KR100208867B1 - 광학활성 퀴놀린메발론산의 디아스테레오머염 - Google Patents

광학활성 퀴놀린메발론산의 디아스테레오머염 Download PDF

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Publication number
KR100208867B1
KR100208867B1 KR1019920011018A KR920011018A KR100208867B1 KR 100208867 B1 KR100208867 B1 KR 100208867B1 KR 1019920011018 A KR1019920011018 A KR 1019920011018A KR 920011018 A KR920011018 A KR 920011018A KR 100208867 B1 KR100208867 B1 KR 100208867B1
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KR
South Korea
Prior art keywords
acid
optically active
formula
quinolinemevalonic
quinolinemevalonic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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KR1019920011018A
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English (en)
Korean (ko)
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KR930000486A (ko
Inventor
요시오 오하라
미끼오 스즈끼
요시노부 야나가와
히로시 이와사끼
노부히데 미야찌
Original Assignee
도쿠시마 히데이치
닛산 가가쿠 고교 가부시키 가이샤
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Application filed by 도쿠시마 히데이치, 닛산 가가쿠 고교 가부시키 가이샤 filed Critical 도쿠시마 히데이치
Publication of KR930000486A publication Critical patent/KR930000486A/ko
Application granted granted Critical
Publication of KR100208867B1 publication Critical patent/KR100208867B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1019920011018A 1991-06-24 1992-06-24 광학활성 퀴놀린메발론산의 디아스테레오머염 Expired - Lifetime KR100208867B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP91-151810 1991-06-24
JP15181091 1991-06-24
JP12727792A JP3528186B2 (ja) 1991-06-24 1992-05-20 光学活性キノリンメバロン酸のジアステレオマー塩
JP92-127277 1992-05-20

Publications (2)

Publication Number Publication Date
KR930000486A KR930000486A (ko) 1993-01-15
KR100208867B1 true KR100208867B1 (ko) 1999-07-15

Family

ID=26463266

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920011018A Expired - Lifetime KR100208867B1 (ko) 1991-06-24 1992-06-24 광학활성 퀴놀린메발론산의 디아스테레오머염

Country Status (10)

Country Link
US (3) US5284953A (enExample)
EP (2) EP0520406B1 (enExample)
JP (1) JP3528186B2 (enExample)
KR (1) KR100208867B1 (enExample)
AT (1) ATE170513T1 (enExample)
CA (1) CA2072162C (enExample)
DE (1) DE69226822T2 (enExample)
DK (1) DK0520406T3 (enExample)
ES (1) ES2120973T3 (enExample)
TW (1) TW293007B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101270586B1 (ko) * 2010-11-26 2013-06-03 주식회사 아미노로직스 광학적으로 순수한 2,2'-디히드록시-1,1'-바이나프틸-3-카르복실산의 제조방법

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CN1136183C (zh) * 1994-02-25 2004-01-28 代科化学工业株式会社 光学活性甲羟戊酸内酯类化合物的制造方法
BR9609872A (pt) 1995-07-17 1999-03-23 Warner Lambert Co Hemi sal de cálcio de ácido (R-(R*R*)]-2-(4-fluorfenil-)-beta delta-diidróxi-5-(1-metiletil)-3-fenil-4- [(fenilamino) carbonil]-1H- pirrol-1heptanóico (atorvasta-tina)c ristalino
DK0814782T3 (da) * 1995-12-22 2002-12-16 Nissan Chemical Ind Ltd Farmaceutisk præparat stabiliseret med et basisk middel
GB9614804D0 (en) * 1996-07-15 1996-09-04 Chiroscience Ltd Resolution process
AU755543B2 (en) * 1997-12-19 2002-12-12 Warner-Lambert Export Limited Process for the synthesis of 1,3-diols
PT1099694E (pt) 1998-07-23 2005-10-31 Nissan Chemical Ind Ltd Processo para a preparacao de um derivado de quinolina e um intermediario para esse fim
KR100311645B1 (ko) * 1999-12-24 2001-10-12 이홍천 간판
GB0003305D0 (en) 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
AU2002241271B2 (en) * 2001-04-05 2007-01-25 Nissan Chemical Industries, Ltd. Method for preparing 7-quinolinyl-3,5-dihydroxyhept-6-enoate
JP4783998B2 (ja) * 2001-05-15 2011-09-28 宇部興産株式会社 （３ｒ，５ｓ）−７−置換−３，５−ジヒドロキシヘプト−６−エン酸の製法
WO2003027073A1 (fr) * 2001-09-19 2003-04-03 Ube Industries, Ltd. Procede de production d'ester optiquement actif d'acide 7-{2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl}-3,5-dihydroxyhept-6-enoique
US6835838B2 (en) * 2002-01-28 2004-12-28 Novartis Ag Process for the manufacture of organic compounds
DE60326819D1 (de) 2002-01-31 2009-05-07 Novartis Ag Verfahren zur herstellung von inhibitoren der hmg-coa-reduktase
ZA200502325B (en) 2002-09-20 2006-11-29 Nissan Chemical Ind Ltd Method for producing a 3,5-dihydroxy-6-heptenoate
WO2004072040A1 (en) * 2003-02-12 2004-08-26 Ciba Specialty Chemicals Holding Inc. Crystalline forms of pitavastatin calcium
EP1614429A4 (en) * 2003-04-17 2007-05-02 Kowa Co LKLF / KLF2 GEN-EXPRESSIONSPROMOTER
WO2005077916A1 (en) * 2004-01-19 2005-08-25 Ranbaxy Laboratories Limited Salts of hmg-coa reductase inhibitors and use thereof
JP2007512347A (ja) * 2003-11-26 2007-05-17 デューク・ユニバーシティー 緑内障を予防するかまたは治療する方法
TWI328006B (en) * 2003-12-26 2010-08-01 Nissan Chemical Ind Ltd Crystal form of quinoline compound and process for its production
CN101220021B (zh) * 2007-01-12 2010-12-08 上海医药工业研究院 4-取代苯氧基喹啉类化合物及其中间体、制备方法和应用
WO2008111055A1 (en) * 2007-03-12 2008-09-18 In-Dot Ltd. Color sensing for a reader device and the like
WO2010027060A1 (ja) * 2008-09-05 2010-03-11 日産化学工業株式会社 ３，５－ジヒドロキシ－６－ヘプテン酸アミン塩類の製造方法
US20120022102A1 (en) 2010-01-20 2012-01-26 Cadila Healthcare Limited Method for preparation of pitavastatin and its pharmaceutical acceptable salts thereof
JP2013536219A (ja) 2010-08-25 2013-09-19 カディラ・ヘルスケア・リミテッド ピタバスタチンカルシウムおよびその調製方法
WO2012063254A1 (en) * 2010-11-12 2012-05-18 Hetero Research Foundation Novel polymorphs of pitavastatin calcium
WO2012140490A2 (en) 2011-04-11 2012-10-18 Aurobindo Pharma Limited Process for preparing quinoline derivative
JP2011173912A (ja) * 2011-04-28 2011-09-08 Ube Industries Ltd （３ｒ，５ｓ）−７−置換−３，５−ジヒドロキシヘプト−６−エン酸の製法
WO2013037838A1 (en) 2011-09-12 2013-03-21 Farma Grs, D.O.O. Polymorphic form of pitavastatin calcium
JP2013103884A (ja) * 2011-11-10 2013-05-30 Daito Kk ピタバスタチンカルシウム塩の工業的製造方法
CN102653523A (zh) * 2011-12-17 2012-09-05 东莞达信生物技术有限公司 一种匹伐他汀钙重结晶制取方法
WO2013098773A1 (en) * 2011-12-28 2013-07-04 Dr. Reddy's Laboratories Limited Crystalline forms of pitavastatin calcium
CN102653524A (zh) * 2012-01-12 2012-09-05 东莞达信生物技术有限公司 一种匹伐他汀钙中间体的制备方法
EP2978743B1 (en) * 2013-03-29 2019-11-27 Centrient Pharmaceuticals Netherlands B.V. Amine salts of pravastatin and rosuvastatin
MX2015013696A (es) * 2013-03-29 2016-02-26 Dsm Sinochem Pharm Nl Bv Sales de amina de pitavastatina y rosuvastatina.
CN103508949B (zh) * 2013-10-22 2015-12-09 黄河三角洲京博化工研究院有限公司 一种（e）-3-[2-环丙基-4-（4-氟-苯基）-3-喹啉基]丙烯醛的合成方法
WO2016056658A1 (ja) * 2014-10-10 2016-04-14 株式会社エーピーアイ コーポレーション スタチン系化合物の精製方法

Family Cites Families (8)

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CH576447A5 (enExample) * 1972-03-10 1976-06-15 Ciba Geigy Ag
US4567289A (en) * 1979-08-17 1986-01-28 Merck & Co., Inc. Substituted pyranone inhibitors of cholesterol synthesis
CA1336714C (en) * 1987-08-20 1995-08-15 Yoshihiro Fujikawa Quinoline type mevalonolactone inhibitors of cholesterol biosynthesis
DE3905908A1 (de) 1989-02-25 1990-09-06 Bayer Ag Substituierte chinoline, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
FI94339C (fi) * 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
DE3925636A1 (de) * 1989-08-03 1991-02-07 Bayer Ag Imino-substituierte pyridine
EP0430129A3 (en) * 1989-11-30 1992-02-26 Tanabe Seiyaku Co., Ltd. Novel phenylethylene derivatives, processes for preparing the same and intermediates therefor
JPH054943A (ja) * 1990-08-30 1993-01-14 Sagami Chem Res Center 光学活性β，δ−ジケト酸エステル及びその還元体

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101270586B1 (ko) * 2010-11-26 2013-06-03 주식회사 아미노로직스 광학적으로 순수한 2,2'-디히드록시-1,1'-바이나프틸-3-카르복실산의 제조방법
US9725391B2 (en) 2010-11-26 2017-08-08 Aminologics Co., Ltd. Synthetic method of enantiomerically pure 2,2′-dihydroxy-1,1′-binaphthyl-3-carboxylic acid

Also Published As

Publication number Publication date
CA2072162A1 (en) 1992-12-25
EP0742209A3 (en) 1997-05-14
ATE170513T1 (de) 1998-09-15
EP0520406A1 (en) 1992-12-30
DK0520406T3 (da) 1998-12-14
TW293007B (enExample) 1996-12-11
EP0520406B1 (en) 1998-09-02
US5473075A (en) 1995-12-05
JPH05148237A (ja) 1993-06-15
JP3528186B2 (ja) 2004-05-17
KR930000486A (ko) 1993-01-15
US5284953A (en) 1994-02-08
CA2072162C (en) 2002-11-19
EP0742209A2 (en) 1996-11-13
DE69226822T2 (de) 1999-02-11
DE69226822D1 (de) 1998-10-08
US5514804A (en) 1996-05-07
ES2120973T3 (es) 1998-11-16

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