KR100511815B1 - 플루오르화된 17α-알킬 사슬이 있는 항제스타겐성 스테로이드 - Google Patents

플루오르화된 17α-알킬 사슬이 있는 항제스타겐성 스테로이드 Download PDF

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Publication number
KR100511815B1
KR100511815B1 KR10-1999-7007098A KR19997007098A KR100511815B1 KR 100511815 B1 KR100511815 B1 KR 100511815B1 KR 19997007098 A KR19997007098 A KR 19997007098A KR 100511815 B1 KR100511815 B1 KR 100511815B1
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KR
South Korea
Prior art keywords
hydroxy
pentafluoroethyl
estra
group
estr
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR10-1999-7007098A
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English (en)
Korean (ko)
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KR20000070835A (ko
Inventor
볼프강 쉬베데
알베트 클레베
울리히 클라르
귄터 네에프
크리스토프 크발리쯔
마르틴 쉬나이더
울리케 푸르만
홀거 헤스-스툼프
Original Assignee
쉐링 악티엔게젤샤프트
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Publication of KR20000070835A publication Critical patent/KR20000070835A/ko
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Publication of KR100511815B1 publication Critical patent/KR100511815B1/ko
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Pregnancy & Childbirth (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR10-1999-7007098A 1997-02-07 1998-02-09 플루오르화된 17α-알킬 사슬이 있는 항제스타겐성 스테로이드 Expired - Fee Related KR100511815B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19706061.7 1997-02-07
DE19706061A DE19706061A1 (de) 1997-02-07 1997-02-07 Antigestagen wirksame Steroide mit fluorierter 17alpha-Alkylkette
PCT/EP1998/000752 WO1998034947A1 (de) 1997-02-07 1998-02-09 ANTIGESTAGEN WIRKSAME STEROIDE MIT FLUORIERTER 17α-ALKYLKETTE

Publications (2)

Publication Number Publication Date
KR20000070835A KR20000070835A (ko) 2000-11-25
KR100511815B1 true KR100511815B1 (ko) 2005-09-05

Family

ID=7820508

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-1999-7007098A Expired - Fee Related KR100511815B1 (ko) 1997-02-07 1998-02-09 플루오르화된 17α-알킬 사슬이 있는 항제스타겐성 스테로이드

Country Status (35)

Country Link
US (4) US6316432B1 (https=)
EP (1) EP0970103B1 (https=)
JP (1) JP4324249B2 (https=)
KR (1) KR100511815B1 (https=)
CN (2) CN1246865A (https=)
AR (1) AR010887A1 (https=)
AT (1) ATE216397T1 (https=)
AU (1) AU742834B2 (https=)
BG (1) BG63875B1 (https=)
BR (1) BR9807667A (https=)
CA (1) CA2280041C (https=)
CL (1) CL2004001191A1 (https=)
CZ (1) CZ296328B6 (https=)
DE (2) DE19706061A1 (https=)
DK (1) DK0970103T3 (https=)
EA (1) EA003092B1 (https=)
EE (1) EE03831B1 (https=)
ES (1) ES2175673T3 (https=)
HK (1) HK1040718B (https=)
HU (1) HUP0000968A3 (https=)
ID (1) ID22643A (https=)
IL (1) IL131226A (https=)
IS (1) IS2190B (https=)
MY (1) MY118508A (https=)
NO (1) NO313554B1 (https=)
NZ (1) NZ336989A (https=)
PL (1) PL191808B1 (https=)
PT (1) PT970103E (https=)
SI (1) SI0970103T1 (https=)
SK (1) SK283155B6 (https=)
TR (1) TR199901855T2 (https=)
TW (1) TW499434B (https=)
UA (1) UA66783C2 (https=)
WO (1) WO1998034947A1 (https=)
ZA (1) ZA98985B (https=)

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UY26966A1 (es) * 2000-10-18 2002-06-20 Schering Ag Uso de antiprogestinas para la inducción de apoptosis en una célula
EP1326617B9 (en) * 2000-10-18 2006-10-25 Schering Aktiengesellschaft Use of 11beta-(4-acetylphenyl)-17beta-hydroxy-17alpha-(1,1,2,2-pentafluoroethyl)estra-4,9-dien-3-one for the preparation of a medicament for the treatment fo breast, ovarian, endometrial cancer, myeloma and meningioma
DE10051609A1 (de) * 2000-10-18 2002-05-02 Schering Ag Hemmung der Wachstumsfaktorabhängigkeit von Tumorzellen
UY26965A1 (es) * 2000-10-18 2002-06-20 Schering Ag Uso de antiprogestinas para la profilaxis y el tratamiento de enfermedades dependientes de hormonas
EP1328276B1 (en) 2000-10-18 2005-11-23 Schering Aktiengesellschaft Use of antiprogestins for prophylaxis and treatment of hormone-dependent diseases
AU2002215958B2 (en) * 2000-10-18 2006-08-17 Schering Ag Use of inhibitors of progesterone receptor for treating cancer
PL361689A1 (en) * 2001-01-09 2004-10-04 Schering Aktiengesellschaft The use of antigestagens for inhibiting accelerated endometrial maturation during infertility treatment
US20020143000A1 (en) * 2001-01-09 2002-10-03 Christa Hegele-Hartung Use of antigestagens for inhibiting accelerated endometrial maturation during infertility treatment
US20030013694A1 (en) * 2001-05-25 2003-01-16 Jens Hoffmann Use and compositions of antiprogestins for treatment of prostate diseases
UY27301A1 (es) * 2001-05-25 2003-02-28 Schering Ag Uso y composiciones de antiprogestinas para el tratamiento de enfermedades de la próstata
DE10159217A1 (de) 2001-11-27 2003-06-05 Schering Ag 17alpha-Alkyl-17ß-oxy-estratriene und Zwischenprodukte zu deren Herstellung, Verwendung der 17alpha-Alkyl-17ß-oxy-estratriene zur Herstellung von Arzneimitteln sowie pharmazeutische Präparate
DE10221034A1 (de) * 2002-05-03 2003-11-20 Schering Ag 17alpha-Fluoralkyl-11ß-benzaldoxim-Steroide, Verfahren zu deren Herstellung, diese Steroide enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
ATE307823T1 (de) * 2002-05-03 2005-11-15 Schering Ag 17a-fluoralkyl-11beta-benzaldoxim-steroide, verfahren zu deren herstellung, diese steroide enthaltende pharmazeutische präparate sowie deren verwendung zur herstellung von arzneimitteln
US20040242551A1 (en) * 2003-05-28 2004-12-02 Schering Ag Composition comprising antiprogestins and pure antiestrogens for prophylaxis and treatment of hormone-dependent diseases
EA010485B1 (ru) 2003-07-23 2008-10-30 Байер Фамэсьютиклс Копэрейшн Производное n,n'-дифенилмочевины, фармацевтическая композиция (варианты) и способ лечения и предупреждения заболеваний и состояний с его использованием (варианты)
US7593347B2 (en) * 2003-12-29 2009-09-22 Intel Corporation Method and apparatus to exchange channel information
EP1862468A1 (de) * 2006-06-02 2007-12-05 Bayer Schering Pharma Aktiengesellschaft Kristallines 11beta-(4-Acetylphenyl)-20,20,21,21,21-pentafluor-17-hydroxy-19-nor-17alpha-pregna-4,9-dien-3-on
HUE036870T2 (hu) 2006-10-24 2018-08-28 Repros Therapeutics Inc Az endometriális proliferáció elnyomására szolgáló készítmények és módszerek
DE102006054535A1 (de) * 2006-11-15 2008-05-21 Bayer Schering Pharma Aktiengesellschaft Progesteronrezeptorantagonisten
US20080268041A1 (en) * 2007-04-23 2008-10-30 Jens Hoffmann Combination of progesterone-receptor antagonist together with none-steroidal antiestrogen for use in brca mediated diseases
EP2136796A2 (en) * 2007-04-23 2009-12-30 Bayer Schering Pharma Aktiengesellschaft Progesterone-receptor antagonist for use in brca-mediated cancer alone or as combination with antiestrogen
TWI539953B (zh) 2008-04-28 2016-07-01 瑞波若斯治療學公司 用於治療乳癌之組成物和方法
EP2123279A1 (de) * 2008-05-14 2009-11-25 Bayer Schering Pharma Aktiengesellschaft Sequentielle Verabreichung von 20,20,21,21,21-Pentafluor-17-hydroxy-1 1beta-[4-(hydroxyacetyl) phenyl]-19-nor-17alpha-pregna-4,9-dien-3-on und einem oder mehreren Gestagenen zur Behandlung gynäkologischer Erkrankungen
US20100087402A1 (en) * 2008-09-29 2010-04-08 Vivus, Inc. Methods and compositions for the treatment of estrogen-dependent hyperproliferative uterine disorders
DE102009034366A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-methylenoxyalkylenaryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
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DE102009034368A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-acyloxyalkylenphenyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
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US5006518A (en) * 1987-12-30 1991-04-09 Roussel Uclaf Novel 17β-hydroxy-19-nor-steroids
US5132299A (en) * 1987-07-16 1992-07-21 Schering Aktiengesellschaft 11β-phenyl-4,9,15-estratrienes, their manufacture and pharmaceutical preparations containing same

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Also Published As

Publication number Publication date
US20020045774A1 (en) 2002-04-18
DE19706061A1 (de) 1998-08-13
CN1324802A (zh) 2001-12-05
HUP0000968A3 (en) 2001-03-28
CN1246865A (zh) 2000-03-08
US6503895B2 (en) 2003-01-07
CZ296328B6 (cs) 2006-02-15
EA199900644A1 (ru) 2000-04-24
HK1040718B (zh) 2005-12-09
US6316432B1 (en) 2001-11-13
NO993811L (no) 1999-10-04
IL131226A (en) 2004-12-15
WO1998034947A1 (de) 1998-08-13
BG63875B1 (bg) 2003-04-30
PL334878A1 (en) 2000-03-27
HUP0000968A2 (hu) 2000-10-28
KR20000070835A (ko) 2000-11-25
MY118508A (en) 2004-11-30
UA66783C2 (en) 2004-06-15
DE59803856D1 (de) 2002-05-23
SK283155B6 (sk) 2003-03-04
ZA98985B (en) 1999-08-03
ID22643A (id) 1999-12-02
US20050080060A1 (en) 2005-04-14
IS2190B (is) 2007-01-15
US6806263B2 (en) 2004-10-19
EE03831B1 (et) 2002-08-15
SI0970103T1 (en) 2002-10-31
EP0970103B1 (de) 2002-04-17
AR010887A1 (es) 2000-07-12
BR9807667A (pt) 2000-02-15
NO313554B1 (no) 2002-10-21
EP0970103A1 (de) 2000-01-12
ES2175673T3 (es) 2002-11-16
CL2004001191A1 (es) 2005-03-28
AU742834B2 (en) 2002-01-10
BG103603A (en) 2000-06-30
US7148213B2 (en) 2006-12-12
IL131226A0 (en) 2001-01-28
JP2001510479A (ja) 2001-07-31
AU6100598A (en) 1998-08-26
CZ280599A3 (cs) 2000-01-12
TW499434B (en) 2002-08-21
IS5147A (is) 1999-08-04
CA2280041A1 (en) 1998-08-13
TR199901855T2 (xx) 2000-04-21
CA2280041C (en) 2007-10-23
SK103899A3 (en) 2000-05-16
CN1202120C (zh) 2005-05-18
NZ336989A (en) 2001-04-27
HK1040718A1 (en) 2002-06-21
US20030134834A1 (en) 2003-07-17
EA003092B1 (ru) 2002-12-26
DK0970103T3 (da) 2002-07-22
JP4324249B2 (ja) 2009-09-02
PL191808B1 (pl) 2006-07-31
ATE216397T1 (de) 2002-05-15
EE9900339A (et) 2000-02-15
PT970103E (pt) 2002-09-30
NO993811D0 (no) 1999-08-06

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