ES2152409T3 - Encapsulado multiple de sustancias oleofilicas. - Google Patents

Encapsulado multiple de sustancias oleofilicas.

Info

Publication number
ES2152409T3
ES2152409T3 ES95924932T ES95924932T ES2152409T3 ES 2152409 T3 ES2152409 T3 ES 2152409T3 ES 95924932 T ES95924932 T ES 95924932T ES 95924932 T ES95924932 T ES 95924932T ES 2152409 T3 ES2152409 T3 ES 2152409T3
Authority
ES
Spain
Prior art keywords
polymer
oleophilic
cross
oleophilic substance
substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95924932T
Other languages
English (en)
Inventor
Stasia Boyle
Kuei-Tu Chang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2152409T3 publication Critical patent/ES2152409T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fats And Perfumes (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Materials For Medical Uses (AREA)
  • Fodder In General (AREA)

Abstract

METODO PARA PRODUCIR UNA COMPOSICION DE UNA SUSTANCIA OLEOFILICA ENCAPSULADA POR UN POLIMERO QUE SUPONE (A) LA INCORPORACION DE UNA SUSTANCIA OLEOFILICA EN UNA SOLUCION QUE CONTIENE UN POLIMERO PRIMARIO Y (B) LA SOLIDIFICACION DEL POLIMERO PRIMARIO BAJO CONDICIONES DE MEZCLA PARA ENCAPSULAR LA SUSTANCIA OLEOFILICA EN EL POLIMERO (PRIMARIO); Y OPCIONALMENTE (C) LA MEZCLA DE LA SUSTANCIA OLEOFILICA ENCAPSULADA POR UN POLIMERO PRIMARIO ASI PRODUCIDA COMO PARTICULA CON UN POLIMERO MAS (SECUNDARIO) PARA ENCAPSULAR LAS PARTICULAS DE LA SUSTANCIA OLEOFILICA ENCAPSULADAS POR UN POLIMERO PRIMARIO EN UN POLIMERO SECUNDARIO, Y, TAMBIEN OPCIONALMENTE (D) LA MEZCLA DE LAS PARTICULAS DE LA SUSTANCIA OLEOFILICA ENCAPSULADA POR LOS POLIMEROS PRIMARIO Y SECUNDARIO ASI PRODUCIDAS CON OTRO POLIMERO (TERCIARIO) PARA CONSEGUIR UNA NUEVA ENCAPSULACION. LA COMPOSICION PREFERIBLEMENTE CONTIENE LA SUSTANCIA OLEOFILICA, P.E. VITAMINA A, D, E O K O DERIVADO DE ESTAS, EN UNA CANTIDAD QUE OSCILA ENTRE EL 30% Y EL 90% DE PESO, Y PUEDE ADEMAS CONVERTIRSE COMO MATERIAL PARTICULADO DE LIBRE CIRCULACION EN COMPRIMIDOS, CAPSULAS, PREMEZCLAS, SUSPENSIONES, EMULSIONES, ETC, QUE TIENEN UTILIDAD EN LA ALIMENTACION HUMANA Y ANIMAL Y EN APLICACIONES FARMACEUTICAS.
ES95924932T 1994-07-01 1995-06-24 Encapsulado multiple de sustancias oleofilicas. Expired - Lifetime ES2152409T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26972094A 1994-07-01 1994-07-01
US08/439,787 US5938990A (en) 1994-07-01 1995-05-24 Encapsulation of oleophilic substances and compositions produced thereby

Publications (1)

Publication Number Publication Date
ES2152409T3 true ES2152409T3 (es) 2001-02-01

Family

ID=26953853

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95924932T Expired - Lifetime ES2152409T3 (es) 1994-07-01 1995-06-24 Encapsulado multiple de sustancias oleofilicas.

Country Status (10)

Country Link
US (5) US5938990A (es)
EP (1) EP0768870B1 (es)
JP (1) JPH10502621A (es)
KR (1) KR100392215B1 (es)
CN (1) CN1141935C (es)
AT (1) ATE197397T1 (es)
DE (1) DE69519378T2 (es)
DK (1) DK0768870T3 (es)
ES (1) ES2152409T3 (es)
WO (1) WO1996001103A1 (es)

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GB9325445D0 (en) 1993-12-13 1994-02-16 Cortecs Ltd Pharmaceutical formulations
US5938990A (en) * 1994-07-01 1999-08-17 Roche Vitamins Inc. Encapsulation of oleophilic substances and compositions produced thereby
TW367247B (en) * 1998-02-03 1999-08-21 Otsuka Pharma Co Ltd Storage container for Vitamin D solution and transfusion container
US6303167B1 (en) * 1998-11-09 2001-10-16 Archer-Daniels-Midland Company Method of producing vitamin powders
US6770572B1 (en) 1999-01-26 2004-08-03 Alliedsignal Inc. Use of multifunctional si-based oligomer/polymer for the surface modification of nanoporous silica films
US6914073B2 (en) * 1999-03-18 2005-07-05 Bristol Myers Squibb Company Vitamin formulation for cardiovascular health
DE60019239T3 (de) 1999-12-09 2017-03-02 Dsm Ip Assets B.V. Fettlösliche Vitamine enthaltende Zusammensetzungen
DK1106174T4 (en) * 1999-12-09 2017-01-23 Dsm Ip Assets Bv Compositions containing fat-soluble vitamins
JP2001219487A (ja) * 2000-02-10 2001-08-14 Mitsubishi Heavy Ind Ltd 紙製品の製造方法及び製造装置並びに紙接合用糊及び紙接合用糊のマイクロカプセル製造方法
US8178150B2 (en) 2000-02-22 2012-05-15 Suzanne Jaffe Stillman Water containing soluble fiber
US7892586B2 (en) 2001-02-22 2011-02-22 Suzanne Jaffe Stillman Water containing soluble fiber
JP2004509739A (ja) 2000-09-27 2004-04-02 ベリオン　インコーポレイテッド 即時水溶解性カプセルおよびその製法
KR100439068B1 (ko) * 2001-09-07 2004-07-05 주식회사 코리아나화장품 레티놀을 3중으로 안정화한 화장료
US7442227B2 (en) * 2001-10-09 2008-10-28 Washington Unniversity Tightly agglomerated non-oxide particles and method for producing the same
ES2355135T5 (es) † 2001-12-20 2015-09-16 Société des Produits Nestlé S.A. Un producto alimenticio que contiene cápsulas o comprimidos de gel
US6974592B2 (en) † 2002-04-11 2005-12-13 Ocean Nutrition Canada Limited Encapsulated agglomeration of microcapsules and method for the preparation thereof
EP1503632A1 (en) * 2002-05-02 2005-02-09 Volker Kuellmer Coated, agglomerated phytochemicals
DE60308405T2 (de) 2002-07-23 2007-03-08 Wm. Wrigley Jr. Comp., Chicago Verkapselte aromastoffe und kaugummi damit
US20040115226A1 (en) * 2002-12-12 2004-06-17 Wenji Li Free-flowing solid formulations with improved bio-availability of poorly water soluble drugs and process for making the same
US20050214367A1 (en) * 2004-03-22 2005-09-29 Volker Kuellmer Processes for making coated phytochemicals and tocopherols and products formed therefrom
WO2005105040A2 (en) * 2004-04-26 2005-11-10 Micelle Products, Inc. Water-soluble formulations of fat soluble vitamins and pharmaceutical agents and their applications
US8075910B2 (en) * 2004-05-20 2011-12-13 Pbm Pharmaceuticals, Inc. Oral compositions comprising edible oils and vitamins and/or minerals and methods for making oral compositions
DE102004036437A1 (de) * 2004-07-27 2006-03-23 Röhm GmbH & Co. KG Multipartikuläre Arzneiform für wenig lösliche Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform
AU2006318357B2 (en) * 2005-11-28 2009-09-24 U.S. Nutraceuticals Llc Dba Valensa International Algal and algal extract dietary supplement composition
US7282225B1 (en) 2006-09-27 2007-10-16 Occular Technologies, Inc. Composition and methods for improving retinal health
GB201102557D0 (en) * 2011-02-14 2011-03-30 Univ Nottingham Oil bodies
CN108366605A (zh) * 2015-12-10 2018-08-03 帝斯曼知识产权资产管理有限公司 维生素制剂
CN112641121B (zh) * 2020-10-10 2022-04-19 广州玖洲胶囊生物科技有限公司 一种羟丙甲基纤维素和卡拉胶的填充空心胶囊制备方法
CN112753778A (zh) * 2020-12-31 2021-05-07 大连臻鼎科技有限责任公司 一种高稳定性油脂微粒制品及其制备方法

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US4182778A (en) * 1978-05-17 1980-01-08 General Foods Corporation Encapsulation of vitamin and mineral nutrients
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US5008254A (en) * 1982-09-03 1991-04-16 Weibel Michael K Sugar beet pectins and their use in comestibles
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EP0595030A3 (en) * 1992-10-01 1995-06-07 Tanabe Seiyaku Co Composition of microspheres with several delayed release nuclei and its preparation process.
ES2068762B1 (es) * 1993-07-21 1995-12-01 Lipotec Sa Un nuevo preparado farmaceutico para mejorar la biodisponibilidad de drogas de dificil absorcion y procedimiento para su obtencion.
US5938990A (en) * 1994-07-01 1999-08-17 Roche Vitamins Inc. Encapsulation of oleophilic substances and compositions produced thereby

Also Published As

Publication number Publication date
WO1996001103A1 (en) 1996-01-18
US6146825A (en) 2000-11-14
KR970703755A (ko) 1997-08-09
DE69519378T2 (de) 2001-07-19
US5938990A (en) 1999-08-17
DK0768870T3 (da) 2001-02-05
CN1151694A (zh) 1997-06-11
US6001554A (en) 1999-12-14
EP0768870B1 (en) 2000-11-08
JPH10502621A (ja) 1998-03-10
EP0768870A1 (en) 1997-04-23
KR100392215B1 (ko) 2003-11-20
US6150086A (en) 2000-11-21
ATE197397T1 (de) 2000-11-11
CN1141935C (zh) 2004-03-17
DE69519378D1 (de) 2000-12-14
US5925381A (en) 1999-07-20

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