KR920019346A - 비타민 d 안정제제 - Google Patents

비타민 d 안정제제 Download PDF

Info

Publication number
KR920019346A
KR920019346A KR1019920005930A KR920005930A KR920019346A KR 920019346 A KR920019346 A KR 920019346A KR 1019920005930 A KR1019920005930 A KR 1019920005930A KR 920005930 A KR920005930 A KR 920005930A KR 920019346 A KR920019346 A KR 920019346A
Authority
KR
South Korea
Prior art keywords
active compound
heat
vitamin
labile vitamin
labile
Prior art date
Application number
KR1019920005930A
Other languages
English (en)
Other versions
KR100231633B1 (ko
Inventor
히로끼 이또오
데쓰로 다바따
준이찌 기꾸따
Original Assignee
모리따 가쓰라
다께다야꾸힝 고오교 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 모리따 가쓰라, 다께다야꾸힝 고오교 가부시끼가이샤 filed Critical 모리따 가쓰라
Publication of KR920019346A publication Critical patent/KR920019346A/ko
Application granted granted Critical
Publication of KR100231633B1 publication Critical patent/KR100231633B1/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

비타민 D 안정제제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (20)

  1. 열-불안정성 비타민 D 활성 화합물이 염기성 중합체에 분산되어 있음을 특징으로 하는 열-불안정성 비타민 D 활성 화합물의 조성물.
  2. 제1항에 있어서, 열-불안정성 비타민 D 활성 화합물이 열-불안정성 비타민 D2활성 화합물인 조성물.
  3. 열-불안정성 비타민 D 활성 화합물이 염기성 중합체에 분산된 조성물을 함유함을 특징으로하는 고체 약학 조성물.
  4. 제3항에 있어서, 열-불안정성 비타민 D 활성 화합물이 열-불안정성 비타민 D2활성 화합물인 고체 약학 제제.
  5. 제3항에 있어서, 정제, 캡슐, 과립 또는 분말 형태인 고체 약학 제제.
  6. 유기용매에 가용성인 부형제, 열-불안정성 비타민 D2활성 화합물 및 염기성 물질을 함유함을 특징으로 하는 열-불안정성 비타민 D2활성 화합물의 조성물.
  7. 제6항에 있어서, 열-불안정성 비타민 D2활성 화합물 및 염기성 물질이 유기용매에 가용성인 부형제에 분산된 조성물.
  8. 유기용매에 가용성인 부형제, 열-불안정성 비타민 D2활성 화합물 및 염기성 물질을 함유하는 조성물을 함유함을 특징으로 하는 고체 약학 제제.
  9. 제8항에 있어서, 정제, 캡슐, 과립 또는 분말 형태인 고체 약학 제제.
  10. 수용성 부형제 및 염기성 물질에 균질 분산된 미분쇄 열-불안정성 비타민 D 활성 화합물을 함유함을 특징으로 하는 열-불안정성 비타민 D 활성 화합물의 조성물.
  11. 제10항에 있어서, 열-불안정성 비타민 D 활성 화합물이 열-불안정성 비타민 D2활성 화합물인 조성물.
  12. 수용성 부형제 및 염기성 물질에 균질 분산된 미분쇄 열-불안정성 비타민 D 활성 화합물을 함유하는 조성물을 함유함을 특징으로 하는 고체약학 제제.
  13. 제12항에 있어서, 열-불안정성 비타민 D 활성 화합물이 열-불안정성 비타민 D2활성 화합물인 고체 약학 제제.
  14. 제12항에 있어서, 정제, 캡슐, 과립 또는 분말 형태인 고체 약학 제제.
  15. 제12항에 있어서, 약학 제제가 피복된 고체 약학 제제.
  16. 제15항에 있어서, 피복물이 차단용 피복물인 고체 약학 제제.
  17. 수용성 부형제 및 염기성 물질에 미분쇄 열-불안정성 비타민 D 활성 화합물을 배합함을 특징으로 하는 조성물의 제조방법.
  18. 제17항에 있어서, 열-불안정성 비타민 D 활성 화합물이 열-불안정성 비타민 D2활성 화합물인 방법.
  19. 제17항에 있어서, 미분쇄 열-불안정성 비타민 D 활성 화합물이 열-불안전성 비타민 D 활성 화합물은 용해시키지 않고 수용성 부형제는 용해시키는 용매중에서 수용성 부형제 및 염기성 물질에 배합되는 방법.
  20. 제19항에 있어서, 용매가 물인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920005930A 1991-04-09 1992-04-09 비타민 d 안정제제 KR100231633B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP91-076210 1991-04-09
JP7621091 1991-04-09
JP92-19099 1992-02-04
JP1909992 1992-02-04

Publications (2)

Publication Number Publication Date
KR920019346A true KR920019346A (ko) 1992-11-19
KR100231633B1 KR100231633B1 (ko) 1999-11-15

Family

ID=26355908

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920005930A KR100231633B1 (ko) 1991-04-09 1992-04-09 비타민 d 안정제제

Country Status (14)

Country Link
US (1) US5487900A (ko)
EP (1) EP0508756B1 (ko)
JP (1) JPH05279260A (ko)
KR (1) KR100231633B1 (ko)
AT (1) ATE144424T1 (ko)
AU (1) AU649802B2 (ko)
CA (1) CA2065603C (ko)
DE (1) DE69214704T2 (ko)
DK (1) DK0508756T3 (ko)
ES (1) ES2094290T3 (ko)
GR (1) GR3021892T3 (ko)
IE (1) IE75709B1 (ko)
NZ (1) NZ242271A (ko)
TW (1) TW212761B (ko)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19701264A1 (de) * 1997-01-16 1998-07-23 Kief Lizenz Verwertungsgesells Heilmittel, enthaltend Betasitosterin und/oder Phytosterol/Betasitosteringemische
IL153378A0 (en) * 2000-07-18 2003-07-06 Bone Care Internat Inc STABILIZED 1alpha-HYDROXY VITAMIN D
CN1449289A (zh) * 2000-08-30 2003-10-15 中外制药株式会社 Oct制剂
US20030191093A1 (en) * 2001-12-03 2003-10-09 Novacea, Inc. Pharmaceutical compositions comprising active vitamin D compounds
US7148211B2 (en) * 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
US20040058895A1 (en) * 2002-09-18 2004-03-25 Bone Care International, Inc. Multi-use vessels for vitamin D formulations
US20040053895A1 (en) * 2002-09-18 2004-03-18 Bone Care International, Inc. Multi-use vessels for vitamin D formulations
US20050026877A1 (en) * 2002-12-03 2005-02-03 Novacea, Inc. Pharmaceutical compositions comprising active vitamin D compounds
US20050020546A1 (en) * 2003-06-11 2005-01-27 Novacea, Inc. Pharmaceutical compositions comprising active vitamin D compounds
US20060189586A1 (en) * 2003-06-11 2006-08-24 Cleland Jeffrey L Pharmaceutical compositions comprising active vitamin D compounds
EP3047847A1 (en) * 2005-10-12 2016-07-27 OPKO Renal, LLC Methods and articles for treating 25-hydroxyvitamin d insufficiency and deficiency
DK1993559T3 (en) 2006-02-03 2016-10-03 Opko Renal Llc Treatment of vitamin D deficiency and MALFUNCTION with 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3
ES2670029T3 (es) 2006-06-21 2018-05-29 Opko Ireland Global Holdings, Ltd. Terapia usando agente de repleción de la vitamina D y agente de reemplazo de la hormona de la vitamina D
DK2481400T3 (da) 2007-04-25 2014-09-29 Opko Ip Holdings Ii Inc Orale præparater med kontrolleret frigivelse omfattende en vitamin D-forbindelse og en voksagtig bærer
KR101495578B1 (ko) 2007-04-25 2015-02-25 사이토크로마 인코포레이티드 비타민 ｄ 부족 및 결핍의 치료 방법
EP3225243A1 (en) 2007-04-25 2017-10-04 Opko Renal, LLC Method of safely and effectively treating and preventing secondary hyperparathyroidism in chronic kidney disease
CA2684778C (en) 2007-04-25 2017-09-05 Cytochroma Inc. Methods and compounds for vitamin d therapy
ES2954932T3 (es) 2008-04-02 2023-11-27 Eirgen Pharma Ltd Métodos, composiciones, usos y kits útiles para la deficiencia de vitamina D y trastornos relacionados
CN105796530A (zh) 2010-03-29 2016-07-27 赛特克罗公司 用于降低甲状旁腺水平的方法和组合物
CA2698160C (en) * 2010-03-30 2017-07-25 Alphora Research Inc. Stabilized doxercalciferol and process for manufacturing the same
EP2468265A3 (en) * 2010-12-04 2013-01-02 DEEF Pharmaceutical Industries Co. Homogeneous preparations containing vitamin D
KR101847947B1 (ko) 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 안정화되고 변형된 비타민 ｄ 방출 제형
US10220047B2 (en) 2014-08-07 2019-03-05 Opko Ireland Global Holdings, Ltd. Adjunctive therapy with 25-hydroxyvitamin D and articles therefor
IL290855B2 (en) 2016-03-28 2024-06-01 Eirgen Pharma Ltd Treatment methods using vitamin D
JP7085105B2 (ja) * 2016-11-10 2022-06-16 日産化学株式会社 ビタミンｄ３誘導体の製剤
DE202019005769U1 (de) * 2018-08-31 2022-01-13 Eirgen Pharma Ltd. Pädiatrische Darreichungsformen von Vitamin D und Verwendung

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59155309A (ja) * 1983-02-22 1984-09-04 Teijin Ltd 活性型ビタミンｄ↓３類組成物
JPS6217A (ja) * 1985-02-14 1987-01-06 Chugai Pharmaceut Co Ltd 安定な活性型ビタミンｄ３類製剤
DE3612212A1 (de) * 1986-04-11 1987-10-15 Basf Ag Verfahren zur herstellung von festen pharmazeutischen formen
JP2525478B2 (ja) * 1989-03-01 1996-08-21 帝人株式会社 安定性の改良された活性型ビタミンｄ▲下３▼類固型製剤
JPH04198129A (ja) * 1990-11-28 1992-07-17 Sumitomo Pharmaceut Co Ltd 活性型ビタミンｄ↓３類含有組成物

Also Published As

Publication number Publication date
CA2065603C (en) 2007-04-03
IE921126A1 (en) 1992-10-21
CA2065603A1 (en) 1992-10-10
TW212761B (ko) 1993-09-11
DE69214704T2 (de) 1997-04-17
DK0508756T3 (da) 1997-03-24
EP0508756B1 (en) 1996-10-23
JPH05279260A (ja) 1993-10-26
EP0508756A1 (en) 1992-10-14
GR3021892T3 (en) 1997-03-31
ATE144424T1 (de) 1996-11-15
ES2094290T3 (es) 1997-01-16
IE75709B1 (en) 1997-09-10
US5487900A (en) 1996-01-30
DE69214704D1 (de) 1996-11-28
AU1480492A (en) 1992-10-15
AU649802B2 (en) 1994-06-02
KR100231633B1 (ko) 1999-11-15
NZ242271A (en) 1993-10-26

Similar Documents

Publication Publication Date Title
KR920019346A (ko) 비타민 d 안정제제
CA2027592A1 (en) Solid pharmaceutical preparations of active form of vitamin d_ of improved stability
ATE108647T1 (de) Arzneimittel mit langsamer wirkstofffreisetzung.
KR880000089A (ko) 서방형 약제 조성물
GR3030528T3 (en) Viscoelastic compositions of fluorinated organic compounds
DK334188A (da) Pulverformigt carotinoid- eller retinoidpraeparat
FR2779648B1 (fr) Composition cosmetique ou pharmaceutique se presentant sous forme de solide et pouvant etre deformable
NO860971L (no) Nye derivater av gamma-cyklodextrin.
ATE197397T1 (de) Mehrfache verkapselung von öllösliche verbindungen
DE3382587D1 (de) Injizierbares langwirkendes mikroteilchen-praeparat zur verabreichung entzuendungshemmender mittel.
ES2055904T3 (es) Composiciones para suministro de farmacos.
MY101847A (en) Composition for solid pharmaceutical preparations of active vitamins d 3 and process for preparation thereof.
KR900701251A (ko) 약제학적 피막 형성 조성물
ES2175073T3 (es) Procedimiento de preparacion de formas para la administracion oral de antibioticos beta-lactamicos de rapida dispersabilidad en agua.
DE69020541D1 (de) Granulate mit hohem ibuprofengehalt.
NO940523D0 (no) Nye pyrazin-derivater
KR910011241A (ko) 정제로 직접 압착 가능한 약제학적 분말 조성물을 제조하기 위한 분무 건조법
KR920012110A (ko) 산화형 글루타티온 알킬 에스테르
EA200000664A1 (ru) Фармацевтические композиции, содержащие микронизированные бициклические лекарственные средства
KR940013347A (ko) 티로신 동물 사료 프리믹스
KR930012018A (ko) 약제학적 조성물
JPS6176416A (ja) 活性型ビタミンｄ↓３誘導体のカプセル剤用組成物
KR870000925A (ko) 활성물질의 조절 및 지연 방출성을 갖는 약제학적 제제의 제조방법
KR900013945A (ko) 건조제 타블렛
ATE175870T1 (de) Pharmazeutische zubereitung zur rektalen verabreichung von pharmakologisch wirksamen verbindungen

Legal Events

Date Code Title Description
A201 Request for examination
AMND Amendment
E902 Notification of reason for refusal
AMND Amendment
E601 Decision to refuse application
J201 Request for trial against refusal decision
B701 Decision to grant
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20050829

Year of fee payment: 7

LAPS Lapse due to unpaid annual fee