JPS55153755A - Triiodoisophthalic acid diamide derivative* its manufacture and x ray contrast agent containing it - Google Patents

Triiodoisophthalic acid diamide derivative* its manufacture and x ray contrast agent containing it

Info

Publication number
JPS55153755A
JPS55153755A JP2822480A JP2822480A JPS55153755A JP S55153755 A JPS55153755 A JP S55153755A JP 2822480 A JP2822480 A JP 2822480A JP 2822480 A JP2822480 A JP 2822480A JP S55153755 A JPS55153755 A JP S55153755A
Authority
JP
Japan
Prior art keywords
alkyl
ray contrast
manufacture
contrast agent
agent containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2822480A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6341898B2 (cg-RX-API-DMAC7.html
Inventor
Supetsuku Ururihi
Burasutsukibuitsutsu Peetaa
Zaideruman Deiitaa
Kuriigaa Eerihi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of JPS55153755A publication Critical patent/JPS55153755A/ja
Publication of JPS6341898B2 publication Critical patent/JPS6341898B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyamides (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Catalysts (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Paints Or Removers (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
JP2822480A 1979-03-08 1980-03-07 Triiodoisophthalic acid diamide derivative* its manufacture and x ray contrast agent containing it Granted JPS55153755A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792909439 DE2909439A1 (de) 1979-03-08 1979-03-08 Neue nichtionische roentgenkontrastmittel

Publications (2)

Publication Number Publication Date
JPS55153755A true JPS55153755A (en) 1980-11-29
JPS6341898B2 JPS6341898B2 (cg-RX-API-DMAC7.html) 1988-08-19

Family

ID=6065014

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2822480A Granted JPS55153755A (en) 1979-03-08 1980-03-07 Triiodoisophthalic acid diamide derivative* its manufacture and x ray contrast agent containing it

Country Status (22)

Country Link
US (1) US4364921A (cg-RX-API-DMAC7.html)
EP (1) EP0015867B1 (cg-RX-API-DMAC7.html)
JP (1) JPS55153755A (cg-RX-API-DMAC7.html)
AT (1) ATE1061T1 (cg-RX-API-DMAC7.html)
AU (1) AU529565B2 (cg-RX-API-DMAC7.html)
CA (1) CA1130316A (cg-RX-API-DMAC7.html)
CS (1) CS226408B2 (cg-RX-API-DMAC7.html)
DE (2) DE2909439A1 (cg-RX-API-DMAC7.html)
DK (1) DK159772C (cg-RX-API-DMAC7.html)
EG (1) EG14530A (cg-RX-API-DMAC7.html)
ES (2) ES489337A1 (cg-RX-API-DMAC7.html)
FI (1) FI73199C (cg-RX-API-DMAC7.html)
GR (1) GR66668B (cg-RX-API-DMAC7.html)
HU (1) HU182684B (cg-RX-API-DMAC7.html)
IE (1) IE49647B1 (cg-RX-API-DMAC7.html)
IL (1) IL59542A (cg-RX-API-DMAC7.html)
MX (1) MX9203691A (cg-RX-API-DMAC7.html)
NO (1) NO148884C (cg-RX-API-DMAC7.html)
PH (1) PH18301A (cg-RX-API-DMAC7.html)
PT (1) PT70915A (cg-RX-API-DMAC7.html)
YU (1) YU61780A (cg-RX-API-DMAC7.html)
ZA (1) ZA801350B (cg-RX-API-DMAC7.html)

Cited By (6)

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JPS58131970A (ja) * 1982-01-11 1983-08-06 マリンクロツド・インコ−ポレイテツド Ｘ線造影剤
JPS5982355A (ja) * 1982-10-01 1984-05-12 ニユエガ−ド・アンド・コンパニ−・アクシエ／セルカペト Ｘ線造影剤
JP2009518325A (ja) * 2005-12-05 2009-05-07 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト 医薬目的のために適切なイオプロミドの母液からの回収方法
JP2011518878A (ja) * 2008-04-30 2011-06-30 エルジー・ライフ・サイエンシーズ・リミテッド イオプロミドの新規な製造方法
JP2012509290A (ja) * 2008-11-18 2012-04-19 ブラッコ・イメージング・ソシエタ・ペル・アチオニ ヨウ化造影剤の製造方法
JP2012510510A (ja) * 2008-12-05 2012-05-10 ダエウン ファーマシューティカル カンパニー リミテッド イオプロミドのｚ異性体を選択的に結晶化する方法

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DE3038853A1 (de) * 1980-10-10 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii)
DE3150916A1 (de) * 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel"
US5204086A (en) * 1982-10-01 1993-04-20 Nycomed Imaging As X-ray contrast agent
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US4954348A (en) * 1985-08-09 1990-09-04 Cook Imaging Corporation Non-ionic polyol contrast media from ionic contrast media
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DE3689330T2 (de) * 1985-08-09 1994-05-19 Cook Imaging Corp Nichtionische polyolkontrastmittel aus ionischen kontrastmitteln.
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FR2632304B1 (fr) * 1988-06-02 1991-05-17 Guerbert Sa Composes triodobenzeniques non ioniques, leur procede de preparation et produits de contraste les contenant
US5043152A (en) * 1988-06-02 1991-08-27 Guerbet S.A. Novel iodinated non-ionic triiodobenzene compounds and contrast media containing them
FR2643077B1 (fr) * 1989-01-23 1991-10-31 Guerbet Sa Nouveaux composes non ioniques iodes et produits de contraste les contenant
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US5232685A (en) * 1989-11-03 1993-08-03 Schering Aktiengesellschaft Nonionic x-ray contrast medium with high iodine content
DE3937118A1 (de) * 1989-11-03 1991-05-08 Schering Ag Nichtionische roentgenkontrastmittel mit hohem jodgehalt
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US4997983A (en) * 1990-01-31 1991-03-05 Mallinckrodt, Inc. Process for production of ioversol
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US5019371A (en) * 1990-11-21 1991-05-28 Mallinckrodt Medical, Inc. Novel x-ray contrast agents, compositions and methods
US5356613A (en) * 1991-03-18 1994-10-18 Mallinckrodt Medical, Inc. X-ray contrast agents, compositions and methods
DE4109169A1 (de) * 1991-03-20 1992-09-24 Koehler Chemie Dr Franz Wasserloesliche nicht ionische roentgenkontrastmittel sowie mittel und verfahren zu ihrer herstellung
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CN102126986B (zh) * 2010-12-24 2012-01-18 浙江司太立制药股份有限公司 一种三碘苯化合物及含有该化合物的造影剂
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CN102964269B (zh) * 2012-11-29 2015-01-28 浙江海昌药业有限公司 碘普罗胺的新制备方法
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CN107253917A (zh) * 2017-06-16 2017-10-17 成都丽璟科技有限公司 碘普罗胺的制备方法及中间体的用途
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JPS52130923A (en) * 1976-04-27 1977-11-02 Mallinckrodt Chemical Works Xxray photographic agent

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58131970A (ja) * 1982-01-11 1983-08-06 マリンクロツド・インコ−ポレイテツド Ｘ線造影剤
JPS5982355A (ja) * 1982-10-01 1984-05-12 ニユエガ−ド・アンド・コンパニ−・アクシエ／セルカペト Ｘ線造影剤
JP2009518325A (ja) * 2005-12-05 2009-05-07 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト 医薬目的のために適切なイオプロミドの母液からの回収方法
JP2011518878A (ja) * 2008-04-30 2011-06-30 エルジー・ライフ・サイエンシーズ・リミテッド イオプロミドの新規な製造方法
JP2012509290A (ja) * 2008-11-18 2012-04-19 ブラッコ・イメージング・ソシエタ・ペル・アチオニ ヨウ化造影剤の製造方法
JP2012510510A (ja) * 2008-12-05 2012-05-10 ダエウン ファーマシューティカル カンパニー リミテッド イオプロミドのｚ異性体を選択的に結晶化する方法

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NO800657L (no) 1980-09-09
EP0015867A1 (de) 1980-09-17
FI73199C (fi) 1987-09-10
EG14530A (en) 1984-03-31
AU529565B2 (en) 1983-06-09
DK91880A (da) 1980-09-09
DK159772B (da) 1990-12-03
DE2909439A1 (de) 1980-09-18
PH18301A (en) 1985-05-29
ATE1061T1 (de) 1982-06-15
IL59542A (en) 1983-03-31
DK159772C (da) 1991-04-22
IL59542A0 (en) 1980-06-30
ES8107165A1 (es) 1980-12-01
PT70915A (de) 1980-04-01
CA1130316A (en) 1982-08-24
IE800467L (en) 1980-09-08
ES489337A1 (es) 1980-08-16
US4364921A (en) 1982-12-21
FI73199B (fi) 1987-05-29
GR66668B (cg-RX-API-DMAC7.html) 1981-04-08
JPS6341898B2 (cg-RX-API-DMAC7.html) 1988-08-19
EP0015867B1 (de) 1982-05-19
FI800696A7 (fi) 1980-09-09
IE49647B1 (en) 1985-11-13
HU182684B (en) 1984-02-28
AU5627280A (en) 1980-09-11
ES491254A0 (es) 1980-12-01
ZA801350B (en) 1981-03-25
MX9203691A (es) 1992-09-01
DE3060434D1 (en) 1982-07-08
CS226408B2 (en) 1984-03-19
YU61780A (en) 1983-12-31
NO148884C (no) 1984-01-04
NO148884B (no) 1983-09-26

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