JPH05279260A - 安定化されたビタミンｄ類製剤 - Google Patents

安定化されたビタミンｄ類製剤

Info

Publication number
JPH05279260A
JPH05279260A JP4088666A JP8866692A JPH05279260A JP H05279260 A JPH05279260 A JP H05279260A JP 4088666 A JP4088666 A JP 4088666A JP 8866692 A JP8866692 A JP 8866692A JP H05279260 A JPH05279260 A JP H05279260A
Authority
JP
Japan
Prior art keywords
active vitamin
weight
vitamin
composition
parts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP4088666A
Other languages
English (en)
Japanese (ja)
Inventor
Hiroki Ito
弘樹 伊藤
Tetsuro Tabata
哲朗 田畑
Junichi Kikuta
潤一 菊田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of JPH05279260A publication Critical patent/JPH05279260A/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP4088666A 1991-04-09 1992-04-09 安定化されたビタミンｄ類製剤 Withdrawn JPH05279260A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP3-76210 1991-04-09
JP7621091 1991-04-09
JP4-19099 1992-02-04
JP1909992 1992-02-04

Publications (1)

Publication Number Publication Date
JPH05279260A true JPH05279260A (ja) 1993-10-26

Family

ID=26355908

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4088666A Withdrawn JPH05279260A (ja) 1991-04-09 1992-04-09 安定化されたビタミンｄ類製剤

Country Status (14)

Country Link
US (1) US5487900A (OSRAM)
EP (1) EP0508756B1 (OSRAM)
JP (1) JPH05279260A (OSRAM)
KR (1) KR100231633B1 (OSRAM)
AT (1) ATE144424T1 (OSRAM)
AU (1) AU649802B2 (OSRAM)
CA (1) CA2065603C (OSRAM)
DE (1) DE69214704T2 (OSRAM)
DK (1) DK0508756T3 (OSRAM)
ES (1) ES2094290T3 (OSRAM)
GR (1) GR3021892T3 (OSRAM)
IE (1) IE75709B1 (OSRAM)
NZ (1) NZ242271A (OSRAM)
TW (1) TW212761B (OSRAM)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004504295A (ja) * 2000-07-18 2004-02-12 ボーン　ケア　インターナショナル　インコーポレイテッド 安定化１α−ヒドロキシビタミンＤ
JP2018080168A (ja) * 2016-11-10 2018-05-24 日産化学工業株式会社 ビタミンｄ３誘導体の製剤
JP2021535155A (ja) * 2018-08-31 2021-12-16 オプコ アイルランド グローバル ホールディングス リミテッド ビタミンｄ小児用剤形、製造方法および使用方法

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19701264A1 (de) * 1997-01-16 1998-07-23 Kief Lizenz Verwertungsgesells Heilmittel, enthaltend Betasitosterin und/oder Phytosterol/Betasitosteringemische
CA2425367A1 (en) * 2000-08-30 2003-04-07 Chugai Seiyaku Kabushiki Kaisha Oct formulations
JP2005515996A (ja) * 2001-12-03 2005-06-02 ノバセア インコーポレイティッド 活性型ビタミンｄ化合物を含む薬学的組成物
US20040058895A1 (en) * 2002-09-18 2004-03-25 Bone Care International, Inc. Multi-use vessels for vitamin D formulations
US20040053895A1 (en) * 2002-09-18 2004-03-18 Bone Care International, Inc. Multi-use vessels for vitamin D formulations
US7148211B2 (en) * 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
US20050026877A1 (en) * 2002-12-03 2005-02-03 Novacea, Inc. Pharmaceutical compositions comprising active vitamin D compounds
US20060189586A1 (en) * 2003-06-11 2006-08-24 Cleland Jeffrey L Pharmaceutical compositions comprising active vitamin D compounds
US20050020546A1 (en) * 2003-06-11 2005-01-27 Novacea, Inc. Pharmaceutical compositions comprising active vitamin D compounds
CA2924200C (en) * 2005-10-12 2017-09-05 Proventiv Therapeutics, Llc Methods and articles for treating 25-hydroxyvitamin d insufficiency and deficiency
WO2007092755A2 (en) 2006-02-03 2007-08-16 Proventiv Therapeutics, Llc Treating vitamin d insufficiency and deficiency with 25-hydroxyvitamin d2 and 25-hydroxyvitamin d3
US8329677B2 (en) 2006-06-21 2012-12-11 Cytochroma, Inc. Method of treating and preventing secondary hyperparathyroidism
WO2008134518A2 (en) 2007-04-25 2008-11-06 Cytochroma Inc. Methods and compounds for vitamin d therapy
EP3335712B1 (en) 2007-04-25 2025-09-10 Opko Renal, LLC Method of safely and effectively treating and preventing secondary hyperparathyroidism in chronic kidney disease
WO2009047644A2 (en) 2007-04-25 2009-04-16 Cytochroma Inc. Method of treating vitamin d insufficiency and deficiency
EP2148661B1 (en) 2007-04-25 2012-12-12 Cytochroma Inc. Oral controlled release compositions comprising vitamin d compound and waxy carrier
ES2593356T3 (es) 2008-04-02 2016-12-07 Opko Ireland Global Holdings, Ltd. Métodos, composiciones, usos y kits útiles para la deficiencia de la vitamina D y trastornos relacionados
CA2797537C (en) 2010-03-29 2021-11-23 Cytochroma Inc. Use of 25-hydroxyvitamin d compound for reducing parathyroid levels
CA2698160C (en) * 2010-03-30 2017-07-25 Alphora Research Inc. Stabilized doxercalciferol and process for manufacturing the same
EP2468265A3 (en) * 2010-12-04 2013-01-02 DEEF Pharmaceutical Industries Co. Homogeneous preparations containing vitamin D
KR101847947B1 (ko) 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 안정화되고 변형된 비타민 ｄ 방출 제형
US10220047B2 (en) 2014-08-07 2019-03-05 Opko Ireland Global Holdings, Ltd. Adjunctive therapy with 25-hydroxyvitamin D and articles therefor
JP7032322B2 (ja) 2016-03-28 2022-03-08 オプコ アイルランド グローバル ホールディングス リミテッド ビタミンｄ治療法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59155309A (ja) * 1983-02-22 1984-09-04 Teijin Ltd 活性型ビタミンｄ↓３類組成物
JPS6217A (ja) * 1985-02-14 1987-01-06 Chugai Pharmaceut Co Ltd 安定な活性型ビタミンｄ３類製剤
DE3612212A1 (de) * 1986-04-11 1987-10-15 Basf Ag Verfahren zur herstellung von festen pharmazeutischen formen
JP2525478B2 (ja) * 1989-03-01 1996-08-21 帝人株式会社 安定性の改良された活性型ビタミンｄ▲下３▼類固型製剤
JPH04198129A (ja) * 1990-11-28 1992-07-17 Sumitomo Pharmaceut Co Ltd 活性型ビタミンｄ↓３類含有組成物

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004504295A (ja) * 2000-07-18 2004-02-12 ボーン　ケア　インターナショナル　インコーポレイテッド 安定化１α−ヒドロキシビタミンＤ
JP2018080168A (ja) * 2016-11-10 2018-05-24 日産化学工業株式会社 ビタミンｄ３誘導体の製剤
JP2021535155A (ja) * 2018-08-31 2021-12-16 オプコ アイルランド グローバル ホールディングス リミテッド ビタミンｄ小児用剤形、製造方法および使用方法

Also Published As

Publication number Publication date
US5487900A (en) 1996-01-30
GR3021892T3 (en) 1997-03-31
KR920019346A (ko) 1992-11-19
ATE144424T1 (de) 1996-11-15
EP0508756B1 (en) 1996-10-23
CA2065603A1 (en) 1992-10-10
IE921126A1 (en) 1992-10-21
EP0508756A1 (en) 1992-10-14
DE69214704T2 (de) 1997-04-17
KR100231633B1 (ko) 1999-11-15
DE69214704D1 (de) 1996-11-28
ES2094290T3 (es) 1997-01-16
DK0508756T3 (da) 1997-03-24
CA2065603C (en) 2007-04-03
NZ242271A (en) 1993-10-26
AU1480492A (en) 1992-10-15
TW212761B (OSRAM) 1993-09-11
IE75709B1 (en) 1997-09-10
AU649802B2 (en) 1994-06-02

Similar Documents

Publication Publication Date Title
JPH05279260A (ja) 安定化されたビタミンｄ類製剤
JP2525478B2 (ja) 安定性の改良された活性型ビタミンｄ▲下３▼類固型製剤
US4404183A (en) Sustained release pharmaceutical composition of solid medical material
KR100415897B1 (ko) 생체 이용율이 높은 페노피브레이트 제약학적 조성물
JP3536106B2 (ja) 製剤及びその製造方法
JP2845342B2 (ja) ビタミンｄ▲下３▼誘導体含有固形製剤組成物
JPH06116138A (ja) 経口製剤用組成物
JP2002503686A (ja) 経口投与可能な吸収促進剤を含む即時遊離且つ延長遊離剤形およびこの吸収促進剤の使用
JP7196239B2 (ja) Ｅｄ－７１の固体分散体および油分分散体を含む医薬組成物
JP2007517879A (ja) Ｃｃｉ−７７９経口投与用の直接圧縮可能な医薬組成物
EA027869B1 (ru) Стабилизированная композиция такролимуса
EP0559645A1 (en) Composition for solid pharmaceutical preparations containing active vitamins d 3? and process for preparation thereof
WO2019106043A1 (en) Pharmaceutical composition comprising obeticholic acid
JP3037393B2 (ja) 経口投与用固形薬剤の製造方法
AU2004251439A1 (en) Tablet comprising fluvastatin and carmellose calcium
JP2974734B2 (ja) 安定な活性型ビタミンｄ▲下３▼類製剤
US20040138295A1 (en) Solid pharmaceutical formulation containing lovastatin and simvastatin respectively, and its preparation
CN117769412A (zh) 一种难溶性药物渗透泵控释片剂及其制备方法
EP3441064B1 (en) Extended release liquid compositions of guaifenesin
JPH0640921A (ja) 活性型ビタミンｄ３ 類組成物
JP2914690B2 (ja) 安定なビタミンｄ▲下３▼類含有製剤
JP2963718B2 (ja) ビタミンｄ▲下３▼類含有製剤
JP2016503782A (ja) Ｎ−［５−［２−（３，５−ジメトキシフェニル）エチル］−２ｈ−ピラゾール−３−イル］−４−［（３ｒ，５ｓ）−３，５−ジメチルピペラジン−１−イル］ベンズアミドの医薬製剤
JP3572620B2 (ja) ビタミンｄ３含有固形製剤組成物
JPH05246854A (ja) ビタミンｄ３含有固形製剤組成物

Legal Events

Date Code Title Description
A300 Application deemed to be withdrawn because no request for examination was validly filed

Free format text: JAPANESE INTERMEDIATE CODE: A300

Effective date: 19990706