TW513439B - Altered thermostable DNA polymerases for sequencing - Google Patents
Altered thermostable DNA polymerases for sequencing Download PDFInfo
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- TW513439B TW513439B TW087114826A TW87114826A TW513439B TW 513439 B TW513439 B TW 513439B TW 087114826 A TW087114826 A TW 087114826A TW 87114826 A TW87114826 A TW 87114826A TW 513439 B TW513439 B TW 513439B
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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- C12N9/1252—DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/6895—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
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| EP2264045B1 (en) * | 1996-08-14 | 2015-10-21 | Life Technologies Corporation | Stable compositions for nucleic acid amplification and sequencing |
| US7875440B2 (en) * | 1998-05-01 | 2011-01-25 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
| US6780591B2 (en) * | 1998-05-01 | 2004-08-24 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
| US20030138834A1 (en) * | 1998-08-19 | 2003-07-24 | Dawson Elliott P. | Method for determining polynucleotide sequence variations |
| US20040121394A1 (en) * | 1998-08-19 | 2004-06-24 | Dawson Elliott P. | Method for determining polynucleotide sequence variations |
| US7501245B2 (en) * | 1999-06-28 | 2009-03-10 | Helicos Biosciences Corp. | Methods and apparatuses for analyzing polynucleotide sequences |
| US6818395B1 (en) * | 1999-06-28 | 2004-11-16 | California Institute Of Technology | Methods and apparatus for analyzing polynucleotide sequences |
| EP1210440B1 (en) * | 1999-08-21 | 2005-07-20 | Amersham Biosciences Corp. | Taq dna polymerases having an amino acid substitution at e681 and homologs thereof exhibiting improved salt tolerance |
| US7179590B2 (en) * | 2000-04-18 | 2007-02-20 | Roche Molecular Systems, Inc | High temperature reverse transcription using mutant DNA polymerases |
| US6214557B1 (en) * | 2000-06-06 | 2001-04-10 | Washington University | Cold sensitive mutant DNA polymerases |
| EP1368497A4 (en) | 2001-03-12 | 2007-08-15 | California Inst Of Techn | METHODS AND APPARATUS FOR ANALYZING ASYNCHRONOUS BASE EXTENSION POLYNUCLEOTIDE SEQUENCES |
| DK1370690T3 (da) * | 2001-03-16 | 2012-07-09 | Kalim Mir | Arrays og fremgangsmåder til anvendelse heraf |
| AU2002316586A1 (en) | 2001-07-06 | 2003-01-21 | Amersham Biosciences Corp | Novel dna polymerases having amino acid substitutions and homologs thereof |
| WO2003068991A1 (en) * | 2002-02-12 | 2003-08-21 | Applera Corporation | Polymerase compositions |
| DE10315640A1 (de) * | 2003-04-04 | 2004-10-14 | Ignatov, Konstantin | Verfahren zur kontrollierten Freisetzung von Komponenten in eine Lösung |
| KR100571808B1 (ko) * | 2003-04-16 | 2006-04-17 | 삼성전자주식회사 | 다층 박막 구조를 가진 ｄｎａ 칩 |
| US7820030B2 (en) * | 2003-04-16 | 2010-10-26 | Handylab, Inc. | System and method for electrochemical detection of biological compounds |
| US20050170367A1 (en) * | 2003-06-10 | 2005-08-04 | Quake Stephen R. | Fluorescently labeled nucleoside triphosphates and analogs thereof for sequencing nucleic acids |
| US7572581B2 (en) * | 2003-06-30 | 2009-08-11 | Roche Molecular Systems, Inc. | 2′-terminator nucleotide-related methods and systems |
| US7169560B2 (en) | 2003-11-12 | 2007-01-30 | Helicos Biosciences Corporation | Short cycle methods for sequencing polynucleotides |
| US20060172408A1 (en) * | 2003-12-01 | 2006-08-03 | Quake Steven R | Device for immobilizing chemical and biochemical species and methods of using same |
| EP1716254B1 (en) | 2004-02-19 | 2010-04-07 | Helicos Biosciences Corporation | Methods for analyzing polynucleotide sequences |
| US20060046258A1 (en) * | 2004-02-27 | 2006-03-02 | Lapidus Stanley N | Applications of single molecule sequencing |
| US20050239085A1 (en) * | 2004-04-23 | 2005-10-27 | Buzby Philip R | Methods for nucleic acid sequence determination |
| US7476734B2 (en) * | 2005-12-06 | 2009-01-13 | Helicos Biosciences Corporation | Nucleotide analogs |
| US20070117104A1 (en) * | 2005-11-22 | 2007-05-24 | Buzby Philip R | Nucleotide analogs |
| US20070117103A1 (en) * | 2005-11-22 | 2007-05-24 | Buzby Philip R | Nucleotide analogs |
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1998
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- 1998-09-03 CA CA002243985A patent/CA2243985C/en not_active Expired - Lifetime
- 1998-09-05 EP EP98116786A patent/EP0902035B1/en not_active Expired - Lifetime
- 1998-09-05 ES ES98116786T patent/ES2374910T3/es not_active Expired - Lifetime
- 1998-09-05 AT AT98116786T patent/ATE530567T1/de not_active IP Right Cessation
- 1998-09-07 IL IL12610098A patent/IL126100A/xx not_active IP Right Cessation
- 1998-09-07 HU HU9802024A patent/HUP9802024A3/hu unknown
- 1998-09-07 TW TW087114826A patent/TW513439B/zh not_active IP Right Cessation
- 1998-09-09 CZ CZ19982874A patent/CZ293217B6/cs not_active IP Right Cessation
- 1998-09-10 AU AU84161/98A patent/AU741366B2/en not_active Ceased
- 1998-09-10 KR KR1019980037299A patent/KR100561122B1/ko not_active Expired - Fee Related
- 1998-09-10 NO NO19984157A patent/NO327476B1/no not_active IP Right Cessation
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- 1998-09-11 RU RU98117244A patent/RU2238978C2/ru not_active IP Right Cessation
- 1998-09-11 PL PL98328525A patent/PL328525A1/xx not_active Application Discontinuation
- 1998-09-11 CN CNB981245269A patent/CN1197962C/zh not_active Expired - Lifetime
- 1998-09-11 JP JP25841498A patent/JP4417452B2/ja not_active Expired - Lifetime
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2002
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| US7598032B2 (en) | 2009-10-06 |
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| ATE530567T1 (de) | 2011-11-15 |
| KR19990029676A (ko) | 1999-04-26 |
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| NO984157D0 (no) | 1998-09-10 |
| HUP9802024A2 (hu) | 1999-05-28 |
| JP4417452B2 (ja) | 2010-02-17 |
| CZ293217B6 (cs) | 2004-03-17 |
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| RU2238978C2 (ru) | 2004-10-27 |
| CN1218832A (zh) | 1999-06-09 |
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| ES2374910T3 (es) | 2012-02-23 |
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| AU8416198A (en) | 1999-03-25 |
| CN1197962C (zh) | 2005-04-20 |
| HK1018796A1 (en) | 2000-01-07 |
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