JPS62228167A - 固相分析装置及びその使用法 - Google Patents
固相分析装置及びその使用法Info
- Publication number
- JPS62228167A JPS62228167A JP61234728A JP23472886A JPS62228167A JP S62228167 A JPS62228167 A JP S62228167A JP 61234728 A JP61234728 A JP 61234728A JP 23472886 A JP23472886 A JP 23472886A JP S62228167 A JPS62228167 A JP S62228167A
- Authority
- JP
- Japan
- Prior art keywords
- analyte
- assay
- sample
- matrix
- particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
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- JPXMTWWFLBLUCD-UHFFFAOYSA-N nitro blue tetrazolium(2+) Chemical compound COC1=CC(C=2C=C(OC)C(=CC=2)[N+]=2N(N=C(N=2)C=2C=CC=CC=2)C=2C=CC(=CC=2)[N+]([O-])=O)=CC=C1[N+]1=NC(C=2C=CC=CC=2)=NN1C1=CC=C([N+]([O-])=O)C=C1 JPXMTWWFLBLUCD-UHFFFAOYSA-N 0.000 description 2
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- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 1
- 241000588807 Bordetella Species 0.000 description 1
- 241000588832 Bordetella pertussis Species 0.000 description 1
- 244000304921 Charybdis maritima Species 0.000 description 1
- ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical compound N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 description 1
- 241000194032 Enterococcus faecalis Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
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- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
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- 210000004381 amniotic fluid Anatomy 0.000 description 1
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- 230000000890 antigenic effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
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- 238000006731 degradation reaction Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
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- 229940047650 haemophilus influenzae Drugs 0.000 description 1
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- 239000002184 metal Substances 0.000 description 1
- YLJRCXSSKLWCDE-UHFFFAOYSA-N methyl ethanesulfonate Chemical compound CCS(=O)(=O)OC YLJRCXSSKLWCDE-UHFFFAOYSA-N 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
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- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
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- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G01N33/521—Single-layer analytical elements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G01N33/521—Single-layer analytical elements
- G01N33/523—Single-layer analytical elements the element being adapted for a specific analyte
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G01N33/528—Atypical element structures, e.g. gloves, rods, tampons, toilet paper
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54386—Analytical elements
- G01N33/54387—Immunochromatographic test strips
- G01N33/54391—Immunochromatographic test strips based on vertical flow
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
- G01N33/5761—Hepatitis B
- G01N33/5764—Hepatitis B surface antigen
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/805—Test papers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/97—Test strip or test slide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/971—Capture of complex after antigen-antibody reaction
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Measurement Of Resistance Or Impedance (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Stabilization Of Oscillater, Synchronisation, Frequency Synthesizers (AREA)
- Electrotherapy Devices (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US831013 | 1977-09-06 | ||
| US78441685A | 1985-10-04 | 1985-10-04 | |
| US784416 | 1985-10-04 | ||
| US83101386A | 1986-02-18 | 1986-02-18 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3355456A Division JPH05180841A (ja) | 1985-10-04 | 1991-11-28 | 固相アッセイ装置 |
| JP3355455A Division JP2514878B2 (ja) | 1985-10-04 | 1991-11-28 | 固相アッセイ装置及びその使用法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62228167A true JPS62228167A (ja) | 1987-10-07 |
| JPH0588785B2 JPH0588785B2 (US20090233946A1-20090917-C00069.png) | 1993-12-24 |
Family
ID=27120280
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61234728A Granted JPS62228167A (ja) | 1985-10-04 | 1986-10-03 | 固相分析装置及びその使用法 |
| JP3355455A Expired - Fee Related JP2514878B2 (ja) | 1985-10-04 | 1991-11-28 | 固相アッセイ装置及びその使用法 |
| JP3355456A Pending JPH05180841A (ja) | 1985-10-04 | 1991-11-28 | 固相アッセイ装置 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3355455A Expired - Fee Related JP2514878B2 (ja) | 1985-10-04 | 1991-11-28 | 固相アッセイ装置及びその使用法 |
| JP3355456A Pending JPH05180841A (ja) | 1985-10-04 | 1991-11-28 | 固相アッセイ装置 |
Country Status (11)
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS64463A (en) * | 1987-03-11 | 1989-01-05 | Hitachi Ltd | Method, instrument and kit for inspection |
| JPH01199165A (ja) * | 1987-10-08 | 1989-08-10 | Becton Dickinson & Co | 検体分析用試験装置およびその製造方法 |
| JPH01244369A (ja) * | 1987-12-03 | 1989-09-28 | Monoclonal Antibodies Inc | 焦点化した試料の適用による改良された膜アッセイ |
| JPH01299464A (ja) * | 1988-03-28 | 1989-12-04 | Abbott Lab | 固相分析装置 |
| JPH01313760A (ja) * | 1988-04-28 | 1989-12-19 | Boehringer Mannheim Gmbh | 試料液体成分の分析測定用試薬支持体及び試料液体成分の免疫学的分析測定法 |
| JPH0216451A (ja) * | 1988-03-23 | 1990-01-19 | Becton Dickinson & Co | 流体標本を診断装置に供給する装置および分析成分の検定法 |
| JPH05273211A (ja) * | 1992-01-31 | 1993-10-22 | Boehringer Mannheim Gmbh | 免疫測定用分析要素 |
| WO2001071341A1 (fr) * | 2000-03-24 | 2001-09-27 | Arkray, Inc. | Dispositif auxiliaire d'introduction d'echantillons |
| JP2002509253A (ja) * | 1997-12-30 | 2002-03-26 | ファルマシア・アンド・アップジョン・ディアグノスティクス・アクチエボラーグ | 粒子を使用した分析法および本方法を行うための試験キット |
| JP2009075125A (ja) * | 1997-07-22 | 2009-04-09 | Roche Diagnostics Gmbh | 検出方法において干渉性のサンプルを検出するためのコントロール領域の使用 |
Families Citing this family (160)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4740468A (en) * | 1985-02-14 | 1988-04-26 | Syntex (U.S.A.) Inc. | Concentrating immunochemical test device and method |
| US5879881A (en) * | 1985-04-04 | 1999-03-09 | Hybritech, Incorporated | Solid phase system for use in ligand-receptor assays |
| US5160701A (en) * | 1986-02-18 | 1992-11-03 | Abbott Laboratories | Solid-phase analytical device and method for using same |
| AU7385687A (en) * | 1986-06-09 | 1987-12-10 | Ortho Diagnostic Systems Inc. | Immunoglobulin immunoassay with internalized control assays |
| US5763262A (en) * | 1986-09-18 | 1998-06-09 | Quidel Corporation | Immunodiagnostic device |
| EP0342771B1 (en) * | 1986-09-18 | 1993-01-27 | Pacific Biotech Inc. | Method for impregnating antibodies or antigens into a matrix |
| DE3786388T2 (de) * | 1986-10-16 | 1994-01-05 | Abbott Lab | Analytisches Gerät und Verfahren zum Nachweis von Chlamydia Trachomatis und Neisseria Gonorrhoeae. |
| EP0269876B1 (en) * | 1986-11-24 | 1993-08-18 | Abbott Laboratories | Sample focuser for solid-phase analytical device |
| US6270961B1 (en) * | 1987-04-01 | 2001-08-07 | Hyseq, Inc. | Methods and apparatus for DNA sequencing and DNA identification |
| ATE92635T1 (de) * | 1987-04-22 | 1993-08-15 | Abbott Lab | Verschliess-einschubbehaelter und zugehoeriger wegwerf-probentraeger. |
| EP0288793A3 (en) * | 1987-04-22 | 1990-04-25 | Abbott Laboratories | Cartridge and methods for performing a solid-phase immunoassay |
| JPS63305251A (ja) * | 1987-06-05 | 1988-12-13 | Dai Ichi Pure Chem Co Ltd | ラテツクス凝集反応を利用する免疫学的測定方法 |
| EP0299359A3 (en) * | 1987-07-16 | 1990-09-26 | Abbott Laboratories | Reagent delivery system for use in solid-phase analytical devices |
| WO1989001158A1 (en) * | 1987-08-05 | 1989-02-09 | Calypte Biomedical Company | Self-contained multi-immunoassay diagnostic system |
| US5447837A (en) * | 1987-08-05 | 1995-09-05 | Calypte, Inc. | Multi-immunoassay diagnostic system for antigens or antibodies or both |
| FI80476C (fi) * | 1987-10-09 | 1990-06-11 | Orion Yhtymae Oy | Foerbaettrat hybridisationsfoerfarande, vid foerfarandet anvaent redskap och reagensfoerpackning. |
| US5002883A (en) * | 1987-10-30 | 1991-03-26 | Abbott Laboratories | Covalent attachment of antibodies and antigens to solid phases using extended length heterobifunctional coupling agents |
| US5256372A (en) * | 1987-11-06 | 1993-10-26 | Idexx Corporation | Dipstick test device including a removable filter assembly |
| US4959303A (en) * | 1987-12-21 | 1990-09-25 | Syntex (U.S.A.) Inc. | Assay for antigens by binding immune complexes to solid supports free of protein and non-ionic binders |
| CA1339723C (en) * | 1988-01-19 | 1998-03-17 | Philip Mcmahon | Immunoassay with multiple test spots |
| EP0327395A3 (en) * | 1988-02-05 | 1990-12-27 | Idexx Corp. | Assay kit and method |
| NL8800796A (nl) * | 1988-03-29 | 1989-10-16 | X Flow Bv | Werkwijze voor de chemische analyse van bestanddelen van een lichaamsvloeistof, alsmede een testinrichting en testpakket voor een dergelijke analyse. |
| US5268299A (en) * | 1988-04-14 | 1993-12-07 | Eastman Kodak Company | Diluent composition useful in the detection of antibodies in assays |
| US5077198A (en) * | 1988-04-14 | 1991-12-31 | Eastman Kodak Company | Diagnostic kit and method for rapid detection of antibodies |
| AU2684488A (en) * | 1988-06-27 | 1990-01-04 | Carter-Wallace, Inc. | Test device and method for colored particle immunoassay |
| US4959197A (en) * | 1988-09-07 | 1990-09-25 | Bio-Rad Laboratories, Inc. | Filter canister for immunoassays |
| US5441048A (en) * | 1988-09-08 | 1995-08-15 | Sudor Partners | Method and apparatus for determination of chemical species in perspiration |
| US4957108A (en) * | 1988-09-08 | 1990-09-18 | Sudor Partners | Method and apparatus for determination of chemical species in body fluid |
| US5203327A (en) * | 1988-09-08 | 1993-04-20 | Sudor Partners | Method and apparatus for determination of chemical species in body fluid |
| US5465713A (en) * | 1988-09-08 | 1995-11-14 | Sudor Partners | Energy-assisted transdermal collection patch for accelerated analyte collection and method of use |
| US5817012A (en) * | 1988-09-08 | 1998-10-06 | Sudormed, Inc. | Method of determining an analyte |
| US5445147A (en) * | 1988-09-08 | 1995-08-29 | Sudor Partners | Method and apparatus for determination of chemical species in body fluid |
| US5899856A (en) * | 1988-09-08 | 1999-05-04 | Sudormed, Inc. | Dermal patch detecting long-term alcohol consumption and method of use |
| IT1227293B (it) * | 1988-10-06 | 1991-04-05 | Boehringer Biochemia Srl | Dispositivo e metodo per la diagnosi di gravidanza |
| CA2008304C (en) * | 1989-01-31 | 2001-03-27 | Craig S. Hill | Assay for bone alkaline phosphatase |
| US5147609A (en) * | 1989-05-19 | 1992-09-15 | Pb Diagnostic Systems, Inc. | Assay element |
| US5479937A (en) * | 1989-09-21 | 1996-01-02 | Epitope, Inc. | Oral collection device |
| US5339829A (en) * | 1989-09-21 | 1994-08-23 | Epitope, Inc. | Oral collection device |
| US5075078A (en) * | 1989-10-05 | 1991-12-24 | Abbott Laboratories | Self-performing immunochromatographic device |
| KR910014706A (ko) * | 1990-01-10 | 1991-08-31 | 원본미기재 | 세척이 필요없는 개량된 이뮤노어세이(immunoassay)장치 |
| CA2035646A1 (en) * | 1990-04-12 | 1991-10-13 | Kollen K. Messenger | Chlamydia half-sandwich immunoassay |
| CA2035595A1 (en) * | 1990-04-12 | 1991-10-13 | Carol A. Miller | Immunoassay test device with thread control element |
| DE69117097T2 (de) * | 1990-05-11 | 1996-09-05 | Eastman Kodak Co | Testvorrichtungen |
| US5132085A (en) * | 1991-02-28 | 1992-07-21 | Eastman Kodak Company | Test device with novel control symbolism |
| US5266497A (en) * | 1990-08-31 | 1993-11-30 | Japan Synthetic Rubber Co., Ltd. | Immunochromatographic assay with improved colored latex |
| US5219525A (en) * | 1990-09-11 | 1993-06-15 | Harrison Phillip D | Appartus and method for determining impurities in liquids |
| GB9025471D0 (en) * | 1990-11-22 | 1991-01-09 | Ares Serono Res & Dev Ltd | Method of assay |
| US5726064A (en) * | 1990-11-22 | 1998-03-10 | Applied Research Systems Ars Holding Nv | Method of assay having calibration within the assay |
| DK0834575T3 (da) * | 1990-12-06 | 2002-04-02 | Affymetrix Inc A Delaware Corp | Identifikation af nucleinsyrer i prøver |
| CA2038776A1 (en) * | 1991-03-21 | 1992-09-22 | Kevin Kearns | Assay using an absorbent material |
| WO1992018869A1 (en) * | 1991-04-17 | 1992-10-29 | Medix Biotech, Inc. | Colorfast reference device for immunoassays |
| US5998220A (en) | 1991-05-29 | 1999-12-07 | Beckman Coulter, Inc. | Opposable-element assay devices, kits, and methods employing them |
| US5877028A (en) | 1991-05-29 | 1999-03-02 | Smithkline Diagnostics, Inc. | Immunochromatographic assay device |
| US6168956B1 (en) | 1991-05-29 | 2001-01-02 | Beckman Coulter, Inc. | Multiple component chromatographic assay device |
| US5451504A (en) * | 1991-07-29 | 1995-09-19 | Serex, Inc. | Method and device for detecting the presence of analyte in a sample |
| GB9201089D0 (en) * | 1992-01-18 | 1992-03-11 | Scient Generics Ltd | A diagnostic article |
| EP0583980A1 (en) * | 1992-08-20 | 1994-02-23 | Eli Lilly And Company | Method for generating monoclonal antibodies from rabbits |
| US5356782A (en) * | 1992-09-03 | 1994-10-18 | Boehringer Mannheim Corporation | Analytical test apparatus with on board negative and positive control |
| US5354692A (en) * | 1992-09-08 | 1994-10-11 | Pacific Biotech, Inc. | Analyte detection device including a hydrophobic barrier for improved fluid flow |
| JP3299330B2 (ja) * | 1993-03-18 | 2002-07-08 | 持田製薬株式会社 | 簡易測定装置および方法 |
| US5441894A (en) * | 1993-04-30 | 1995-08-15 | Abbott Laboratories | Device containing a light absorbing element for automated chemiluminescent immunoassays |
| GB9314584D0 (en) * | 1993-07-14 | 1993-08-25 | Cortecs Ltd | Test device |
| WO1995006256A1 (en) * | 1993-08-23 | 1995-03-02 | Biotech Australia Pty. Limited | Apparatus and assay method |
| US5837546A (en) | 1993-08-24 | 1998-11-17 | Metrika, Inc. | Electronic assay device and method |
| US5541059A (en) * | 1993-12-29 | 1996-07-30 | Chu; Albert E. | Immunoassay device having an internal control of protein A and methods of using same |
| US5658801A (en) * | 1994-05-03 | 1997-08-19 | Spectral Diagnostics Inc. | Medical test kit |
| US6686170B1 (en) | 1994-08-17 | 2004-02-03 | Abbott Laboratories | Assay devices with mobile control reagents |
| US5707818A (en) * | 1994-12-13 | 1998-01-13 | Bsi Corporation | Device and method for simultaneously performing multiple competitive immunoassays |
| AU1970195A (en) * | 1995-01-09 | 1996-07-31 | Robert Chen | Immunodiagnostic kit and method for rapid detection of HIV-1 and HIV-2 antibodies |
| US20010051350A1 (en) | 1995-05-02 | 2001-12-13 | Albert Nazareth | Diagnostic detection device and method |
| AUPN527995A0 (en) * | 1995-09-07 | 1995-09-28 | Agen Biomedical Limited | Method and apparatus for semiquantification of an analyte |
| US5981294A (en) * | 1995-11-29 | 1999-11-09 | Metrika, Inc. | Device for blood separation in a diagnostic device |
| JP4245664B2 (ja) * | 1996-07-29 | 2009-03-25 | ナノスフェアー インコーポレイテッド | オリゴヌクレオチドを備えた金ナノ粒子を使用して標的該酸を検出する方法 |
| US5660790A (en) * | 1996-08-13 | 1997-08-26 | Litmus Concepts, Inc. | PH and amine test elements |
| US6133436A (en) | 1996-11-06 | 2000-10-17 | Sequenom, Inc. | Beads bound to a solid support and to nucleic acids |
| US5879951A (en) | 1997-01-29 | 1999-03-09 | Smithkline Diagnostics, Inc. | Opposable-element assay device employing unidirectional flow |
| US6057165A (en) * | 1997-02-07 | 2000-05-02 | Becton, Dickinson And Company | Quality control procedure for membrane flow-through diagnostic assay devices |
| US5939252A (en) | 1997-05-09 | 1999-08-17 | Lennon; Donald J. | Detachable-element assay device |
| US6177283B1 (en) | 1997-05-28 | 2001-01-23 | Flexsite Diagnostics, Inc. | Diagnostic assay |
| US6265223B1 (en) * | 1997-05-28 | 2001-07-24 | Flexsite Diagnostics, Inc. | Diagnostic assay |
| US6258548B1 (en) | 1997-06-05 | 2001-07-10 | A-Fem Medical Corporation | Single or multiple analyte semi-quantitative/quantitative rapid diagnostic lateral flow test system for large molecules |
| US6394952B1 (en) | 1998-02-03 | 2002-05-28 | Adeza Biomedical Corporation | Point of care diagnostic systems |
| US6267722B1 (en) | 1998-02-03 | 2001-07-31 | Adeza Biomedical Corporation | Point of care diagnostic systems |
| USD434153S (en) * | 1998-04-20 | 2000-11-21 | Adeza Biomedical Corporation | Point of care analyte detector system |
| USD432244S (en) * | 1998-04-20 | 2000-10-17 | Adeza Biomedical Corporation | Device for encasing an assay test strip |
| US6355419B1 (en) | 1998-04-27 | 2002-03-12 | Hyseq, Inc. | Preparation of pools of nucleic acids based on representation in a sample |
| US6824997B1 (en) * | 1998-09-18 | 2004-11-30 | Binax, Inc. | Process and materials for the rapid detection of streptococcus pneumoniae employing purified antigen-specific antibodies |
| US20080096236A1 (en) * | 1998-08-25 | 2008-04-24 | Binax, Inc. | Method for Detecting the Presence of Target Bacteria or a Target Component Carbohydrate Antigen Thereof |
| US9134303B1 (en) | 1998-08-25 | 2015-09-15 | Alere Scarborough, Inc. | ICT immunoassay for Legionella pneumophila serogroup 1 antigen employing affinity purified antibodies thereto |
| US6140136A (en) * | 1998-09-18 | 2000-10-31 | Syntron Bioresearch, Inc. | Analytical test device and method of use |
| US6372514B1 (en) | 1998-09-18 | 2002-04-16 | Syntron Bioresearch, Inc. | Even fluid front for liquid sample on test strip device |
| GB2342443A (en) * | 1998-10-02 | 2000-04-12 | Abp Diagnostics Limited | Immunoassay device |
| US6136610A (en) * | 1998-11-23 | 2000-10-24 | Praxsys Biosystems, Inc. | Method and apparatus for performing a lateral flow assay |
| US6287783B1 (en) | 1999-03-18 | 2001-09-11 | Biostar, Inc. | Optical assay device and method |
| US7011940B1 (en) * | 1999-04-14 | 2006-03-14 | Medical Discovery Partners Llc | Quality control for cytochemical assays |
| EP1203343A4 (en) * | 1999-07-13 | 2006-08-23 | Chromavision Med Sys Inc | AUTOMATIC DETECTION OF OBJECTS IN A BIOLOGICAL SAMPLE |
| US6306665B1 (en) | 1999-10-13 | 2001-10-23 | A-Fem Medical Corporation | Covalent bonding of molecules to an activated solid phase material |
| US6699722B2 (en) | 2000-04-14 | 2004-03-02 | A-Fem Medical Corporation | Positive detection lateral-flow apparatus and method for small and large analytes |
| AU7446501A (en) * | 2000-06-14 | 2001-12-24 | J.Mitra And Co. Ltd. | Diagnostic kit for invitro detection of hepatitis c |
| US7531362B2 (en) * | 2001-06-07 | 2009-05-12 | Medmira Inc. | Rapid diagnostic assay |
| CN1164949C (zh) * | 2001-08-17 | 2004-09-01 | 上海数康生物科技有限公司 | 用于同时检测多种传染性疾病的试剂盒及其制备方法 |
| AU2002331408B2 (en) * | 2001-08-20 | 2008-05-08 | Proteome Systems Ltd | Diagnostic testing process and apparatus |
| US6855561B2 (en) * | 2001-09-10 | 2005-02-15 | Quidel Corporation | Method for adding an apparent non-signal line to a lateral flow assay |
| US7393696B2 (en) * | 2001-09-28 | 2008-07-01 | Aspenbio Pharma, Inc. | Bovine pregnancy test |
| US7875435B2 (en) * | 2001-12-12 | 2011-01-25 | Proteome Systems Ltd | Diagnostic testing process |
| US20030119203A1 (en) | 2001-12-24 | 2003-06-26 | Kimberly-Clark Worldwide, Inc. | Lateral flow assay devices and methods for conducting assays |
| US6837171B1 (en) | 2002-04-29 | 2005-01-04 | Palmer/Snyder Furniture Company | Lightweight table with unitized table top |
| US7285424B2 (en) | 2002-08-27 | 2007-10-23 | Kimberly-Clark Worldwide, Inc. | Membrane-based assay devices |
| US7432105B2 (en) | 2002-08-27 | 2008-10-07 | Kimberly-Clark Worldwide, Inc. | Self-calibration system for a magnetic binding assay |
| US7781172B2 (en) | 2003-11-21 | 2010-08-24 | Kimberly-Clark Worldwide, Inc. | Method for extending the dynamic detection range of assay devices |
| JP2007506102A (ja) * | 2003-09-19 | 2007-03-15 | クイデル コーポレイション | 偽陽性及び偽陰性の読取に対して低い感受性しかもたないアイコン的比色試験デバイス |
| US7713748B2 (en) | 2003-11-21 | 2010-05-11 | Kimberly-Clark Worldwide, Inc. | Method of reducing the sensitivity of assay devices |
| US7943395B2 (en) | 2003-11-21 | 2011-05-17 | Kimberly-Clark Worldwide, Inc. | Extension of the dynamic detection range of assay devices |
| WO2005062052A1 (ja) * | 2003-12-24 | 2005-07-07 | Denka Seiken Co.,Ltd. | 簡易メンブレンアッセイ法及びキット |
| US7435577B2 (en) | 2004-02-03 | 2008-10-14 | Polymer Technology Systems, Inc. | Direct measurement of chlolesterol from low density lipoprotein with test strip |
| US7625721B2 (en) | 2004-02-03 | 2009-12-01 | Polymer Technology Systems, Inc. | Non-precipitating bodily fluid analysis system |
| WO2005078442A1 (en) * | 2004-02-10 | 2005-08-25 | Dantini Daniel C | Comprehensive food allergy test |
| US20050191704A1 (en) * | 2004-03-01 | 2005-09-01 | Kimberly-Clark Worldwide, Inc. | Assay devices utilizing chemichromic dyes |
| WO2005095967A1 (en) * | 2004-03-23 | 2005-10-13 | Quidel Corporation | Hybrid phase lateral flow assay |
| US7943294B2 (en) * | 2004-07-30 | 2011-05-17 | Hologic, Inc. | Methods for detecting oncofetal fibronectin |
| US20060062690A1 (en) | 2004-08-17 | 2006-03-23 | Polymer Technology Systems, Inc. | Apparatus and method of manufacturing bodily fluid test strip |
| CA2576453C (en) * | 2004-08-17 | 2013-12-03 | Polymer Technology Systems, Inc. | Non-precipitating bodily fluid analysis system |
| GB2420850A (en) | 2004-12-03 | 2006-06-07 | Orion Diagnostica Oy | Particle based binding assay |
| US7704753B2 (en) * | 2005-03-03 | 2010-04-27 | Inverness Medical Switzerland Gmbh | Devices and methods for analyte assays with built-in result reporting using recognizable symbols |
| US7939342B2 (en) | 2005-03-30 | 2011-05-10 | Kimberly-Clark Worldwide, Inc. | Diagnostic test kits employing an internal calibration system |
| US7439079B2 (en) | 2005-04-29 | 2008-10-21 | Kimberly-Clark Worldwide, Inc. | Assay devices having detection capabilities within the hook effect region |
| US7858384B2 (en) | 2005-04-29 | 2010-12-28 | Kimberly-Clark Worldwide, Inc. | Flow control technique for assay devices |
| US7803319B2 (en) | 2005-04-29 | 2010-09-28 | Kimberly-Clark Worldwide, Inc. | Metering technique for lateral flow assay devices |
| GB2426334A (en) * | 2005-05-20 | 2006-11-22 | Orion Diagnostica Oy | Application of a reagent to a matrix material |
| EP1891447B1 (en) * | 2005-05-23 | 2011-07-06 | Phadia AB | Two step lateral flow assay methods and devices |
| US20070015166A1 (en) * | 2005-07-14 | 2007-01-18 | Nilsen Thor W | Lateral flow methods and devices for detection of nucleic acid binding proteins |
| US7829347B2 (en) * | 2005-08-31 | 2010-11-09 | Kimberly-Clark Worldwide, Inc. | Diagnostic test kits with improved detection accuracy |
| US8003399B2 (en) * | 2005-08-31 | 2011-08-23 | Kimberly-Clark Worldwide, Inc. | Nitrite detection technique |
| US7504235B2 (en) * | 2005-08-31 | 2009-03-17 | Kimberly-Clark Worldwide, Inc. | Enzyme detection technique |
| US7279136B2 (en) | 2005-12-13 | 2007-10-09 | Takeuchi James M | Metering technique for lateral flow assay devices |
| US7618810B2 (en) | 2005-12-14 | 2009-11-17 | Kimberly-Clark Worldwide, Inc. | Metering strip and method for lateral flow assay devices |
| US20070141723A1 (en) * | 2005-12-16 | 2007-06-21 | Sompuram Seshi A | Immunohistochemistry staining controls |
| US7794656B2 (en) * | 2006-01-23 | 2010-09-14 | Quidel Corporation | Device for handling and analysis of a biological sample |
| US7871568B2 (en) * | 2006-01-23 | 2011-01-18 | Quidel Corporation | Rapid test apparatus |
| US7749775B2 (en) * | 2006-10-03 | 2010-07-06 | Jonathan Scott Maher | Immunoassay test device and method of use |
| US8012761B2 (en) * | 2006-12-14 | 2011-09-06 | Kimberly-Clark Worldwide, Inc. | Detection of formaldehyde in urine samples |
| US7935538B2 (en) | 2006-12-15 | 2011-05-03 | Kimberly-Clark Worldwide, Inc. | Indicator immobilization on assay devices |
| US8377379B2 (en) * | 2006-12-15 | 2013-02-19 | Kimberly-Clark Worldwide, Inc. | Lateral flow assay device |
| US7846383B2 (en) * | 2006-12-15 | 2010-12-07 | Kimberly-Clark Worldwide, Inc. | Lateral flow assay device and absorbent article containing same |
| WO2011012848A1 (en) | 2009-07-27 | 2011-02-03 | Suresensors Ltd | Improvements relating to sensor devices |
| US8012770B2 (en) | 2009-07-31 | 2011-09-06 | Invisible Sentinel, Inc. | Device for detection of antigens and uses thereof |
| CN102612555A (zh) | 2009-10-09 | 2012-07-25 | 因威瑟堡善迪诺有限公司 | 用于检测抗原的装置及其应用 |
| US8956859B1 (en) | 2010-08-13 | 2015-02-17 | Aviex Technologies Llc | Compositions and methods for determining successful immunization by one or more vaccines |
| US8828329B2 (en) | 2010-10-01 | 2014-09-09 | Church & Dwight, Co., Inc. | Electronic analyte assaying device |
| ES2745140T3 (es) | 2011-01-27 | 2020-02-27 | Invisible Sentinel Inc | Dispositivos de detección de analitos, dispositivos multiplex y de sobremesa para la detección de analitos y usos de los mismos |
| EP3578980B1 (en) | 2012-03-09 | 2021-09-15 | Invisible Sentinel, Inc. | Methods and compositions for detecting multiple analytes with a single signal |
| CA2870635C (en) | 2012-04-17 | 2019-04-09 | Joel R. L. Ehrenkranz | Device for performing a diagnostic test and methods for use thereof |
| US9285323B2 (en) | 2012-08-08 | 2016-03-15 | Scanadu Incorporated | Quantifying color changes of chemical test pads induced concentrations of biological analytes under different lighting conditions |
| WO2014025415A2 (en) | 2012-08-08 | 2014-02-13 | Scanadu Incorporated | Method and apparatus for performing and quantifying color changes induced by specific concentrations of biological analytes in an automatically calibrated environment |
| US9528941B2 (en) | 2012-08-08 | 2016-12-27 | Scanadu Incorporated | Method and apparatus for determining analyte concentration by quantifying and interpreting color information captured in a continuous or periodic manner |
| JP6114465B2 (ja) * | 2013-08-01 | 2017-04-12 | アガフラ カンパニー リミテッド | 幼児用飲料容器 |
| EP3180596A4 (en) | 2014-08-15 | 2018-09-26 | Scanadu Incorporated | Precision luxmeter methods for digital cameras to quantify colors in uncontrolled lighting environments |
| US20160313320A1 (en) * | 2015-04-23 | 2016-10-27 | Ted Titmus | Mechanical attachment of test pads to a diagnostic test strip |
| CN117448315A (zh) | 2017-09-18 | 2024-01-26 | 相达生物科技国际有限公司 | 使用双水相系统来分离、纯化和/或浓缩短链核酸片段的方法 |
| US20220381778A1 (en) | 2019-11-15 | 2022-12-01 | Abbott Rapid Diagnostics International Unlimited Company | Device for Digital Read of Lateral Flow Assay |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54126088A (en) * | 1978-01-26 | 1979-09-29 | Miles Lab | Method and testing implement for detecting presence of constituent of liquid sample |
| US4280816A (en) * | 1979-10-25 | 1981-07-28 | Nasik Elahi | Macroencapsulated immunosorbent assay technique and element therefor |
| US4338094A (en) * | 1979-10-25 | 1982-07-06 | Nasik Elahi | Macroencapsulated immunosorbent assay technique |
| JPS57200862A (en) * | 1981-06-05 | 1982-12-09 | Fuji Photo Film Co Ltd | Mutilayer analysis element utilizing unique binding reaction |
| JPS5876763A (ja) * | 1981-10-13 | 1983-05-09 | ランス・エイ・リオツタ | 抗原の存在を検出する方法及びこれに用いる装置 |
| JPS58177862U (ja) * | 1982-05-21 | 1983-11-28 | 大日本印刷株式会社 | 検査体 |
| JPS59170768A (ja) * | 1983-03-17 | 1984-09-27 | Fuji Photo Film Co Ltd | 非アイソト−プアツセイ用多層分析要素およびそれを用いるアツセイ方法 |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3260413A (en) * | 1964-08-31 | 1966-07-12 | Scientific Industries | Automatic chemical analyzer |
| GB1420916A (en) * | 1971-09-08 | 1976-01-14 | Bagshawe K D | Performance of chemical or biological reactions |
| CA983358A (en) * | 1971-09-08 | 1976-02-10 | Kenneth D. Bagshawe | Performance of chemical or biological reactions |
| US3843324A (en) * | 1972-09-13 | 1974-10-22 | Research Corp | Method of cell fractionation and apparatus therefor |
| US3951748A (en) * | 1974-11-11 | 1976-04-20 | Medical Products, Inc. | Sensitized matrix for detection of disease |
| US3992096A (en) * | 1975-08-04 | 1976-11-16 | Minnesota Mining And Manufacturing Company | Detecting system |
| US4059407A (en) * | 1976-04-14 | 1977-11-22 | Becton, Dickinson And Company | Disposable chemical indicators |
| US4219335A (en) * | 1978-09-18 | 1980-08-26 | E. I. Du Pont De Nemours And Company | Immunochemical testing using tagged reagents |
| US4631174A (en) * | 1978-05-02 | 1986-12-23 | Fuji Photo Film Co., Ltd. | Multilayer chemical analysis member having an outer waterproof layer |
| JPS587332Y2 (ja) * | 1978-06-06 | 1983-02-08 | 富士写真フイルム株式会社 | 多層血液化学分析材料 |
| US4254083A (en) * | 1979-07-23 | 1981-03-03 | Eastman Kodak Company | Structural configuration for transport of a liquid drop through an ingress aperture |
| US4246339A (en) * | 1978-11-01 | 1981-01-20 | Millipore Corporation | Test device |
| US4533629A (en) * | 1981-04-17 | 1985-08-06 | Syva Company | Simultaneous calibration heterogeneous immunoassay |
| US4540659A (en) * | 1981-04-17 | 1985-09-10 | Syva Company | Simultaneous calibration heterogeneous immunoassay |
| US4340564A (en) * | 1980-07-21 | 1982-07-20 | Daryl Laboratories, Inc. | Immunoadsorptive surface coating for solid-phase immunosubstrate and solid-phase immunosubstrate |
| DE3029579C2 (de) * | 1980-08-05 | 1985-12-12 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und Mittel zur Abtrennung von Plasma oder Serum aus Vollblut |
| US4472353A (en) * | 1980-08-07 | 1984-09-18 | Gerald Moore | Gas detector badge |
| US4366241A (en) * | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| DE3044385A1 (de) * | 1980-11-25 | 1982-06-24 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur durchfuehrung analytischer bestimmungen und hierfuer geeignetes rotoreinsatzelement |
| US4517288A (en) * | 1981-01-23 | 1985-05-14 | American Hospital Supply Corp. | Solid phase system for ligand assay |
| US4425438A (en) * | 1981-03-13 | 1984-01-10 | Bauman David S | Assay method and device |
| SE8102316L (sv) * | 1981-04-10 | 1982-10-11 | Pharmacia Diagnostics Ab | Anordning for genomforande av analyser |
| AR231590A1 (es) * | 1981-04-29 | 1984-12-28 | Ciba Geigy Ag | Dispositivo de analisis inmunologico y procedimiento para obtenerlo |
| JPS5818167A (ja) * | 1981-07-24 | 1983-02-02 | Fuji Photo Film Co Ltd | 分析フイルム及びこれを用いる分析方法 |
| JPS59102388A (ja) * | 1982-12-03 | 1984-06-13 | Fuji Photo Film Co Ltd | 生物学的反応層およびその製造方法 |
| US4591570A (en) * | 1983-02-02 | 1986-05-27 | Centocor, Inc. | Matrix of antibody-coated spots for determination of antigens |
| US4558013A (en) * | 1983-04-08 | 1985-12-10 | Mast Immunosystems, Ltd. | Calibrated reaction measurement system |
| US4496654A (en) * | 1983-04-08 | 1985-01-29 | Quidel | Detection of HCG with solid phase support having avidin coating |
| US4704255A (en) * | 1983-07-15 | 1987-11-03 | Pandex Laboratories, Inc. | Assay cartridge |
| US4552839A (en) * | 1983-08-01 | 1985-11-12 | Syntex (U.S.A.) Inc. | Determination of analytes in particle-containing medium |
| DE3468139D1 (en) * | 1983-08-03 | 1988-01-28 | Owens Corning Fiberglass Corp | Method of depositing a membrane within a conduit |
| US4541987A (en) * | 1983-09-29 | 1985-09-17 | Helena Laboratories Corporation | Test pad for detecting occult blood |
| CA1225574A (en) * | 1983-11-07 | 1987-08-18 | Anand Kumar | Reflective particle-containing solvent extraction reagent composition |
| US4717656A (en) * | 1983-12-02 | 1988-01-05 | Vertrik Bioteknik Ab | Device for chemical analyses and use thereof |
| US4703017C1 (en) * | 1984-02-14 | 2001-12-04 | Becton Dickinson Co | Solid phase assay with visual readout |
| US4632901A (en) * | 1984-05-11 | 1986-12-30 | Hybritech Incorporated | Method and apparatus for immunoassays |
| IL75464A (en) * | 1984-06-12 | 1990-08-31 | Orgenics Ltd | Method and apparatus for multi-analyte assay |
| CA1261743A (en) * | 1984-07-23 | 1989-09-26 | Shai Inbar | Biological diagnostic assay product, and process utilizing labeled fab fragments |
| WO1986001603A1 (en) * | 1984-08-28 | 1986-03-13 | Hybritech Incorporated | Article for diagnostic assays |
| EP0177352A1 (en) * | 1984-10-04 | 1986-04-09 | The State Of Victoria | Improvements in or relating to enzyme-linked immunosorbent assay |
| US4740468A (en) * | 1985-02-14 | 1988-04-26 | Syntex (U.S.A.) Inc. | Concentrating immunochemical test device and method |
| US4649121A (en) * | 1985-02-26 | 1987-03-10 | Miles Laboratories, Inc. | Viability test device |
| CA1272127A (en) * | 1985-04-04 | 1990-07-31 | Hybritech Incorporated | Solid phase system for use in ligand-receptor assays |
| EP0248892A1 (en) * | 1985-12-10 | 1987-12-16 | Murex Corporation | Particle-bound binding component immunoassay |
| US4916056A (en) * | 1986-02-18 | 1990-04-10 | Abbott Laboratories | Solid-phase analytical device and method for using same |
| AU7385687A (en) * | 1986-06-09 | 1987-12-10 | Ortho Diagnostic Systems Inc. | Immunoglobulin immunoassay with internalized control assays |
| EP0342771B1 (en) * | 1986-09-18 | 1993-01-27 | Pacific Biotech Inc. | Method for impregnating antibodies or antigens into a matrix |
| US4748042A (en) * | 1987-03-31 | 1988-05-31 | V-Tech, Inc. | Method and apparatus for imprinting membranes with patterns of antibody |
-
1986
- 1986-09-02 TW TW080104571A patent/TW203120B/zh active
- 1986-09-11 GR GR862328A patent/GR862328B/el unknown
- 1986-10-02 KR KR1019860008272A patent/KR940002520B1/ko not_active IP Right Cessation
- 1986-10-02 ES ES8602370A patent/ES2001811A6/es not_active Expired
- 1986-10-03 DE DE198686113657T patent/DE217403T1/de active Pending
- 1986-10-03 CA CA000519755A patent/CA1281642C/en not_active Expired - Lifetime
- 1986-10-03 EP EP90109680A patent/EP0389003B1/en not_active Expired - Lifetime
- 1986-10-03 AU AU63502/86A patent/AU593285B2/en not_active Ceased
- 1986-10-03 AT AT86113657T patent/ATE78597T1/de not_active IP Right Cessation
- 1986-10-03 JP JP61234728A patent/JPS62228167A/ja active Granted
- 1986-10-03 DE DE9090109680T patent/DE3687276T2/de not_active Expired - Lifetime
- 1986-10-03 DE DE8686113657T patent/DE3686116T2/de not_active Expired - Lifetime
- 1986-10-03 EP EP86113657A patent/EP0217403B1/en not_active Expired - Lifetime
-
1989
- 1989-09-21 AU AU41702/89A patent/AU613797B2/en not_active Ceased
-
1990
- 1990-02-06 US US07/475,591 patent/US5008080A/en not_active Expired - Lifetime
- 1990-05-21 US US07/528,277 patent/US5149622A/en not_active Expired - Fee Related
- 1990-05-22 AT AT90109680T patent/ATE83325T1/de not_active IP Right Cessation
- 1990-12-06 CA CA000615951A patent/CA1301648C/en not_active Expired - Lifetime
-
1991
- 1991-11-28 JP JP3355455A patent/JP2514878B2/ja not_active Expired - Fee Related
- 1991-11-28 JP JP3355456A patent/JPH05180841A/ja active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54126088A (en) * | 1978-01-26 | 1979-09-29 | Miles Lab | Method and testing implement for detecting presence of constituent of liquid sample |
| US4280816A (en) * | 1979-10-25 | 1981-07-28 | Nasik Elahi | Macroencapsulated immunosorbent assay technique and element therefor |
| US4338094A (en) * | 1979-10-25 | 1982-07-06 | Nasik Elahi | Macroencapsulated immunosorbent assay technique |
| JPS57200862A (en) * | 1981-06-05 | 1982-12-09 | Fuji Photo Film Co Ltd | Mutilayer analysis element utilizing unique binding reaction |
| JPS5876763A (ja) * | 1981-10-13 | 1983-05-09 | ランス・エイ・リオツタ | 抗原の存在を検出する方法及びこれに用いる装置 |
| JPS58177862U (ja) * | 1982-05-21 | 1983-11-28 | 大日本印刷株式会社 | 検査体 |
| JPS59170768A (ja) * | 1983-03-17 | 1984-09-27 | Fuji Photo Film Co Ltd | 非アイソト−プアツセイ用多層分析要素およびそれを用いるアツセイ方法 |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS64463A (en) * | 1987-03-11 | 1989-01-05 | Hitachi Ltd | Method, instrument and kit for inspection |
| JPH01199165A (ja) * | 1987-10-08 | 1989-08-10 | Becton Dickinson & Co | 検体分析用試験装置およびその製造方法 |
| JPH01244369A (ja) * | 1987-12-03 | 1989-09-28 | Monoclonal Antibodies Inc | 焦点化した試料の適用による改良された膜アッセイ |
| JPH0216451A (ja) * | 1988-03-23 | 1990-01-19 | Becton Dickinson & Co | 流体標本を診断装置に供給する装置および分析成分の検定法 |
| JPH01299464A (ja) * | 1988-03-28 | 1989-12-04 | Abbott Lab | 固相分析装置 |
| JPH01313760A (ja) * | 1988-04-28 | 1989-12-19 | Boehringer Mannheim Gmbh | 試料液体成分の分析測定用試薬支持体及び試料液体成分の免疫学的分析測定法 |
| JPH05273211A (ja) * | 1992-01-31 | 1993-10-22 | Boehringer Mannheim Gmbh | 免疫測定用分析要素 |
| JP2009075125A (ja) * | 1997-07-22 | 2009-04-09 | Roche Diagnostics Gmbh | 検出方法において干渉性のサンプルを検出するためのコントロール領域の使用 |
| JP2002509253A (ja) * | 1997-12-30 | 2002-03-26 | ファルマシア・アンド・アップジョン・ディアグノスティクス・アクチエボラーグ | 粒子を使用した分析法および本方法を行うための試験キット |
| WO2001071341A1 (fr) * | 2000-03-24 | 2001-09-27 | Arkray, Inc. | Dispositif auxiliaire d'introduction d'echantillons |
Also Published As
| Publication number | Publication date |
|---|---|
| GR862328B (en) | 1987-01-19 |
| ATE78597T1 (de) | 1992-08-15 |
| EP0389003A1 (en) | 1990-09-26 |
| KR940002520B1 (ko) | 1994-03-25 |
| JPH0650973A (ja) | 1994-02-25 |
| EP0217403A3 (en) | 1988-06-22 |
| JPH05180841A (ja) | 1993-07-23 |
| US5149622A (en) | 1992-09-22 |
| US5008080A (en) | 1991-04-16 |
| AU613797B2 (en) | 1991-08-08 |
| KR870004305A (ko) | 1987-05-08 |
| DE217403T1 (de) | 1988-09-01 |
| EP0217403B1 (en) | 1992-07-22 |
| DE3687276D1 (de) | 1993-01-21 |
| JP2514878B2 (ja) | 1996-07-10 |
| DE3686116D1 (de) | 1992-08-27 |
| CA1281642C (en) | 1991-03-19 |
| CA1301648C (en) | 1992-05-26 |
| AU593285B2 (en) | 1990-02-08 |
| ES2001811A6 (es) | 1988-06-16 |
| TW203120B (US20090233946A1-20090917-C00069.png) | 1993-04-01 |
| EP0389003B1 (en) | 1992-12-09 |
| ATE83325T1 (de) | 1992-12-15 |
| DE3686116T2 (de) | 1993-01-28 |
| EP0217403A2 (en) | 1987-04-08 |
| JPH0588785B2 (US20090233946A1-20090917-C00069.png) | 1993-12-24 |
| AU4170289A (en) | 1990-05-10 |
| AU6350286A (en) | 1987-04-09 |
| DE3687276T2 (de) | 1993-05-06 |
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