NO308600B1 - Substituerte chinolin-2-karboksylsyreamider, deres fremstilling og deres anvendelse for fremstilling av legemidler og farmasøytiske preparater, legemiddel inneholdende disse sÕvel som mellomprodukter til forbindelsene - Google Patents

Substituerte chinolin-2-karboksylsyreamider, deres fremstilling og deres anvendelse for fremstilling av legemidler og farmasøytiske preparater, legemiddel inneholdende disse sÕvel som mellomprodukter til forbindelsene

Info

Publication number
NO308600B1
NO308600B1 NO964093A NO964093A NO308600B1 NO 308600 B1 NO308600 B1 NO 308600B1 NO 964093 A NO964093 A NO 964093A NO 964093 A NO964093 A NO 964093A NO 308600 B1 NO308600 B1 NO 308600B1
Authority
NO
Norway
Prior art keywords
alkyl
opt
alkoxy
substd
cycloalkyl
Prior art date
Application number
NO964093A
Other languages
English (en)
Other versions
NO964093D0 (no
NO964093L (no
Inventor
Klaus Weidmann
Karl-Heinz Baringhaus
Georg Tschank
Martin Bickel
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19536263A external-priority patent/DE19536263A1/de
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NO964093D0 publication Critical patent/NO964093D0/no
Publication of NO964093L publication Critical patent/NO964093L/no
Publication of NO308600B1 publication Critical patent/NO308600B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Electroluminescent Light Sources (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO964093A 1995-09-28 1996-09-27 Substituerte chinolin-2-karboksylsyreamider, deres fremstilling og deres anvendelse for fremstilling av legemidler og farmasøytiske preparater, legemiddel inneholdende disse sÕvel som mellomprodukter til forbindelsene NO308600B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19536263A DE19536263A1 (de) 1995-09-28 1995-09-28 Substituierte Chinolin-2-carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
DE19605170 1996-02-13

Publications (3)

Publication Number Publication Date
NO964093D0 NO964093D0 (no) 1996-09-27
NO964093L NO964093L (no) 1997-04-01
NO308600B1 true NO308600B1 (no) 2000-10-02

Family

ID=26019051

Family Applications (1)

Application Number Title Priority Date Filing Date
NO964093A NO308600B1 (no) 1995-09-28 1996-09-27 Substituerte chinolin-2-karboksylsyreamider, deres fremstilling og deres anvendelse for fremstilling av legemidler og farmasøytiske preparater, legemiddel inneholdende disse sÕvel som mellomprodukter til forbindelsene

Country Status (20)

Country Link
US (2) US5719164A (no)
EP (1) EP0765871B1 (no)
JP (1) JPH09124606A (no)
KR (1) KR970061869A (no)
CN (2) CN1120157C (no)
AT (1) ATE263155T1 (no)
AU (1) AU728208B2 (no)
CA (1) CA2186717A1 (no)
CZ (1) CZ283396A3 (no)
DE (1) DE59610950D1 (no)
ES (1) ES2215184T3 (no)
HU (1) HUP9602685A3 (no)
IL (2) IL135495A (no)
MX (1) MX9604378A (no)
MY (1) MY133647A (no)
NO (1) NO308600B1 (no)
NZ (1) NZ299455A (no)
PL (1) PL316321A1 (no)
SG (1) SG45503A1 (no)
SI (1) SI9600287A (no)

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DE19746287A1 (de) * 1997-10-20 1999-04-22 Hoechst Marion Roussel De Gmbh Substituierte Isochinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
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EP2295060B1 (en) 2001-12-06 2018-10-31 Fibrogen, Inc. Treatment or prevention of ischemic or hypoxic conditions
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US8124582B2 (en) * 2002-12-06 2012-02-28 Fibrogen, Inc. Treatment of diabetes
US7618940B2 (en) * 2002-12-06 2009-11-17 Fibrogen, Inc. Fat regulation
US8614204B2 (en) 2003-06-06 2013-12-24 Fibrogen, Inc. Enhanced erythropoiesis and iron metabolism
CN1816527A (zh) 2003-06-06 2006-08-09 菲布罗根有限公司 含氮杂芳基化合物及其在增加内源性促红细胞生成素中的用途
WO2005034929A2 (en) * 2003-10-10 2005-04-21 Fibrogen, Inc. Tissue remodeling and vascularization
EP1893186A2 (en) * 2005-06-06 2008-03-05 Fibrogen, Inc. Improved treatment for anemia using a hif-alpha stabilising agent
AU2006259352A1 (en) 2005-06-15 2006-12-28 Fibrogen, Inc. Use of HIF 1alfa modulators for treatment of cancer
ES2341489T3 (es) 2005-07-27 2010-06-21 F.Hoffmann-La Roche Ag Derivados de 4-ariloxi quinolina como moduladores de 5-ht6.
CA2634168C (en) * 2005-12-09 2013-04-23 Amgen Inc. Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, and compositions, and uses thereof
CN101374815B (zh) * 2006-01-27 2013-07-17 菲布罗根有限公司 使低氧诱导因子（hif）稳定的氰基异喹啉化合物
US7745461B1 (en) 2006-02-27 2010-06-29 Alcon Research, Ltd. Method of treating dry eye disorders
US7625927B2 (en) * 2006-02-27 2009-12-01 Alcon Research, Ltd. Method of treating glaucoma
PL2008460T3 (pl) * 2006-03-30 2017-10-31 Lg Electronics Inc Sposób i urządzenie do dekodowania/kodowania sygnału wideo
BRPI0710527B8 (pt) * 2006-04-04 2021-05-25 Fibrogen Inc compostos de pirrolo- e tiazolo-piridina e composição farmacêutica que os compreende
HUE041300T2 (hu) 2006-06-26 2019-05-28 Akebia Therapeutics Inc Prolilhidroxiláz inhibitorok és alkalmazási eljárások
ES2393326T3 (es) * 2006-12-18 2012-12-20 Amgen, Inc Compuestos basados en azaquinolona que presentan actividad inhibidora de prolil hidroxilasas, composiciones y usos de los mismos
EP2111399A2 (en) * 2006-12-18 2009-10-28 Amgen Inc. Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof
US7569726B2 (en) * 2007-04-18 2009-08-04 Amgen Inc. Indanone derivatives that inhibit prolyl hydroxylase
CA2683956C (en) * 2007-04-18 2012-12-18 Amgen Inc. Quinolones and azaquinolones that inhibit prolyl hydroxylase
CA2685219C (en) * 2007-05-04 2012-06-19 Amgen Inc. Diazaquinolones that inhibit prolyl hydroxylase activity
ES2389063T3 (es) * 2007-05-04 2012-10-22 Amgen, Inc Derivados de tienopiridina y tiazolopiridina que inhiben la actividad prolil hidroxilasa
US8962530B2 (en) * 2007-06-27 2015-02-24 Regents Of The University Of Colorado Inflammatory bowel disease therapies
JP5649584B2 (ja) 2008-11-14 2015-01-07 フィブロジェン インコーポレイテッド Ｈｉｆヒドロキシラーゼ阻害剤としてのチオクロメン誘導体
UA107360C2 (en) 2009-08-05 2014-12-25 Biogen Idec Inc Bicyclic aryl sphingosine 1-phosphate analogs
BR112012014180A2 (pt) 2009-12-17 2015-09-15 Merck Sharp & Dohme composto, composição farmacêutica, uso da composição farmacêutica, e, método para tratar uma doença ou em distúrbio.
EA026745B8 (ru) 2011-02-07 2022-01-31 Байоджен Ма Инк. Модуляторы s1p
NO2686520T3 (no) 2011-06-06 2018-03-17
AU2013229922B2 (en) 2012-03-09 2017-09-28 Fibrogen, Inc. 4 -hydroxy- isoquinoline compounds as HIF hydroxylase inhibitors
LT2872488T (lt) 2012-07-16 2018-10-25 Fibrogen, Inc. Kristalinės prolilhidroksilazės inhibitoriaus formos
US8883823B2 (en) 2012-07-16 2014-11-11 Fibrogen, Inc. Crystalline forms of a prolyl hydroxylase inhibitor
US9340511B2 (en) 2012-07-16 2016-05-17 Fibrogen, Inc. Process for making isoquinoline compounds
CN104768541B (zh) * 2012-07-27 2018-08-17 比奥根艾迪克Ma公司 Atx调节剂
RU2666144C2 (ru) 2013-01-24 2018-09-06 Фиброген, Инк. Кристаллические формы { [1-циано-5-(4-хлорофенокси)-4-гидроксиизохинолин-3-карбонил]-амино} -уксусной кислоты
NZ714963A (en) 2013-06-13 2020-07-31 Akebia Therapeutics Inc Compositions and methods for treating anemia
TWI665190B (zh) 2013-11-15 2019-07-11 阿克比治療有限公司 ｛［５－（３－氯苯基）－３－羥基吡啶－２－羰基］胺基｝乙酸之固體型式，其組合物及用途
AU2016209126A1 (en) 2015-01-23 2017-08-10 Akebia Therapeutics, Inc. Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
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Also Published As

Publication number Publication date
PL316321A1 (en) 1997-04-01
MX9604378A (es) 1997-03-29
HUP9602685A2 (hu) 1998-09-28
EP0765871A1 (de) 1997-04-02
IL135495A (en) 2002-12-01
NZ299455A (en) 1997-06-24
ATE263155T1 (de) 2004-04-15
CN1282737A (zh) 2001-02-07
HUP9602685A3 (en) 2001-04-28
EP0765871B1 (de) 2004-03-31
IL119302A0 (en) 1996-12-05
CN1154365A (zh) 1997-07-16
NO964093D0 (no) 1996-09-27
CA2186717A1 (en) 1997-03-29
SG45503A1 (en) 1998-01-16
HU9602685D0 (en) 1996-11-28
AU728208B2 (en) 2001-01-04
US5719164A (en) 1998-02-17
SI9600287A (en) 1997-04-30
KR970061869A (ko) 1997-09-12
CN1120157C (zh) 2003-09-03
ES2215184T3 (es) 2004-10-01
US5726305A (en) 1998-03-10
MY133647A (en) 2007-11-30
CZ283396A3 (en) 1997-04-16
AU6583896A (en) 1997-04-10
JPH09124606A (ja) 1997-05-13
DE59610950D1 (de) 2004-05-06
NO964093L (no) 1997-04-01

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