JP6830580B2 - セラミド含量増加剤 - Google Patents
セラミド含量増加剤 Download PDFInfo
- Publication number
- JP6830580B2 JP6830580B2 JP2017561557A JP2017561557A JP6830580B2 JP 6830580 B2 JP6830580 B2 JP 6830580B2 JP 2017561557 A JP2017561557 A JP 2017561557A JP 2017561557 A JP2017561557 A JP 2017561557A JP 6830580 B2 JP6830580 B2 JP 6830580B2
- Authority
- JP
- Japan
- Prior art keywords
- anhydroglucitol
- ceramide
- galloyl
- acid
- digalloyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229940106189 ceramide Drugs 0.000 title claims description 119
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 title claims description 114
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 title claims description 114
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 title claims description 114
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 title claims description 113
- -1 2,6-anhydro-L-gulonic acid methyl ester Chemical class 0.000 claims description 146
- 150000001875 compounds Chemical class 0.000 claims description 104
- 239000000203 mixture Substances 0.000 claims description 42
- 230000015572 biosynthetic process Effects 0.000 claims description 36
- 150000003839 salts Chemical class 0.000 claims description 36
- 238000003786 synthesis reaction Methods 0.000 claims description 35
- 239000002253 acid Substances 0.000 claims description 21
- 238000002360 preparation method Methods 0.000 claims description 19
- 239000003795 chemical substances by application Substances 0.000 claims description 17
- 229940125532 enzyme inhibitor Drugs 0.000 claims description 17
- 239000002532 enzyme inhibitor Substances 0.000 claims description 17
- 230000000593 degrading effect Effects 0.000 claims description 9
- 230000002265 prevention Effects 0.000 claims description 8
- 230000008099 melanin synthesis Effects 0.000 claims description 7
- 230000003405 preventing effect Effects 0.000 claims description 7
- KDNLOICXXVYUKB-PJIALRRASA-N 1-hydroxy-1-[(2S,3S,4R,5S)-3,4,5-trihydroxyoxan-2-yl]nonan-2-one Chemical compound C(CCCCCCC)(=O)C([C@@H]1[C@H]([C@@H]([C@H](CO1)O)O)O)O KDNLOICXXVYUKB-PJIALRRASA-N 0.000 claims description 4
- PVRCWDNAHBVETM-OOAQSJESSA-N 1-hydroxy-1-[(2r,3r,4r,5s)-3,4,5-triacetyl-3,4,5-trihydroxyoxan-2-yl]propan-2-one Chemical compound CC(=O)C(O)[C@H]1OC[C@@](O)(C(C)=O)[C@](O)(C(C)=O)[C@@]1(O)C(C)=O PVRCWDNAHBVETM-OOAQSJESSA-N 0.000 claims description 3
- VRIPKMFWYJUWFT-RFHZKXQOSA-N 3-hydroxy-3-[(2R,3S,4R,5S)-3,4,5-trihydroxyoxan-2-yl]propanoic acid Chemical compound C(=O)(O)CC([C@@H]1[C@H]([C@@H]([C@H](CO1)O)O)O)O VRIPKMFWYJUWFT-RFHZKXQOSA-N 0.000 claims description 3
- SQVRNKJHWKZAKO-PFQGKNLYSA-N N-acetyl-beta-neuraminic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-PFQGKNLYSA-N 0.000 claims description 3
- XUZYVFYOPRXTRB-UHFFFAOYSA-N Tellimagrandin I Natural products OC1COC(=O)C2=CC(O)=C(O)C(O)=C2C2=C(O)C(O)=C(O)C=C2C(=O)OC1C(C(OC(=O)C=1C=C(O)C(O)=C(O)C=1)C=O)OC(=O)C1=CC(O)=C(O)C(O)=C1 XUZYVFYOPRXTRB-UHFFFAOYSA-N 0.000 claims description 3
- YKDNTEQLKGYZHT-HTCCRONFSA-N Tellimagrandin I Chemical compound O([C@H]1[C@@H]2OC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC[C@H]2OC([C@@H]1OC(=O)C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 YKDNTEQLKGYZHT-HTCCRONFSA-N 0.000 claims description 3
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims description 3
- KYIOVQZVBFQNEB-QTBDOELSSA-N (2s,3s,4r,5s)-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound O[C@H]1CO[C@H](C(O)=O)[C@@H](O)[C@@H]1O KYIOVQZVBFQNEB-QTBDOELSSA-N 0.000 claims 2
- BJHIKXHVCXFQLS-PUFIMZNGSA-N D-psicose Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)C(=O)CO BJHIKXHVCXFQLS-PUFIMZNGSA-N 0.000 claims 2
- 230000001629 suppression Effects 0.000 claims 2
- HOVAGTYPODGVJG-UHFFFAOYSA-N methyl beta-galactoside Natural products COC1OC(CO)C(O)C(O)C1O HOVAGTYPODGVJG-UHFFFAOYSA-N 0.000 claims 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 39
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 39
- 230000000694 effects Effects 0.000 description 34
- 235000002639 sodium chloride Nutrition 0.000 description 31
- 238000000034 method Methods 0.000 description 25
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 24
- 210000004027 cell Anatomy 0.000 description 24
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 22
- 210000003491 skin Anatomy 0.000 description 22
- 230000002401 inhibitory effect Effects 0.000 description 20
- 125000002252 acyl group Chemical group 0.000 description 18
- 239000000243 solution Substances 0.000 description 18
- 125000001424 substituent group Chemical group 0.000 description 18
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- 206010012438 Dermatitis atopic Diseases 0.000 description 13
- 201000008937 atopic dermatitis Diseases 0.000 description 13
- 201000010099 disease Diseases 0.000 description 13
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 13
- 102000004201 Ceramidases Human genes 0.000 description 11
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 11
- 125000003118 aryl group Chemical group 0.000 description 11
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- 102000004190 Enzymes Human genes 0.000 description 10
- 108090000790 Enzymes Proteins 0.000 description 10
- 125000003545 alkoxy group Chemical group 0.000 description 10
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- 230000007812 deficiency Effects 0.000 description 10
- 235000014113 dietary fatty acids Nutrition 0.000 description 10
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- 125000001072 heteroaryl group Chemical group 0.000 description 10
- 230000006872 improvement Effects 0.000 description 10
- 210000002374 sebum Anatomy 0.000 description 10
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 9
- 125000005645 linoleyl group Chemical group 0.000 description 9
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 description 9
- 125000004432 carbon atom Chemical group C* 0.000 description 8
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 8
- 239000003814 drug Substances 0.000 description 8
- 150000002148 esters Chemical class 0.000 description 8
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- 125000000547 substituted alkyl group Chemical group 0.000 description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 7
- 230000004888 barrier function Effects 0.000 description 7
- 125000000753 cycloalkyl group Chemical group 0.000 description 7
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 7
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- 230000003020 moisturizing effect Effects 0.000 description 7
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- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 6
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 6
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- 125000005842 heteroatom Chemical group 0.000 description 6
- 125000000592 heterocycloalkyl group Chemical group 0.000 description 6
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- 239000003112 inhibitor Substances 0.000 description 6
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 6
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 6
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 6
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- 125000005415 substituted alkoxy group Chemical group 0.000 description 6
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 5
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- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 5
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 5
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- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 5
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- 238000004445 quantitative analysis Methods 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 235000005875 quercetin Nutrition 0.000 description 1
- 229960001285 quercetin Drugs 0.000 description 1
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- OXGUCUVFOIWWQJ-HQBVPOQASA-N quercitrin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OXGUCUVFOIWWQJ-HQBVPOQASA-N 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
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- 238000011160 research Methods 0.000 description 1
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- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 1
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- 229960004555 rutoside Drugs 0.000 description 1
- NGFMICBWJRZIBI-UJPOAAIJSA-N salicin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=CC=C1CO NGFMICBWJRZIBI-UJPOAAIJSA-N 0.000 description 1
- 229940120668 salicin Drugs 0.000 description 1
- CQRYARSYNCAZFO-UHFFFAOYSA-N salicyl alcohol Chemical compound OCC1=CC=CC=C1O CQRYARSYNCAZFO-UHFFFAOYSA-N 0.000 description 1
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- 235000017709 saponins Nutrition 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 235000020374 simple syrup Nutrition 0.000 description 1
- 230000036559 skin health Effects 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
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- 239000000661 sodium alginate Substances 0.000 description 1
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- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000004320 sodium erythorbate Substances 0.000 description 1
- 235000010352 sodium erythorbate Nutrition 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
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- 235000010265 sodium sulphite Nutrition 0.000 description 1
- RBWSWDPRDBEWCR-RKJRWTFHSA-N sodium;(2r)-2-[(2r)-3,4-dihydroxy-5-oxo-2h-furan-2-yl]-2-hydroxyethanolate Chemical compound [Na+].[O-]C[C@@H](O)[C@H]1OC(=O)C(O)=C1O RBWSWDPRDBEWCR-RKJRWTFHSA-N 0.000 description 1
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- 239000000454 talc Substances 0.000 description 1
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- 235000018553 tannin Nutrition 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- XKXIQBVKMABYQJ-UHFFFAOYSA-M tert-butyl carbonate Chemical compound CC(C)(C)OC([O-])=O XKXIQBVKMABYQJ-UHFFFAOYSA-M 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 description 1
- 229960002663 thioctic acid Drugs 0.000 description 1
- 238000001269 time-of-flight mass spectrometry Methods 0.000 description 1
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- 229960000716 tonics Drugs 0.000 description 1
- LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 description 1
- LOIYMIARKYCTBW-OWOJBTEDSA-N trans-urocanic acid Chemical compound OC(=O)\C=C\C1=CNC=N1 LOIYMIARKYCTBW-OWOJBTEDSA-N 0.000 description 1
- LOIYMIARKYCTBW-UHFFFAOYSA-N trans-urocanic acid Natural products OC(=O)C=CC1=CNC=N1 LOIYMIARKYCTBW-UHFFFAOYSA-N 0.000 description 1
- 150000003625 trehaloses Chemical class 0.000 description 1
- SZEMGTQCPRNXEG-UHFFFAOYSA-M trimethyl(octadecyl)azanium;bromide Chemical compound [Br-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C SZEMGTQCPRNXEG-UHFFFAOYSA-M 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229940045136 urea Drugs 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical group NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- TUUBOHWZSQXCSW-UHFFFAOYSA-N vanillic acid Natural products COC1=CC(O)=CC(C(O)=O)=C1 TUUBOHWZSQXCSW-UHFFFAOYSA-N 0.000 description 1
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- 239000001993 wax Substances 0.000 description 1
- 229940012185 zinc palmitate Drugs 0.000 description 1
- GJAPSKMAVXDBIU-UHFFFAOYSA-L zinc;hexadecanoate Chemical compound [Zn+2].CCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCC([O-])=O GJAPSKMAVXDBIU-UHFFFAOYSA-L 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7012—Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Pyrane Compounds (AREA)
- Cosmetics (AREA)
Description
〔1〕 式(I)で表される化合物又はその医薬上許容される塩からなる、セラミド含量増加剤。
R2はそれぞれ独立して、水素原子、置換されていてもよいアルキル、置換されていてもよいアルケニル、置換されていてもよいアルキニル、置換されていてもよいシクロアルキル、置換されていてもよいシクロアルケニル、置換されていてもよいアリール、置換されていてもよいヘテロアリール、又は置換されていてもよいアシルであり;
R3は水素原子、−CH2OR4、−CHOR4−CH2OR4、もしくは−COOR4であり、ここでR4は水素原子、置換されていてもよいアルキル、置換されていてもよいアルケニル、置換されていてもよいアルキニル、置換されていてもよいシクロアルキル、置換されていてもよいシクロアルケニル、置換されていてもよいアリール、置換されていてもよいヘテロアリール、又は置換されていてもよいアシルであり;
nは0又は1である)
〔2〕 前記式(I)で表される化合物又はその医薬上許容される塩からなる、セラミド分解酵素阻害剤。
〔3〕 式(II)で表される化合物又はその医薬上許容される塩を含む、セラミド合成促進剤。
〔4〕 前記〔1〕記載のセラミド含量増加剤、前記〔2〕記載のセラミド分解酵素阻害剤、又は、前記〔3〕記載のセラミド合成促進剤を含有してなる組成物。
〔5〕 下記式で表される化合物。
〔7〕 前記〔2〕に記載の式(I)で表される化合物、前記〔3〕に記載の式(II)で表される化合物、又はそれらの医薬上許容される塩の有効量を、下記(i)〜(iii)から選ばれるいずれかの予防又は改善を必要とする個体に投与する工程を含む、下記(i)〜(iii)から選ばれるいずれかを予防及び/又は改善する方法。
(i) アトピー性皮膚炎又はアトピー性皮膚炎が起因となる疾患の症状
(ii) 皮脂欠乏症又は皮脂欠乏症が起因となる疾患の症状
(iii) 創傷
〔8〕 細胞におけるセラミド量を増加するための、前記〔2〕に記載の式(I)で表される化合物、前記〔3〕に記載の式(II)で表される化合物、又はそれらの医薬上許容される塩。
〔9〕 下記(i)〜(iii)から選ばれるいずれかを予防及び/又は改善するための、前記〔2〕に記載の式(I)で表される化合物、前記〔3〕に記載の式(II)で表される化合物、又はそれらの医薬上許容される塩。
(i) アトピー性皮膚炎又はアトピー性皮膚炎が起因となる疾患の症状
(ii) 皮脂欠乏症又は皮脂欠乏症が起因となる疾患の症状
(iii) 創傷
〔10〕 細胞におけるセラミド量を増加するための、前記〔2〕に記載の式(I)で表される化合物、前記〔3〕に記載の式(II)で表される化合物、又はそれらの医薬上許容される塩の使用。
〔11〕 下記(i)〜(iii)から選ばれるいずれかを予防及び/又は改善するための、前記〔2〕に記載の式(I)で表される化合物、前記〔3〕に記載の式(II)で表される化合物、又はそれらの医薬上許容される塩の使用。
(i) アトピー性皮膚炎又はアトピー性皮膚炎が起因となる疾患の症状
(ii) 皮脂欠乏症又は皮脂欠乏症が起因となる疾患の症状
(iii) 創傷
〔12〕 細胞におけるセラミド量を増加するための組成物の調製における、前記〔2〕に記載の式(I)で表される化合物、前記〔3〕に記載の式(II)で表される化合物、又はそれらの医薬上許容される塩の使用。
〔13〕 下記(i)〜(iii)から選ばれるいずれかを予防及び/又は改善するための組成物の調製における、前記〔2〕に記載の式(I)で表される化合物、前記〔3〕に記載の式(II)で表される化合物、又はそれらの医薬上許容される塩の使用。
(i) アトピー性皮膚炎又はアトピー性皮膚炎が起因となる疾患の症状
(ii) 皮脂欠乏症又は皮脂欠乏症が起因となる疾患の症状
(iii) 創傷
本発明のセラミド分解酵素阻害剤は、前記式(I)で示される5員環又は6員環の糖を基本骨格とする誘導体であることを特徴とする。なお、式(I)で表される化合物及びその医薬上許容される塩のことを、まとめて本発明の態様1の化合物と記載することもある。
1,5−anhydroglucitol, 1,4−anhydroglucitol, 1,5−anhydrogalactitol, 1,4−anhydrogalactitol, 1,4−anhydro−L−arabinitol, 1,4−anhydro−D−arabinitol, 1,5−anhydroxylitol, 1,4−anhydroxylitol, 1−deoxycellobiose, 1−deoxymaltose, 1−deoxylactose, trehalose, arbutin, salicin, phlorhizin, aesculin, apiin, daidzin, quercitrin, rutin, hesperidin, naringin, ruberythric acid, indicant, digitoxin, digitonin, 2,6−anhydro−L−gulonic acid, glucuronic acid, galacturonic acid, gluconolactone, baicalin, glycyrrhizin, 6−octanoyl−1,5−anhydroglucitol, n−octyl−β−D−glucopyranoside, hyaluronic acid, 6−carboxymetyl−1,5−anhydroglucitol, 2,3,4,6−tetraacetyl−1,5−anhydroglucitol, penta−O−acetyl−β−D−glucoside, penta−O−acetyl−α−D−glucoside, penta−O−acetyl−α−D−galactoside, α−D−cellobiose octaacetate, tetraacetyl ribofuranoside, neohesperidin, carminic acid, N−acetylneuraminic acid, 3,4,6−triacetyl−2−deoxy−D−glucose, 1,2,3,4−tetraacetyl−α−L−fucopyranoside, Neu5Ac α(2−3)Gal β(1−4)GlcNAc−β−pNP, methyl 1,2,3,4−tetra−O−acetyl−β−D−glucuronate, 2,3,4−tri−O−acetyl−1,5−anhydroglucuronic acid methylester, 1−deoxyglucuronic acid methylester, pentagalloylglucose, casuarictin, tellimagrandin I, tellimagrandin II, coriariin A, punicalagin, alienanin B, melasquanin A, melasquanin B, melasquanin C, melasquanin D, castamollinin, anogeissinin A, anogeissinin B, agrimoniin, rugosin A, strictinin, 2−galloyl−1,5−anhydroglucitol, 3−galloyl−1,5−anhydroglucitol, 4−galloyl−1,5−anhydroglucitol, 6−galloyl−1,5−anhydroglucitol, 2,3−digalloyl−1,5−anhydroglucitol, 2,4−digalloyl−1,5−anhydroglucitol, 2,6−digalloyl−1,5−anhydroglucitol, 3,6−digalloyl−1,5−anhydroglucitol, 4,6−digalloyl−1,5−anhydroglucitol, 2,3,6−trigalloyl−1,5−anhydroglucitol, 2,4,6−trigalloyl−1,5−anhydroglucitol, 2,3,4,6−tetragalloyl−1,5−anhydroglucitol
hyaluronic acid sodium salt, hyaluronic acid potassium salt, hyaluronic acid calcium salt, hyaluronic acid ammonium salt
本発明のセラミド合成促進剤は、前記式(II)で示されるように、6員環の糖(1,5-アンヒドロ-D-グルシトール、以降、「1,5-AG」と記載する場合もある)を基本骨格とし、少なくとも1個の水酸基に没食子酸のカルボキシル基がエステル結合した化合物であることを特徴とする。以降、式(II)で表される化合物及びその医薬上許容される塩のことを、まとめて本発明の態様2の化合物と記載することもある。なお、本明細書における用語「基」又は「置換基」は1価基を意味し、置換基の説明において、「基」なる用語を省略する場合もある。
〔下記(2)〕
[α]D 25: +15.3°(c1.0, chloroform); m.p. : 162-164 ℃;
1H NMR (CDCl3, 300 MHz) : δ3.30 (t, 1H), 3.72 (m, 3H), 4.04-4.15 (m, 3H), 4.56-4.81 (m, 5H), 5.03-5.11 (m, 13H), 5.32 (t, 1H), 7.23-7.43 (m, 44H);
13C NMR (CDCl3, 75 MHz) : δ 63.5, 68.3, 71.1, 71.3, 73.5, 75.1, 78.2, 83.0, 109.2, 109.5, 124.6, 124.8, 127.5, 127.6, 127.9, 128.1, 128.2, 128.5, 136.6, 136.8, 137.4, 137.5, 137.9;
IR (KBr) 465, 588, 696, 750, 860, 912, 977, 1027, 1120, 1203, 1338, 1373, 1427, 1500, 1589, 1720, 1810, 1880, 1953, 2867, 2938, 3031, 3064 cm-1.
〔下記(3)〕
[α]D 25: +63.4°(c1.0, methanol);
1H NMR (CD3OD, 300 MHz) : δ3.57-3.59(m, 2H), 3.66-3.72 (m, 1H), 3.94 (dd, 1H), 4.10 (dd, 1H), 4.34 (d, 1H), 5.03 (m, 1H), 7.01-7.20 (m, 4H);
13C NMR (CD3OD, 75 MHz) : δ 64.2, 71.0, 71.5, 72.6, 77.7, 78.2, 110.3, 110.4, 121.2, 121.3, 129.2, 129. 9, 139.9, 140.0, 146.4, 167.6, 168.1;
IR (KBr) 526, 565, 607, 661, 763, 811, 867, 997, 1037, 1099, 1240, 1348, 1452, 1540, 1616, 1700, 3396 cm-1;
ESI-TOFMS m/z : calcd for 491.08016; found, 491.07917.
Bligh, E. G., Dyer, W. J. (1959) A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol, 37, 911-917に記載の方法に従って、下記に示す化合物を合成した。
13C NMR (CD3OD, 75 MHz) : δ55.1, 67.2, 70.4, 71.1, 72.5, 74.0, 99.4, 111.2, 111.3, 122.0, 139.8, 147.5, 147.6, 169.4.
各化合物のin vitroセラミド分解酵素阻害活性を測定した。なお、上記製造例1で製造したサンプル以外は、市販品や公知の方法に従って合成したものを用いた。
各化合物によるin vivoのセラミド量増加を測定した。
3.0cm×3.0cm四方のSEKISUI シュープリームテープE(基材ポリプロピレン、アクリル系粘着剤)を軽く押し当てた後はがす操作を5回行い、各部位において5枚のテープを採取する。
得られたテープ5枚をメタノール90mL及びクロロホルム10mLの混合溶液に浸け、超音波を用いて約20分間抽出した後、メンブランフィルター(5μm)を通し、得られた溶液を25℃以下にて溶媒を留去する。得られた残差を真空ポンプを用いて乾燥させた後、これにクロロホルム/メタノール=99.5/0.5(v/v)溶液100mLを加えて溶解し、次いでwaters社製 Sep-Pak(登録商標)Vac RC(500mg)に通液する。得られたSep-Pak(登録商標)カートリッジにクロロホルム/メタノール=99.5/0.5(v/v)溶液60mLを通液した後、クロロホルム/メタノール=95/5(v/v)溶液60mLを通液する。クロロホルム/メタノール=95/5(v/v)溶液60mLを通液したフラクションを25℃以下で減圧濃縮した後、残差にクロロホルム/メタノール=9/1(v/v)0.5mLを加えて均一に溶解したものをサンプルとする。
各サンプル(A、B、C、D)それぞれ20μL及びセラミド標準品としてMatoreya社製 N-Tetracosanoyl-D-erythro-sphingosine(5mg/10mLクロロホルム溶液)10μLを、薄層クロマトグラフ板としてメルク社製薄層クロマトグラフ板(TLC Silica gel 60F254 ガラスプレート)、移動相としてクロロホルム/メタノール/酢酸=190/10/1(v/v/v)を用いて展開した後、8%硫酸銅水溶液、10%リン酸水溶液を順次噴霧した後、160℃で15分間加熱する。得られたスポットをImageJを用いて分析し、未塗布部位Dの発色を1とした場合の塗布部位A、B、Cの相対値を算出し、サンプル塗布による皮膚セラミド量の増加度合いを分析する。
各化合物のin vitroセラミド合成量を測定した。なお、上記製造例1及び2で製造したサンプル以外は、市販品や公知の方法に従って合成したものを用いた。
6-galloyl-1,5-anhydro-D-glucitolによる創傷治癒効果を評価した。
Claims (12)
- 6−galloyl−1,5−anhydroglucitol, 2−galloyl−1,5−anhydroglucitol, 2,6−digalloyl−1,5−anhydroglucitol,及び 2,3,4,6−tetragalloyl−1,5−anhydroglucitolからなる群より選択される1種以上の化合物又はその医薬上許容される塩を含む、セラミド含量増加剤(但し、シミの予防又はメラニン生成抑制のために使用するものを除く)。
- 3−galloyl−1,5−anhydroglucitol, 4−galloyl−1,5−anhydroglucitol, 2,3−digalloyl−1,5−anhydroglucitol, 2,4−digalloyl−1,5−anhydroglucitol, 3,6−digalloyl−1,5−anhydroglucitol, 4,6−digalloyl−1,5−anhydroglucitol, 2,3,4−trigalloyl−1,5−anhydroglucitol, 2,4,6−trigalloyl−1,5−anhydroglucitol, 6−galloyl−methylglucoside, 6−carboxymetyl−1,5−anhydroglucitol, 2,6−anhydro−L−gulonic acid, 2,6−anhydro−L−gulonic acid methyl ester, tellimagrandin I, baicalin, D-psicose, galacturonic acid, 6−octanoyl−1,5−anhydroglucitol, 2,3,4,6−tetraacetyl−1,5−anhydroglucitol, penta−O−acetyl−β−D−glucoside, penta−O−acetyl−α−D−galactoside,及びN−acetylneuraminic acidからなる群より選択される1種以上の化合物又はその医薬上許容される塩を含む、セラミド含量増加剤。
- 6−galloyl−1,5−anhydroglucitol, 2−galloyl−1,5−anhydroglucitol, 2,6−digalloyl−1,5−anhydroglucitol,及び 2,3,4,6−tetragalloyl−1,5−anhydroglucitolからなる群より選択される1種以上の化合物又はその医薬上許容される塩を含む、セラミド分解酵素阻害剤(但し、シミの予防又はメラニン生成抑制のために使用するものを除く)。
- 3−galloyl−1,5−anhydroglucitol, 4−galloyl−1,5−anhydroglucitol, 2,3−digalloyl−1,5−anhydroglucitol, 2,4−digalloyl−1,5−anhydroglucitol, 3,6−digalloyl−1,5−anhydroglucitol, 4,6−digalloyl−1,5−anhydroglucitol, 2,3,4−trigalloyl−1,5−anhydroglucitol, 2,4,6−trigalloyl−1,5−anhydroglucitol, 6−carboxymetyl−1,5−anhydroglucitol, 2,6−anhydro−L−gulonic acid, 2,6−anhydro−L−gulonic acid methyl ester, tellimagrandin I, baicalin, D-psicose, galacturonic acid, 6−octanoyl−1,5−anhydroglucitol, 2,3,4,6−tetraacetyl−1,5−anhydroglucitol, penta−O−acetyl−β−D−glucoside, penta−O−acetyl−α−D−galactoside,及びN−acetylneuraminic acidからなる群より選択される1種以上の化合物又はその医薬上許容される塩を含む、セラミド分解酵素阻害剤。
- 4,6-digalloyl-1,5-anhydroglucitolである、請求項4記載のセラミド分解酵素阻害剤。
- 6−galloyl−1,5−anhydroglucitol, 2−galloyl−1,5−anhydroglucitol,及び 2,6−digalloyl−1,5−anhydroglucitolからなる群より選択される1種以上の化合物又はその医薬上許容される塩を含む、セラミド合成促進剤(但し、シミの予防又はメラニン生成抑制のために使用するものを除く)。
- 3−galloyl−1,5−anhydroglucitol, 4−galloyl−1,5−anhydroglucitol, 2,3−digalloyl−1,5−anhydroglucitol, 2,4−digalloyl−1,5−anhydroglucitol, 4,6−digalloyl−1,5−anhydroglucitol, 2,3,4−trigalloyl−1,5−anhydroglucitol, 2,4,6−trigalloyl−1,5−anhydroglucitol,及び 6−galloyl−methylglucosideからなる群より選択される1種以上の化合物又はその医薬上許容される塩からなる、セラミド合成促進剤。
- 4,6-digalloyl-1,5-anhydroglucitolである、請求項7記載のセラミド合成促進剤。
- 6−galloyl−methylglucosideである、請求項7記載のセラミド合成促進剤。
- 下記式で表される化合物。
- 細胞におけるセラミド量を増加するための組成物(但し、シミの予防又はメラニン生成抑制のために使用するものを除く)の調製における、請求項1に記載の化合物又はその医薬上許容される塩の使用。
- 細胞におけるセラミド量を増加するための組成物の調製における、請求項2に記載の化合物又はその医薬上許容される塩の使用。
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