DK0520406T3 - Diastereomert salt af optisk aktiv quinolinmevalonsyre - Google Patents
Diastereomert salt af optisk aktiv quinolinmevalonsyreInfo
- Publication number
- DK0520406T3 DK0520406T3 DK92110636T DK92110636T DK0520406T3 DK 0520406 T3 DK0520406 T3 DK 0520406T3 DK 92110636 T DK92110636 T DK 92110636T DK 92110636 T DK92110636 T DK 92110636T DK 0520406 T3 DK0520406 T3 DK 0520406T3
- Authority
- DK
- Denmark
- Prior art keywords
- optically active
- diastereomeric salt
- mevalonic acid
- active quinoline
- quinoline
- Prior art date
Links
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 2
- KJTLQQUUPVSXIM-ZCFIWIBFSA-N (R)-mevalonic acid Chemical compound OCC[C@](O)(C)CC(O)=O KJTLQQUUPVSXIM-ZCFIWIBFSA-N 0.000 title 1
- KJTLQQUUPVSXIM-UHFFFAOYSA-N DL-mevalonic acid Natural products OCCC(O)(C)CC(O)=O KJTLQQUUPVSXIM-UHFFFAOYSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- KFPZNZVASUJWQQ-AWKYBWMHSA-N C1=CC=CC2=NC(C(O)C[C@](O)(C)CC(O)=O)=CC=C21 Chemical compound C1=CC=CC2=NC(C(O)C[C@](O)(C)CC(O)=O)=CC=C21 KFPZNZVASUJWQQ-AWKYBWMHSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15181091 | 1991-06-24 | ||
| JP12727792A JP3528186B2 (ja) | 1991-06-24 | 1992-05-20 | 光学活性キノリンメバロン酸のジアステレオマー塩 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0520406T3 true DK0520406T3 (da) | 1998-12-14 |
Family
ID=26463266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK92110636T DK0520406T3 (da) | 1991-06-24 | 1992-06-24 | Diastereomert salt af optisk aktiv quinolinmevalonsyre |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US5284953A (enExample) |
| EP (2) | EP0520406B1 (enExample) |
| JP (1) | JP3528186B2 (enExample) |
| KR (1) | KR100208867B1 (enExample) |
| AT (1) | ATE170513T1 (enExample) |
| CA (1) | CA2072162C (enExample) |
| DE (1) | DE69226822T2 (enExample) |
| DK (1) | DK0520406T3 (enExample) |
| ES (1) | ES2120973T3 (enExample) |
| TW (1) | TW293007B (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1136183C (zh) * | 1994-02-25 | 2004-01-28 | 代科化学工业株式会社 | 光学活性甲羟戊酸内酯类化合物的制造方法 |
| BR9609872A (pt) | 1995-07-17 | 1999-03-23 | Warner Lambert Co | Hemi sal de cálcio de ácido (R-(R*R*)]-2-(4-fluorfenil-)-beta delta-diidróxi-5-(1-metiletil)-3-fenil-4- [(fenilamino) carbonil]-1H- pirrol-1heptanóico (atorvasta-tina)c ristalino |
| DK0814782T3 (da) * | 1995-12-22 | 2002-12-16 | Nissan Chemical Ind Ltd | Farmaceutisk præparat stabiliseret med et basisk middel |
| GB9614804D0 (en) * | 1996-07-15 | 1996-09-04 | Chiroscience Ltd | Resolution process |
| AU755543B2 (en) * | 1997-12-19 | 2002-12-12 | Warner-Lambert Export Limited | Process for the synthesis of 1,3-diols |
| PT1099694E (pt) | 1998-07-23 | 2005-10-31 | Nissan Chemical Ind Ltd | Processo para a preparacao de um derivado de quinolina e um intermediario para esse fim |
| KR100311645B1 (ko) * | 1999-12-24 | 2001-10-12 | 이홍천 | 간판 |
| GB0003305D0 (en) | 2000-02-15 | 2000-04-05 | Zeneca Ltd | Pyrimidine derivatives |
| AU2002241271B2 (en) * | 2001-04-05 | 2007-01-25 | Nissan Chemical Industries, Ltd. | Method for preparing 7-quinolinyl-3,5-dihydroxyhept-6-enoate |
| JP4783998B2 (ja) * | 2001-05-15 | 2011-09-28 | 宇部興産株式会社 | （３ｒ，５ｓ）−７−置換−３，５−ジヒドロキシヘプト−６−エン酸の製法 |
| WO2003027073A1 (fr) * | 2001-09-19 | 2003-04-03 | Ube Industries, Ltd. | Procede de production d'ester optiquement actif d'acide 7-{2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl}-3,5-dihydroxyhept-6-enoique |
| US6835838B2 (en) * | 2002-01-28 | 2004-12-28 | Novartis Ag | Process for the manufacture of organic compounds |
| DE60326819D1 (de) | 2002-01-31 | 2009-05-07 | Novartis Ag | Verfahren zur herstellung von inhibitoren der hmg-coa-reduktase |
| ZA200502325B (en) | 2002-09-20 | 2006-11-29 | Nissan Chemical Ind Ltd | Method for producing a 3,5-dihydroxy-6-heptenoate |
| WO2004072040A1 (en) * | 2003-02-12 | 2004-08-26 | Ciba Specialty Chemicals Holding Inc. | Crystalline forms of pitavastatin calcium |
| EP1614429A4 (en) * | 2003-04-17 | 2007-05-02 | Kowa Co | LKLF / KLF2 GEN-EXPRESSIONSPROMOTER |
| WO2005077916A1 (en) * | 2004-01-19 | 2005-08-25 | Ranbaxy Laboratories Limited | Salts of hmg-coa reductase inhibitors and use thereof |
| JP2007512347A (ja) * | 2003-11-26 | 2007-05-17 | デューク・ユニバーシティー | 緑内障を予防するかまたは治療する方法 |
| TWI328006B (en) * | 2003-12-26 | 2010-08-01 | Nissan Chemical Ind Ltd | Crystal form of quinoline compound and process for its production |
| CN101220021B (zh) * | 2007-01-12 | 2010-12-08 | 上海医药工业研究院 | 4-取代苯氧基喹啉类化合物及其中间体、制备方法和应用 |
| WO2008111055A1 (en) * | 2007-03-12 | 2008-09-18 | In-Dot Ltd. | Color sensing for a reader device and the like |
| WO2010027060A1 (ja) * | 2008-09-05 | 2010-03-11 | 日産化学工業株式会社 | ３，５－ジヒドロキシ－６－ヘプテン酸アミン塩類の製造方法 |
| US20120022102A1 (en) | 2010-01-20 | 2012-01-26 | Cadila Healthcare Limited | Method for preparation of pitavastatin and its pharmaceutical acceptable salts thereof |
| JP2013536219A (ja) | 2010-08-25 | 2013-09-19 | カディラ・ヘルスケア・リミテッド | ピタバスタチンカルシウムおよびその調製方法 |
| WO2012063254A1 (en) * | 2010-11-12 | 2012-05-18 | Hetero Research Foundation | Novel polymorphs of pitavastatin calcium |
| KR101270586B1 (ko) * | 2010-11-26 | 2013-06-03 | 주식회사 아미노로직스 | 광학적으로 순수한 2,2'-디히드록시-1,1'-바이나프틸-3-카르복실산의 제조방법 |
| WO2012140490A2 (en) | 2011-04-11 | 2012-10-18 | Aurobindo Pharma Limited | Process for preparing quinoline derivative |
| JP2011173912A (ja) * | 2011-04-28 | 2011-09-08 | Ube Industries Ltd | （３ｒ，５ｓ）−７−置換−３，５−ジヒドロキシヘプト−６−エン酸の製法 |
| WO2013037838A1 (en) | 2011-09-12 | 2013-03-21 | Farma Grs, D.O.O. | Polymorphic form of pitavastatin calcium |
| JP2013103884A (ja) * | 2011-11-10 | 2013-05-30 | Daito Kk | ピタバスタチンカルシウム塩の工業的製造方法 |
| CN102653523A (zh) * | 2011-12-17 | 2012-09-05 | 东莞达信生物技术有限公司 | 一种匹伐他汀钙重结晶制取方法 |
| WO2013098773A1 (en) * | 2011-12-28 | 2013-07-04 | Dr. Reddy's Laboratories Limited | Crystalline forms of pitavastatin calcium |
| CN102653524A (zh) * | 2012-01-12 | 2012-09-05 | 东莞达信生物技术有限公司 | 一种匹伐他汀钙中间体的制备方法 |
| EP2978743B1 (en) * | 2013-03-29 | 2019-11-27 | Centrient Pharmaceuticals Netherlands B.V. | Amine salts of pravastatin and rosuvastatin |
| MX2015013696A (es) * | 2013-03-29 | 2016-02-26 | Dsm Sinochem Pharm Nl Bv | Sales de amina de pitavastatina y rosuvastatina. |
| CN103508949B (zh) * | 2013-10-22 | 2015-12-09 | 黄河三角洲京博化工研究院有限公司 | 一种（e）-3-[2-环丙基-4-（4-氟-苯基）-3-喹啉基]丙烯醛的合成方法 |
| WO2016056658A1 (ja) * | 2014-10-10 | 2016-04-14 | 株式会社エーピーアイ コーポレーション | スタチン系化合物の精製方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH576447A5 (enExample) * | 1972-03-10 | 1976-06-15 | Ciba Geigy Ag | |
| US4567289A (en) * | 1979-08-17 | 1986-01-28 | Merck & Co., Inc. | Substituted pyranone inhibitors of cholesterol synthesis |
| CA1336714C (en) * | 1987-08-20 | 1995-08-15 | Yoshihiro Fujikawa | Quinoline type mevalonolactone inhibitors of cholesterol biosynthesis |
| DE3905908A1 (de) | 1989-02-25 | 1990-09-06 | Bayer Ag | Substituierte chinoline, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
| FI94339C (fi) * | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| DE3925636A1 (de) * | 1989-08-03 | 1991-02-07 | Bayer Ag | Imino-substituierte pyridine |
| EP0430129A3 (en) * | 1989-11-30 | 1992-02-26 | Tanabe Seiyaku Co., Ltd. | Novel phenylethylene derivatives, processes for preparing the same and intermediates therefor |
| JPH054943A (ja) * | 1990-08-30 | 1993-01-14 | Sagami Chem Res Center | 光学活性β，δ−ジケト酸エステル及びその還元体 |
-
1992
- 1992-05-20 JP JP12727792A patent/JP3528186B2/ja not_active Expired - Lifetime
- 1992-06-12 TW TW081104622A patent/TW293007B/zh active
- 1992-06-23 CA CA002072162A patent/CA2072162C/en not_active Expired - Lifetime
- 1992-06-23 US US07/902,863 patent/US5284953A/en not_active Expired - Lifetime
- 1992-06-24 DE DE69226822T patent/DE69226822T2/de not_active Expired - Lifetime
- 1992-06-24 AT AT92110636T patent/ATE170513T1/de active
- 1992-06-24 EP EP92110636A patent/EP0520406B1/en not_active Expired - Lifetime
- 1992-06-24 DK DK92110636T patent/DK0520406T3/da active
- 1992-06-24 EP EP96107815A patent/EP0742209A3/en not_active Withdrawn
- 1992-06-24 KR KR1019920011018A patent/KR100208867B1/ko not_active Expired - Lifetime
- 1992-06-24 ES ES92110636T patent/ES2120973T3/es not_active Expired - Lifetime
-
1993
- 1993-09-20 US US08/123,117 patent/US5473075A/en not_active Expired - Lifetime
-
1995
- 1995-05-25 US US08/450,383 patent/US5514804A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2072162A1 (en) | 1992-12-25 |
| EP0742209A3 (en) | 1997-05-14 |
| ATE170513T1 (de) | 1998-09-15 |
| EP0520406A1 (en) | 1992-12-30 |
| TW293007B (enExample) | 1996-12-11 |
| KR100208867B1 (ko) | 1999-07-15 |
| EP0520406B1 (en) | 1998-09-02 |
| US5473075A (en) | 1995-12-05 |
| JPH05148237A (ja) | 1993-06-15 |
| JP3528186B2 (ja) | 2004-05-17 |
| KR930000486A (ko) | 1993-01-15 |
| US5284953A (en) | 1994-02-08 |
| CA2072162C (en) | 2002-11-19 |
| EP0742209A2 (en) | 1996-11-13 |
| DE69226822T2 (de) | 1999-02-11 |
| DE69226822D1 (de) | 1998-10-08 |
| US5514804A (en) | 1996-05-07 |
| ES2120973T3 (es) | 1998-11-16 |
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