JPS62500519A - （スレオ）−１−アリ−ル−２−アシルアミド−３−フルオル−１−プロパノ−ル類の製造 - Google Patents

（スレオ）−１−アリ−ル−２−アシルアミド−３−フルオル−１−プロパノ−ル類の製造

Info

Publication number
JPS62500519A
JPS62500519A JP60504073A JP50407385A JPS62500519A JP S62500519 A JPS62500519 A JP S62500519A JP 60504073 A JP60504073 A JP 60504073A JP 50407385 A JP50407385 A JP 50407385A JP S62500519 A JPS62500519 A JP S62500519A
Authority
JP
Japan
Prior art keywords
aryl
formulas
acid
fluoro
threo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP60504073A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0529216B2 (enExample
Inventor
ナガブシヤン，タツタナハリ・ラクシユミナラヤン
マツクコムビー，スチユアート・ウオルター
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of JPS62500519A publication Critical patent/JPS62500519A/ja
Publication of JPH0529216B2 publication Critical patent/JPH0529216B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • C07D301/03—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds
    • C07D301/14—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with organic peracids, or salts, anhydrides or esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/34—Compounds containing oxirane rings with hydrocarbon radicals, substituted by sulphur, selenium or tellurium atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP60504073A 1984-09-19 1985-09-17 （スレオ）−１−アリ−ル−２−アシルアミド−３−フルオル−１−プロパノ−ル類の製造 Granted JPS62500519A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US651980 1984-09-19
US06/651,980 US4582918A (en) 1984-09-19 1984-09-19 Preparation of intermediates for (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols

Publications (2)

Publication Number Publication Date
JPS62500519A true JPS62500519A (ja) 1987-03-05
JPH0529216B2 JPH0529216B2 (enExample) 1993-04-28

Family

ID=24615030

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60504073A Granted JPS62500519A (ja) 1984-09-19 1985-09-17 （スレオ）−１−アリ−ル−２−アシルアミド−３−フルオル−１−プロパノ−ル類の製造

Country Status (18)

Country Link
US (1) US4582918A (enExample)
EP (1) EP0200739B1 (enExample)
JP (1) JPS62500519A (enExample)
KR (1) KR900001509B1 (enExample)
AR (1) AR245445A1 (enExample)
AT (1) ATE44735T1 (enExample)
AU (1) AU577622B2 (enExample)
CA (1) CA1262553A (enExample)
DE (1) DE3571613D1 (enExample)
DK (1) DK173703B1 (enExample)
ES (1) ES8702339A1 (enExample)
HU (1) HU196198B (enExample)
IE (1) IE58491B1 (enExample)
IL (1) IL76432A (enExample)
NZ (1) NZ213508A (enExample)
SG (1) SG39092G (enExample)
WO (1) WO1986001799A1 (enExample)
ZA (1) ZA857132B (enExample)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4973750A (en) * 1984-09-19 1990-11-27 Schering Corporation Preparation of (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols
DE3543021A1 (de) * 1985-12-05 1987-06-11 Boehringer Mannheim Gmbh Verbesserte verfahren zur herstellung von d-threo-1-(p-methylsulfonylphenyl) -2-dichloracetamido-propandiol-1,3-(thiamphenicol) sowie verwendung geeigneter zwischenprodukte
US5084583A (en) * 1989-10-12 1992-01-28 E. I. Du Pont De Nemours And Company Epoxidation of fluorine containing olefins
IT1249048B (it) 1991-02-21 1995-02-11 Zambon Spa Processo per la preparazione di trans-(5r)-2-ossazoline -2,4,5, trisostituite
US5346828A (en) * 1991-03-27 1994-09-13 Celgene Corporation Stereoisomeric enrichment of 2-amino-3-hydroxy-3-phenylpropionic acids using d-threonine aldolase
IL134144A (en) * 1999-02-19 2004-02-08 Akzo Nobel Nv Process for the preparation of a-droxy organic acids
CN1649829A (zh) * 2002-03-08 2005-08-03 先灵-普劳有限公司 新型氟苯尼考类抗生素
US20040202762A1 (en) * 2003-04-08 2004-10-14 Ducharme Paul E Smoked nonfibrous casing
US7126005B2 (en) 2003-10-06 2006-10-24 Aurobindo Pharma Limited Process for preparing florfenicol
WO2006020689A1 (en) 2004-08-13 2006-02-23 Schering-Plough Ltd. Pharmaceutical formulation comprising an antibiotic, a triazole and a corticosteroid
CN101065352A (zh) 2004-09-23 2007-10-31 先灵-普劳有限公司 使用新的三氟甲磺酰苯胺肟醚衍生物控制动物中的寄生虫
MX2007006072A (es) * 2004-11-19 2007-07-11 Schering Plough Ltd Control de parasitos en animales mediante el uso de derivados del parasiticida 2-fenil-3-(1h-pirrol-2-il)acrilonitrilo.
US8680154B2 (en) * 2004-12-21 2014-03-25 Intervet International B.V. Injectable veterinary composition
MX2007015729A (es) * 2005-06-09 2008-02-21 Schering Plough Ltd Control de parasitos en animales con derivados de n-[(feniloxi)fenil]-1,1,1-trifluorometansulfonamida y de n[(fenilsulfanil)fenil]-1,1,1-trifluorometansulfonamida.
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
US7518017B2 (en) 2006-02-17 2009-04-14 Idexx Laboratories Fenicol compounds and methods synthesizing 2-trifluoroacetamido-3-substituted propiophenone compounds
EP2091909A1 (en) * 2006-12-13 2009-08-26 Schering-Plough Ltd. Water-soluble prodrugs of florfenicol and its analogs
CA2672795A1 (en) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof
MX2009011642A (es) * 2007-04-27 2010-01-29 Schering Plough Ltd Compuestos y metodos para potenciar la solubilidad de florfenicol y antibioticos estructuralmente relacionados utilizando ciclodextrinas.
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
EP3351243A1 (en) 2007-06-27 2018-07-25 E. I. du Pont de Nemours and Company Animal pest control method
WO2009061780A1 (en) * 2007-11-09 2009-05-14 Schering-Plough Limited Fast release solid formulation, preparation and use thereof
TWI468407B (zh) 2008-02-06 2015-01-11 Du Pont 中離子農藥
KR20110038723A (ko) * 2008-07-30 2011-04-14 인터벳 인터내셔널 비.브이. 플로르페니콜에 대한 중간체로서 유용한 옥사졸린-보호된 아미노디올 화합물의 제조 방법
UA107804C2 (en) 2009-08-05 2015-02-25 Du Pont Mixtures of pesticides mezoionnyh
JP2013501063A (ja) 2009-08-05 2013-01-10 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー メソイオン性殺虫剤
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
BR112012002519A2 (pt) 2009-08-05 2019-09-24 Du Pont "pesticidas mesoiônicos"
BRPI1002023A2 (pt) 2010-03-01 2011-10-25 Nanocore Biotecnologia S A forma farmacêutica sólida de dissolução rápida para tratamento de infecções bacterianas
MD4363C1 (ro) 2010-05-27 2016-03-31 E.I. Du Pont De Nemours And Company Forma cristalină a 4-[5-[3-cloro-5-(trifluorometil)fenil]-4,5-dihidro-5-(trifluorometil)-3-izoxazolil]-N-[2-oxo-2-[(2,2,2-trifluoroetil)amino]etil]-1-naftalencarboxamidei şi utilizările sale
JP5716349B2 (ja) * 2010-10-22 2015-05-13 住友化学株式会社 エポキシアルコール化合物の取得方法、並びにエポキシアルコール化合物及びトリアゾール化合物の製造方法
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD83161A (enExample) *
US3849482A (en) * 1967-10-30 1974-11-19 Merck & Co Inc Amine salts of cis-propenylphosphonic acid
LU79970A1 (fr) * 1978-07-13 1980-02-14 Continental Pharma Procede de preparation de derives de 1-phenyl-1-propanol
ES488154A0 (es) * 1979-02-05 1981-04-16 Schering Corp Un procedimiento para la preparacion de un compuesto d-(treo-1-aril-2-acilamido-3-fluor-1-propanol
US4235892A (en) * 1979-02-05 1980-11-25 Schering Corporation, Patent Dept. 1-Aryl-2-acylamido-3-fluoro-1-propanols, methods for their use as antibacterial agents and compositions useful therefor

Also Published As

Publication number Publication date
DK224086A (da) 1986-05-14
EP0200739B1 (en) 1989-07-19
SG39092G (en) 1992-05-22
ATE44735T1 (de) 1989-08-15
EP0200739A1 (en) 1986-11-12
AU4809785A (en) 1986-04-08
AU577622B2 (en) 1988-09-29
KR900001509B1 (ko) 1990-03-12
IL76432A0 (en) 1986-01-31
DK224086D0 (da) 1986-05-14
IE852296L (en) 1986-03-19
JPH0529216B2 (enExample) 1993-04-28
ZA857132B (en) 1986-05-28
NZ213508A (en) 1989-05-29
KR870700614A (ko) 1987-12-30
ES8702339A1 (es) 1986-12-16
HU196198B (en) 1988-10-28
US4582918A (en) 1986-04-15
CA1262553A (en) 1989-10-31
WO1986001799A1 (en) 1986-03-27
ES547083A0 (es) 1986-12-16
AR245445A1 (es) 1994-01-31
IL76432A (en) 1989-02-28
HUT45243A (en) 1988-06-28
IE58491B1 (en) 1993-09-22
DK173703B1 (da) 2001-07-09
DE3571613D1 (en) 1989-08-24

Similar Documents

Publication Publication Date Title
JPS62500519A (ja) （スレオ）−１−アリ−ル−２−アシルアミド−３−フルオル−１−プロパノ−ル類の製造
US4973750A (en) Preparation of (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols
FR2530626A1 (fr) Composes de carbostyryle
JPH0670048B2 (ja) ペルゴリド中間体の脱シアン化
CN119219601A (zh) 一种4-(2,2-二甲基-2-氰基乙基)-β-内酰胺衍生物的制备方法
US4677214A (en) Intermediates for preparation of (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols
JPS6087251A (ja) 置換ベンズアミド誘導体の製造法
JPH0421662B2 (enExample)
JPH03279348A (ja) ２，４，５―トリフルオロ―３―アルコキシ安息香酸の製造方法
JPS5959664A (ja) アントラニル酸エステル類
HUP0201263A2 (en) Synthesis of 3-amino-3-aryl propanoates and intermediates
US4111951A (en) Process for L-3,4-dehydroproline
JPS6124568A (ja) ジヒドロピリジンエステルの製造法
JP3013760B2 (ja) ４−ヒドロキシ−２−ピロリドンの製法
JPS5852995B2 (ja) フルフラ−ル誘導体の製造法
JPH0535142B2 (enExample)
JPS5951251A (ja) ベンジルシアニド類の製法
JPS61200984A (ja) ピロ−ル誘導体の製造方法
HK42192A (en) Preparation of (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols
JPS60109553A (ja) アミノカルボキサミドのアルフアーフエニルベンジリデン誘導体の新規な調製法および中間体
JPH04149174A (ja) アザスピロヘプタン誘導体の塩
JPS6058224B2 (ja) メトクロプラミドの製造方法
JPH02209866A (ja) １，４―ジヒドロピリジン誘導体の製造方法
JPH01246282A (ja) インドロキノリチジン誘導体
JPS6176485A (ja) 新規なγ−ピラン誘導体

Legal Events

Date Code Title Description
R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term