ES2094290T3 - Preparacion estabilizada de vitamina d. - Google Patents

Preparacion estabilizada de vitamina d.

Info

Publication number
ES2094290T3
ES2094290T3 ES92303129T ES92303129T ES2094290T3 ES 2094290 T3 ES2094290 T3 ES 2094290T3 ES 92303129 T ES92303129 T ES 92303129T ES 92303129 T ES92303129 T ES 92303129T ES 2094290 T3 ES2094290 T3 ES 2094290T3
Authority
ES
Spain
Prior art keywords
vitamin
active compound
pharmaceutical composition
heat
readily soluble
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92303129T
Other languages
English (en)
Inventor
Hiroki Itoh
Tetsuro Tabata
Jun-Ichi Kikuta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ES2094290T3 publication Critical patent/ES2094290T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Abstract

PREPARACION DE VITAMINA D ESTABILIZADA. LA PRESENTE INVENCION PROPORCIONA UNA COMPOSICION FARMACEUTICA DE UN COMPUESTO ACTIVO DE VITAMINA D TERMOLABIL DISPERSADO EN UN POLIMERO BASICO; UNA COMPOSICION FARMACEUTICA, QUE SE COMPONE DE UN EXCIPIENTE FACILMENTE SOLUBLE EN UN DISOLVENTE ORGANICO, UN COMPUESTO ACTIVO DE VITAMINA D2 TERMOLABIL Y UNA SUSTANCIA BASICA; O UNA COMPOSICION FARMACEUTICA, QUE SE COMPONE DE UNA DISPERSION HOMOGENEA DE UN COMPUESTO ACTIVO DE VITAMINA D TERMOLABIL FINAMENTE PULVERIZADO EN UNA SUSTANCIA BASICA Y UN EXCIPIENTE FACILMENTE SOLUBLE EN AGUA. EN LA COMPOSICION DE ESTA INVENCION, SE REDUCE DE FORMA NOTABLE LA ISOMERIZACION TERMICA, LA DESCOMPOSICION Y LA DECOLORACION, MANTENIENDO UNA EXCELENTE ESTABILIDAD.
ES92303129T 1991-04-09 1992-04-08 Preparacion estabilizada de vitamina d. Expired - Lifetime ES2094290T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7621091 1991-04-09
JP1909992 1992-02-04

Publications (1)

Publication Number Publication Date
ES2094290T3 true ES2094290T3 (es) 1997-01-16

Family

ID=26355908

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92303129T Expired - Lifetime ES2094290T3 (es) 1991-04-09 1992-04-08 Preparacion estabilizada de vitamina d.

Country Status (14)

Country Link
US (1) US5487900A (es)
EP (1) EP0508756B1 (es)
JP (1) JPH05279260A (es)
KR (1) KR100231633B1 (es)
AT (1) ATE144424T1 (es)
AU (1) AU649802B2 (es)
CA (1) CA2065603C (es)
DE (1) DE69214704T2 (es)
DK (1) DK0508756T3 (es)
ES (1) ES2094290T3 (es)
GR (1) GR3021892T3 (es)
IE (1) IE75709B1 (es)
NZ (1) NZ242271A (es)
TW (1) TW212761B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19701264A1 (de) * 1997-01-16 1998-07-23 Kief Lizenz Verwertungsgesells Heilmittel, enthaltend Betasitosterin und/oder Phytosterol/Betasitosteringemische
JP2004504295A (ja) * 2000-07-18 2004-02-12 ボーン　ケア　インターナショナル　インコーポレイテッド 安定化１α−ヒドロキシビタミンＤ
CA2425367A1 (en) * 2000-08-30 2003-04-07 Chugai Seiyaku Kabushiki Kaisha Oct formulations
WO2003047595A1 (en) * 2001-12-03 2003-06-12 Novacea, Inc. Pharmaceutical compositions comprising active vitamin d compounds
US20040053895A1 (en) * 2002-09-18 2004-03-18 Bone Care International, Inc. Multi-use vessels for vitamin D formulations
US7148211B2 (en) * 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
US20040058895A1 (en) * 2002-09-18 2004-03-25 Bone Care International, Inc. Multi-use vessels for vitamin D formulations
US20050026877A1 (en) * 2002-12-03 2005-02-03 Novacea, Inc. Pharmaceutical compositions comprising active vitamin D compounds
US20060189586A1 (en) * 2003-06-11 2006-08-24 Cleland Jeffrey L Pharmaceutical compositions comprising active vitamin D compounds
US20050020546A1 (en) * 2003-06-11 2005-01-27 Novacea, Inc. Pharmaceutical compositions comprising active vitamin D compounds
EP3047847A1 (en) * 2005-10-12 2016-07-27 OPKO Renal, LLC Methods and articles for treating 25-hydroxyvitamin d insufficiency and deficiency
CA2640094C (en) 2006-02-03 2015-04-14 Proventiv Therapeutics, Llc Treating vitamin d insufficiency and deficiency with 25-hydroxyvitamin d2 and 25-hydroxyvitamin d3
PT3357496T (pt) 2006-06-21 2020-05-12 Opko Ireland Global Holdings Ltd Terapia utilizando um agente de repleção de vitamina d e um agente de substituição hormonal de vitamina d
JP5501956B2 (ja) 2007-04-25 2014-05-28 シトクロマ インコーポレイテッド ビタミンｄ化合物およびワックス状担体を含有する制御放出性経口組成物
WO2008134518A2 (en) 2007-04-25 2008-11-06 Cytochroma Inc. Methods and compounds for vitamin d therapy
EP2148683A4 (en) 2007-04-25 2012-09-12 Proventiv Therapeutics Llc METHOD FOR THE SAFE AND EFFECTIVE TREATMENT AND PREVENTION OF SECONDARY HYPERPARATHYREOSIS IN CHRONIC KIDNEY DISEASE
CN101668532B (zh) 2007-04-25 2014-08-20 赛特克罗公司 治疗维生素d不足和缺乏、继发性甲状旁腺功能亢进症和维生素d-响应疾病的组合物及其相应的制药用途
CA2714996C (en) 2008-04-02 2020-04-07 Cytochroma Inc. Methods, compositions, uses, and kits useful for vitamin d deficiency and related disorders
CN105796530A (zh) 2010-03-29 2016-07-27 赛特克罗公司 用于降低甲状旁腺水平的方法和组合物
CA2698160C (en) * 2010-03-30 2017-07-25 Alphora Research Inc. Stabilized doxercalciferol and process for manufacturing the same
EP2468265A3 (en) * 2010-12-04 2013-01-02 DEEF Pharmaceutical Industries Co. Homogeneous preparations containing vitamin D
KR101847947B1 (ko) 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 안정화되고 변형된 비타민 ｄ 방출 제형
AU2015298858A1 (en) 2014-08-07 2017-03-02 Opko Ireland Global Holdings Ltd. Adjunctive therapy with 25-hydroxyvitamin D
IL290855B1 (en) 2016-03-28 2024-02-01 Eirgen Pharma Ltd Treatment methods using vitamin D
JP7085105B2 (ja) * 2016-11-10 2022-06-16 日産化学株式会社 ビタミンｄ３誘導体の製剤
MX2020011740A (es) * 2018-08-31 2021-04-19 Opko Ireland Global Holdings Ltd Formas de dosificación pediátricas de vitamina d, métodos de elaboración y uso.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59155309A (ja) * 1983-02-22 1984-09-04 Teijin Ltd 活性型ビタミンｄ↓３類組成物
JPS6217A (ja) * 1985-02-14 1987-01-06 Chugai Pharmaceut Co Ltd 安定な活性型ビタミンｄ３類製剤
DE3612212A1 (de) * 1986-04-11 1987-10-15 Basf Ag Verfahren zur herstellung von festen pharmazeutischen formen
JP2525478B2 (ja) * 1989-03-01 1996-08-21 帝人株式会社 安定性の改良された活性型ビタミンｄ▲下３▼類固型製剤
JPH04198129A (ja) * 1990-11-28 1992-07-17 Sumitomo Pharmaceut Co Ltd 活性型ビタミンｄ↓３類含有組成物

Also Published As

Publication number Publication date
DE69214704D1 (de) 1996-11-28
ATE144424T1 (de) 1996-11-15
GR3021892T3 (en) 1997-03-31
IE921126A1 (en) 1992-10-21
JPH05279260A (ja) 1993-10-26
EP0508756A1 (en) 1992-10-14
DK0508756T3 (da) 1997-03-24
US5487900A (en) 1996-01-30
CA2065603A1 (en) 1992-10-10
EP0508756B1 (en) 1996-10-23
KR920019346A (ko) 1992-11-19
AU1480492A (en) 1992-10-15
DE69214704T2 (de) 1997-04-17
NZ242271A (en) 1993-10-26
CA2065603C (en) 2007-04-03
KR100231633B1 (ko) 1999-11-15
AU649802B2 (en) 1994-06-02
TW212761B (es) 1993-09-11
IE75709B1 (en) 1997-09-10

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