KR100739250B1 - 신규 갈락토실세라미드 유사체, 이를 사용한β-글루코세레브로시다제 활성화제, 피부 외용제 및β-글루코세레브로시다제 활성화 방법 - Google Patents

신규 갈락토실세라미드 유사체, 이를 사용한β-글루코세레브로시다제 활성화제, 피부 외용제 및β-글루코세레브로시다제 활성화 방법 Download PDF

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KR100739250B1
KR100739250B1 KR1020037016943A KR20037016943A KR100739250B1 KR 100739250 B1 KR100739250 B1 KR 100739250B1 KR 1020037016943 A KR1020037016943 A KR 1020037016943A KR 20037016943 A KR20037016943 A KR 20037016943A KR 100739250 B1 KR100739250 B1 KR 100739250B1
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glucocerebrosidase
formula
skin
carbon atoms
alkenyl group
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KR20040048381A (ko
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리에 우에마쯔
후미오 나까지마
마사히로 요시다
교꼬 후꾸나가
마리꼬 하라
신따로 이노우에
신이찌로 니시무라
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카오 가부시키가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Cosmetics (AREA)
KR1020037016943A 2001-06-28 2002-06-27 신규 갈락토실세라미드 유사체, 이를 사용한β-글루코세레브로시다제 활성화제, 피부 외용제 및β-글루코세레브로시다제 활성화 방법 Expired - Lifetime KR100739250B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JPJP-P-2001-00196016 2001-06-28
JP2001196016A JP4070966B2 (ja) 2001-06-28 2001-06-28 新規ガラクトシルセラミド類縁体及び用途
PCT/JP2002/006532 WO2003002584A1 (en) 2001-06-28 2002-06-27 NOVEL GALACTOSYLCERAMIDE ANALOGS AND β-GLUCOCEREBROSIDASE ACTIVATORS, EXTERNAL SKIN PREPARATIONS AND METHOD OF ACTIVATING β-GLUCOCEREBROSIDASE USING THE ANALOGS

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KR20040048381A KR20040048381A (ko) 2004-06-09
KR100739250B1 true KR100739250B1 (ko) 2007-07-12

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KR1020037016943A Expired - Lifetime KR100739250B1 (ko) 2001-06-28 2002-06-27 신규 갈락토실세라미드 유사체, 이를 사용한β-글루코세레브로시다제 활성화제, 피부 외용제 및β-글루코세레브로시다제 활성화 방법

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US (2) US7183261B2 (enExample)
EP (1) EP1408045B1 (enExample)
JP (1) JP4070966B2 (enExample)
KR (1) KR100739250B1 (enExample)
CN (1) CN1247605C (enExample)
DE (1) DE60232449D1 (enExample)
TW (2) TWI322151B (enExample)
WO (1) WO2003002584A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20130054029A (ko) * 2011-11-16 2013-05-24 (주)아모레퍼시픽 글리코실 세라마이드 유사 화합물, 이의 제조방법 및 이를 함유하는 화장료 조성물

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5918168B2 (ja) * 2012-04-27 2016-05-18 富士フイルム株式会社 β−グルコセレブロシダーゼ活性増強剤
EP2903622A1 (en) 2012-10-03 2015-08-12 INSERM - Institut National de la Santé et de la Recherche Médicale Methods and pharmaceutical compositions for the prophylactic treatment of bacterial superinfections post-influenza with invariant nkt cell agonists
KR101589633B1 (ko) * 2014-09-18 2016-02-01 한국과학기술연구원 당세라마이드 유도체 및 이의 제조방법
KR102662215B1 (ko) 2014-11-06 2024-05-02 비알 - 알&디 인베스트먼츠, 에스.에이. 치환된 피라졸로(1,5-a)피리미딘 및 의학적 장애의 치료에서의 그의 용도
ES2958391T3 (es) 2014-11-06 2024-02-08 Bial R&D Invest S A Imidazo[1,5-a]pirimidinas sustituidas y su uso en el tratamiento de trastornos médicos
US20180185368A1 (en) 2014-11-06 2018-07-05 Lysosomal Therapeutics Inc. Substituted pyrrolo[1,2-a]pyrimidines and their use in the treatment of medical disorders
WO2017027848A1 (en) * 2015-08-12 2017-02-16 The Arizona Board Of Regents On Behalf Of The University Of Arizona Glycosylated peptides with pseudoproline residues and having enhanced half-lives and ability to cross the blood brain barrier
EP3344276B1 (en) 2015-09-03 2020-04-22 The Board of Regents of the University of Oklahoma Peptide inhibitors of clostridium difficile tcdb toxin
KR20230104752A9 (ko) 2016-04-06 2024-11-15 비알 - 알&디 인베스트먼츠, 에스.에이. 피라졸로[1,5-a]피리미디닐 카르복스아미드 화합물및 의학적 장애의 치료에서의 그의 용도
CA3020310A1 (en) 2016-04-06 2017-10-12 Lysosomal Therapeutics Inc. Pyrrolo[1,2-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
US10787454B2 (en) 2016-04-06 2020-09-29 BIAL—BioTech Investments, Inc. Imidazo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
JP7164774B2 (ja) 2016-05-05 2022-11-02 ビアル－アール・アンド・ディ・インベストメンツ・ソシエダーデ・アノニマ 置換イミダゾ［１，２－ｂ］ピリダジン、置換イミダゾ［１，５－ｂ］ピリダジン、関連化合物、および医学的障害の治療におけるその使用
EP3452455A4 (en) 2016-05-05 2019-11-13 Lysosomal Therapeutics Inc. SUBSTITUTED IMDAZO [1,2-] PYRIDINES, SUBSTITUTED IMIDAZO [1,2-] PYRAZINES, RELATED COMPOUNDS AND THEIR USE IN THE TREATMENT OF ILLNESSES
WO2017207040A1 (en) 2016-06-01 2017-12-07 Vib Vzw ANTI-CANCER THERAPY USING A LEPTIN ANTAGONIST AND AN iNKT-CELL ACTIVATOR
US10933126B2 (en) 2018-05-03 2021-03-02 The Board Of Regents Of The University Of Oklahoma Clostridium difficile immunogenic compositions and methods of use
FR3147951A1 (fr) * 2023-04-19 2024-10-25 Paris Sciences Et Lettres Particules de monosaccharides modifies par une chaine hydrophobe et de cyclodextrine.

Citations (1)

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Publication number Priority date Publication date Assignee Title
JPH05186491A (ja) * 1990-09-25 1993-07-27 D D S Kenkyusho:Kk 酸性糖脂質及び微粒子キャリヤー

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JP2774417B2 (ja) 1991-08-07 1998-07-09 株式会社ディ・ディ・エス研究所 ペプチド骨格を有する分枝鎖型糖複合体及び微粒子キャリヤー
IT1271624B (it) 1994-03-21 1997-06-04 Lifegroup Spa Derivati glucosidici di n-acil alchilamine capaci di esercitare effetto o neuroprotettivo utilizzabili nelle patologie acute e croniche del sistema nervoso centrale correlate ad eccitotossicita'
JP2896321B2 (ja) * 1994-10-27 1999-05-31 鐘紡株式会社 β−グルコセレブロシダーゼの活性化方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05186491A (ja) * 1990-09-25 1993-07-27 D D S Kenkyusho:Kk 酸性糖脂質及び微粒子キャリヤー

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Carbohydrate Research 327(3), 223-260, 2000

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20130054029A (ko) * 2011-11-16 2013-05-24 (주)아모레퍼시픽 글리코실 세라마이드 유사 화합물, 이의 제조방법 및 이를 함유하는 화장료 조성물
KR101936685B1 (ko) 2011-11-16 2019-01-11 (주)아모레퍼시픽 글리코실 세라마이드 유사 화합물, 이의 제조방법 및 이를 함유하는 화장료 조성물

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KR20040048381A (ko) 2004-06-09
JP4070966B2 (ja) 2008-04-02
DE60232449D1 (de) 2009-07-09
TW201002734A (en) 2010-01-16
EP1408045B1 (en) 2009-05-27
WO2003002584A1 (en) 2003-01-09
EP1408045A4 (en) 2005-12-28
JP2003012684A (ja) 2003-01-15
US20070111951A1 (en) 2007-05-17
EP1408045A1 (en) 2004-04-14
CN1247605C (zh) 2006-03-29
CN1522263A (zh) 2004-08-18
US20040242499A1 (en) 2004-12-02
TWI322151B (enExample) 2010-03-21
US7183261B2 (en) 2007-02-27
HK1067642A1 (en) 2005-04-15

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