ATE197397T1 - Mehrfache verkapselung von öllösliche verbindungen - Google Patents

Mehrfache verkapselung von öllösliche verbindungen

Info

Publication number
ATE197397T1
ATE197397T1 AT95924932T AT95924932T ATE197397T1 AT E197397 T1 ATE197397 T1 AT E197397T1 AT 95924932 T AT95924932 T AT 95924932T AT 95924932 T AT95924932 T AT 95924932T AT E197397 T1 ATE197397 T1 AT E197397T1
Authority
AT
Austria
Prior art keywords
polymer
oleophilic
oil soluble
soluble compounds
multiple encapsulation
Prior art date
Application number
AT95924932T
Other languages
English (en)
Inventor
Stasia Boyle
Kuei-Tu Chang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE197397T1 publication Critical patent/ATE197397T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fats And Perfumes (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Fodder In General (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Jellies, Jams, And Syrups (AREA)
  • Grain Derivatives (AREA)
  • Materials For Medical Uses (AREA)
AT95924932T 1994-07-01 1995-06-24 Mehrfache verkapselung von öllösliche verbindungen ATE197397T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26972094A 1994-07-01 1994-07-01
US08/439,787 US5938990A (en) 1994-07-01 1995-05-24 Encapsulation of oleophilic substances and compositions produced thereby
PCT/EP1995/002468 WO1996001103A1 (en) 1994-07-01 1995-06-24 Multiple encapsulation of oleophilic substances

Publications (1)

Publication Number Publication Date
ATE197397T1 true ATE197397T1 (de) 2000-11-11

Family

ID=26953853

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95924932T ATE197397T1 (de) 1994-07-01 1995-06-24 Mehrfache verkapselung von öllösliche verbindungen

Country Status (10)

Country Link
US (5) US5938990A (de)
EP (1) EP0768870B1 (de)
JP (1) JPH10502621A (de)
KR (1) KR100392215B1 (de)
CN (1) CN1141935C (de)
AT (1) ATE197397T1 (de)
DE (1) DE69519378T2 (de)
DK (1) DK0768870T3 (de)
ES (1) ES2152409T3 (de)
WO (1) WO1996001103A1 (de)

Families Citing this family (32)

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US5938990A (en) * 1994-07-01 1999-08-17 Roche Vitamins Inc. Encapsulation of oleophilic substances and compositions produced thereby
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
TW367247B (en) * 1998-02-03 1999-08-21 Otsuka Pharma Co Ltd Storage container for Vitamin D solution and transfusion container
US6303167B1 (en) * 1998-11-09 2001-10-16 Archer-Daniels-Midland Company Method of producing vitamin powders
US6770572B1 (en) 1999-01-26 2004-08-03 Alliedsignal Inc. Use of multifunctional si-based oligomer/polymer for the surface modification of nanoporous silica films
US6914073B2 (en) * 1999-03-18 2005-07-05 Bristol Myers Squibb Company Vitamin formulation for cardiovascular health
EP1106174B9 (de) * 1999-12-09 2017-05-31 DSM IP Assets B.V. Fettlösliche Vitamine enthaltende Zusammensetzungen
ES2238963T5 (es) 1999-12-09 2017-04-04 Dsm Ip Assets B.V. Composiciones que contienen vitaminas solubles en grasas
JP2001219487A (ja) * 2000-02-10 2001-08-14 Mitsubishi Heavy Ind Ltd 紙製品の製造方法及び製造装置並びに紙接合用糊及び紙接合用糊のマイクロカプセル製造方法
US8178150B2 (en) 2000-02-22 2012-05-15 Suzanne Jaffe Stillman Water containing soluble fiber
US7892586B2 (en) 2001-02-22 2011-02-22 Suzanne Jaffe Stillman Water containing soluble fiber
US7115297B2 (en) 2000-02-22 2006-10-03 Suzanne Jaffe Stillman Nutritionally fortified liquid composition with added value delivery systems/elements/additives
EP1343581A2 (de) 2000-09-27 2003-09-17 Verion Inc. Sofortige wasserlösliche kapsel und ihr herstellungsverfahren
KR100439068B1 (ko) * 2001-09-07 2004-07-05 주식회사 코리아나화장품 레티놀을 3중으로 안정화한 화장료
US7442227B2 (en) * 2001-10-09 2008-10-28 Washington Unniversity Tightly agglomerated non-oxide particles and method for producing the same
BR0215010A (pt) † 2001-12-20 2004-11-09 Nestle Sa Produto alimentar contendo comprimidos ou cápsulas de gel
US6974592B2 (en) † 2002-04-11 2005-12-13 Ocean Nutrition Canada Limited Encapsulated agglomeration of microcapsules and method for the preparation thereof
WO2003092406A1 (en) * 2002-05-02 2003-11-13 Volker Kuellmer Coated, agglomerated phytochemicals
ES2268432T3 (es) 2002-07-23 2007-03-16 Wm. Wrigley Jr. Company Sabores encapsulados y goma de mascar que emplea los mismos.
US20040115226A1 (en) * 2002-12-12 2004-06-17 Wenji Li Free-flowing solid formulations with improved bio-availability of poorly water soluble drugs and process for making the same
US20050214367A1 (en) * 2004-03-22 2005-09-29 Volker Kuellmer Processes for making coated phytochemicals and tocopherols and products formed therefrom
WO2005105040A2 (en) * 2004-04-26 2005-11-10 Micelle Products, Inc. Water-soluble formulations of fat soluble vitamins and pharmaceutical agents and their applications
US8075910B2 (en) * 2004-05-20 2011-12-13 Pbm Pharmaceuticals, Inc. Oral compositions comprising edible oils and vitamins and/or minerals and methods for making oral compositions
DE102004036437A1 (de) * 2004-07-27 2006-03-23 Röhm GmbH & Co. KG Multipartikuläre Arzneiform für wenig lösliche Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform
CN101325961A (zh) * 2005-11-28 2008-12-17 以瓦伦萨国际营业的美国营养品有限公司 藻类的和藻类提取物饮食补充组合物
US7282225B1 (en) 2006-09-27 2007-10-16 Occular Technologies, Inc. Composition and methods for improving retinal health
GB201102557D0 (en) * 2011-02-14 2011-03-30 Univ Nottingham Oil bodies
JP5752310B1 (ja) * 2014-11-18 2015-07-22 ユニ・チャーム株式会社 ペットフードの給餌方法、粒状ペットフード、およびペットフード包装体
EP3386320B1 (de) * 2015-12-10 2025-11-26 DSM IP Assets B.V. Vitaminformulierung
CN112641121B (zh) * 2020-10-10 2022-04-19 广州玖洲胶囊生物科技有限公司 一种羟丙甲基纤维素和卡拉胶的填充空心胶囊制备方法
CN112753778A (zh) * 2020-12-31 2021-05-07 大连臻鼎科技有限责任公司 一种高稳定性油脂微粒制品及其制备方法

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US4182778A (en) * 1978-05-17 1980-01-08 General Foods Corporation Encapsulation of vitamin and mineral nutrients
JPS574916A (en) * 1980-05-28 1982-01-11 Furointo Sangyo Kk Activation of medical preparation
US4389419A (en) * 1980-11-10 1983-06-21 Damon Corporation Vitamin encapsulation
US4415703A (en) * 1981-01-13 1983-11-15 Daicel Chemical Industries, Ltd. Aqueous dispersion of a cellulose derivative
DE3135329A1 (de) * 1981-09-05 1983-03-24 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von trockenpulvern oxidationsempfindlicher substanzen
US5008254A (en) * 1982-09-03 1991-04-16 Weibel Michael K Sugar beet pectins and their use in comestibles
US4537783A (en) * 1983-04-20 1985-08-27 The Procter & Gamble Company Control of particle size distribution during continuous heat-setting of meat analog
US4670247A (en) * 1983-07-05 1987-06-02 Hoffman-Laroche Inc. Process for preparing fat-soluble vitamin active beadlets
IE59287B1 (en) * 1984-02-10 1994-02-09 Benzon Pharma As Diffusion coated multiple-units dosage form
US4826689A (en) * 1984-05-21 1989-05-02 University Of Rochester Method for making uniformly sized particles from water-insoluble organic compounds
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US4861627A (en) * 1987-05-01 1989-08-29 Massachusetts Institute Of Technology Preparation of multiwall polymeric microcapsules
US5051261A (en) * 1987-11-24 1991-09-24 Fmc Corporation Method for preparing a solid sustained release form of a functionally active composition
US4898734A (en) * 1988-02-29 1990-02-06 Massachusetts Institute Of Technology Polymer composite for controlled release or membrane formation
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FR2663222A1 (fr) * 1990-06-13 1991-12-20 Medgenix Group Sa Microcapsule de liquide huileux.
ATE117202T1 (de) * 1991-01-28 1995-02-15 Hoffmann La Roche Vitamin enthaltende formulierungen und deren herstellung.
US5223268A (en) * 1991-05-16 1993-06-29 Sterling Drug, Inc. Low solubility drug-coated bead compositions
EP0595030A3 (de) * 1992-10-01 1995-06-07 Tanabe Seiyaku Co Mehrkern-Mikrosphären mit verzögerter Wirkstoffabgabe und Verfahren zu deren Herstellung.
ES2068762B1 (es) * 1993-07-21 1995-12-01 Lipotec Sa Un nuevo preparado farmaceutico para mejorar la biodisponibilidad de drogas de dificil absorcion y procedimiento para su obtencion.
US5938990A (en) * 1994-07-01 1999-08-17 Roche Vitamins Inc. Encapsulation of oleophilic substances and compositions produced thereby

Also Published As

Publication number Publication date
DE69519378T2 (de) 2001-07-19
ES2152409T3 (es) 2001-02-01
CN1151694A (zh) 1997-06-11
US5938990A (en) 1999-08-17
EP0768870B1 (de) 2000-11-08
CN1141935C (zh) 2004-03-17
WO1996001103A1 (en) 1996-01-18
US6146825A (en) 2000-11-14
KR100392215B1 (ko) 2003-11-20
US6150086A (en) 2000-11-21
KR970703755A (ko) 1997-08-09
US5925381A (en) 1999-07-20
DE69519378D1 (de) 2000-12-14
JPH10502621A (ja) 1998-03-10
DK0768870T3 (da) 2001-02-05
US6001554A (en) 1999-12-14
EP0768870A1 (de) 1997-04-23

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Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee