KR0143566B1 - 매크로리드 화합물 - Google Patents

매크로리드 화합물

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Publication number
KR0143566B1
KR0143566B1 KR1019890018791A KR890018791A KR0143566B1 KR 0143566 B1 KR0143566 B1 KR 0143566B1 KR 1019890018791 A KR1019890018791 A KR 1019890018791A KR 890018791 A KR890018791 A KR 890018791A KR 0143566 B1 KR0143566 B1 KR 0143566B1
Authority
KR
South Korea
Prior art keywords
compound
medium
acid
culture
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019890018791A
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English (en)
Korean (ko)
Other versions
KR900009681A (ko
Inventor
드와인 보엑 라베른
지오 항
에드워드 이톤 탐
쥬니어 오티스 웹스터 갇프레이
하인츠 미쉘 칼
미쭈오 나가쭈가사 윌터
체-퐁 야오 레이몬드
Original Assignee
리로이 휘테커
일라이 릴리 앤드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 리로이 휘테커, 일라이 릴리 앤드 캄파니 filed Critical 리로이 휘테커
Publication of KR900009681A publication Critical patent/KR900009681A/ko
Application granted granted Critical
Publication of KR0143566B1 publication Critical patent/KR0143566B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Agronomy & Crop Science (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Electrotherapy Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1019890018791A 1988-12-19 1989-12-18 매크로리드 화합물 Expired - Fee Related KR0143566B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US28659188A 1988-12-19 1988-12-19
US7/286.591 1988-12-19
US42944189A 1989-10-30 1989-10-30
US429.441 1989-10-30

Publications (2)

Publication Number Publication Date
KR900009681A KR900009681A (ko) 1990-07-05
KR0143566B1 true KR0143566B1 (ko) 1998-07-15

Family

ID=26963932

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890018791A Expired - Fee Related KR0143566B1 (ko) 1988-12-19 1989-12-18 매크로리드 화합물

Country Status (32)

Country Link
US (2) US5496931A (enExample)
EP (1) EP0375316B1 (enExample)
JP (1) JP2535080B2 (enExample)
KR (1) KR0143566B1 (enExample)
CN (1) CN1035391C (enExample)
AT (1) ATE116325T1 (enExample)
AU (1) AU624458B2 (enExample)
BG (1) BG60520B1 (enExample)
BR (1) BR8906547A (enExample)
CA (1) CA2005784C (enExample)
CZ (1) CZ285992B6 (enExample)
DE (2) DE122007000053I2 (enExample)
DK (1) DK174489B1 (enExample)
DZ (1) DZ1375A1 (enExample)
EG (1) EG19191A (enExample)
ES (1) ES2065398T3 (enExample)
FI (2) FI95601C (enExample)
GR (1) GR3015598T3 (enExample)
HU (1) HU208998B (enExample)
IE (1) IE65919B1 (enExample)
IL (1) IL92743A (enExample)
IN (1) IN169756B (enExample)
MA (1) MA21697A1 (enExample)
MY (1) MY111148A (enExample)
NL (1) NL350009I2 (enExample)
NO (1) NO176914C (enExample)
NZ (1) NZ231831A (enExample)
OA (1) OA09249A (enExample)
PE (1) PE5591A1 (enExample)
PL (1) PL161476B1 (enExample)
PT (1) PT92607B (enExample)
YU (1) YU47099B (enExample)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA21697A1 (fr) * 1988-12-19 1990-07-01 Dow Agrosciences Llc Composes de macrolides.
US5362634A (en) * 1989-10-30 1994-11-08 Dowelanco Process for producing A83543 compounds
CN1073483A (zh) * 1991-11-08 1993-06-23 道伊兰科公司 一种发酵杀虫剂化合物及其制备方法
US5227295A (en) * 1991-11-08 1993-07-13 Dowelanco Process for isolating A83543 and its components
US5202242A (en) * 1991-11-08 1993-04-13 Dowelanco A83543 compounds and processes for production thereof
US5539089A (en) * 1991-11-08 1996-07-23 Dowelanco A83543 aglycones and pseudoglycones
US5591606A (en) * 1992-11-06 1997-01-07 Dowelanco Process for the production of A83543 compounds with Saccharopolyspora spinosa
TR28273A (tr) * 1992-12-09 1996-04-25 Dowelanco Yeni a83543 bilesikleri ve bunlari üretmeye mahsus yöntem.
DE69402308T2 (de) * 1993-03-12 1997-10-23 Dowelanco Neue a83543 verbindungen und verfahren zu ihrer herstellung
BR9608380A (pt) * 1995-06-14 1999-01-05 Dowelanco Modificações sintéticas para os compostos de espinosina
US6001981A (en) * 1996-06-13 1999-12-14 Dow Agrosciences Llc Synthetic modification of Spinosyn compounds
GB9624501D0 (en) * 1996-11-26 1997-01-15 Zeneca Ltd Insecticial compositions and method
ID27789A (id) * 1997-12-23 2001-04-26 Novartis Ag Penggunaan makrolida untuk mengendalikan hama
DE19823396A1 (de) * 1998-05-26 1999-12-02 Bayer Ag Synergistische insektizide Mischungen
DE19823397B4 (de) * 1998-05-26 2011-07-28 Bayer CropScience AG, 40789 Verwendung von Spinosynen zum Einsatz als Bodeninsektizide
CN1129430C (zh) * 1998-07-02 2003-12-03 伊莱利利公司 控制人虱的制剂
DE19857967A1 (de) * 1998-12-16 2000-06-21 Bayer Ag Wirkstoffkombinationen
US6933318B1 (en) 1999-08-12 2005-08-23 Eli Lilly And Company Topical organic ectoparasiticidal formulations
ATE289478T1 (de) * 1999-08-12 2005-03-15 Lilly Co Eli Ektoparasitizide wässrige suspensionsformulierungen von spinosynen
WO2001011961A1 (en) * 1999-08-12 2001-02-22 Eli Lilly And Company Control of ectoparasites using spinosyns
CA2379329C (en) * 1999-08-12 2009-10-20 Eli Lilly And Company Oral treatment of companion animals with ectoparasiticidal spinosyns
US6927210B1 (en) 1999-08-12 2005-08-09 Eli Lilly And Company Ectoparasiticidal aqueous suspension formulations of spinosyns
WO2001011962A1 (en) * 1999-08-12 2001-02-22 Eli Lilly And Company Topical treatment for insect pests in companion animals
ATE280176T1 (de) 1999-09-13 2004-11-15 Dow Agrosciences Llc Pestizide makrolide
AUPQ441699A0 (en) 1999-12-02 2000-01-06 Eli Lilly And Company Pour-on formulations
AUPQ634300A0 (en) * 2000-03-20 2000-04-15 Eli Lilly And Company Synergistic formulations
DE10013914A1 (de) 2000-03-21 2001-09-27 Bayer Ag Wirkstoffkombinationen mit insektiziden und akariziden Eigenschaften
US6682925B1 (en) * 2000-04-13 2004-01-27 Agraquest, Inc. Streptomyces strain with insecticidal activity and method of using as an insecticide
DE10055941A1 (de) * 2000-11-10 2002-05-23 Bayer Ag Wirkstoffkombinationen mit insektiziden und akariziden Eigenschaften
US6585990B1 (en) 2001-03-05 2003-07-01 Dow Agrosciences, Llc Compositions and devices using a spinosyn compound for control of insects
TWI275592B (en) * 2001-03-21 2007-03-11 Dow Agrosciences Llc Synthetic derivatives of 21-butenyl and related spinosyns
JP4554158B2 (ja) * 2001-03-21 2010-09-29 ダウ・アグロサイエンス・エル・エル・シー 有害生物防除性スピノシン誘導体
ES2276929T3 (es) * 2001-03-29 2007-07-01 Bayer Cropscience Ag Compuestos intermedios para la obtencion de espinosinas.
US6727228B2 (en) * 2001-04-25 2004-04-27 Johnson & Johnson Consumer Companies, Inc. Pediculicidal and ovacidal treatment compositions and methods for killing head lice and their eggs
DE10135550A1 (de) * 2001-07-20 2003-01-30 Bayer Cropscience Ag Verfahren zum Herstellen von neuen Spinosyn-Derivaten
AR036872A1 (es) 2001-08-13 2004-10-13 Du Pont Compuesto de antranilamida, composicion que lo comprende y metodo para controlar una plaga de invertebrados
US20090227452A1 (en) * 2001-09-14 2009-09-10 Birthisel Timothy D Spent fermented grain soil additive
HUP0500984A3 (en) 2001-09-17 2007-02-28 Lilly Co Eli Synergetic pesticidal formulations
ATE417504T1 (de) * 2001-10-08 2009-01-15 Lilly Co Eli Verfahren zur bekämpfung von käfern
TWI330183B (enExample) * 2001-10-22 2010-09-11 Eisai R&D Man Co Ltd
CN1633237B (zh) 2002-02-19 2010-05-26 道农业科学公司 新的产生spinosyn的聚酮合酶
DE10248257A1 (de) * 2002-10-16 2004-04-29 Bayer Cropscience Ag Wirkstoffkombinationen im insektiziden und akariziden Eigenschaften
DE10320505A1 (de) 2003-05-08 2004-11-25 Bayer Healthcare Ag Mittel zum Bekämpfen von Parasiten an Tieren
DE10333371A1 (de) * 2003-07-23 2005-02-10 Bayer Ag Fungizide Wirkstoffkombinationen
EP1682118B1 (en) * 2003-11-04 2008-10-22 Intervet International BV Ectoparasiticidal formulations of spinosyns and azole pesticides
DE10353281A1 (de) 2003-11-14 2005-06-16 Bayer Cropscience Ag Wirkstoffkombination mit insektiziden und akariziden Eigenschaften
AU2006249441A1 (en) * 2005-05-26 2006-11-30 Eli Lilly And Company Improved fish production
EP1849363A1 (en) * 2006-03-09 2007-10-31 Cheminova A/S Synergistic combination of glutamate- and GABA-gated chloride agonist pesticide and at least one of Vitamin E or Niacin
ES2477465T3 (es) * 2006-05-25 2014-07-17 Dow Agrosciences, Llc Fumigantes de espinosina
DE102007045922A1 (de) 2007-09-26 2009-04-02 Bayer Cropscience Ag Wirkstoffkombinationen mit insektiziden und akariziden Eigenschaften
EP2070416A1 (de) 2007-12-11 2009-06-17 Bayer CropScience AG Verwendung von Wirkstoffkombinationen zur Bekämpfung von tierischen Schädlingen
EP2127522A1 (de) 2008-05-29 2009-12-02 Bayer CropScience AG Wirkstoffkombinationen mit insektiziden und akariziden Eigenschaften
KR20110069118A (ko) 2008-09-22 2011-06-22 크리스틴 크리티코우 스피노신 방오 조성물, 이의 사용 방법 및 생물 오손 유기체의 부착으로부터 보호된 물품
EP2227951A1 (de) 2009-01-23 2010-09-15 Bayer CropScience AG Verwendung von Enaminocarbonylverbindungen zur Bekämpfung von durch Insekten übertragenen Viren
TW201041507A (en) 2009-04-30 2010-12-01 Dow Agrosciences Llc Pesticide compositions exhibiting enhanced activity and methods for preparing same
TW201041509A (en) * 2009-04-30 2010-12-01 Dow Agrosciences Llc Pesticide compositions exhibiting enhanced activity
TW201041510A (en) * 2009-04-30 2010-12-01 Dow Agrosciences Llc Pesticide compositions exhibiting enhanced activity
TW201041508A (en) * 2009-04-30 2010-12-01 Dow Agrosciences Llc Pesticide compositions exhibiting enhanced activity
WO2010150100A1 (en) 2009-06-24 2010-12-29 Entarco Sa The use of spinosyns and spinosyn compositions against diseases caused by protozoans, viral infections and cancer
EP2496085A4 (en) * 2009-11-06 2013-05-08 Agraquest Inc INSECTICIDE FERMENTATION BROTH FROM ACTINOMYCETES
EP2528587B1 (en) * 2010-01-25 2015-03-18 Eli Lilly and Company Spinosyns for use in internally controlling or treating equine bot larvae
WO2011102550A1 (en) * 2010-02-19 2011-08-25 Sumitomo Chemical Company, Limited Pest control composition
EP2382865A1 (de) 2010-04-28 2011-11-02 Bayer CropScience AG Synergistische Wirkstoffkombinationen
RU2580015C2 (ru) 2010-05-11 2016-04-10 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Штаммы spnk
JP4991973B2 (ja) 2010-09-29 2012-08-08 東海ゴム工業株式会社 水系ホース用ゴム組成物およびそれを用いて得られる水系ホース
EP2635122A1 (en) 2010-11-05 2013-09-11 Eli Lilly and Company Methods for inhibiting insect infestations
US20160184340A1 (en) 2010-12-22 2016-06-30 Christine Kritikou The use of spinosyns and spinosyn compositions as local anesthetics and as antiarrhythmic agents
JP5908925B2 (ja) 2010-12-29 2016-04-26 ダウ アグロサイエンシィズ エルエルシー 昆虫を防除する方法
ES2553079T3 (es) 2011-05-03 2015-12-04 Dow Agrosciences Llc Mejora de la producción de espinosinas con proteínas que se unen al oxígeno
JP5760781B2 (ja) 2011-07-13 2015-08-12 住友化学株式会社 有害節足動物防除組成物及び有害節足動物の防除方法
US9631195B2 (en) 2011-12-28 2017-04-25 Dow Agrosciences Llc Identification and characterization of the spinactin biosysnthesis gene cluster from spinosyn producing saccharopolyspora spinosa
SMT201900083T1 (it) 2012-02-06 2019-02-28 Merial Inc Composizioni veterinarie orali parassiticide comprendenti principi attivi che agiscono per via sistematica, loro metodi e loro usi
JO3626B1 (ar) 2012-02-23 2020-08-27 Merial Inc تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها
US9895388B1 (en) * 2012-07-27 2018-02-20 ParaPRO Methods and compositions useful for controlling cutaneous mites
US20150250166A1 (en) 2012-08-23 2015-09-10 Allylix, Inc. Nootkatone as an insecticide and insect repellent
US9839214B2 (en) 2012-12-18 2017-12-12 Evolva, Inc. Solavetivone and 5-epi-beta-vertivone as pest repellants and pesticides
MX378055B (es) 2014-04-17 2025-03-10 Boehringer Ingelheim Animal Health Usa Inc Uso de compuestos de malononitrilo para proteger animales de parásitos.
CA2949511A1 (en) 2014-05-19 2015-11-26 Merial, Inc. Anthelmintic compounds
AU2015276941B2 (en) 2014-06-19 2018-07-19 Boehringer Ingelheim Animal Health USA Inc. Parasiticidal compositions comprising indole derivatives, methods and uses thereof
WO2016022520A1 (en) 2014-08-05 2016-02-11 Kyung-An Han Composition and methods for modulation of the octopamine receptor and its homologs
UY36570A (es) 2015-02-26 2016-10-31 Merial Inc Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas
UY36683A (es) 2015-05-20 2016-12-30 Merial Inc Compuestos depsipeptídicos como anthelmínticos
CN106188184B (zh) * 2015-06-01 2021-01-05 中南大学 多杀菌素衍生物在制备抗肿瘤药物和抗kshv病毒药物方面的应用
AU2017216079B9 (en) 2016-02-01 2021-11-04 Elanco Animal Health Gmbh Rhipicephalus nicotinic acetylcholine receptor and pest control acting thereon
WO2018039508A1 (en) 2016-08-25 2018-03-01 Merial, Inc. Method for reducing unwanted effects in parasiticidal treatments
CA3044038A1 (en) 2016-11-16 2018-05-24 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic depsipeptide compounds
WO2018226893A2 (en) 2017-06-06 2018-12-13 Zymergen Inc. A high-throughput (htp) genomic engineering platform for improving saccharopolyspora spinosa
US10494760B2 (en) 2017-12-12 2019-12-03 EctoGuard, LLC Methods and formulations for controlling human lice infestations
MX2021000293A (es) 2018-07-09 2021-07-15 Boehringer Ingelheim Animal Health Usa Inc Compuestos heterociclicos antihelminticos.
AU2019309520B2 (en) 2018-07-27 2025-04-03 Aperta Biosciences, Llc Spinosyn formulations for treatment of demodex-induced ocular and facial conditions
EP3883648A1 (en) 2018-11-20 2021-09-29 Boehringer Ingelheim Animal Health USA Inc. Indazolylcyanoethylamino compound, compositions of same, method of making, and methods of using thereof
AU2020208145B2 (en) 2019-01-16 2023-02-02 Boehringer Ingelheim Vetmedica Gmbh Topical compositions comprising a neonicotinoid and a macrocyclic lactone, methods and uses thereof
BR112021018631A2 (pt) 2019-03-19 2021-11-23 Boehringer Ingelheim Animal Health Usa Inc Compostos anti-helmínticos de aza-benzotiofeno e aza-benzofurano
EP3955738A4 (en) * 2019-04-17 2022-12-21 Boyce Thompson Institute for Plant Research Inc. Compositions and methods for modulating immunity in plants
JP2023528822A (ja) 2020-05-29 2023-07-06 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド 駆虫性複素環式化合物
CN113461757B (zh) * 2021-06-25 2023-08-22 湖州师范学院 新型十六元大环内酯的制备方法及用途
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WO2025062400A1 (en) 2023-09-21 2025-03-27 Adama Makhteshim Ltd. Photo-protective and thermo-protective agrochemical composition

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2881162A (en) * 1953-11-16 1959-04-07 Abbott Lab Recovery process
US3725385A (en) * 1970-11-02 1973-04-03 Abbott Lab Process for the demethylation of 3-amino macrolides
US4206206A (en) * 1977-03-24 1980-06-03 Kowa Company, Ltd. Antibiotics of the KA-6606 series and pharmaceutical compositions thereof
AU520409B2 (en) * 1977-05-25 1982-01-28 Commonwealth Scientific And Industrial Research Organisation Controlled release composition
US4213966A (en) * 1977-06-02 1980-07-22 E. R. Squibb & Sons, Inc. Method for isolating polyether antibiotics
US4148883A (en) * 1977-08-18 1979-04-10 Pfizer Inc. Antibiotics produced by new species of nocardia
US4224314A (en) * 1979-03-02 1980-09-23 Pfizer Inc. Antibiotics produced by species of Nocardia
JPS5943929B2 (ja) * 1979-08-13 1984-10-25 サッポロビール株式会社 多糖体ｒｂｓ物質，その製法およびそれを有効成分とする抗腫瘍性剤
MX6021E (es) * 1979-09-12 1984-09-24 Lilly Co Eli Dispositivo para administrar compuestos farmaceuticos de liberacion controlada a los rumiantes cuando es retenido en la porcion reticular del estomago de los mismos
US4273920A (en) * 1979-09-12 1981-06-16 Eli Lilly And Company Polymerization process and product
US4251511A (en) * 1979-10-02 1981-02-17 The Upjohn Company Antibiotic and fermentation process of preparing
US4293651A (en) * 1979-10-02 1981-10-06 The Upjohn Company Process for producing antibiotic using saccharopolyspora
US4321329A (en) * 1979-10-02 1982-03-23 The Upjohn Company Saccharopolyspora culture
EP0043197A1 (en) * 1980-07-02 1982-01-06 Beecham Group Plc Beta-Lactam antibiotic, its preparation and use
DE3162169D1 (en) * 1980-07-15 1984-03-15 Kowa Co Process for production of antibiotics, and novel antibiotics produced thereby
US4448970A (en) * 1981-02-19 1984-05-15 The Upjohn Company Nargenicin derivatives
IT1195299B (it) * 1981-11-27 1988-10-12 Pierrel Spa Procedimento chimico di sintesi per la preparazione di antibiotici macrolidici
FR2517697B1 (fr) * 1981-12-08 1987-07-10 Toyo Jozo Kk Nouveaux aminoglycosides antibiotiques appeles saccharocines et leur production
JPS58189114A (ja) * 1982-04-30 1983-11-04 Ss Pharmaceut Co Ltd 抗潰瘍剤
US4508647A (en) * 1982-07-26 1985-04-02 Bristol-Myers Company Antitumor antibiotics BBM-2040A and BBM-2040B
IT1194181B (it) * 1983-03-30 1988-09-14 Erba Farmitalia Procedimento migliorato per la purificazione della tilosina
US4530835A (en) * 1983-07-08 1985-07-23 Warner-Lambert Company CL-1577 Antibiotic compounds and their production
US4560509A (en) * 1983-11-16 1985-12-24 Eli Lilly And Company Antibiotic A39079 factor S-1
JPS625990A (ja) * 1985-06-20 1987-01-12 Sumitomo Chem Co Ltd 抗生物質およびその製造方法
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina
US4831016A (en) * 1986-10-31 1989-05-16 Merck & Co., Inc. Reduced avermectin derivatives
US5003056A (en) * 1987-12-24 1991-03-26 Nippon Kayaku Kabushiki Kaisha Antibiotic NK86-0279, process for production of the same and application of the same
US5362634A (en) * 1989-10-30 1994-11-08 Dowelanco Process for producing A83543 compounds
MA21697A1 (fr) * 1988-12-19 1990-07-01 Dow Agrosciences Llc Composes de macrolides.
US5028536A (en) * 1989-03-15 1991-07-02 Bristol-Myers Squibb Company Antitumor antibiotic BMY-41339
BR9006982A (pt) * 1989-10-30 1991-12-24 Lilly Co Eli Processo de recuperacao de a83543
US5227295A (en) * 1991-11-08 1993-07-13 Dowelanco Process for isolating A83543 and its components
CN1073483A (zh) * 1991-11-08 1993-06-23 道伊兰科公司 一种发酵杀虫剂化合物及其制备方法
US5202242A (en) * 1991-11-08 1993-04-13 Dowelanco A83543 compounds and processes for production thereof

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US5496931A (en) 1996-03-05
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