JPH11137284A5 - - Google Patents

Info

Publication number
JPH11137284A5
JPH11137284A5 JP1998258414A JP25841498A JPH11137284A5 JP H11137284 A5 JPH11137284 A5 JP H11137284A5 JP 1998258414 A JP1998258414 A JP 1998258414A JP 25841498 A JP25841498 A JP 25841498A JP H11137284 A5 JPH11137284 A5 JP H11137284A5
Authority
JP
Japan
Prior art keywords
xaa
amino acid
polymerase
thermostable dna
dna polymerase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1998258414A
Other languages
English (en)
Japanese (ja)
Other versions
JPH11137284A (ja
JP4417452B2 (ja
Filing date
Publication date
Application filed filed Critical
Publication of JPH11137284A publication Critical patent/JPH11137284A/ja
Publication of JPH11137284A5 publication Critical patent/JPH11137284A5/ja
Application granted granted Critical
Publication of JP4417452B2 publication Critical patent/JP4417452B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP25841498A 1997-09-11 1998-09-11 配列決定のための変更された熱安定性ｄｎａポリメラーゼ Expired - Lifetime JP4417452B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5852597P 1997-09-11 1997-09-11
US60/058525 1997-09-11

Publications (3)

Publication Number Publication Date
JPH11137284A JPH11137284A (ja) 1999-05-25
JPH11137284A5 true JPH11137284A5 (enExample) 2005-10-27
JP4417452B2 JP4417452B2 (ja) 2010-02-17

Family

ID=22017355

Family Applications (1)

Application Number Title Priority Date Filing Date
JP25841498A Expired - Lifetime JP4417452B2 (ja) 1997-09-11 1998-09-11 配列決定のための変更された熱安定性ｄｎａポリメラーゼ

Country Status (17)

Country Link
US (3) US6346379B1 (enExample)
EP (1) EP0902035B1 (enExample)
JP (1) JP4417452B2 (enExample)
KR (1) KR100561122B1 (enExample)
CN (1) CN1197962C (enExample)
AT (1) ATE530567T1 (enExample)
AU (1) AU741366B2 (enExample)
BR (1) BR9803419B1 (enExample)
CA (1) CA2243985C (enExample)
CZ (1) CZ293217B6 (enExample)
ES (1) ES2374910T3 (enExample)
HU (1) HUP9802024A3 (enExample)
IL (1) IL126100A (enExample)
NO (1) NO327476B1 (enExample)
PL (1) PL328525A1 (enExample)
RU (1) RU2238978C2 (enExample)
TW (1) TW513439B (enExample)

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US20070128610A1 (en) * 2005-12-02 2007-06-07 Buzby Philip R Sample preparation method and apparatus for nucleic acid sequencing
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ATE518010T1 (de) * 2005-12-22 2011-08-15 Pacific Biosciences California Aktive oberflächengekoppelte polymerasen
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US7397546B2 (en) 2006-03-08 2008-07-08 Helicos Biosciences Corporation Systems and methods for reducing detected intensity non-uniformity in a laser beam
US8962293B2 (en) 2006-10-18 2015-02-24 Roche Molecular Systems, Inc. DNA polymerases and related methods
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US20100081927A1 (en) * 2008-09-29 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Histological facilitation systems and methods
US20100081915A1 (en) * 2008-09-29 2010-04-01 Searete Llc, Alimited Liability Corporation Of The State Of Delaware Histological facilitation systems and methods
US20100081926A1 (en) * 2008-09-29 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Histological facilitation systems and methods
US20100081928A1 (en) * 2008-09-29 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Histological Facilitation systems and methods
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FR2940125B1 (fr) * 2008-12-23 2013-03-22 Isp Investments Inc Composition cosmetique ou pharmaceutique apaisante comprenant un peptide activateur de la hmg-coa reductase
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FR2944445B1 (fr) 2009-04-15 2013-08-16 Isp Investments Inc Composition cosmetique et/ou pharmaceutique comprenant un hydrolysat peptidique apaisant
FR2944526B1 (fr) 2009-04-15 2013-05-10 Isp Investments Inc Composition cosmetique et/ou pharmaceutique comprenant un hydrolysat peptidique capable de renforcer la fonction barriere
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JP5926247B2 (ja) 2010-06-18 2016-05-25 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 増大した３’末端ミスマッチ識別能を有するｄｎａポリメラーゼ
EP2582806B1 (en) 2010-06-18 2015-12-16 Roche Diagnostics GmbH Dna polymerases with increased 3'-mismatch discrimination
JP5876477B2 (ja) 2010-06-18 2016-03-02 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 増大した３’末端ミスマッチ識別能を有するｄｎａポリメラーゼ
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JP6224613B2 (ja) 2011-12-08 2017-11-01 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 改善された活性を有するｄｎａポリメラーゼ
WO2013083263A1 (en) 2011-12-08 2013-06-13 Roche Diagnostics Gmbh Dna polymerases with improved activity
CA2858264C (en) 2011-12-08 2018-01-02 F. Hoffmann-La Roche Ag Dna polymerases with improved activity
JP6088710B2 (ja) 2013-08-19 2017-03-01 シンギュラー・バイオ・インコーポレイテッド 単分子検出アッセイおよびその使用
CN108064278B (zh) 2014-11-14 2022-02-08 亿明达股份有限公司 聚合酶
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US10526588B2 (en) * 2015-05-14 2020-01-07 Roche Sequencing Solutions, Inc. Polymerase variants and uses thereof
WO2017090684A1 (ja) 2015-11-27 2017-06-01 国立大学法人九州大学 Ｄｎａポリメラーゼ変異体
CN112703248B (zh) 2018-09-13 2025-03-25 豪夫迈·罗氏有限公司 具有改良链置换能力的突变型dna聚合酶
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