JPWO2013005446A1 - 抗ウイルス性樹脂部材 - Google Patents
抗ウイルス性樹脂部材 Download PDFInfo
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- JPWO2013005446A1 JPWO2013005446A1 JP2013522479A JP2013522479A JPWO2013005446A1 JP WO2013005446 A1 JPWO2013005446 A1 JP WO2013005446A1 JP 2013522479 A JP2013522479 A JP 2013522479A JP 2013522479 A JP2013522479 A JP 2013522479A JP WO2013005446 A1 JPWO2013005446 A1 JP WO2013005446A1
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- antiviral
- resin
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- virus
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Abstract
Description
(実施例1)
市販のヨウ化銅(I)粉末(日本化学産業株式会社製)を乾式粉砕にて、平均粒子径150nmに粉砕したヨウ化銅微粒子を得た。
抗ウイルス性樹脂部材において、ヨウ化銅6質量%、カチオン系界面活性剤1質量%になるようにポリエチレン樹脂ペレット、マスターバッチペレット、カチオン系界面活性剤を混合した以外は、実施例1と同様の条件で抗ウイルス性を有する成形部材を得た。
実施例1で用いたカチオン系界面活性剤の代わりに、カチオン系界面活性剤(ライオン株式会社製、アーカード2HPフレーク)を用い、抗ウイルス性樹脂部材において、ヨウ化銅3質量%、カチオン系界面活性剤0.1質量%になるようにポリエチレン樹脂ペレット、マスターバッチペレット、カチオン系界面活性剤を混合した以外は、実施例1と同様の条件で抗ウイルス性を有する樹脂部材を得た。
抗ウイルス性樹脂部材において、ヨウ化銅6質量%、カチオン系界面活性剤0.5質量%になるようにポリエチレン樹脂ペレット、マスターバッチペレット、カチオン系界面活性剤を混合した以外は、実施例3と同様の条件で抗ウイルス性を有する樹脂部材を得た。
実施例1で用いたカチオン系界面活性剤の代わりに、カチオン系界面活性剤(ライオン株式会社製、アーマックHTフレーク)を用い、抗ウイルス性樹脂部材において、ヨウ化銅3質量%、カチオン系界面活性剤1質量%になるようにポリエチレン樹脂ペレット、マスターバッチペレット、カチオン系界面活性剤を混合した以外は、実施例1と同様の条件で抗ウイルス性を有する樹脂部材を得た。
抗ウイルス性樹脂部材において、ヨウ化銅6質量%、カチオン系界面活性剤0.1質量%になるようにポリエチレン樹脂ペレット、マスターバッチペレット、カチオン系界面活性剤を混合した以外は、実施例5と同様の条件で抗ウイルス性を有する樹脂部材を得た。
抗ウイルス剤として、市販のヨウ化銀(I)粉末(和光純薬工業株式会社製、化学用)を乾式粉砕にて、平均粒子径1.6μmに粉砕したヨウ化銀微粒子を得た。
抗ウイルス性樹脂部材において、ヨウ化銀20質量%、カチオン系界面活性剤2質量%になるようにポリエチレン樹脂ペレット、マスターバッチペレット、カチオン系界面活性剤を混合した以外は、実施例7と同様の条件で抗ウイルス性を有する成形部材を得た。
抗ウイルス剤として、市販の塩化銅(I)粉末(和光純薬工業株式会社製 和光一級)を乾式粉砕にて、平均粒子径150nmに粉砕した塩化銅微粒子を得た。
抗ウイルス性樹脂部材において、塩化銅40質量%、カチオン系界面活性剤0.01質量%になるようにポリエチレン樹脂ペレット、マスターバッチペレット、カチオン系界面活性剤を混合した以外は、実施例9と同様の条件で抗ウイルス性を有する成形部材を得た。
抗ウイルス剤として、市販の酸化銅(I)粉末(和光純薬工業株式会社製 和光一級)を乾式粉砕にて、平均粒子径400nmに粉砕したヨウ化銀微粒子を得た。
抗ウイルス性樹脂部材において、酸化銅5質量%、カチオン系界面活性剤3質量%になるようにポリエチレン樹脂ペレット、マスターバッチペレット、カチオン系界面活性剤を混合した以外は、実施例11と同様の条件で抗ウイルス性を有する樹脂部材を得た。
ヨウ化銅、界面活性剤を含有せずポリエチレン樹脂ペレットのみで、射出成形機にて射出成形部材を得た。
抗ウイルス性樹脂部材において、界面活性剤を含有せず、ヨウ化銅3質量%になるようにポリエチレン樹脂ペレットとマスターバッチペレットを混合した以外は、実施例1と同様の条件で樹脂部材を得た。
抗ウイルス性樹脂部材において、ヨウ化銅を含有せず、カチオン系界面活性剤(ライオン株式会社製、アーカード22−80)0.5質量%になるようにポリエチレン樹脂ペレットと混合した以外は、比較例1と同様の条件で樹脂部材を得た。
抗ウイルス性樹脂部材において、ヨウ化銅を含有せず、カチオン系界面活性剤(ライオン株式会社製、アーカード2HPフレーク)0.5質量%になるようにポリエチレン樹脂ペレットと混合した以外は、比較例3と同様の条件で樹脂部材を得た。
抗ウイルス性樹脂部材において、ヨウ化銅を含有せず、カチオン系界面活性剤(ライオン株式会社製、アーマックHTフレーク)0.5質量%になるようにポリエチレン樹脂ペレットと混合した以外は、比較例3と同様の条件で樹脂部材を得た。
実施例1で用いたカチオン系界面活性剤の代わりに、ノニオン系界面活性剤(ライオン株式会社製、エレクトロストリッパーTS‐3B)を用い、抗ウイルス性樹脂部材において、ヨウ化銅3質量%、ノニオン系界面活性剤0.5質量%になるようにポリエチレン樹脂ペレット、マスターバッチペレット、カチオン系界面活性剤を混合した以外は、実施例1と同様の条件で樹脂部材を得た。
実施例1で用いたカチオン系界面活性剤の代わりに、アニオン系界面活性剤(テイカ株式会社製、テイカパワーLN2450)を用い、抗ウイルス性樹脂部材において、ヨウ化銅3質量%、アニオン系界面活性剤0.5質量%になるようにポリエチレン樹脂ペレット、マスターバッチペレット、カチオン系界面活性剤を混合した以外は、実施例1と同様の条件で樹脂部材を得た。
(実施例13)
市販のヨウ化銅(I)粉末(日本化学産業株式会社製)を乾式粉砕にて、平均粒子径120nmに粉砕したヨウ化銅微粒子を得た。
シート成形部材において、ヨウ化銅5質量%、カチオン系界面活性剤0.1質量%になるようにポリエチレン樹脂ペレット、マスターバッチペレット、カチオン系界面活性剤を混合した以外は、実施例13と同様の条件で抗ウイルス性を有するシート状の樹脂部材を得た。
実施例13で用いたポリエチレン樹脂ペレットの代わりに、ポリプロピレン樹脂ペレット(日本ポリプロ株式会社製)を用い、厚みを300μmにした以外は、実施例13と同様の条件で抗ウイルス性を有するシート状の樹脂部材を得た。
シート成形部材において、ヨウ化銅5質量%、カチオン系界面活性剤0.1質量%になるようにポリプロピレン樹脂ペレット、マスターバッチペレット、カチオン系界面活性剤を混合した以外は、実施例15と同様の条件で抗ウイルス性を有するシート状の樹脂部材を得た。
シート成形部材において、実施例13で得られたシート状の樹脂部材を、テンターによる延伸倍率1.5倍で2軸延伸加工をすることで抗ウイルス性を有するシート状の樹脂部材を得た。
シート成形部材において、実施例15で得られたシート状の樹脂部材を、テンターによる延伸倍率10倍で2軸延伸加工をすることで抗ウイルス性を有するシート状の樹脂部材を得た。
シート成形部材において、ヨウ化銅0.3質量%、カチオン系界面活性剤0.1質量%になるようにポリエチレン樹脂ペレット、マスターバッチペレット、カチオン系界面活性剤を混合した以外は、実施例13と同様の条件で抗ウイルス性を有するシート状の樹脂部材を得た。
ヨウ化銅、界面活性剤を含有せずポリエチレン樹脂ペレットのみで、Tダイ押出成形機にて厚み50μmのシート状の樹脂部材を得た。
ヨウ化銅、界面活性剤を含有せずポリプロピレン樹脂ペレットのみで、Tダイ押出成形機にて厚み300μmのシート状の樹脂部材を得た。
(実施例20)
市販のヨウ化銅(I)粉末(日本化学産業株式会社製)を乾式粉砕にて、平均粒子径150nmに粉砕したヨウ化銅微粒子を得た。
実施例20において、マスターバッチペレット、カチオン系界面活性剤を混合させず、抗ウイルス剤を含有しない以外は、実施例20と同様の方法にて樹脂繊維を得た。
樹脂部材のウイルス不活化性の測定は、エンベロープを持つウイルスとして、MDCK細胞を用いて培養したインフルエンザウイルス(influenza A/北九州/159/93(H3N2))を用い、エンベロープを持たないウイルスとして、ノロウイルスの代替ウイルスとして一般によく用いられるネコカリシウイルスを用いた。
実施例および比較例の射出成形、シート状部材(20mm×20mm)をプラスチックシャーレにいれ、ウイルス液25μLを滴下し、室温で60分間作用させた。このとき樹脂部材の試験品の上面をPPフィルム(20mm×20mm)で覆うことで、ウイルス液と試験品の接触面積を一定にし、試験を行った。60分間作用させたのち、反応を停止させるためSCDLP培地を975μL添加し、ピペッティングによりウイルスを洗い出した。その後、各反応後のウイルス液が10-2〜10-5になるまでMEM希釈液にて希釈を行い(10倍段階希釈)、サンプル液を作成した。シャーレに培養したMDCK細胞にサンプル液100μLを接種した。60分間静置しウイルスを細胞へ吸着させた後、0.7%寒天培地を重層し、48時間、34℃、5%CO2インキュベータにて培養後、ホルマリン固定、メチレンブルー染色を行い形成されたプラーク数をカウントして、ウイルスの感染価(PFU/0.1mL、Log10);(PFU:plaque−formingunits)を算出した。
実施例20および比較例10の繊維(繊維表面積が400mm2になる量)を滅菌済みの1.5mLチューブに入れ、ウイルス液200μLを滴下し、室温で60分間作用させた。60分間作用させたのち、SCDLP培地1800μLを添加し、ボルテックスによりウイルスを洗い出した。その後、各反応サンプルが10-2〜10-5になるまでMEM希釈液にて希釈を行った(10倍段階希釈)。シャーレに培養したMDCK細胞にサンプル液100μLを接種した。60分間静置しウイルスを細胞へ吸着させた後、0.7%寒天培地を重層し、48時間、34℃、5%CO2インキュベータにて培養後、ホルマリン固定、メチレンブルー染色を行い形成されたプラーク数をカウントして、ウイルスの感染価(PFU/0.1mL,Log10);(PFU:plaque-forming units)を算出した。
表面電位は、実施例および比較例の樹脂部材を10×25mmの大きさに切り取り、ゼータ電位測定システム(大塚電子株式会社製、ELSZ−1)を用いて測定した。
実施例および比較例のシート状部材(40mm×40mm)を5mLチューブに入れ、生理食塩水4mLに60分間浸漬させた。60分間浸漬させた後、生理食塩水に溶出した銅イオンの量を、原子吸光光度計(日立ハイテクノロジーズ社製)を用いて定量した。そして、浸漬させた部材の単位表面積あたりの溶出量を算出した。
20:抗ウイルス剤
30:表面電位制御剤
Claims (7)
- 樹脂と、抗ウイルス剤と、カチオン系界面活性剤からなる表面電位制御剤と、を含む抗ウイルス性樹脂部材であって、前記表面電位制御剤は前記抗ウイルス性樹脂部材の表面の電位を前記樹脂単体の表面の電位よりもプラス方向に変化させることを特徴とする抗ウイルス性樹脂部材。
- 前記抗ウイルス剤は、ヨウ素と、周期律表の第4周期から第6周期かつ8族から15族の元素のうちの少なくとも1種の元素と、からなるヨウ化物の粒子を有効成分として含むことを特徴とする請求項1に記載の抗ウイルス性樹脂部材。
- 前記周期律表の第4周期から第6周期かつ8族から15族の元素が、Cu、Ag、Sb、Ir、Ge、Sn、Tl、Pt、Pd、Bi、Au、Fe、Co、Ni、Zn、In、又はHgであることを特徴とする請求項2に記載の抗ウイルス性樹脂部材。
- 前記抗ウイルス剤は、少なくとも1種の一価の銅化合物の粒子を有効成分として含むことを特徴とする請求項1から3のいずれか1つに記載の抗ウイルス性樹脂部材。
- 前記一価の銅化合物が、塩化物、酢酸化合物、硫化物、ヨウ化物、臭化物、過酸化物、酸化物、またはチオシアン化物であることを特徴とする請求項4に記載の抗ウイルス性樹脂部材。
- 前記抗ウイルス性樹脂部材は、成形後、さらに加熱延伸された成形体であることを特徴とする請求項1から5のいずれか1つに記載の抗ウイルス性樹脂部材。
- 樹脂と、抗ウイルス剤と、カチオン系界面活性剤からなる表面電位制御剤と、を用いて樹脂に抗ウイルス剤とカチオン系界面活性剤が分散した成形体を形成し、
前記成形体を加熱延伸することを特徴とする抗ウイルス性樹脂部材の製造方法。
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