JPS62500301A - ２４―ホモビタミンｄ誘導体 - Google Patents

２４―ホモビタミンｄ誘導体

Info

Publication number
JPS62500301A
JPS62500301A JP60503924A JP50392485A JPS62500301A JP S62500301 A JPS62500301 A JP S62500301A JP 60503924 A JP60503924 A JP 60503924A JP 50392485 A JP50392485 A JP 50392485A JP S62500301 A JPS62500301 A JP S62500301A
Authority
JP
Japan
Prior art keywords
compound according
group
compound
carbon
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP60503924A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0569103B2 (it
Inventor
デルーカ，ヘクター　エフ
池川　信夫
洋子 田中
Original Assignee
ウイスコンシン　アラムナイ　リサ−チ　フオンデ−シヨン
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ウイスコンシン　アラムナイ　リサ−チ　フオンデ−シヨン filed Critical ウイスコンシン　アラムナイ　リサ−チ　フオンデ−シヨン
Publication of JPS62500301A publication Critical patent/JPS62500301A/ja
Publication of JPH0569103B2 publication Critical patent/JPH0569103B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP60503924A 1984-10-04 1985-08-19 ２４―ホモビタミンｄ誘導体 Granted JPS62500301A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65754984A 1984-10-04 1984-10-04
US657549 1984-10-04

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP4150044A Division JPH0635475B2 (ja) 1984-10-04 1992-05-19 １α，３β，２５−トリヒドロキシ−２４−ホモコレスタ−５，２２−ジエン化合物
JP4150045A Division JPH0689022B2 (ja) 1984-10-04 1992-05-19 １α，３β，２５−トリヒドロキシ−２４−ホモコレスタ−５，７−ジエン類似体

Publications (2)

Publication Number Publication Date
JPS62500301A true JPS62500301A (ja) 1987-02-05
JPH0569103B2 JPH0569103B2 (it) 1993-09-30

Family

ID=24637652

Family Applications (3)

Application Number Title Priority Date Filing Date
JP60503924A Granted JPS62500301A (ja) 1984-10-04 1985-08-19 ２４―ホモビタミンｄ誘導体
JP4150045A Expired - Lifetime JPH0689022B2 (ja) 1984-10-04 1992-05-19 １α，３β，２５−トリヒドロキシ−２４−ホモコレスタ−５，７−ジエン類似体
JP4150044A Expired - Lifetime JPH0635475B2 (ja) 1984-10-04 1992-05-19 １α，３β，２５−トリヒドロキシ−２４−ホモコレスタ−５，２２−ジエン化合物

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP4150045A Expired - Lifetime JPH0689022B2 (ja) 1984-10-04 1992-05-19 １α，３β，２５−トリヒドロキシ−２４−ホモコレスタ−５，７−ジエン類似体
JP4150044A Expired - Lifetime JPH0635475B2 (ja) 1984-10-04 1992-05-19 １α，３β，２５−トリヒドロキシ−２４−ホモコレスタ−５，２２−ジエン化合物

Country Status (13)

Country Link
EP (1) EP0197949A1 (it)
JP (3) JPS62500301A (it)
AU (2) AU582789B2 (it)
BE (1) BE903376A (it)
CH (1) CH672920A5 (it)
DE (2) DE3590488T (it)
DK (5) DK154290C (it)
FR (1) FR2571369B1 (it)
GB (2) GB2167070B (it)
IE (1) IE58104B1 (it)
IT (1) IT1190401B (it)
NL (1) NL8520265A (it)
WO (1) WO1986002078A1 (it)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04505468A (ja) * 1990-02-14 1992-09-24 ウイスコンシン　アラムナイ　リサーチ　フオンデーシヨン 同族化されたビタミンＤ↓２化合物および対応する１α―ヒドロキシル化誘導体

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0412110B1 (en) * 1988-04-21 1993-07-07 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Novel vitamin d analogues
US4927815A (en) * 1988-04-29 1990-05-22 Wisconsin Alumni Research Foundation Compounds effective in inducing cell differentiation and process for preparing same
AU629831B2 (en) * 1988-04-29 1992-10-15 Wisconsin Alumni Research Foundation Side chain unsaturated 1 alpha-hydroxyvitamin d homologs for the treatment of leukemia
GB2229921B (en) * 1989-04-05 1992-12-16 Chugai Pharmaceutical Co Ltd Treatment for hyperparathyroidism with use of vitamin d derivatives
DE3933034A1 (de) * 1989-10-02 1991-04-11 Schering Ag 24-homo-vitamin-d-derivate, verfahren zu ihrer herstellung
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
US5891865A (en) * 1996-10-04 1999-04-06 Wisconsin Alumni Research Foundation Treatment of arthritic disease induced by infectious agents
JP2008519808A (ja) 2004-11-12 2008-06-12 ビオエクセル エスピーエー 膀胱癌治療のためのビタミンｄ誘導体及び抗増殖薬の併用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3833622A (en) * 1969-03-17 1974-09-03 Upjohn Co Crystalline 25-hydroxycholecalciferol hydrate and structurally related compounds
US3880894A (en) * 1974-05-24 1975-04-29 Wisconsin Alumni Res Found 1,25-Dihydroxyergocalciferol
AU527805B2 (en) * 1978-07-27 1983-03-24 Research Institute For Medicine And Chemistry Inc. 1alpha, 1beta dihydroxy steroid-5-enes
US4225596A (en) * 1978-10-13 1980-09-30 Wisconsin Alumni Research Foundation Method for treating calcium imbalance and improving calcium absorption in mammals
US4448721A (en) * 1982-09-20 1984-05-15 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 compounds and process for preparing same
US4508651A (en) * 1983-03-21 1985-04-02 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxyergocalciferol
CH665834A5 (de) * 1983-05-09 1988-06-15 Wisconsin Alumni Res Found Verfahren zur herstellung von 1alpha,25-dihydroxyliertem vitamin d(2) und verwandten verbindungen.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04505468A (ja) * 1990-02-14 1992-09-24 ウイスコンシン　アラムナイ　リサーチ　フオンデーシヨン 同族化されたビタミンＤ↓２化合物および対応する１α―ヒドロキシル化誘導体

Also Published As

Publication number Publication date
DK15290D0 (da) 1990-01-19
AU605007B2 (en) 1991-01-03
GB2167070B (en) 1988-09-01
DK15390A (da) 1990-01-19
DK158990C (da) 1991-01-21
GB2188932B (en) 1988-09-01
DK15390D0 (da) 1990-01-19
JPH0635475B2 (ja) 1994-05-11
DK158990B (da) 1990-08-13
DK158989B (da) 1990-08-13
DK154290B (da) 1988-10-31
BE903376A (fr) 1986-02-03
GB8524479D0 (en) 1985-11-06
IE58104B1 (en) 1993-06-30
DE3590488C2 (it) 1992-10-01
JPH05222089A (ja) 1993-08-31
GB2188932A (en) 1987-10-14
IT8522359A0 (it) 1985-10-04
DK260086D0 (da) 1986-06-03
AU582789B2 (en) 1989-04-13
DK159389C (da) 1991-03-11
DK158991C (da) 1991-01-21
GB2167070A (en) 1986-05-21
DK158989C (da) 1991-01-21
IE852443L (en) 1986-04-04
DK158991B (da) 1990-08-13
DK111188A (da) 1988-03-02
DK260086A (da) 1986-06-03
NL8520265A (nl) 1986-09-01
DK154290C (da) 1989-03-28
EP0197949A1 (en) 1986-10-22
JPH0569103B2 (it) 1993-09-30
DK159389B (da) 1990-10-08
IT1190401B (it) 1988-02-16
AU4776185A (en) 1986-04-17
DK15290A (da) 1990-01-19
GB8709579D0 (en) 1987-05-28
DE3590488T (de) 1986-10-09
DK177489D0 (da) 1989-04-13
FR2571369A1 (fr) 1986-04-11
JPH05178887A (ja) 1993-07-20
DK111188D0 (da) 1988-03-02
WO1986002078A1 (en) 1986-04-10
JPH0689022B2 (ja) 1994-11-09
CH672920A5 (it) 1990-01-15
FR2571369B1 (fr) 1987-12-04
AU2761488A (en) 1989-06-08
DK177489A (da) 1989-04-13

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