JPH0832624B2 - 水溶性ペプチドの徐放性製剤 - Google Patents

水溶性ペプチドの徐放性製剤

Info

Publication number
JPH0832624B2
JPH0832624B2 JP2177665A JP17766590A JPH0832624B2 JP H0832624 B2 JPH0832624 B2 JP H0832624B2 JP 2177665 A JP2177665 A JP 2177665A JP 17766590 A JP17766590 A JP 17766590A JP H0832624 B2 JPH0832624 B2 JP H0832624B2
Authority
JP
Japan
Prior art keywords
drug
water
octreotide
polymer
microgranules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2177665A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0368511A (ja
Inventor
デビツド・ボドマー
ジヨーンズ・ウイング・フオング
トーマス・キセル
ホーキンズ・バリアント・モールデイング
オスカル・ナゲレ
ジエイン・エドナ・ピアソン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of JPH0368511A publication Critical patent/JPH0368511A/ja
Publication of JPH0832624B2 publication Critical patent/JPH0832624B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/095—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
JP2177665A 1989-07-07 1990-07-06 水溶性ペプチドの徐放性製剤 Expired - Lifetime JPH0832624B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US37702389A 1989-07-07 1989-07-07
US41134789A 1989-09-22 1989-09-22
US411347 1989-09-22
US377023 1995-01-20

Related Child Applications (3)

Application Number Title Priority Date Filing Date
JP7116486A Division JP2931773B2 (ja) 1989-07-07 1995-04-18 ミクロ粒剤の製造方法
JP7116539A Division JPH07309897A (ja) 1989-07-07 1995-04-18 オクトレオチド−パモン酸塩及びその製造方法
JP7228646A Division JPH08198771A (ja) 1989-07-07 1995-08-15 水溶性ペプチドの徐放性製剤

Publications (2)

Publication Number Publication Date
JPH0368511A JPH0368511A (ja) 1991-03-25
JPH0832624B2 true JPH0832624B2 (ja) 1996-03-29

Family

ID=27007654

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2177665A Expired - Lifetime JPH0832624B2 (ja) 1989-07-07 1990-07-06 水溶性ペプチドの徐放性製剤
JP7116539A Pending JPH07309897A (ja) 1989-07-07 1995-04-18 オクトレオチド−パモン酸塩及びその製造方法
JP7116486A Expired - Lifetime JP2931773B2 (ja) 1989-07-07 1995-04-18 ミクロ粒剤の製造方法
JP7228646A Pending JPH08198771A (ja) 1989-07-07 1995-08-15 水溶性ペプチドの徐放性製剤
JP2001006486A Pending JP2001233897A (ja) 1989-07-07 2001-01-15 オクトレオチド−パモン酸塩

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP7116539A Pending JPH07309897A (ja) 1989-07-07 1995-04-18 オクトレオチド−パモン酸塩及びその製造方法
JP7116486A Expired - Lifetime JP2931773B2 (ja) 1989-07-07 1995-04-18 ミクロ粒剤の製造方法
JP7228646A Pending JPH08198771A (ja) 1989-07-07 1995-08-15 水溶性ペプチドの徐放性製剤
JP2001006486A Pending JP2001233897A (ja) 1989-07-07 2001-01-15 オクトレオチド−パモン酸塩

Country Status (27)

Country Link
JP (5) JPH0832624B2 (da)
KR (2) KR100303681B1 (da)
AT (1) AT406225B (da)
AU (2) AU641407B2 (da)
BE (1) BE1004486A3 (da)
CA (1) CA2020477C (da)
CH (1) CH685230A5 (da)
CY (1) CY1965A (da)
DE (2) DE4042752B4 (da)
DK (1) DK175849B1 (da)
FI (3) FI108611B (da)
FR (1) FR2649319A1 (da)
GB (2) GB2234896B (da)
GR (1) GR1001121B (da)
HK (2) HK97695A (da)
HU (2) HU221294B1 (da)
IE (2) IE64216B1 (da)
IL (3) IL131880A (da)
IT (1) IT1241460B (da)
LU (1) LU87764A1 (da)
MY (1) MY106722A (da)
NL (1) NL195027C (da)
NO (2) NO302928B1 (da)
NZ (1) NZ234384A (da)
PT (1) PT94628B (da)
SE (1) SE512992C2 (da)
SG (1) SG26416G (da)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015056805A1 (en) 2013-10-15 2015-04-23 Otsuka Pharmaceutical Co., Ltd. Drug for preventing and/or treating polycystic kidney disease

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US6013853A (en) * 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
US5876452A (en) * 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
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AU4198793A (en) † 1992-07-24 1994-01-27 Takeda Chemical Industries Ltd. Microparticle preparation and production thereof
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US6270795B1 (en) 1995-11-09 2001-08-07 Microbiological Research Authority Method of making microencapsulated DNA for vaccination and gene therapy
DE19545257A1 (de) 1995-11-24 1997-06-19 Schering Ag Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln
US5817343A (en) * 1996-05-14 1998-10-06 Alkermes, Inc. Method for fabricating polymer-based controlled-release devices
US5968895A (en) * 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
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GB9810236D0 (en) * 1998-05-13 1998-07-08 Microbiological Res Authority Improvements relating to encapsulation of bioactive agents
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US6226656B1 (en) 1998-11-12 2001-05-01 Sourcefinder, Inc. System and method for creating, generating and processing user-defined generic specs
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US6824822B2 (en) * 2001-08-31 2004-11-30 Alkermes Controlled Therapeutics Inc. Ii Residual solvent extraction method and microparticles produced thereby
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KR100741867B1 (ko) * 2005-07-05 2007-07-24 전북대학교산학협력단 수중유적 및 용매 증발법을 이용한 이중층 미립구의제조방법
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JP5808413B2 (ja) * 2010-09-30 2015-11-10 エボニック コーポレイションＥｖｏｎｉｋ Ｃｏｒｐｏｒａｔｉｏｎ 微粒子から残留有機溶剤を除去する方法
JP2013538855A (ja) * 2010-09-30 2013-10-17 エボニック コーポレイション 低い残留有機溶剤の微粒子を製造するためのエマルション法
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015056805A1 (en) 2013-10-15 2015-04-23 Otsuka Pharmaceutical Co., Ltd. Drug for preventing and/or treating polycystic kidney disease

Also Published As

Publication number Publication date
AU5874690A (en) 1991-01-10
GB2265311A (en) 1993-09-29
PT94628A (pt) 1991-03-20
HUT54037A (en) 1991-01-28
GB9306204D0 (en) 1993-05-19
HU903974D0 (en) 1990-11-28
FI109543B (fi) 2002-08-30
FI109334B (fi) 2002-07-15
JPH07285853A (ja) 1995-10-31
NO983923D0 (no) 1998-08-26
NZ234384A (en) 1994-05-26
AU2332195A (en) 1995-09-07
DE4021517A1 (de) 1991-01-17
GB9014704D0 (en) 1990-08-22
IL94983A (en) 1999-08-17
FR2649319A1 (fr) 1991-01-11
IT9048113A0 (it) 1990-07-05
HK97695A (en) 1995-06-23
GB2234896A (en) 1991-02-20
AU687553B2 (en) 1998-02-26
IL94983A0 (en) 1991-06-10
SE512992C2 (sv) 2000-06-12
IL131881A (en) 2001-12-23
NL195027B (nl) 2003-08-01
GB2234896B (en) 1994-01-19
HK197496A (en) 1996-11-08
NO320444B1 (no) 2005-12-05
HU211602A9 (en) 1995-12-28
KR100442931B1 (ko) 2004-08-02
FI20000060A (fi) 2000-01-12
SG26416G (en) 1995-09-01
AU641407B2 (en) 1993-09-23
SE9002364L (sv) 1991-01-08
DE4021517B4 (de) 2009-04-09
JPH07309897A (ja) 1995-11-28
FI108611B (fi) 2002-02-28
FR2649319B1 (da) 1994-12-09
DE4042752B4 (de) 2009-05-07
KR910002430A (ko) 1991-02-25
GB2265311B (en) 1994-02-09
SE9002364D0 (sv) 1990-07-05
GR900100513A (en) 1991-12-10
FI903429A0 (fi) 1990-07-06
IT1241460B (it) 1994-01-17
CH685230A5 (de) 1995-05-15
CA2020477C (en) 2000-11-21
JPH0368511A (ja) 1991-03-25
MY106722A (en) 1995-07-31
IT9048113A1 (it) 1992-01-05
DK175849B1 (da) 2005-03-29
IE902435A1 (en) 1991-02-13
KR100303681B1 (ko) 2002-05-16
CY1965A (en) 1997-07-04
NO983923L (no) 1991-01-08
AT406225B (de) 2000-03-27
NO903001L (no) 1991-01-08
CA2020477A1 (en) 1991-01-08
IE64216B1 (en) 1995-07-26
IL131880A (en) 2001-12-23
IE64411B1 (en) 1995-08-09
HU221294B1 (en) 2002-09-28
FI20000059A (fi) 2000-01-12
DK162590A (da) 1991-01-08
DK162590D0 (da) 1990-07-05
NL9001537A (nl) 1991-02-01
GR1001121B (el) 1993-04-28
NO903001D0 (no) 1990-07-05
LU87764A1 (fr) 1992-03-11
NO302928B1 (no) 1998-05-11
JP2001233897A (ja) 2001-08-28
PT94628B (pt) 1997-06-30
JP2931773B2 (ja) 1999-08-09
JPH08198771A (ja) 1996-08-06
NL195027C (nl) 2003-12-02
BE1004486A3 (fr) 1992-12-01
ATA144090A (de) 1999-08-15

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