GB2167070B - Vitamin d derivatives pharmaceutical compositions containing them and precursors thereof - Google Patents

Vitamin d derivatives pharmaceutical compositions containing them and precursors thereof

Info

Publication number
GB2167070B
GB2167070B GB08524479A GB8524479A GB2167070B GB 2167070 B GB2167070 B GB 2167070B GB 08524479 A GB08524479 A GB 08524479A GB 8524479 A GB8524479 A GB 8524479A GB 2167070 B GB2167070 B GB 2167070B
Authority
GB
United Kingdom
Prior art keywords
precursors
vitamin
pharmaceutical compositions
compositions containing
derivatives pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08524479A
Other versions
GB8524479D0 (en
GB2167070A (en
Inventor
Hector F Deluca
Nobuo Ikekawa
Yoko Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of GB8524479D0 publication Critical patent/GB8524479D0/en
Publication of GB2167070A publication Critical patent/GB2167070A/en
Application granted granted Critical
Publication of GB2167070B publication Critical patent/GB2167070B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GB08524479A 1984-10-04 1985-10-04 Vitamin d derivatives pharmaceutical compositions containing them and precursors thereof Expired GB2167070B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65754984A 1984-10-04 1984-10-04

Publications (3)

Publication Number Publication Date
GB8524479D0 GB8524479D0 (en) 1985-11-06
GB2167070A GB2167070A (en) 1986-05-21
GB2167070B true GB2167070B (en) 1988-09-01

Family

ID=24637652

Family Applications (2)

Application Number Title Priority Date Filing Date
GB08524479A Expired GB2167070B (en) 1984-10-04 1985-10-04 Vitamin d derivatives pharmaceutical compositions containing them and precursors thereof
GB08709579A Expired GB2188932B (en) 1984-10-04 1987-04-23 Steroidal compounds and process for lengthening the side-chain of certain steroids

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB08709579A Expired GB2188932B (en) 1984-10-04 1987-04-23 Steroidal compounds and process for lengthening the side-chain of certain steroids

Country Status (13)

Country Link
EP (1) EP0197949A1 (en)
JP (3) JPS62500301A (en)
AU (2) AU582789B2 (en)
BE (1) BE903376A (en)
CH (1) CH672920A5 (en)
DE (2) DE3590488T (en)
DK (5) DK154290C (en)
FR (1) FR2571369B1 (en)
GB (2) GB2167070B (en)
IE (1) IE58104B1 (en)
IT (1) IT1190401B (en)
NL (1) NL8520265A (en)
WO (1) WO1986002078A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0412110B1 (en) * 1988-04-21 1993-07-07 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Novel vitamin d analogues
US4927815A (en) * 1988-04-29 1990-05-22 Wisconsin Alumni Research Foundation Compounds effective in inducing cell differentiation and process for preparing same
AU629831B2 (en) * 1988-04-29 1992-10-15 Wisconsin Alumni Research Foundation Side chain unsaturated 1 alpha-hydroxyvitamin d homologs for the treatment of leukemia
GB2229921B (en) * 1989-04-05 1992-12-16 Chugai Pharmaceutical Co Ltd Treatment for hyperparathyroidism with use of vitamin d derivatives
DE3933034A1 (en) * 1989-10-02 1991-04-11 Schering Ag 24-HOMO-VITAMIN-D DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF
US5030772A (en) * 1990-02-14 1991-07-09 Deluca Hector F Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
US5891865A (en) * 1996-10-04 1999-04-06 Wisconsin Alumni Research Foundation Treatment of arthritic disease induced by infectious agents
JP2008519808A (en) 2004-11-12 2008-06-12 ビオエクセル エスピーエー Combination of vitamin D derivatives and antiproliferative drugs for the treatment of bladder cancer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3833622A (en) * 1969-03-17 1974-09-03 Upjohn Co Crystalline 25-hydroxycholecalciferol hydrate and structurally related compounds
US3880894A (en) * 1974-05-24 1975-04-29 Wisconsin Alumni Res Found 1,25-Dihydroxyergocalciferol
AU527805B2 (en) * 1978-07-27 1983-03-24 Research Institute For Medicine And Chemistry Inc. 1alpha, 1beta dihydroxy steroid-5-enes
US4225596A (en) * 1978-10-13 1980-09-30 Wisconsin Alumni Research Foundation Method for treating calcium imbalance and improving calcium absorption in mammals
US4448721A (en) * 1982-09-20 1984-05-15 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 compounds and process for preparing same
US4508651A (en) * 1983-03-21 1985-04-02 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxyergocalciferol
CH665834A5 (en) * 1983-05-09 1988-06-15 Wisconsin Alumni Res Found METHOD FOR PRODUCING 1ALPHA, 25-DIHYDROXYLATED VITAMIN D (2) AND RELATED COMPOUNDS.

Also Published As

Publication number Publication date
DK15290D0 (en) 1990-01-19
AU605007B2 (en) 1991-01-03
DK15390A (en) 1990-01-19
DK158990C (en) 1991-01-21
GB2188932B (en) 1988-09-01
DK15390D0 (en) 1990-01-19
JPH0635475B2 (en) 1994-05-11
DK158990B (en) 1990-08-13
DK158989B (en) 1990-08-13
DK154290B (en) 1988-10-31
BE903376A (en) 1986-02-03
GB8524479D0 (en) 1985-11-06
IE58104B1 (en) 1993-06-30
DE3590488C2 (en) 1992-10-01
JPH05222089A (en) 1993-08-31
GB2188932A (en) 1987-10-14
IT8522359A0 (en) 1985-10-04
DK260086D0 (en) 1986-06-03
AU582789B2 (en) 1989-04-13
DK159389C (en) 1991-03-11
DK158991C (en) 1991-01-21
GB2167070A (en) 1986-05-21
DK158989C (en) 1991-01-21
IE852443L (en) 1986-04-04
DK158991B (en) 1990-08-13
DK111188A (en) 1988-03-02
DK260086A (en) 1986-06-03
NL8520265A (en) 1986-09-01
DK154290C (en) 1989-03-28
EP0197949A1 (en) 1986-10-22
JPH0569103B2 (en) 1993-09-30
DK159389B (en) 1990-10-08
IT1190401B (en) 1988-02-16
AU4776185A (en) 1986-04-17
DK15290A (en) 1990-01-19
GB8709579D0 (en) 1987-05-28
DE3590488T (en) 1986-10-09
JPS62500301A (en) 1987-02-05
DK177489D0 (en) 1989-04-13
FR2571369A1 (en) 1986-04-11
JPH05178887A (en) 1993-07-20
DK111188D0 (en) 1988-03-02
WO1986002078A1 (en) 1986-04-10
JPH0689022B2 (en) 1994-11-09
CH672920A5 (en) 1990-01-15
FR2571369B1 (en) 1987-12-04
AU2761488A (en) 1989-06-08
DK177489A (en) 1989-04-13

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19981004