent/NO20052543D0/no
Publication of NO20052543L publication Critical patent/NO20052543L/no
Publication of NO330860B1 publication Critical patent/NO330860B1/no

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Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0202133D0 (sv) * 2002-07-08 2002-07-08 Astrazeneca Ab Novel compounds
AU2003293129B2 (en) * 2002-11-27 2009-03-12 Incyte Holdings Corporation 3-aminopyrrolidine derivatives as modulators of chemokine receptors
US7378409B2 (en) 2003-08-21 2008-05-27 Bristol-Myers Squibb Company Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity
SE0302755D0 (sv) * 2003-10-17 2003-10-17 Astrazeneca Ab Novel compounds
US20070021498A1 (en) * 2004-10-14 2007-01-25 Nafizal Hossain Novel tricyclic spiroderivatives as modulators of chemokine receptor activity
SE0303090D0 (sv) * 2003-11-20 2003-11-20 Astrazeneca Ab Novel compounds
KR100859027B1 (ko) * 2003-12-18 2008-09-17 인사이트 코포레이션 케모킨 수용체의 조절제로서의3-사이클로알킬아미노피롤리딘 유도체
SE0303541D0 (sv) 2003-12-22 2003-12-22 Astrazeneca Ab New compounds
AU2005234596B8 (en) * 2004-04-13 2011-06-16 Incyte Holdings Corporation Piperazinylpiperidine derivatives as chemokine receptor antagonists
US7307086B2 (en) 2004-05-11 2007-12-11 Incyte Corporation 3-(4-heteroarylcyclohexylamino)cyclopentanecarboxamides as modulators of chemokine receptors
CN1329374C (zh) * 2004-06-09 2007-08-01 上海靶点药物有限公司 作为ccr5拮抗剂的化合物
CN102382088A (zh) 2004-06-28 2012-03-21 因赛特公司 作为趋化因子受体调节剂的3-氨基环戊烷甲酰胺类
EP1763351B9 (en) 2004-06-28 2017-05-31 Incyte Holdings Corporation 3-aminocyclopentanecarboxamides as modulators of chemokine receptors
GB0417801D0 (en) * 2004-08-10 2004-09-15 Novartis Ag Organic compounds
PA8653301A1 (es) * 2004-11-22 2006-11-09 Incyte Corp Incyte Corp Sales de la n-[2-({(3r)-1-[trans-4-hidroxi-4-(6-metoxipiridin-3-il) ciclohexil)pirrolidin
JP5118975B2 (ja) 2004-12-24 2013-01-16 アストラゼネカ・アクチエボラーグ Ccr2bアンタゴニストとしてのヘテロ環式化合物
US8067415B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
US8067457B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
GB0525957D0 (en) 2005-12-21 2006-02-01 Astrazeneca Ab Methods
CN101553493B (zh) * 2006-07-19 2012-07-04 阿斯利康(瑞典)有限公司 三环螺哌啶化合物、它们的合成和它们作为趋化因子受体活性调节剂的用途
TW200831497A (en) * 2006-10-12 2008-08-01 Epix Delaware Inc Carboxamide compounds and their use
MX2009005252A (es) 2006-11-17 2009-05-28 Abbott Lab Aminopirrolidinas como antagonistas del receptor de quimiocina.
WO2008063714A1 (en) * 2006-11-20 2008-05-29 N.V. Organon Metabolically-stabilized inhibitors of fatty acid amide hydrolase
ATE531945T1 (de) 2008-01-07 2011-11-15 Univ Vanderbilt Magnetventilanordnung
US7496166B1 (en) * 2008-04-29 2009-02-24 International Business Machines Corporation Dual clock spread for low clock emissions with recovery
EP2309857B1 (de) 2008-07-17 2013-07-03 Bayer CropScience AG Heterocyclische verbindungen als schädlingsbekämpfungsmittel
US20110230428A1 (en) * 2008-07-22 2011-09-22 John Wityak Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
PE20110928A1 (es) * 2008-12-10 2012-01-05 Janssen Pharmaceutica Nv Derivados de 4-azetidinil-1-heteroaril-ciclohexanol como antagonistas de ccr2
KR101084551B1 (ko) * 2008-12-26 2011-11-17 양지화학 주식회사 Ccr2 길항제로서의 3-아미노피롤리딘 유도체
EP2419417B1 (en) * 2009-04-16 2015-03-25 Janssen Pharmaceutica NV 4-azetidinyl-1-heteroaryl-cyclohexane antagonists of ccr2
MX2011010964A (es) * 2009-04-17 2011-11-02 Janssen Pharmaceutica Nv Antagonistas del receptor 2 de citocina quimioatrayente de 4- azetidinil-1-fenil-ciclohexano.
MX2011010963A (es) * 2009-04-17 2011-11-02 Janssen Pharmaceutica Nv Antagonistas del receptor 2 de citocina quimiotrayente de ciclohexano unido al 4-azetidinil-1-heteroatomo.
KR101151415B1 (ko) 2009-07-10 2012-06-01 양지화학 주식회사 Ccr2 길항제로서의 피페라지닐에틸 3-아미노피롤리딘 유도체
TW201211027A (en) * 2010-06-09 2012-03-16 Janssen Pharmaceutica Nv Cyclohexyl-azetidinyl antagonists of CCR2
CA2801934A1 (en) * 2010-06-17 2011-12-22 Janssen Pharmaceutica Nv Cyclohexyl-azetidinyl antagonists of ccr2
KR101318656B1 (ko) 2010-10-08 2013-10-16 양지화학 주식회사 항천식 활성을 가진 3-아미노피롤리딘 유도체를 포함하는 약학 조성물
WO2012125661A1 (en) * 2011-03-17 2012-09-20 Merck Sharp & Dohme Corp. Substituted 3-azabicyclo[3.1.0]hexane derivatives useful as ccr2 antagonists
EP2751086A4 (en) 2011-08-30 2015-09-16 Chdi Foundation Inc KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS THEREOF AND METHOD OF USE THEREOF
KR102181011B1 (ko) 2011-08-30 2020-11-20 씨에이치디아이 파운데이션, 인코포레이티드 키뉴레닌-3-모노옥시게나제 억제제, 약학적 조성물 및 이의 사용 방법
WO2013047813A1 (ja) 2011-09-30 2013-04-04 大鵬薬品工業株式会社 1,2,4-トリアジン-6-カルボキサミド誘導体
HUE033114T2 (en) 2011-11-18 2017-11-28 Heptares Therapeutics Ltd Muscarin M1 receptor agonists
WO2013149376A1 (en) * 2012-04-02 2013-10-10 Abbott Laboratories Chemokine receptor antagonists
EP3169684B1 (en) 2014-07-17 2019-06-26 CHDI Foundation, Inc. Combination of kmo inhibitor 6-(3-chloro-4-cyclopropoxyphenyl)pyrimidine-4-carboxylic acid with antiviral agent for treating hiv related neurological disorders
GB201513743D0 (en) 2015-08-03 2015-09-16 Heptares Therapeutics Ltd Muscarinic agonists
RU2606230C1 (ru) * 2015-10-20 2017-01-10 Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (Z)-Этил 2-(4-(4-хлорфенил)-2,4-диоксо-3-(3-оксо-3,4-дигидрохиноксалин-2(1Н)-илиден)бутанамидо)-4-метил-5-фенилтиофен-3-карбоксилат, обладающий противодиабетической активностью, и способ его получения
CN109563085B (zh) 2016-07-28 2022-08-09 爱杜西亚药品有限公司 哌啶cxcr7受体调节剂
GB201617454D0 (en) 2016-10-14 2016-11-30 Heptares Therapeutics Limited Pharmaceutical compounds
US10610104B2 (en) 2016-12-07 2020-04-07 Progenity, Inc. Gastrointestinal tract detection methods, devices and systems
CA3045310A1 (en) 2016-12-14 2018-06-21 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor
AU2018358160B2 (en) 2017-11-02 2023-03-16 Abbvie Inc. Modulators of the integrated stress pathway
EP3743422B1 (en) 2018-01-26 2024-03-13 Idorsia Pharmaceuticals Ltd Crystalline forms of the cxcr7 receptor antagonist (3s,4s)-1-cyclopropylmethyl-4-{[5-(2,4-difluoro-phenyl)-isoxazole-3-carbonyl]-amino}-piperidine-3-carboxylic acid (1-pyrimidin-2-yl-cyclopropyl)-amide
GB201810239D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
US20220249814A1 (en) 2018-11-19 2022-08-11 Progenity, Inc. Methods and devices for treating a disease with biotherapeutics
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
EP3947388A4 (en) 2019-04-02 2022-12-21 Aligos Therapeutics, Inc. LINKS DIRECTED AGAINST PRMT5
GB202020191D0 (en) 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds
US11707610B2 (en) 2019-12-13 2023-07-25 Biora Therapeutics, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
AR127055A1 (es) 2021-09-14 2023-12-13 Lilly Co Eli Sales agonistas de sstr4
WO2023081662A1 (en) * 2021-11-02 2023-05-11 Aria Pharmaceuticals, Inc. Bicyclic derivatives as ccr2 modulators
TW202334135A (zh) * 2021-11-02 2023-09-01 美商雅力雅製藥公司 化合物、組合物及方法
WO2023081665A1 (en) * 2021-11-02 2023-05-11 Aria Pharmaceuticals, Inc. Compounds as crr2 modulators
WO2023081661A1 (en) * 2021-11-02 2023-05-11 Aria Pharmaceuticals, Inc. Bicyclic derivatives as ccr2 modulators

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US26186A (en) * 1859-11-22 Cut-off arrangement for steam-valves
CH580582A5 (no) 1972-04-03 1976-10-15 Robins Co Inc A H
US4026836A (en) * 1975-12-29 1977-05-31 Texaco Development Corporation Isocyanurate foam catalyst
HU175454B (hu) * 1977-07-25 1980-08-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija novykh predel'nykh i chastichno predel'nykh n-acil-pirrol-2,5-dionov
US4333734A (en) * 1980-01-18 1982-06-08 Sloan-Kettering Institute For Cancer Research Diagnostic device for fecal occult blood and method of use
US4785119A (en) * 1985-10-11 1988-11-15 Tokyo Kasei Kogyo Co., Ltd. 3-aminopyrrolidine compound and process for preparation thereof
AU7665694A (en) * 1993-09-21 1995-04-10 Yamanouchi Pharmaceutical Co., Ltd. N-(3-pyrrolidinyl)benzamide derivative
US5770573A (en) 1993-12-06 1998-06-23 Cytel Corporation CS-1 peptidomimetics, compositions and methods of using the same
WO1997044329A1 (en) 1996-05-20 1997-11-27 Teijin Limited Diarylalkyl cyclic diamine derivatives as chemokine receptor antagonists
AU729415B2 (en) 1996-07-12 2001-02-01 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
JP4166296B2 (ja) 1997-04-25 2008-10-15 塩野義製薬株式会社 ドーパミン受容体拮抗作用を有する化合物
CA2293408A1 (en) 1997-06-18 1998-12-23 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonists
WO1999025686A1 (en) * 1997-11-18 1999-05-27 Teijin Limited Cyclic amine derivatives and their use as drugs
US6312689B1 (en) 1998-07-23 2001-11-06 Millennium Pharmaceuticals, Inc. Anti-CCR2 antibodies and methods of use therefor
US6197974B1 (en) 1998-10-26 2001-03-06 Abbott Laboratories Enantioselective synthesis of 3-aminopyrrolidines
CA2348879A1 (en) * 1998-11-02 2000-05-11 Welfide Corporation Pyrrolidine compound and pharmaceutical use thereof
US7217714B1 (en) 1998-12-23 2007-05-15 Agouron Pharmaceuticals, Inc. CCR5 modulators
US6248755B1 (en) 1999-04-06 2001-06-19 Merck & Co., Inc. Pyrrolidine modulators of chemokine receptor activity
AU4796700A (en) 1999-05-13 2000-12-05 Dupont Pharmaceuticals Research Laboratories, Inc. Ureido-substituted cyclic amine derivatives and their use as drug
US7390830B1 (en) 1999-05-18 2008-06-24 Teijin Limited Remedies or prophylactics for diseases in association with chemokines
JP2003506364A (ja) * 1999-07-30 2003-02-18 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド システインプロテアーゼインヒビターとして有益な新規スクシネート誘導体化合物
CN1192773C (zh) 1999-08-04 2005-03-16 帝人株式会社 环胺ccr3拮抗剂
JP2001131145A (ja) 1999-08-20 2001-05-15 Toray Ind Inc 光学活性3−アミノピロリジン誘導体の製造法
DE60003702T2 (de) 1999-09-13 2004-04-22 Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield Heterocyclische verbindungen als reversible inhibitoren von cysteinproteasen
GB2355263A (en) * 1999-09-30 2001-04-18 Merck & Co Inc Lactam and cyclic urea derivatives useful as alpha 1a adrenoceptor antagonists
CA2384240A1 (en) * 1999-10-15 2001-04-26 Dean A. Wacker Benzylcycloalkyl amines as modulators of chemokine receptor activity
DE60005401T2 (de) 1999-12-21 2004-05-06 Smithkline Beecham Corp. Carboxamidderivate von pyrrolidine und piperidine als urotensin-ii rezeptorantagonisten
US6362177B1 (en) * 2000-05-16 2002-03-26 Teijin Limited Cyclic amine derivatives and their use as drugs
GB0011838D0 (en) 2000-05-17 2000-07-05 Astrazeneca Ab Chemical compounds
US20020094989A1 (en) * 2000-10-11 2002-07-18 Hale Jeffrey J. Pyrrolidine modulators of CCR5 chemokine receptor activity
US7125887B2 (en) 2000-10-11 2006-10-24 Merck & Co., Inc. Pyrrolidine modulators of CCR5 chemokine receptor activity
US6670364B2 (en) * 2001-01-31 2003-12-30 Telik, Inc. Antagonists of MCP-1 function and methods of use thereof
US6538017B2 (en) 2001-03-09 2003-03-25 Ortho-Mcneil Pharmaceutical, Inc. Aminopyrrolidine sulfonamides as serine protease inhibitors
DE60322877D1 (de) 2002-04-29 2008-09-25 Merck Sharp & Dohme Tetrahydropyranylcyclopentyltetrahydroisochino-linmodulatoren der chemokinrezeptoraktivität
MY129850A (en) 2002-04-29 2007-05-31 Merck Sharp & Dohme Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
PT1501507E (pt) 2002-04-29 2008-08-12 Merck Sharp & Dohme Tetrahidropiranil ciclopentil tetrahidropiridopiridinas moduladoras da actividade dos receptores de quimioquinas
AU2003260072A1 (en) 2002-08-27 2004-03-19 Bristol-Myers Squibb Company Antagonists of chemokine receptors
JP2004083511A (ja) 2002-08-28 2004-03-18 Yamanouchi Pharmaceut Co Ltd アクリルアミド誘導体
RU2005111589A (ru) * 2002-09-17 2006-01-20 Актелион Фармасьютиклз Лтд. (Ch) Производные 1-пиридин-4-илмочевины
US7491737B2 (en) 2002-10-30 2009-02-17 Merck & Co., Inc. Heterarylpiperidine modulators of chemokine receptor activity
WO2004041161A2 (en) 2002-10-30 2004-05-21 Merck & Co., Inc. Tetrahydropyranyl cyclopentyl benzylamide modulators of chemokine receptor activity
EP1558576A4 (en) 2002-10-30 2008-04-16 Merck & Co Inc PIPERIDINYLCYCLOPENTYLARYLBENZYLAMIDE MODULATORS OF CHEMOKIN RECEPTORACTIVITY
JP2006514618A (ja) 2002-10-30 2006-05-11 メルク エンド カムパニー インコーポレーテッド ケモカイン受容体活性のピペリジニル−アルファ−アミノアミドモジュレーター
US7247725B2 (en) 2002-10-30 2007-07-24 Merck & Co., Inc. Gamma-aminoamide modulators of chemokine receptor activity
AU2003293129B2 (en) * 2002-11-27 2009-03-12 Incyte Holdings Corporation 3-aminopyrrolidine derivatives as modulators of chemokine receptors
AR045875A1 (es) 2003-10-27 2005-11-16 Merck & Co Inc Procedimiento para la preparacion del antagonista ccr-2
BRPI0415836A (pt) 2003-10-27 2007-01-02 Merck & Co Inc composto, métodos para a modulação da atividade de receptor de quimocina em um mamìfero, e para o tratamento, a melhoria, o controle ou a redução do risco de uma doença ou distúrbio inflamatório e imunorregulatório, e de artrite reumatóide, composição farmacêutica
KR100859027B1 (ko) * 2003-12-18 2008-09-17 인사이트 코포레이션 케모킨 수용체의 조절제로서의3-사이클로알킬아미노피롤리딘 유도체
US20070117797A1 (en) 2004-01-02 2007-05-24 Goble Stephen D Alkylamino, arylamino, and sulfonamido cyclopentyl amide modulators of chemokine receptor activity
JP2007518799A (ja) 2004-01-20 2007-07-12 メルク エンド カムパニー インコーポレーテッド ケモカイン受容体活性モジュレーターとしての2,6−二置換ピペリジン
CA2554387A1 (en) 2004-01-28 2005-08-11 Merck & Co., Inc. Aminocyclopentyl pyridopyrazinone modulators of chemokine receptor activity
AU2005234596B8 (en) * 2004-04-13 2011-06-16 Incyte Holdings Corporation Piperazinylpiperidine derivatives as chemokine receptor antagonists
US7307086B2 (en) * 2004-05-11 2007-12-11 Incyte Corporation 3-(4-heteroarylcyclohexylamino)cyclopentanecarboxamides as modulators of chemokine receptors
CN102382088A (zh) * 2004-06-28 2012-03-21 因赛特公司 作为趋化因子受体调节剂的3-氨基环戊烷甲酰胺类
EP1763351B9 (en) * 2004-06-28 2017-05-31 Incyte Holdings Corporation 3-aminocyclopentanecarboxamides as modulators of chemokine receptors
PA8653301A1 (es) * 2004-11-22 2006-11-09 Incyte Corp Incyte Corp Sales de la n-[2-({(3r)-1-[trans-4-hidroxi-4-(6-metoxipiridin-3-il) ciclohexil)pirrolidin
TWI439452B (zh) 2005-05-13 2014-06-01 Otsuka Pharma Co Ltd 吡咯烷化合物(二)
MEP1008A (xx) * 2005-12-21 2010-02-10 Incyte Corp 3-aminociklopentankarboksamidi kao modulatori receptora hemokina

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US7985730B2 (en) 2011-07-26
KR100895968B1 (ko) 2009-05-07
RU2355679C2 (ru) 2009-05-20
BR0316732A (pt) 2005-10-18
NO330860B1 (no) 2011-08-01
US7834021B2 (en) 2010-11-16
EA010027B1 (ru) 2008-06-30
US20090247474A1 (en) 2009-10-01
US8729063B2 (en) 2014-05-20
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AU2003293129A1 (en) 2004-06-23
CO5690550A2 (es) 2006-10-31
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WO2004050024A3 (en) 2004-07-29
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PL376925A1 (pl) 2006-01-09
JP4828829B2 (ja) 2011-11-30
HK1079773A1 (en) 2006-04-13
MXPA05005660A (es) 2005-10-18
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