DK91880A - Nye ikke-ioniske roentgenkontrastmidler - Google Patents

Nye ikke-ioniske roentgenkontrastmidler

Info

Publication number
DK91880A
DK91880A DK91880A DK91880A DK91880A DK 91880 A DK91880 A DK 91880A DK 91880 A DK91880 A DK 91880A DK 91880 A DK91880 A DK 91880A DK 91880 A DK91880 A DK 91880A
Authority
DK
Denmark
Prior art keywords
alkyl
mono
roentgen
contractors
ionic
Prior art date
Application number
DK91880A
Other languages
English (en)
Other versions
DK159772B (da
DK159772C (da
Inventor
U Speck
P Blaszkiewics
D Seidelmann
E Klieger
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of DK91880A publication Critical patent/DK91880A/da
Publication of DK159772B publication Critical patent/DK159772B/da
Application granted granted Critical
Publication of DK159772C publication Critical patent/DK159772C/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyamides (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Paints Or Removers (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Catalysts (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK091880A 1979-03-08 1980-03-04 Trijod-isophthalsyrediamider og roentgenkontrastmidler indeholdende disse forbindelser DK159772C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2909439 1979-03-08
DE19792909439 DE2909439A1 (de) 1979-03-08 1979-03-08 Neue nichtionische roentgenkontrastmittel

Publications (3)

Publication Number Publication Date
DK91880A true DK91880A (da) 1980-09-09
DK159772B DK159772B (da) 1990-12-03
DK159772C DK159772C (da) 1991-04-22

Family

ID=6065014

Family Applications (1)

Application Number Title Priority Date Filing Date
DK091880A DK159772C (da) 1979-03-08 1980-03-04 Trijod-isophthalsyrediamider og roentgenkontrastmidler indeholdende disse forbindelser

Country Status (22)

Country Link
US (1) US4364921A (da)
EP (1) EP0015867B1 (da)
JP (1) JPS55153755A (da)
AT (1) ATE1061T1 (da)
AU (1) AU529565B2 (da)
CA (1) CA1130316A (da)
CS (1) CS226408B2 (da)
DE (2) DE2909439A1 (da)
DK (1) DK159772C (da)
EG (1) EG14530A (da)
ES (2) ES489337A1 (da)
FI (1) FI73199C (da)
GR (1) GR66668B (da)
HU (1) HU182684B (da)
IE (1) IE49647B1 (da)
IL (1) IL59542A (da)
MX (1) MX9203691A (da)
NO (1) NO148884C (da)
PH (1) PH18301A (da)
PT (1) PT70915A (da)
YU (1) YU61780A (da)
ZA (1) ZA801350B (da)

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1193211B (it) * 1979-08-09 1988-06-15 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono
DE3038853A1 (de) * 1980-10-10 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii)
DE3150916A1 (de) * 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel"
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US5204086A (en) * 1982-10-01 1993-04-20 Nycomed Imaging As X-ray contrast agent
JP2568166B2 (ja) * 1982-10-01 1996-12-25 ニユコメド・イメージング・アクシェセルカペト Ｘ線造影剤
FR2541272A1 (fr) * 1983-02-23 1984-08-24 Guerbet Sa Composes bromes et produits opacifiants en contenant
DE3689330T2 (de) * 1985-08-09 1994-05-19 Cook Imaging Corp Nichtionische polyolkontrastmittel aus ionischen kontrastmitteln.
US4954348A (en) * 1985-08-09 1990-09-04 Cook Imaging Corporation Non-ionic polyol contrast media from ionic contrast media
US5035877A (en) * 1985-08-09 1991-07-30 Cook Imaging Corporation Non-ionic contrast media from ionic contrast media
DE3731542A1 (de) * 1987-09-17 1989-03-30 Schering Ag Neue dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6-triiod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel
EP0410974A4 (en) * 1988-03-01 1991-09-11 Mallinckrodt, Inc. Nonionic x-ray contrast agents, compositions and methods
FR2632304B1 (fr) * 1988-06-02 1991-05-17 Guerbert Sa Composes triodobenzeniques non ioniques, leur procede de preparation et produits de contraste les contenant
US5043152A (en) * 1988-06-02 1991-08-27 Guerbet S.A. Novel iodinated non-ionic triiodobenzene compounds and contrast media containing them
FR2656865B1 (fr) * 1990-01-05 1993-03-26 Guerbet Sa Compose non ionique iode, son procede de preparation et produit de contraste le contenant.
FR2643077B1 (fr) * 1989-01-23 1991-10-31 Guerbet Sa Nouveaux composes non ioniques iodes et produits de contraste les contenant
IL90326A (en) * 1988-06-02 1993-05-13 Guerbet Sa Non-ionic triiodobenzene compounds and contrast media containing them
GB8906130D0 (en) * 1989-03-17 1989-05-04 Nycomed As Compositions
IL94718A (en) * 1989-07-05 1994-10-21 Schering Ag Non-ionic carboxamide contrast agent and method of preparation
US5698739A (en) * 1989-07-05 1997-12-16 Schering Aktiengesellschaft Carboxamide non-ionic contrast media
US5232685A (en) * 1989-11-03 1993-08-03 Schering Aktiengesellschaft Nonionic x-ray contrast medium with high iodine content
DE3937118A1 (de) * 1989-11-03 1991-05-08 Schering Ag Nichtionische roentgenkontrastmittel mit hohem jodgehalt
US5869024A (en) * 1989-11-29 1999-02-09 Bracco International B.V. Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures
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ES2037605B1 (es) * 1991-11-18 1994-02-01 Invest Justesa Imagen S A Cent Metodo para preparar nuevos agentes yodados no ionicos de constraste a los rayos x.
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FR2717799B1 (fr) * 1994-03-22 1996-07-19 Guerbet Sa Composés polyiodes : procédé de préparation ; composition de diagnostic.
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DE19510864A1 (de) * 1995-03-16 1996-09-19 Schering Ag Röntgenkontrastmittel für die Computertomographie und Urographie
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US6774278B1 (en) 1995-06-07 2004-08-10 Cook Incorporated Coated implantable medical device
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DE19641197C2 (de) * 1996-09-24 1999-02-18 Schering Ag Ionenpaare und ihre Verwendung als Kontrastmittel
US5925683A (en) * 1996-10-17 1999-07-20 Target Therapeutics, Inc. Liquid embolic agents
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DE19731591C2 (de) * 1997-07-17 1999-09-16 Schering Ag Pharmazeutische Mittel enthaltend perfluoralkylgruppenhaltige Trijodaromaten und ihre Verwendung in der Tumortherapie und interventionellen Radiologie
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US7723544B2 (en) 2005-12-08 2010-05-25 Bayer Schering Pharma Ag Process for recovery of iopromide, suitable for pharmaceutical purposes, from mother liquors
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JP2012514622A (ja) 2009-01-09 2012-06-28 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影製剤組成物
CN102126986B (zh) * 2010-12-24 2012-01-18 浙江司太立制药股份有限公司 一种三碘苯化合物及含有该化合物的造影剂
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CN102351735B (zh) * 2011-07-21 2012-10-10 浙江司太立制药股份有限公司 一种碘普罗胺的制备方法
CN102336681B (zh) * 2011-07-21 2013-11-13 浙江司太立制药股份有限公司 一种三碘苯类化合物造影剂
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CN102964269B (zh) * 2012-11-29 2015-01-28 浙江海昌药业有限公司 碘普罗胺的新制备方法
KR101520187B1 (ko) * 2013-10-25 2015-05-13 주식회사 대웅제약 이오프로마이드의 중간체의 제조방법
CN105017063B (zh) * 2014-04-18 2018-11-20 沈阳中海生物技术开发有限公司 5-氨基-2,4,6-三碘间苯二甲酸衍生物及其盐、水合物或溶剂化物
CN105001114B (zh) * 2014-04-18 2018-11-20 沈阳中海生物技术开发有限公司 制备碘普罗胺的新方法
CN105017062B (zh) * 2014-04-18 2018-11-20 沈阳中海生物技术开发有限公司 制备碘普罗胺的新方法
CN105001113B (zh) * 2014-04-18 2018-11-20 沈阳中海生物技术开发有限公司 一种碘普罗胺的制备方法
CN103965074B (zh) * 2014-04-30 2016-10-05 淮海工学院 一种合成碘普罗胺的新方法
PT108524B (pt) 2015-06-02 2017-12-15 Hovione Farmaciência S A Processo para a preparação de intermediários úteis na preparação de agentes de contraste não-iónicos
CN106366016B (zh) * 2015-07-22 2019-03-05 连云港润众制药有限公司 一种碘普罗胺的制备方法及其中间体
CN106366015B (zh) * 2015-07-22 2019-01-25 正大天晴药业集团股份有限公司 一种碘普罗胺的制备方法及其中间体
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CN105254521A (zh) * 2015-10-27 2016-01-20 遵义医学院 碘普罗胺中间体的制备工艺
CN107778191A (zh) * 2016-08-26 2018-03-09 正大天晴药业集团股份有限公司 一种碘普罗胺及其中间体的制备方法
CN106699594B (zh) * 2016-12-29 2018-11-06 山东诚汇双达药业有限公司 一种碘普罗胺的制备方法
US11045981B2 (en) 2017-01-30 2021-06-29 Ortho-Space Ltd. Processing machine and methods for processing dip-molded articles
RU2655693C1 (ru) * 2017-06-13 2018-05-29 Алексей Георгиевич Александров Способ получения фармацевтической субстанции на основе йопромида
CN107253917A (zh) * 2017-06-16 2017-10-17 成都丽璟科技有限公司 碘普罗胺的制备方法及中间体的用途
CN109134289B (zh) * 2017-06-16 2021-06-11 成都西岭源药业有限公司 一种造影剂中间体的合成方法及其应用
CN110028419B (zh) * 2019-04-30 2022-01-21 台州学院 一种碘普罗胺的制备方法
CN110078636B (zh) * 2019-05-23 2022-05-17 浙江海洲制药有限公司 一种制备碘普罗胺中间体的方法
CN114436880B (zh) * 2020-11-03 2023-04-28 成都倍特药业股份有限公司 碘普罗胺中间体的制备方法
CN114716340B (zh) * 2022-05-10 2023-11-14 杭州微流汇科技有限公司 一种碘普罗胺中间体的制备方法
CN116003277A (zh) * 2023-01-03 2023-04-25 安庆朗坤药业有限公司 一种造影剂中间体碘化物的制备方法

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Also Published As

Publication number Publication date
MX9203691A (es) 1992-09-01
ATE1061T1 (de) 1982-06-15
DK159772B (da) 1990-12-03
JPS6341898B2 (da) 1988-08-19
ZA801350B (en) 1981-03-25
YU61780A (en) 1983-12-31
DK159772C (da) 1991-04-22
DE3060434D1 (en) 1982-07-08
NO148884B (no) 1983-09-26
GR66668B (da) 1981-04-08
PT70915A (de) 1980-04-01
FI73199C (fi) 1987-09-10
NO800657L (no) 1980-09-09
DE2909439A1 (de) 1980-09-18
FI800696A (fi) 1980-09-09
EP0015867B1 (de) 1982-05-19
IE49647B1 (en) 1985-11-13
IL59542A (en) 1983-03-31
HU182684B (en) 1984-02-28
CA1130316A (en) 1982-08-24
AU529565B2 (en) 1983-06-09
IL59542A0 (en) 1980-06-30
US4364921A (en) 1982-12-21
FI73199B (fi) 1987-05-29
ES491254A0 (es) 1980-12-01
EG14530A (en) 1984-03-31
AU5627280A (en) 1980-09-11
ES8107165A1 (es) 1980-12-01
CS226408B2 (en) 1984-03-19
PH18301A (en) 1985-05-29
NO148884C (no) 1984-01-04
JPS55153755A (en) 1980-11-29
IE800467L (en) 1980-09-08
EP0015867A1 (de) 1980-09-17
ES489337A1 (es) 1980-08-16

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