JPH09124606A5 - - Google Patents

Info

Publication number
JPH09124606A5
JPH09124606A5 JP1996276901A JP27690196A JPH09124606A5 JP H09124606 A5 JPH09124606 A5 JP H09124606A5 JP 1996276901 A JP1996276901 A JP 1996276901A JP 27690196 A JP27690196 A JP 27690196A JP H09124606 A5 JPH09124606 A5 JP H09124606A5
Authority
JP
Japan
Prior art keywords
alkyl
alkoxy
cycloalkyl
carbamoyl
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1996276901A
Other languages
English (en)
Japanese (ja)
Other versions
JPH09124606A (ja
Filing date
Publication date
Priority claimed from DE19536263A external-priority patent/DE19536263A1/de
Application filed filed Critical
Publication of JPH09124606A publication Critical patent/JPH09124606A/ja
Publication of JPH09124606A5 publication Critical patent/JPH09124606A5/ja
Pending legal-status Critical Current

Links

JP8276901A 1995-09-28 1996-09-30 置換キノリン−２−カルボキサミド、それらの製造ならびに薬剤および中間体としてのそれらの使用 Pending JPH09124606A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19536263A DE19536263A1 (de) 1995-09-28 1995-09-28 Substituierte Chinolin-2-carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
DE19605170 1996-02-13
DE19605170:3 1996-02-13
DE19536263:2 1996-02-13

Publications (2)

Publication Number Publication Date
JPH09124606A JPH09124606A (ja) 1997-05-13
JPH09124606A5 true JPH09124606A5 (https=) 2004-10-07

Family

ID=26019051

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8276901A Pending JPH09124606A (ja) 1995-09-28 1996-09-30 置換キノリン−２−カルボキサミド、それらの製造ならびに薬剤および中間体としてのそれらの使用

Country Status (20)

Country Link
US (2) US5726305A (https=)
EP (1) EP0765871B1 (https=)
JP (1) JPH09124606A (https=)
KR (1) KR970061869A (https=)
CN (2) CN1120157C (https=)
AT (1) ATE263155T1 (https=)
AU (1) AU728208B2 (https=)
CA (1) CA2186717A1 (https=)
CZ (1) CZ283396A3 (https=)
DE (1) DE59610950D1 (https=)
ES (1) ES2215184T3 (https=)
HU (1) HUP9602685A3 (https=)
IL (2) IL135495A (https=)
MX (1) MX9604378A (https=)
MY (1) MY133647A (https=)
NO (1) NO308600B1 (https=)
NZ (1) NZ299455A (https=)
PL (1) PL316321A1 (https=)
SG (1) SG45503A1 (https=)
SI (1) SI9600287A (https=)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19650215A1 (de) * 1996-12-04 1998-06-10 Hoechst Ag 3-Hydroxypyridin-2-carbonsäureamidester, ihre Herstellung und ihre Verwendung als Arzneimittel
DE19746287A1 (de) * 1997-10-20 1999-04-22 Hoechst Marion Roussel De Gmbh Substituierte Isochinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
US20020198145A1 (en) * 1999-06-10 2002-12-26 Cognetix, Inc. MuO-conopeptides and their use as local anesthetics
JP4092203B2 (ja) * 2000-12-21 2008-05-28 ニトロメッド，インク． 新規のシクロオキシゲナーゼ２選択的阻害剤としての置換アリール化合物、組成物、および使用方法
JP4590157B2 (ja) 2001-03-21 2010-12-01 アイシス イノヴェイション リミテッド アッセイ、方法および手段
CN102552263A (zh) * 2001-12-06 2012-07-11 法布罗根股份有限公司 提高内源性红细胞生成素(epo)的方法
EP2295060B1 (en) 2001-12-06 2018-10-31 Fibrogen, Inc. Treatment or prevention of ischemic or hypoxic conditions
US8124582B2 (en) * 2002-12-06 2012-02-28 Fibrogen, Inc. Treatment of diabetes
US7618940B2 (en) 2002-12-06 2009-11-17 Fibrogen, Inc. Fat regulation
US8614204B2 (en) * 2003-06-06 2013-12-24 Fibrogen, Inc. Enhanced erythropoiesis and iron metabolism
CA2528232C (en) * 2003-06-06 2010-05-25 Fibrogen, Inc. Novel nitrogen-containing heteroaryl compounds and their use in increasing endogenous erythropoietin
WO2005034929A2 (en) * 2003-10-10 2005-04-21 Fibrogen, Inc. Tissue remodeling and vascularization
US20060276477A1 (en) * 2005-06-06 2006-12-07 Fibrogen, Inc. Treatment method for anemia
AU2006259352A1 (en) 2005-06-15 2006-12-28 Fibrogen, Inc. Use of HIF 1alfa modulators for treatment of cancer
AU2006286654A1 (en) 2005-07-27 2007-03-08 F. Hoffmann-La Roche Ag 4-aryloxy quinoline derivatives as 5-HT6 modulators
JP5202327B2 (ja) * 2005-12-09 2013-06-05 アムジエン・インコーポレーテツド プロリルヒドロキシラーゼ阻害活性を示すキノロンベースの化合物、およびこの組成物、およびこの使用
EP2476669A1 (en) * 2006-01-27 2012-07-18 Fibrogen, Inc. Cyanoisoquinoline compounds and methods of use thereof
WO2007101204A1 (en) * 2006-02-27 2007-09-07 Alcon Research, Ltd. Method of treating glaucoma
US7745461B1 (en) 2006-02-27 2010-06-29 Alcon Research, Ltd. Method of treating dry eye disorders
WO2007114612A1 (en) * 2006-03-30 2007-10-11 Lg Electronics Inc. A method and apparatus for decoding/encoding a video signal
CN103497184A (zh) * 2006-04-04 2014-01-08 菲布罗根有限公司 作为hif调节剂的吡咯并吡啶和噻唑并吡啶化合物
BRPI0713350B1 (pt) 2006-06-26 2022-04-12 Akebia Therapeutics Inc Composto, e, composição
EP2111399A2 (en) * 2006-12-18 2009-10-28 Amgen Inc. Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof
US8048892B2 (en) * 2006-12-18 2011-11-01 Amgen Inc. Azaquinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof
EP2155680B1 (en) * 2007-04-18 2013-12-04 Amgen, Inc Indanone derivatives that inhibit prolyl hydroxylase
EP2142509B1 (en) * 2007-04-18 2013-12-04 Amgen, Inc Quinolones and azaquinolones that inhibit prolyl hydroxylase
US8097620B2 (en) * 2007-05-04 2012-01-17 Amgen Inc. Diazaquinolones that inhibit prolyl hydroxylase activity
ES2389063T3 (es) * 2007-05-04 2012-10-22 Amgen, Inc Derivados de tienopiridina y tiazolopiridina que inhiben la actividad prolil hidroxilasa
US8962530B2 (en) * 2007-06-27 2015-02-24 Regents Of The University Of Colorado Inflammatory bowel disease therapies
WO2010056767A1 (en) 2008-11-14 2010-05-20 Fibrogen, Inc. Thiochromene derivatives as hip hydroxylase inhibitors
UA107360C2 (en) 2009-08-05 2014-12-25 Biogen Idec Inc Bicyclic aryl sphingosine 1-phosphate analogs
US9199939B2 (en) * 2009-12-17 2015-12-01 Merck Sharp & Dohme Corp. Quinoline amide M1 receptor positive allosteric modulators
UA113507C2 (xx) 2011-02-07 2017-02-10 Модулятори s1p
NO2686520T3 (https=) 2011-06-06 2018-03-17
AU2013229922B2 (en) 2012-03-09 2017-09-28 Kyntra Bio, Inc. 4 -hydroxy- isoquinoline compounds as HIF hydroxylase inhibitors
KR20210130849A (ko) 2012-07-16 2021-11-01 피브로겐, 인크. 프롤릴 하이드록실라제 억제제 [(4-하이드록시-1-메틸-7-페녹시-아이소퀴놀린-3-카보닐)-아미노]-아세트산의 결정형
EP2872487B1 (en) 2012-07-16 2017-04-26 Fibrogen, Inc. Process for making isoquinoline compounds
US8883823B2 (en) 2012-07-16 2014-11-11 Fibrogen, Inc. Crystalline forms of a prolyl hydroxylase inhibitor
MX363388B (es) * 2012-07-27 2019-03-20 Biogen Ma Inc Agentes moduladores de autotaxina.
CA2899024C (en) 2013-01-24 2022-01-04 Fibrogen, Inc. Crystalline forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid
SG10201910773VA (en) 2013-06-13 2020-01-30 Akebia Therapeutics Inc Compositions and methods for treating anemia
AR099354A1 (es) 2013-11-15 2016-07-20 Akebia Therapeutics Inc Formas sólidas de ácido {[5-(3-clorofenil)-3-hidroxipiridin-2-carbonil]amino}acético, composiciones, y sus usos
AU2016209126A1 (en) 2015-01-23 2017-08-10 Akebia Therapeutics, Inc. Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
US11324734B2 (en) 2015-04-01 2022-05-10 Akebia Therapeutics, Inc. Compositions and methods for treating anemia
EP3790863A1 (en) 2018-05-09 2021-03-17 Akebia Therapeutics Inc. Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid
CA3118752A1 (en) 2018-11-09 2020-05-14 Vivace Therapeutics, Inc. Bicyclic compounds
HUE070525T2 (hu) 2019-04-16 2025-06-28 Vivace Therapeutics Inc Biciklusos vegyületek
US11524939B2 (en) 2019-11-13 2022-12-13 Akebia Therapeutics, Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4015255A1 (de) * 1990-05-12 1991-11-14 Hoechst Ag Oxalyl-aminosaeurederivate, verfahren zu ihrer herstellung und ihrer verwendung als arzneimittel zur inhibierung der prolyl-hydroxylase
US5192773A (en) * 1990-07-02 1993-03-09 Vertex Pharmaceuticals, Inc. Immunosuppressive compounds
EP0541042A1 (de) * 1991-11-05 1993-05-12 Hoechst Aktiengesellschaft Pyridin-2,4- und 2,5-dicarbonsäureamide und deren Derivate, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel
TW352384B (en) * 1992-03-24 1999-02-11 Hoechst Ag Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals
DE4233124A1 (de) * 1992-10-02 1994-04-07 Hoechst Ag Acylsulfonamido- und Sulfonamidopyridin-2-carbonsäureester sowie ihre Pyridin-N-oxide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DK122693D0 (da) * 1993-10-29 1993-10-29 Hempels Skibsfarve Fab J C Marin struktur
ES2101420T3 (es) * 1993-11-02 1997-07-01 Hoechst Ag Esteres-amidas de acidos carboxilicos heterociclicos sustituidos, su preparacion y su utilizacion como medicamentos.
EP0650961B1 (de) * 1993-11-02 1997-03-05 Hoechst Aktiengesellschaft Substituierte heterocyclische Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
NZ270267A (en) * 1993-12-30 1997-03-24 Hoechst Ag 3-hydroxypyridin-2yl (and -quinolin-2-yl) carboxamide derivatives and pharmaceutical compositions

Similar Documents

Publication Publication Date Title
JPH09124606A5 (https=)
KR950017970A (ko) 치환된 헤테로사이클릭 카복스아미드, 이의 제조방법 및 약제로서의 이의 용도
KR970061869A (ko) 치환된 퀴놀린-2-카복실산 아미드, 이의 제조방법 및 약제로서의 이의 용도와 중간체
KR950014072A (ko) 치환된 헤테로사이클릭 카복스아미드, 이의 제조방법 및 약제로서의 이의 용도
JP2009540004A5 (https=)
KR950014069A (ko) 치환된 헤테로사이클릭 카복스아미드 에스테르, 이의 제조방법 및 약제로서의 이의 용도
JP2009540000A5 (https=)
AU2002362065B2 (en) Stabilization of hypoxia inducible factor (HIF) alpha
US11680048B2 (en) Enhanced erythropoiesis and iron metabolism
JP5410751B2 (ja) がん治療のための化合物および方法
KR950032124A (ko) 설폰아미도카보닐피리딘-2-카복스아미드 및 이의 피리딘-n- 옥사이드, 이의 제조방법 및 약제로서의 이의 용도
US20110015223A1 (en) Compounds and methods for treatment of cancer-related anemia
KR950032127A (ko) 치환된 헤테로사이클릭 카복스아미도에스테르, 이의 제조방법 및 약제로서의 이의 용도
US7713986B2 (en) Compounds and methods for treatment of chemotherapy-induced anemia
US20040121965A1 (en) Method of treating resistant tumors
KR940003939A (ko) 이미다졸리딘 유도체
CA2610956A1 (en) Improved treatment for anemia using a hif-alpha stabilising agent
KR880001696A (ko) 레닌 억제용 디- 및 트리 펩타이드 및 이의 제조방법
JP2014516920A5 (https=)
WO2013070908A1 (en) Therapeutic method
KR950032125A (ko) 치환된 헤테로사이클릭 카복스아미드, 이의 제조방법 및 약제로서의 이의 용도
JPWO2019149782A5 (https=)
AU2008201043B2 (en) Stabilization of hypoxia inducible factor (HIF) alpha
EP2295060B1 (en) Treatment or prevention of ischemic or hypoxic conditions
DE19504226A1 (de) Substituierte Chinoxaline, ihre Herstellung und ihre Verwendung als Arzneimittel