CA2050334A1 - Iodinated non-ionic compounds, process for their preparation and contrast materials containing them - Google Patents

Iodinated non-ionic compounds, process for their preparation and contrast materials containing them

Info

Publication number
CA2050334A1
CA2050334A1 CA2050334A CA2050334A CA2050334A1 CA 2050334 A1 CA2050334 A1 CA 2050334A1 CA 2050334 A CA2050334 A CA 2050334A CA 2050334 A CA2050334 A CA 2050334A CA 2050334 A1 CA2050334 A1 CA 2050334A1
Authority
CA
Canada
Prior art keywords
preparation
materials containing
ionic compounds
contrast materials
iodinated non
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2050334A
Other languages
French (fr)
Other versions
CA2050334C (en
Inventor
Michel Schaefer
Maryse Dugast-Zrihen
Michel Guillemot
Didier Doucet
Dominique Meyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guerbet SA
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2050334A1 publication Critical patent/CA2050334A1/en
Application granted granted Critical
Publication of CA2050334C publication Critical patent/CA2050334C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to compounds of the general formula:

(see fig. I) in which R is selected from 2,3-dihydroxypropyl and 1,3-dihydroxy-2-propyl.
These compounds can be used as X ray contrast media.
CA002050334A 1990-01-05 1990-12-28 Iodinated non-ionic compounds, process for their preparation and contrast materials containing them Expired - Lifetime CA2050334C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9000106A FR2656865B1 (en) 1990-01-05 1990-01-05 NON-IONIC IODINE COMPOUND, PROCESS FOR PREPARING THE SAME, AND CONTRAST PRODUCT CONTAINING THE SAME.
FR9000106 1990-01-05
PCT/FR1990/000969 WO1991009836A1 (en) 1990-01-05 1990-12-28 Nonionic iodinated compounds, method for preparing them, and contrast products containing same

Publications (2)

Publication Number Publication Date
CA2050334A1 true CA2050334A1 (en) 1991-07-06
CA2050334C CA2050334C (en) 1999-09-07

Family

ID=9392557

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002050334A Expired - Lifetime CA2050334C (en) 1990-01-05 1990-12-28 Iodinated non-ionic compounds, process for their preparation and contrast materials containing them

Country Status (25)

Country Link
EP (1) EP0437144B1 (en)
JP (1) JP2529032B2 (en)
KR (1) KR100194506B1 (en)
AT (1) ATE114639T1 (en)
CA (1) CA2050334C (en)
CZ (1) CZ283986B6 (en)
DE (1) DE69014581T2 (en)
DK (1) DK0437144T3 (en)
ES (1) ES2067710T3 (en)
FI (1) FI102746B (en)
FR (1) FR2656865B1 (en)
GR (1) GR3015183T3 (en)
HK (1) HK1006019A1 (en)
HU (1) HUT59079A (en)
IE (1) IE65329B1 (en)
IL (1) IL96812A (en)
NO (1) NO180297C (en)
NZ (1) NZ236675A (en)
PL (1) PL165683B1 (en)
PT (1) PT96410B (en)
RO (1) RO108559B1 (en)
SK (1) SK279646B6 (en)
TR (1) TR24944A (en)
WO (1) WO1991009836A1 (en)
ZA (1) ZA9173B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108947959A (en) * 2017-05-27 2018-12-07 正大天晴药业集团股份有限公司 A kind of preparation method of non-ionic diodone intermediate

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2687669B1 (en) * 1992-02-24 1997-12-19 Guerbet Sa COMPOUNDS FOR USE IN CONTRAST PRODUCTS FOR RADIOGRAPHY.
IT1256163B (en) * 1992-10-27 1995-11-29 Zambon Spa PROCESS FOR THE PREPARATION OF AN INTERMEDIATE OF THE ORGANIC SYNTHESIS
IT1283319B1 (en) * 1996-03-29 1998-04-16 Zambon Spa PROCESS FOR THE PREPARATION OF A USEFUL INTERMEDIATE IN THE SYNTHESIS OF HYDURATED CONTRAST MEDIA
PT108524B (en) 2015-06-02 2017-12-15 Hovione Farmaciência S A PROCESS FOR THE PREPARATION OF USEFUL INTERMEDIARIES IN THE PREPARATION OF NON-IONIC CONTRACTING AGENTS
CN110903275A (en) * 2018-09-14 2020-03-24 苏州科伦药物研究有限公司 Process for producing iobitridol, intermediate therefor, and process for producing the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2909439A1 (en) * 1979-03-08 1980-09-18 Schering Ag NEW NON-ionic x-ray contrast agents
DE3429949A1 (en) * 1984-08-10 1986-02-20 Schering AG, 1000 Berlin und 4709 Bergkamen Novel non-ionic 2,4,6-triiodoisophthalic acid bisamides, process for the preparation thereof and the use thereof as X-ray contrast media
IL90326A (en) * 1988-06-02 1993-05-13 Guerbet Sa Non-ionic triiodobenzene compounds and contrast media containing them

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108947959A (en) * 2017-05-27 2018-12-07 正大天晴药业集团股份有限公司 A kind of preparation method of non-ionic diodone intermediate
CN108947959B (en) * 2017-05-27 2022-09-20 正大天晴药业集团股份有限公司 Preparation method of non-ionic iodine contrast agent intermediate

Also Published As

Publication number Publication date
FI102746B1 (en) 1999-02-15
NO913403D0 (en) 1991-08-30
IE65329B1 (en) 1995-10-18
IL96812A0 (en) 1991-09-16
FR2656865B1 (en) 1993-03-26
HUT59079A (en) 1992-04-28
FI914114A0 (en) 1991-09-02
AU7057491A (en) 1991-07-24
CA2050334C (en) 1999-09-07
ES2067710T3 (en) 1995-04-01
KR100194506B1 (en) 1999-06-15
PL288603A1 (en) 1992-04-06
PT96410A (en) 1991-10-15
HU912860D0 (en) 1992-02-28
EP0437144B1 (en) 1994-11-30
WO1991009836A1 (en) 1991-07-11
JPH05132455A (en) 1993-05-28
ATE114639T1 (en) 1994-12-15
CZ283986B6 (en) 1998-07-15
NO180297C (en) 1997-03-26
PL165683B1 (en) 1995-01-31
JP2529032B2 (en) 1996-08-28
SK279646B6 (en) 1999-01-11
ZA9173B (en) 1992-08-26
DE69014581D1 (en) 1995-01-12
TR24944A (en) 1992-07-01
NZ236675A (en) 1992-08-26
FI102746B (en) 1999-02-15
FI914114A (en) 1992-06-29
NO913403L (en) 1991-08-30
HK1006019A1 (en) 1999-02-05
DE69014581T2 (en) 1995-06-08
RO108559B1 (en) 1994-06-30
FR2656865A1 (en) 1991-07-12
DK0437144T3 (en) 1995-01-23
EP0437144A1 (en) 1991-07-17
GR3015183T3 (en) 1995-05-31
IE910035A1 (en) 1991-07-17
AU641212B2 (en) 1993-09-16
CS648290A3 (en) 1992-02-19
KR920701132A (en) 1992-08-11
NO180297B (en) 1996-12-16
IL96812A (en) 1995-05-26
PT96410B (en) 1998-06-30

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Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry