KR910014706A - 세척이 필요없는 개량된 이뮤노어세이(immunoassay)장치 - Google Patents

세척이 필요없는 개량된 이뮤노어세이(immunoassay)장치 Download PDF

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KR910014706A
KR910014706A KR1019900006412A KR900006412A KR910014706A KR 910014706 A KR910014706 A KR 910014706A KR 1019900006412 A KR1019900006412 A KR 1019900006412A KR 900006412 A KR900006412 A KR 900006412A KR 910014706 A KR910014706 A KR 910014706A
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enzyme
region
phosphate
indicia
inhibitor
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KR1019900006412A
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강 제모
에이. 콜란듀오니 존
윤병우
강 월러
오영호
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원본미기재
프린스톤 바이오메디테크 코포레이션
김채방
주식회사 미원
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/805—Test papers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/963—Methods of stopping an enzyme reaction or stabilizing the test materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/97—Test strip or test slide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
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    • Y10S436/808—Automated or kit
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    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/81—Tube, bottle, or dipstick

Abstract

내용 없음

Description

세척이 필요없는 개량된 이뮤노어세이(immunoassay)장치
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 분석과 대조 인디시아(indicia)를 보여주는 본 발명의 대표적인 막대 모양의 딥스틱(dipstick)장치의 사시도이며, 제2도는 분석과 대조 인디시아를 보여주는 본 발명의 또 다른 형태인 플러스(+)부호 형태의 딥스틱 장치의 사시도이다.

Claims (28)

  1. 베이스 구성체, 상기의 베이스 구성체상에 형성된 테스트 영역, 및 인디시아를 형성하는 형태로 상기 영역상에 배열된 적어도 하나의 고정된 면역성분으로 이루어지고, 상기 면역성분은 상기 영역상에서 타겟 분석물을 통해서, 효소-라벨된 항체에 결합 가능하여 샌드위치 복합체를 형성하고 상기 복합체가 상기 효소에 대한 기질과 접촉하여 상기 인디시아 형태와 상기 테스트 영역 사이에 육안으로 식별할 수 있는 특이성을 창출해내며, 상기 효소에 대한 억제제가 상기 영역을 통해서 분포해 있는 딥스틱 뮤노어세이장치.
  2. 제1항에서, 상기의 고정성분이 항체, 항원 또는 합텐인 분석장치.
  3. 제2항에서, 상기의 고정성분이 항체인 분석장치.
  4. 제1항에서, 상기의 효소가 알카리포스파라제, 호오스래디쉬 퍼옥시다제, 리소자임, 글루코스-6-포스페이트디하이드로 제나제, 테이트 디하이드로제나제, 우레아제, 글루코스 옥시디아제, β-칼락토시다아제, 또는 콜레스테롤옥시다아제인 분석장치.
  5. 제4항에서, 상기의 효소가 알카리 포스파라제인 분석장치.
  6. 제1항에서, 상기의 효소억제제(inhibitor)가 아미노산, 아미노산유도체, 금속킬레이트, 산소결합된 옴이온착제(complex oxygenated anion), 또는 할로겐화 카르복실산 유도체인 분석장치.
  7. 제6항에서, 상기의 억제제가 시스테린, 히스티딘, L-페닐 알라닌, β-페닐-β-알라닌, P-플루오로페닐알라닌, 티로신, 요도벤조산염, 요오도아세트아미드, 시트르산염, 에틸렌디아민 테트라아세트산, 붕산염, 비산염, 인산염, 오르토인산염, 탄산염, 폴리에스트테디올 인산염, 피로인산염, 폴리프로레틴인산염, 또는 P-니트로페닐 인산염등인 분석 장치.
  8. 제7항에서, 상기의 억제제가 P-니트로페닐 인산염인 분석 장치.
  9. 제1항에서, 타겟 분석물이 항원, 항체 또는 합텐인 분석장치.
  10. 제1항에서, 상기의 인디시아 형태가 막대모양, 도트(dot) 모양, 숫자 또는 문자인 분석장치.
  11. 제1항에서, 상기의 베이스 구성체가 플라스틱 또는 유리인 분석장치.
  12. 제1항에서, 상기의 테스트 영역이 나일론, 니트로셀룰로오스, 셀룰로오스, 유리섬유, 폴리설폰, 폴리비닐리덴 미플루오라이드, 또는 폴리에스터를 함유하는 분석장치.
  13. 제1항의 분석장치, 효소라벨된 항체를 함유하는 제1용액, 및 상기의 효소와 접촉하여 불용성 착색 생성물을 형성하도록 조작해주는 기질을 함유하는 제2용액으로 이루어진 키트(Kit).
  14. 베이스 구성체, 상기의 베이스 구성체상에 형성된 테스트 영역, 및 인디시아를 형성하는 형태로 상기 영역상에 배열된 적어도 하나의 고정된 면역성분으로 이루어지고, 상기 면역성분은 상기 영역상에 타겟 분석물을 통해서 알카리 포스파타제 라벨된 항체에 결합 가능하며, 샌드위치 복합체를 형성하고, 상기 복합체가 상기 효소에 대한 기질과 접촉하여 상기 인디시아 형태와 상기 테스트 영역 사이에 육안으로 식별할 수 있는 특이성을 창출해내며, 알카리 포스파라제에 대한 억제제가 상기 영역을 통해서 분포해 있으며, 및 제1폴리올이 상기 영역을 통해서 분포해 있는 딥스틱 이뮤노어세이 장치.
  15. 제14항에 있어서, 상기의 억제제가 아미노산, 아미노산 유도체, 킬레이트시약, 산소 결합된 음이온 착체(acomplex oxygenated anion), 제2경쟁적기질, 또는 할로겐화된 카르복실산 유도체인 분석장치.
  16. 제15항에서, 상기의 억제제가 시스테인, 히스티딘, L-페닐 알라닌, β-페닐-β-알라닌, P-플루오로페닐알라닌, 티오신, 요도벤조산염, 요도아세트아미드, 에틸렌디아민 테트라아세르산, 시트르산염, 오트로인산염, 비산염, 피로인산염, 붕산염, 탄산염, 폴리에스트테디올 인산염, 폴리프로테린 인산염, P-니트로페닐 인산염, 또는 인산염인 분석 장치.
  17. 제16항에서, 상기의 억제제가 P-니트로페닐 인산염인 분석 장치.
  18. 제14항에서, 타겟 분석물이 항원, 항체 또는 합텐인 분석장치.
  19. 제14항에서, 상기의 인디시아 형태가 막대모양, 문자, 숫자 또는 도르(dot) 모양인 분석장치.
  20. 제14항에서, 상기의 베이스 구성체가 플라스틱 또는 유리인 분석장치.
  21. 제14항에서, 상기의 테스트 영역이 나일론, 니트로셀룰로오스, 셀룰로오스, 유리섬유, 폴리설폰, 폴리비닐리덴 미플루오라이드, 또는 폴리에스터를 함유하는 분석장치.
  22. 제14항에서, 상기의 제1폴리올이 폴리비닐알코올, 탄수화물, 폴리에틸렌글리콜, 솔비톨, 폴리프로필렌글리콜, 덱스트란, 메틸셀룰로오스, 밀크, 또는 옥수수전분인 분석장치.
  23. 제22항에서, 상기의 제1폴리올이 폴리비닐알코올인 분석장치.
  24. 제14항의 분석장치, 알카리포스파타제 라벨된 항체를 함유하는 제1용액, 및 상기의 알칼리포스타제와 접촉하여 불용성 착색 생성물과 인산염 이온을 형성하도록 조작해주는 기질을 함유하는 제2용액 및 기본량의 상기의 인산염 이온을 결합 가능하게 해주는 제2폴리올로 이루어진 키트.
  25. 제24항에서, 상기의 제2폴리올이 프로필렌글리콜, 에탄글리콜, 2-아미노-2-메틸-1-프로판올, 부탄디올, 또는 2-아미노-2-메틸-1. 3-프로판-디올인 키트.
  26. 제25항에서, 상기의 제2폴리올이 2-아미노-2-메틸-1-프로판올 인 키트.
  27. 베이스 구성체, 상기의 베이스 구성체상에 형성된 테스트 영역, 및 인디시아를 형성하는 형태로 상기 영역상에 배열된 적어도 하나의 고정된 면역성분으로 이루어지고, 상기 면역성분은 타겟보체(target complement)와 효소-라벨된 보체와 결합가능하며, 상기 효소 라벨된 보체가 상기 효소에 대한 기질과 접촉하여 상기 인디시아 형태와 상기 테스트 영역 사이에 육안으로 식별할 수 있는 특이성을 창출해내며, 상기 효소에 대한 억제제가 상기 테스트 영역을 통해서 분포해 있는 딥스틱 이뮤노어세이 장치.
  28. 베이스 구성체, 상기의 베이스 구성체상에 형성된 테스트 영역, 및 인디시아를 형성하는 형태로 상기 영역상에 배열된 적어도 하나의 고정된 면역성분으로 이루어지고, 상기 면역성분은 상기 영역상에서 타겟 분석물을 통해서, 직접 라벨된 항체(direct labeled antibody)에 결합 가능하여, 샌드위치 복합체를 형성하고, 상기 복합체가 상기 효소에 대한 기질과 접촉하여 상기 인디시아 형태와 상기 테스트 영역사이에 육안으로 식별할 수 있는 특이성을 창출해내는 딥스틱 이뮤노어세이 장치.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900006412A 1990-01-10 1990-05-07 세척이 필요없는 개량된 이뮤노어세이(immunoassay)장치 KR910014706A (ko)

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CH683948A5 (fr) 1994-06-15
AU642905B2 (en) 1993-11-04
FR2656928B1 (fr) 1994-05-13
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US5656448A (en) 1997-08-12
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