DK0437144T3 - Non-ionic iodine-containing compositions, processes for their preparation and contrast agents containing them - Google Patents

Non-ionic iodine-containing compositions, processes for their preparation and contrast agents containing them

Info

Publication number
DK0437144T3
DK0437144T3 DK90403770.2T DK90403770T DK0437144T3 DK 0437144 T3 DK0437144 T3 DK 0437144T3 DK 90403770 T DK90403770 T DK 90403770T DK 0437144 T3 DK0437144 T3 DK 0437144T3
Authority
DK
Denmark
Prior art keywords
processes
preparation
contrast agents
ionic iodine
containing compositions
Prior art date
Application number
DK90403770.2T
Other languages
Danish (da)
Inventor
Michel Schaefer
Maryse Dugast-Zrihen
Michel Guillemot
Didier Doucet
Dominique Meyer
Original Assignee
Guerbet Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guerbet Sa filed Critical Guerbet Sa
Application granted granted Critical
Publication of DK0437144T3 publication Critical patent/DK0437144T3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compounds having general formula (I), wherein R is selected among 2,3-dihydroxypropyl and 1,3-dihydroxy-2-propyl groups. These compounds can be used as contrasting products for X-ray image formation.
DK90403770.2T 1990-01-05 1990-12-26 Non-ionic iodine-containing compositions, processes for their preparation and contrast agents containing them DK0437144T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9000106A FR2656865B1 (en) 1990-01-05 1990-01-05 NON-IONIC IODINE COMPOUND, PROCESS FOR PREPARING THE SAME, AND CONTRAST PRODUCT CONTAINING THE SAME.

Publications (1)

Publication Number Publication Date
DK0437144T3 true DK0437144T3 (en) 1995-01-23

Family

ID=9392557

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90403770.2T DK0437144T3 (en) 1990-01-05 1990-12-26 Non-ionic iodine-containing compositions, processes for their preparation and contrast agents containing them

Country Status (25)

Country Link
EP (1) EP0437144B1 (en)
JP (1) JP2529032B2 (en)
KR (1) KR100194506B1 (en)
AT (1) ATE114639T1 (en)
CA (1) CA2050334C (en)
CZ (1) CZ283986B6 (en)
DE (1) DE69014581T2 (en)
DK (1) DK0437144T3 (en)
ES (1) ES2067710T3 (en)
FI (1) FI102746B1 (en)
FR (1) FR2656865B1 (en)
GR (1) GR3015183T3 (en)
HK (1) HK1006019A1 (en)
HU (1) HUT59079A (en)
IE (1) IE65329B1 (en)
IL (1) IL96812A (en)
NO (1) NO180297C (en)
NZ (1) NZ236675A (en)
PL (1) PL165683B1 (en)
PT (1) PT96410B (en)
RO (1) RO108559B1 (en)
SK (1) SK279646B6 (en)
TR (1) TR24944A (en)
WO (1) WO1991009836A1 (en)
ZA (1) ZA9173B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2687669B1 (en) * 1992-02-24 1997-12-19 Guerbet Sa COMPOUNDS FOR USE IN CONTRAST PRODUCTS FOR RADIOGRAPHY.
IT1256163B (en) * 1992-10-27 1995-11-29 Zambon Spa PROCESS FOR THE PREPARATION OF AN INTERMEDIATE OF THE ORGANIC SYNTHESIS
IT1283319B1 (en) * 1996-03-29 1998-04-16 Zambon Spa PROCESS FOR THE PREPARATION OF A USEFUL INTERMEDIATE IN THE SYNTHESIS OF HYDURATED CONTRAST MEDIA
PT108524B (en) 2015-06-02 2017-12-15 Hovione Farmaciência S A PROCESS FOR THE PREPARATION OF USEFUL INTERMEDIARIES IN THE PREPARATION OF NON-IONIC CONTRACTING AGENTS
CN108947959B (en) * 2017-05-27 2022-09-20 正大天晴药业集团股份有限公司 Preparation method of non-ionic iodine contrast agent intermediate
CN110903275A (en) * 2018-09-14 2020-03-24 苏州科伦药物研究有限公司 Process for producing iobitridol, intermediate therefor, and process for producing the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2909439A1 (en) * 1979-03-08 1980-09-18 Schering Ag NEW NON-ionic x-ray contrast agents
DE3429949A1 (en) * 1984-08-10 1986-02-20 Schering AG, 1000 Berlin und 4709 Bergkamen Novel non-ionic 2,4,6-triiodoisophthalic acid bisamides, process for the preparation thereof and the use thereof as X-ray contrast media
IL90326A (en) * 1988-06-02 1993-05-13 Guerbet Sa Non-ionic triiodobenzene compounds and contrast media containing them

Also Published As

Publication number Publication date
DE69014581D1 (en) 1995-01-12
KR920701132A (en) 1992-08-11
NZ236675A (en) 1992-08-26
JPH05132455A (en) 1993-05-28
AU641212B2 (en) 1993-09-16
SK279646B6 (en) 1999-01-11
CA2050334C (en) 1999-09-07
FR2656865B1 (en) 1993-03-26
IL96812A (en) 1995-05-26
CA2050334A1 (en) 1991-07-06
EP0437144B1 (en) 1994-11-30
HK1006019A1 (en) 1999-02-05
DE69014581T2 (en) 1995-06-08
ES2067710T3 (en) 1995-04-01
ZA9173B (en) 1992-08-26
KR100194506B1 (en) 1999-06-15
FI914114A (en) 1992-06-29
TR24944A (en) 1992-07-01
AU7057491A (en) 1991-07-24
PT96410B (en) 1998-06-30
NO180297B (en) 1996-12-16
EP0437144A1 (en) 1991-07-17
WO1991009836A1 (en) 1991-07-11
PL288603A1 (en) 1992-04-06
HUT59079A (en) 1992-04-28
NO180297C (en) 1997-03-26
NO913403L (en) 1991-08-30
RO108559B1 (en) 1994-06-30
NO913403D0 (en) 1991-08-30
ATE114639T1 (en) 1994-12-15
PT96410A (en) 1991-10-15
CZ283986B6 (en) 1998-07-15
FR2656865A1 (en) 1991-07-12
PL165683B1 (en) 1995-01-31
IE910035A1 (en) 1991-07-17
CS648290A3 (en) 1992-02-19
FI914114A0 (en) 1991-09-02
HU912860D0 (en) 1992-02-28
JP2529032B2 (en) 1996-08-28
IL96812A0 (en) 1991-09-16
GR3015183T3 (en) 1995-05-31
IE65329B1 (en) 1995-10-18
FI102746B (en) 1999-02-15
FI102746B1 (en) 1999-02-15

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