|
CA1270837A
(en)
*
|
1984-12-21 |
1990-06-26 |
Hoffmann-La Roche Limited |
Oxetanones
|
|
CA1328881C
(en)
*
|
1984-12-21 |
1994-04-26 |
Pierre Barbier |
Process for the manufacture of oxetanones
|
|
ZA859574B
(en)
*
|
1984-12-21 |
1986-08-27 |
Hoffmann La Roche |
Process for the manufacture of oxetanones
|
|
JPH0618793Y2
(ja)
*
|
1986-06-13 |
1994-05-18 |
パイオニア株式会社 |
作業台
|
|
US4816477A
(en)
*
|
1987-05-26 |
1989-03-28 |
Merck & Co., Inc. |
Antihypercholesterolemic β-lactones
|
|
US4806564A
(en)
*
|
1987-05-26 |
1989-02-21 |
Merck & Co., Inc. |
Antihypercholesterolemic beta-lactones
|
|
US5484777A
(en)
*
|
1989-04-20 |
1996-01-16 |
Lange, Iii; Louis G. |
Pancreatic cholesterol esterase inhibitor
|
|
US5017565A
(en)
*
|
1989-04-20 |
1991-05-21 |
Lange Iii Louis G |
Use of sulfated polysaccharides to inhibit pancreatic cholesterol esterase
|
|
US5063210A
(en)
*
|
1989-04-20 |
1991-11-05 |
Lange Iii Louis G |
Use of sulfated polysaccharides to decrease cholesterol and fatty acid absorption
|
|
JP2960947B2
(ja)
*
|
1989-12-25 |
1999-10-12 |
日清製粉株式会社 |
脂質分解酵素阻害剤
|
|
US5376640A
(en)
*
|
1989-12-25 |
1994-12-27 |
Nisshin Flour Milling Co., Ltd. |
Lipolytic enzyme inhibitors
|
|
CA2098167C
(en)
*
|
1992-06-24 |
2006-12-19 |
Dorothea Isler |
Foodstuffs and feedstuffs containing a lipase inhibitor
|
|
CA2128044C
(en)
*
|
1993-08-05 |
2007-02-20 |
Klaus-Dieter Bremer |
Pharmaceutical compositions comprising a glucosidase and/or amylase inhibitor, and a lipase inhibitor
|
|
US6262277B1
(en)
|
1994-09-13 |
2001-07-17 |
G.D. Searle And Company |
Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
|
|
US6268392B1
(en)
|
1994-09-13 |
2001-07-31 |
G. D. Searle & Co. |
Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
|
|
US6642268B2
(en)
|
1994-09-13 |
2003-11-04 |
G.D. Searle & Co. |
Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
|
|
MY116591A
(en)
*
|
1996-04-26 |
2004-02-28 |
Hoffmann La Roche |
Process for the production of lipstatin and tetrahydrolipstatin
|
|
KR100479968B1
(ko)
*
|
1997-02-05 |
2005-03-30 |
에프. 호프만-라 로슈 아게 |
위장 리파아제 억제제의 용도
|
|
US6004996A
(en)
*
|
1997-02-05 |
1999-12-21 |
Hoffman-La Roche Inc. |
Tetrahydrolipstatin containing compositions
|
|
US7344713B1
(en)
*
|
1997-07-07 |
2008-03-18 |
Pimentel Julio L |
Decreased fat absorption with an anti-lipase antibody
|
|
RU2234917C2
(ru)
*
|
1997-12-24 |
2004-08-27 |
Кнолль Акциенгезелльшафт |
Терапевтические средства
|
|
GB9727131D0
(en)
*
|
1997-12-24 |
1998-02-25 |
Knoll Ag |
Therapeutic agents
|
|
US6299868B1
(en)
|
1999-07-14 |
2001-10-09 |
Geltex Pharmaceuticals, Inc. |
Fat-binding polymers
|
|
US6264937B1
(en)
|
1998-01-09 |
2001-07-24 |
Geltex Pharmaceuticals, Inc. |
Fat-binding polymers
|
|
US7048917B1
(en)
|
1998-01-09 |
2006-05-23 |
Genzyme Corporation |
Fat-binding polymers
|
|
KR20010079635A
(ko)
|
1998-08-14 |
2001-08-22 |
프리돌린 클라우스너, 롤란드 비. 보레르 |
리파아제 저해제를 함유하는 약학 조성물
|
|
KR20010079636A
(ko)
*
|
1998-08-14 |
2001-08-22 |
프리돌린 클라우스너, 롤란드 비. 보레르 |
라이페이즈 저해제 및 키토산을 포함하는 약학 조성물
|
|
KR20010102965A
(ko)
|
1998-12-23 |
2001-11-17 |
윌리암스 로저 에이 |
심장혈관의 징후에 대한 회장 담즙산 수송 저해제 및담즙산 격리제의 병용
|
|
JP2002533413A
(ja)
|
1998-12-23 |
2002-10-08 |
ジー.ディー.サール エルエルシー |
心臓血管に適用するための回腸胆汁酸輸送阻害剤およびフィブリン酸誘導体の組み合わせ
|
|
ATE242007T1
(de)
|
1998-12-23 |
2003-06-15 |
Searle Llc |
Kombinationen von cholesteryl ester transfer protein inhibitoren und nicotinsäure derivaten für kardiovaskuläre indikationen
|
|
US6462091B1
(en)
|
1998-12-23 |
2002-10-08 |
G.D. Searle & Co. |
Combinations of cholesteryl ester transfer protein inhibitors and HMG coA reductase inhibitors for cardiovascular indications
|
|
DK1140185T3
(da)
|
1998-12-23 |
2003-09-29 |
Searle Llc |
Kombinationer af cholesterylestertransferhæmmere og galdesyre kompleksdannende forbindelser til hjertekar indikationer
|
|
KR20010099937A
(ko)
|
1998-12-23 |
2001-11-09 |
윌리암스 로저 에이 |
심혈관 징후용 콜레스테릴 에스테르 전달 단백질 억제제및 피브르산 유도체의 조합물
|
|
EP1342475A1
(en)
|
1998-12-23 |
2003-09-10 |
G.D. Searle LLC. |
Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications
|
|
DE60000796T2
(de)
*
|
1999-01-29 |
2003-09-18 |
F. Hoffmann-La Roche Ag, Basel |
Reinigung von Lipstatin
|
|
CA2379308A1
(en)
*
|
1999-07-14 |
2001-01-25 |
Geltex Pharmaceuticals, Inc. |
Fat-binding polymers, optionally combined with lipase inhibitors
|
|
AR025609A1
(es)
*
|
1999-09-13 |
2002-12-04 |
Hoffmann La Roche |
Formulaciones lipidas solidas
|
|
AR025587A1
(es)
*
|
1999-09-13 |
2002-12-04 |
Hoffmann La Roche |
Formulaciones en dispersion que contienen inhibidores de lipasa
|
|
EP1132389A1
(en)
|
2000-03-06 |
2001-09-12 |
Vernalis Research Limited |
New aza-indolyl derivatives for the treatment of obesity
|
|
AU2001240115A1
(en)
|
2000-03-10 |
2001-09-24 |
Pharmacia Corporation |
Method for the preparation of tetrahydrobenzothiepines
|
|
DE10021618A1
(de)
*
|
2000-05-04 |
2001-11-15 |
Volker Helmstaedter |
Präparat für Darmerkrankungen und dessen Verwendung
|
|
EP1142572A1
(de)
*
|
2000-04-04 |
2001-10-10 |
Volker Dr. Helmstädter |
Oxetanon-enthaltende Präparate zur Behandlung von Darmerkrankungen
|
|
MXPA02012583A
(es)
*
|
2000-06-27 |
2003-04-10 |
Hoffmann La Roche |
Metodo para preparacion de una composicion.
|
|
JP4265911B2
(ja)
*
|
2000-07-28 |
2009-05-20 |
エフ.ホフマン−ラ ロシュ アーゲー |
新規医薬組成物
|
|
ATE293477T1
(de)
*
|
2000-07-28 |
2005-05-15 |
Hoffmann La Roche |
Neue verwendung von lipase-inhibitoren
|
|
DE60133470T2
(de)
|
2000-08-09 |
2009-05-07 |
F. Hoffmann-La Roche Ag |
Lipase inhibitoren zur behandlung von dyspepsia
|
|
US6900226B2
(en)
*
|
2000-09-06 |
2005-05-31 |
Hoffman-La Roche Inc. |
Neuropeptide Y antagonists
|
|
JP4047723B2
(ja)
|
2000-10-16 |
2008-02-13 |
エフ.ホフマン−ラ ロシュ アーゲー |
インドリン誘導体、および5−ht2受容体リガンドとしてのその使用
|
|
GB0030710D0
(en)
*
|
2000-12-15 |
2001-01-31 |
Hoffmann La Roche |
Piperazine derivatives
|
|
US6610685B2
(en)
|
2000-12-27 |
2003-08-26 |
Hoffmann-La Roche Inc. |
Fused indole derivatives
|
|
GB0106177D0
(en)
*
|
2001-03-13 |
2001-05-02 |
Hoffmann La Roche |
Piperazine derivatives
|
|
US20030072804A1
(en)
*
|
2001-03-19 |
2003-04-17 |
The Procter & Gamble Company |
Use of non-digestible polymeric foams to sequester ingested materials thereby inhibiting their absorption by the body
|
|
US20030091610A1
(en)
*
|
2001-03-19 |
2003-05-15 |
The Procter & Gamble Company |
Use of non-digestible polymeric foams to sequester ingested materials thereby inhibiting their absorption by the body
|
|
AU2002338896B2
(en)
*
|
2001-05-21 |
2006-04-27 |
F.Hoffman-La Roche Ag |
Quinoline derivatives as ligands for the neuropeptide Y receptor
|
|
US6730319B2
(en)
|
2001-06-06 |
2004-05-04 |
Hoffmann-La Roche Inc. |
Pharmaceutical compositions having depressed melting points
|
|
US20030027786A1
(en)
|
2001-06-06 |
2003-02-06 |
Karsten Maeder |
Lipase inhibiting composition
|
|
US7041280B2
(en)
*
|
2001-06-29 |
2006-05-09 |
Genzyme Corporation |
Aryl boronate functionalized polymers for treating obesity
|
|
US7049345B2
(en)
|
2001-06-29 |
2006-05-23 |
Genzyme Corporation |
Fat-binding polymers
|
|
HUP0401298A3
(en)
|
2001-08-30 |
2008-03-28 |
Alizyme Therapeutics Ltd |
Thieno [1,3] oxazin-4-ones with lipase inhibiting activity, process for their preparation and pharmaceutical compositions containing them
|
|
US6787558B2
(en)
*
|
2001-09-28 |
2004-09-07 |
Hoffmann-La Roche Inc. |
Quinoline derivatives
|
|
US20110033542A1
(en)
|
2009-08-07 |
2011-02-10 |
Monosol Rx, Llc |
Sublingual and buccal film compositions
|
|
US8603514B2
(en)
|
2002-04-11 |
2013-12-10 |
Monosol Rx, Llc |
Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
|
|
US8765167B2
(en)
|
2001-10-12 |
2014-07-01 |
Monosol Rx, Llc |
Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
|
|
US11207805B2
(en)
|
2001-10-12 |
2021-12-28 |
Aquestive Therapeutics, Inc. |
Process for manufacturing a resulting pharmaceutical film
|
|
US8900497B2
(en)
|
2001-10-12 |
2014-12-02 |
Monosol Rx, Llc |
Process for making a film having a substantially uniform distribution of components
|
|
US7357891B2
(en)
|
2001-10-12 |
2008-04-15 |
Monosol Rx, Llc |
Process for making an ingestible film
|
|
US20070281003A1
(en)
|
2001-10-12 |
2007-12-06 |
Fuisz Richard C |
Polymer-Based Films and Drug Delivery Systems Made Therefrom
|
|
US8900498B2
(en)
|
2001-10-12 |
2014-12-02 |
Monosol Rx, Llc |
Process for manufacturing a resulting multi-layer pharmaceutical film
|
|
US20190328679A1
(en)
|
2001-10-12 |
2019-10-31 |
Aquestive Therapeutics, Inc. |
Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
|
|
US10285910B2
(en)
|
2001-10-12 |
2019-05-14 |
Aquestive Therapeutics, Inc. |
Sublingual and buccal film compositions
|
|
GB0125659D0
(en)
*
|
2001-10-25 |
2001-12-19 |
Ssl Int Plc |
Spermicides
|
|
JP2005518347A
(ja)
|
2001-11-02 |
2005-06-23 |
ジー.ディー. サール エルエルシー |
頂端ナトリウム共依存性胆汁酸輸送(asbt)およびタウロコール酸塩取り込みの阻害剤としての新規一および二フッ化ベンゾチエピン化合物
|
|
AU2002362061A1
(en)
|
2001-12-04 |
2003-06-17 |
Biogal Gyogyszergyar Rt |
Preparation of orlistat and orlistat crystalline forms
|
|
EP1458882A2
(en)
|
2001-12-04 |
2004-09-22 |
Biogal Gyogyszergyar Rt. |
A fermentation process for lipstatin and method of extracting lipstatin from a fermentation broth
|
|
EA009368B1
(ru)
|
2001-12-20 |
2007-12-28 |
Оси Фармасьютикалз, Инк. |
Соединения-ингибиторы липазы поджелудочной железы, их синтез и применение
|
|
EP1465885A4
(en)
|
2002-01-17 |
2005-04-27 |
Pharmacia Corp |
NOVEL ALKYL / ARYL HYDROXY OR CETOTHIEPINE COMPOUNDS AS INHIBITORS OF BILIARY ACID TRANSPORT OF THE ILEAL TYPE AND ABSORPTION OF TAUROCHOLATE
|
|
GB0202015D0
(en)
*
|
2002-01-29 |
2002-03-13 |
Hoffmann La Roche |
Piperazine Derivatives
|
|
CN100383124C
(zh)
*
|
2002-02-04 |
2008-04-23 |
霍夫曼-拉罗奇有限公司 |
作为npy拮抗剂的喹啉衍生物
|
|
PL372463A1
(en)
*
|
2002-02-28 |
2005-07-25 |
F.Hoffmann-La Roche Ag |
Thiazole derivatives as npy receptor antagonists
|
|
WO2003088975A1
(en)
*
|
2002-04-17 |
2003-10-30 |
The Burnham Institute |
Inhibition of fatty acid synthase by beta-lactones and other compounds for inhibition of cellular proliferation
|
|
US7728153B2
(en)
*
|
2002-04-17 |
2010-06-01 |
The Burnham Institute For Medical Research |
Method for the asymmetric synthesis of beta-lactone compounds
|
|
CN1325050C
(zh)
*
|
2002-04-26 |
2007-07-11 |
霍夫曼-拉罗奇有限公司 |
包含脂肪酶抑制剂和葡甘露聚糖的药物组合物
|
|
US7105526B2
(en)
|
2002-06-28 |
2006-09-12 |
Banyu Pharmaceuticals Co., Ltd. |
Benzimidazole derivatives
|
|
CN1665791A
(zh)
*
|
2002-07-05 |
2005-09-07 |
霍夫曼-拉罗奇有限公司 |
喹唑啉衍生物
|
|
RU2324685C2
(ru)
*
|
2002-08-07 |
2008-05-20 |
Ф.Хоффманн-Ля Рош Аг |
Производные тиазола, способ их получения и применение, фармацевтическая композиция, обладающая свойствами антагонистов рецепторов npy
|
|
PL375878A1
(en)
*
|
2002-09-12 |
2005-12-12 |
F.Hoffmann-La Roche Ag |
N-substituted-1h-indol-5-propionic acid compounds as ppar agonists useful for the treatment of diabetes
|
|
BR0316556A
(pt)
*
|
2002-11-25 |
2005-10-04 |
Hoffmann La Roche |
Compostos, processo para a preparação de um composto, composição farmacêutica que compreende esse composto, sua utilização e método para o tratamento e/ou profilaxia de enfermidades que são moduladas por agonistas ppar(alfa) e/ou ppary
|
|
US8372430B2
(en)
|
2002-12-17 |
2013-02-12 |
The Procter & Gamble Company |
Compositions, methods, and kits useful for the alleviation of gastrointestinal effects
|
|
US7772188B2
(en)
|
2003-01-28 |
2010-08-10 |
Ironwood Pharmaceuticals, Inc. |
Methods and compositions for the treatment of gastrointestinal disorders
|
|
US20040178058A1
(en)
*
|
2003-03-10 |
2004-09-16 |
Hsueh-Chung Chen |
Electro-chemical deposition apparatus and method of preventing cavities in an ECD copper film
|
|
EP1457206A1
(en)
*
|
2003-03-13 |
2004-09-15 |
Fournier Laboratories Ireland Limited |
Combined use of a fibrate and orlistat for the treatment of obesity
|
|
CA2526730A1
(en)
*
|
2003-05-30 |
2004-12-09 |
Ranbaxy Laboratories Limited |
Substituted pyrrole derivatives
|
|
WO2004113314A1
(en)
*
|
2003-06-23 |
2004-12-29 |
Biocon Limited |
Novel boronate esters
|
|
GB0314967D0
(en)
*
|
2003-06-26 |
2003-07-30 |
Hoffmann La Roche |
Piperazine derivatives
|
|
US20060025337A1
(en)
*
|
2003-07-01 |
2006-02-02 |
President And Fellows Of Harvard College |
Sirtuin related therapeutics and diagnostics for neurodegenerative diseases
|
|
AU2003253254A1
(en)
*
|
2003-07-17 |
2005-02-04 |
Biocon Limited |
Preparation of tetrahydrolipstatin by hydrogenation of lipstatin, solvent extraction and purification
|
|
DE602004019939D1
(de)
*
|
2003-08-12 |
2009-04-23 |
Hoffmann La Roche |
Thiazolderivate als npy-antagonisten
|
|
KR20060037435A
(ko)
*
|
2003-08-12 |
2006-05-03 |
에프. 호프만-라 로슈 아게 |
2-아미노-5-벤조일싸이아졸 npy 길항물질
|
|
US20050239859A2
(en)
*
|
2003-09-03 |
2005-10-27 |
Solvay Pharmaceuticals Gmbh |
Novel medical uses of 4,5-dihydro-1h-pyrazole derivatives having cb1- antagonistic activity
|
|
EP1669350B1
(en)
|
2003-09-22 |
2012-02-29 |
Msd K.K. |
Piperidine derivatives
|
|
US20050124660A1
(en)
*
|
2003-10-27 |
2005-06-09 |
Jochen Antel |
Novel medical uses of compounds showing CB1-antagonistic activity and combination treatment involving said compounds
|
|
US20050143441A1
(en)
*
|
2003-10-27 |
2005-06-30 |
Jochen Antel |
Novel medical combination treatment of obesity involving 4,5-dihydro-1H-pyrazole derivatives having CB1-antagonistic activity
|
|
JP2007512359A
(ja)
|
2003-11-19 |
2007-05-17 |
メタバシス・セラピューティクス・インコーポレイテッド |
新規なリン含有甲状腺ホルモン様物質
|
|
US8017634B2
(en)
|
2003-12-29 |
2011-09-13 |
President And Fellows Of Harvard College |
Compositions for treating obesity and insulin resistance disorders
|
|
CA2548671C
(en)
*
|
2003-12-29 |
2015-02-24 |
President And Fellows Of Harvard College |
Compositions for treating or preventing obesity and insulin resistance disorders
|
|
PL209905B1
(pl)
*
|
2004-01-15 |
2011-11-30 |
Bringwell Internat Ab |
Preparat do leczenia otyłości i związanego z nią syndromu metabolicznego
|
|
US20070191495A1
(en)
*
|
2004-01-16 |
2007-08-16 |
Fuji Oil Company, Limited |
Lipase inhibitor
|
|
US7074822B2
(en)
|
2004-02-23 |
2006-07-11 |
Solvay Pharmaceuticals Gmbh |
Alkyl carbamate-substituted β-lactones, process for their preparation, and pharmaceutical compositions containing them
|
|
US20080125403A1
(en)
|
2004-04-02 |
2008-05-29 |
Merck & Co., Inc. |
Method of Treating Men with Metabolic and Anthropometric Disorders
|
|
AU2005239788A1
(en)
|
2004-05-10 |
2005-11-17 |
University Of Copenhagen |
Flaxseeds for body weight management
|
|
EP1771162B1
(en)
*
|
2004-07-19 |
2013-06-05 |
Xenia Pharma |
Capsaicin inhibitors for the treatment of obesity-related disorders
|
|
JP2008517976A
(ja)
|
2004-10-25 |
2008-05-29 |
ゾルファイ ファーマスーティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Cb1カンナビノイド受容体拮抗薬及びカリウムチャンネルオープナーから成る、真性糖尿病1型、肥満及び関連症状の治療用の医薬組成物
|
|
MX2007005137A
(es)
*
|
2004-11-23 |
2007-06-22 |
Warner Lambert Co |
Derivados del acido 7-(2h-pyrazol-3-il)-3, 5-dihidroxi-heptanoico como inhibidores de hmg co-a reductasa para el tratamiento de lipidemia.
|
|
US20060246141A1
(en)
*
|
2005-04-12 |
2006-11-02 |
Elan Pharma International, Limited |
Nanoparticulate lipase inhibitor formulations
|
|
CA2609634C
(en)
*
|
2005-05-03 |
2011-02-01 |
F. Hoffmann-La Roche Ag |
Tetracyclic azapyrazinoindolines as 5-ht2 ligands
|
|
EP1892241B1
(en)
|
2005-05-30 |
2016-03-30 |
Msd K.K. |
Novel piperidine derivative
|
|
WO2006138418A2
(en)
*
|
2005-06-14 |
2006-12-28 |
President And Fellows Of Harvard College |
Improvement of cognitive performance with sirtuin activators
|
|
US20070149466A1
(en)
*
|
2005-07-07 |
2007-06-28 |
Michael Milburn |
Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders
|
|
JPWO2007018248A1
(ja)
|
2005-08-10 |
2009-02-19 |
萬有製薬株式会社 |
ピリドン化合物
|
|
EP1945635B1
(en)
*
|
2005-08-18 |
2009-05-06 |
F.Hoffmann-La Roche Ag |
Thiazolyl piperidine derivatives useful as h3 receptor modulators
|
|
JPWO2007024004A1
(ja)
|
2005-08-24 |
2009-03-05 |
萬有製薬株式会社 |
フェニルピリドン誘導体
|
|
US20090264426A1
(en)
|
2005-09-07 |
2009-10-22 |
Shunji Sakuraba |
Bicyclic aromatic substituted pyridone derivative
|
|
US7355055B2
(en)
*
|
2005-09-08 |
2008-04-08 |
Reliance Life Sciences Pvt. Ltd. |
Compounds for treatment of lipase-mediated diseases
|
|
US7741317B2
(en)
|
2005-10-21 |
2010-06-22 |
Bristol-Myers Squibb Company |
LXR modulators
|
|
WO2007048027A2
(en)
|
2005-10-21 |
2007-04-26 |
Novartis Ag |
Combination of a renin-inhibitor and an anti-dyslipidemic agent and/or an antiobesity agent
|
|
WO2007049798A1
(ja)
|
2005-10-27 |
2007-05-03 |
Banyu Pharmaceutical Co., Ltd. |
新規ベンゾオキサチイン誘導体
|
|
JP2009514851A
(ja)
*
|
2005-11-08 |
2009-04-09 |
ランバクシー ラボラトリーズ リミテッド |
(3r,5r)−7−[2−(4−フルオロフェニル)−5−イソプロピル−3−フェニル−4−[(4−ヒドロキシメチルフェニルアミノ)カルボニル]−ピロール−1−イル]−3,5−ジヒドロキシ−ヘプタン酸ヘミカルシウム塩の製法
|
|
CA2629018C
(en)
|
2005-11-10 |
2013-12-31 |
Banyu Pharmaceutical Co., Ltd. |
Aza-substituted spiro derivative
|
|
US7888376B2
(en)
|
2005-11-23 |
2011-02-15 |
Bristol-Myers Squibb Company |
Heterocyclic CETP inhibitors
|
|
CA2630270A1
(en)
*
|
2005-11-30 |
2007-06-07 |
F. Hoffmann-La Roche Ag |
5-substituted indole-2-carboxamide derivatives
|
|
BRPI0619268A2
(pt)
*
|
2005-11-30 |
2011-09-20 |
Hoffmann La Roche |
compostos, processo para a sua manufatura, composições farmacêuticas, método para o tratamento e/ou prevenção de enfermidades que estão associadas com a modulação de receptores de h3, uso dos compostos e método para o tratamento ou prevenção de obesidade e de diabetes do tipo ii em um ser humano ou animal
|
|
RU2412182C2
(ru)
*
|
2005-11-30 |
2011-02-20 |
Ф.Хоффманн-Ля Рош Аг |
Производные 1,1-диоксотиоморфолинилиндолилметанона для применения в качестве модуляторов гистамина 3 (н3)
|
|
CA2631128A1
(en)
*
|
2005-12-09 |
2007-06-14 |
F. Hoffmann-La Roche Ag |
Tricyclic amide derivatives useful for treating obesity
|
|
DE602006010738D1
(de)
*
|
2005-12-15 |
2010-01-07 |
Hoffmann La Roche |
Pyrroloä2,3-cüpyridinderivate
|
|
WO2007068641A1
(en)
*
|
2005-12-16 |
2007-06-21 |
F. Hoffmann-La Roche Ag |
Pyrrolo [2 , 3-b] pyridine derivatives as h3 receptor modulators
|
|
SK22006A3
(sk)
*
|
2006-01-03 |
2007-08-02 |
Biotika, A. S. |
Kmeň Streptomyces toxytricini produkujúci lipstatín a príprava lipstatínu s uvedeným kmeňom
|
|
US20080021092A1
(en)
*
|
2006-01-06 |
2008-01-24 |
Deepak Murpani |
Stable pharmaceutical compositions of orlistat
|
|
BRPI0707916A2
(pt)
*
|
2006-01-13 |
2011-05-17 |
Hoffmann La Roche |
compostos, processo para a sua manufatura, composições farmacêuticas que os compreendem e uso destes compostos
|
|
ES2349160T3
(es)
*
|
2006-01-23 |
2010-12-28 |
F. Hoffmann-La Roche Ag |
Derivados de la ciclohexil sulfonamida con actividad frente a los receptores h3.
|
|
WO2008020314A2
(en)
*
|
2006-03-14 |
2008-02-21 |
Ranbaxy Laboratories Limited |
Statin stabilizing dosage formulations
|
|
KR101252635B1
(ko)
|
2006-04-20 |
2013-04-10 |
(주)아모레퍼시픽 |
리파아제 저해제 및 친유성 오일흡수제를 포함하는 약학조성물 및 이로부터 제조된 경구 투여용 제제
|
|
US7432255B2
(en)
*
|
2006-05-16 |
2008-10-07 |
Hoffmann-La Roche Inc. |
1H-indol-5-yl-piperazin-1-yl-methanone derivatives
|
|
MX2008014532A
(es)
*
|
2006-05-30 |
2008-11-27 |
Hoffmann La Roche |
Derivados de piperidinil pirimidinas.
|
|
AR063469A1
(es)
*
|
2006-07-14 |
2009-01-28 |
Ranbaxy Lab Ltd |
Formas polimorficas de ácido (3r,5r)-7-[2-(4-fluorofenil)-5-isopropil-3-fenil-4-[(4-hidroximetilfenilamino)carbonil]-pirrol-1-il]-3, 5-dihidroxi-heptanoico, sal hemicalcio, metodos de preparacion de las mismas, una composicion farmaceutica que las comprende y su uso en el tratamiento de enfermedades
|
|
US7514433B2
(en)
|
2006-08-03 |
2009-04-07 |
Hoffmann-La Roche Inc. |
1H-indole-6-yl-piperazin-1-yl-methanone derivatives
|
|
AU2007301126A1
(en)
|
2006-09-28 |
2008-04-03 |
Banyu Pharmaceutical Co., Ltd. |
Diaryl ketimine derivative
|
|
US20100210633A1
(en)
*
|
2006-10-12 |
2010-08-19 |
Epix Delaware, Inc. |
Carboxamide compounds and their use
|
|
WO2008070496A2
(en)
|
2006-12-01 |
2008-06-12 |
Bristol-Myers Squibb Company |
N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
|
|
US20080146559A1
(en)
|
2006-12-08 |
2008-06-19 |
Li Chen |
4,5,6,7-Tetrahydro-Thieno [2,3-C] Pyridine Derivatives
|
|
US20080200422A1
(en)
*
|
2007-01-09 |
2008-08-21 |
Cavener Douglas R |
Methods for reduction of adipose tissue mass
|
|
JP5319518B2
(ja)
|
2007-04-02 |
2013-10-16 |
Msd株式会社 |
インドールジオン誘導体
|
|
WO2008124122A1
(en)
*
|
2007-04-09 |
2008-10-16 |
Scidose, Llc |
Combinations of statins and anti-obesity agent and glitazones
|
|
US20080248115A1
(en)
*
|
2007-04-09 |
2008-10-09 |
Palepu Nageswara R |
Combinations of statins and anti-obesity agent
|
|
CA2687964A1
(en)
*
|
2007-06-01 |
2009-02-19 |
The Trustees Of Princeton University |
Treatment of viral infections by modulation of host cell metabolic pathways
|
|
US8969514B2
(en)
|
2007-06-04 |
2015-03-03 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
|
|
EP2170930B3
(en)
|
2007-06-04 |
2013-10-02 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
|
|
WO2008149321A2
(en)
*
|
2007-06-06 |
2008-12-11 |
Ranbaxy Laboratories Limited |
Process for the preparation of orlistat
|
|
US9066536B2
(en)
|
2007-09-12 |
2015-06-30 |
University Of Copenhagen |
Compositions and methods for increasing the suppression of hunger and reducing the digestibility of non-fat energy satiety
|
|
US20100196464A1
(en)
*
|
2007-09-17 |
2010-08-05 |
Dr. Reddy's Laboratories Limited |
Orlistat pharmaceutical formulations
|
|
WO2009044380A2
(en)
|
2007-10-05 |
2009-04-09 |
Ranbaxy Laboratories Limited |
Formulations containing orlistat particles having controlled particle size
|
|
EP2219614A1
(en)
*
|
2007-10-15 |
2010-08-25 |
Inventis DDS Pvt Limited |
Pharmaceutical composition of orlistat
|
|
US8298583B2
(en)
*
|
2007-10-19 |
2012-10-30 |
Monosol Rx, Llc |
Film delivery system for tetrahydrolipstatin
|
|
EP2280766A1
(en)
|
2007-12-11 |
2011-02-09 |
CytoPathfinder, Inc. |
Carboxamide compounds and their use as chemokine receptor agonists
|
|
US20090214682A1
(en)
*
|
2008-02-22 |
2009-08-27 |
Heuer Marvin A |
Composition and methods for weight loss in a subject
|
|
JPWO2009110510A1
(ja)
|
2008-03-06 |
2011-07-14 |
Msd株式会社 |
アルキルアミノピリジン誘導体
|
|
ES2755736T3
(es)
*
|
2008-03-26 |
2020-04-23 |
Biocon Ltd |
Proceso de fermentación mejorado para un coeficiente de rendimiento más alto de inhibidor de lipasa respecto al ácido graso consumido
|
|
US20110015198A1
(en)
|
2008-03-28 |
2011-01-20 |
Banyu Pharmaceutical Co., Inc. |
Diarylmethylamide derivative having melanin-concentrating hormone receptor antagonism
|
|
JP2011522828A
(ja)
|
2008-06-04 |
2011-08-04 |
シナジー ファーマシューティカルズ インコーポレイテッド |
胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
|
|
EP2301936A1
(en)
|
2008-06-19 |
2011-03-30 |
Banyu Pharmaceutical Co., Ltd. |
Spirodiamine-diarylketoxime derivative
|
|
EP2141236A1
(en)
|
2008-07-03 |
2010-01-06 |
KRKA, D.D., Novo Mesto |
Process for production of lipstatin and microorganisms therefore
|
|
EP2321341B1
(en)
|
2008-07-16 |
2017-02-22 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
|
|
EP2319841A1
(en)
|
2008-07-30 |
2011-05-11 |
Msd K.K. |
(5-membered)-(5-membered) or (5-membered)-(6-membered) fused ring cycloalkylamine derivative
|
|
EP2347660A4
(en)
|
2008-10-03 |
2014-06-11 |
Sigma Alimentos Sa De Cv |
COMPOSITION FOR PROMOTING THE CONTROL OF TOTAL AND LDL CHOLESTERIN AND / OR WEIGHT REDUCTION AND / OR THERMOGENESIS
|
|
US8309107B2
(en)
*
|
2008-10-06 |
2012-11-13 |
Banner Pharmacaps, Inc. |
Stable solutions of orlistat for pharmaceutical dosage forms
|
|
WO2010043592A1
(en)
*
|
2008-10-15 |
2010-04-22 |
Revotar Biopharmaceuticals Ag |
Lipase inhibitors for use for the treatment of obesity
|
|
AU2009307884B2
(en)
|
2008-10-22 |
2014-07-31 |
Merck Sharp & Dohme Corp. |
Novel cyclic benzimidazole derivatives useful anti-diabetic agents
|
|
CN102271509A
(zh)
|
2008-10-31 |
2011-12-07 |
默沙东公司 |
用于抗糖尿病药的新型环苯并咪唑衍生物
|
|
US20120046364A1
(en)
|
2009-02-10 |
2012-02-23 |
Metabasis Therapeutics, Inc. |
Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use
|
|
US20120053172A1
(en)
|
2009-02-12 |
2012-03-01 |
Cooperatieve Mirzorg U.A. |
Use of a combination of diazoxide and metformin for treating obesity or obesity related disorders
|
|
US20100215635A1
(en)
*
|
2009-02-23 |
2010-08-26 |
Zoltan Kiss |
Small molecules to induce weight loss or to reduce weight gain
|
|
US8993509B2
(en)
|
2009-03-31 |
2015-03-31 |
Robert Zimmerman |
Method for treatment of cachexia by administering inhibitors of adipose triglyceride lipase expression or activity
|
|
WO2010112569A1
(en)
|
2009-03-31 |
2010-10-07 |
Robert Zimmermann |
Modulation of adipose triglyceride lipase for prevention and treatment of cachexia, loss of weight and muscle atrophy and methods of screening therefor
|
|
BRPI0901602B8
(pt)
|
2009-04-03 |
2021-05-25 |
Ems S/A |
formulação farmacêuticas
|
|
RU2412713C2
(ru)
*
|
2009-05-14 |
2011-02-27 |
Открытое Акционерное Общество Завод Экологической Техники И Экопитания "Диод" |
Фармацевтическая композиция, биологически активная добавка и способ уменьшения поглощения жира из пищи
|
|
EP2473515A4
(en)
|
2009-09-04 |
2013-11-27 |
Univ Toledo |
PROCESS FOR PREPARING OPTICALLY PURE BETA LACTONS FROM ALDEHYDE AND COMPOSITIONS MADE THEREOF
|
|
JP5696156B2
(ja)
|
2009-11-02 |
2015-04-08 |
ファイザー・インク |
ジオキサ−ビシクロ[3.2.1]オクタン−2,3,4−トリオール誘導体
|
|
UA107369C2
(en)
|
2010-02-01 |
2014-12-25 |
Lab Bago S A |
Pharmaceutical composition with anti-obesity activity comprising a premixture of pure orlistat and preparation process
|
|
US8524909B2
(en)
|
2010-02-02 |
2013-09-03 |
Hoffmann-La Roche Inc. |
Tetrahydro-pyran derivatives
|
|
RU2441654C2
(ru)
*
|
2010-02-17 |
2012-02-10 |
Лабораториос Баго С.А. |
Фармацевтическая композиция с активностью против ожирения, включающая премикс чистого орлистата, и способ ее изготовления
|
|
US8895596B2
(en)
|
2010-02-25 |
2014-11-25 |
Merck Sharp & Dohme Corp |
Cyclic benzimidazole derivatives useful as anti-diabetic agents
|
|
US8450350B2
(en)
|
2010-05-05 |
2013-05-28 |
Infinity Pharmaceuticals, Inc. |
Triazoles as inhibitors of fatty acid synthase
|
|
EP2566853B1
(en)
|
2010-05-05 |
2017-01-25 |
Infinity Pharmaceuticals, Inc. |
Tetrazolones as inhibitors of fatty acid synthase
|
|
JP2013528172A
(ja)
|
2010-05-21 |
2013-07-08 |
ファイザー・インク |
2−フェニルベンゾイルアミド
|
|
ES2662710T3
(es)
|
2010-05-24 |
2018-04-09 |
Swedish Oat Fiber Ab |
Dispersión acuosa que comprende galactolípidos y método de producción de la misma
|
|
EP2392327A1
(en)
|
2010-06-04 |
2011-12-07 |
Universitätsmedizin der Johannes Gutenberg-Universität Mainz |
Use of orlistat for the anti-parasitic treatment of a parasitic disease
|
|
WO2012004588A2
(en)
|
2010-07-06 |
2012-01-12 |
Astrazeneca Ab |
Therapeutic agents 976
|
|
CN101885713B
(zh)
*
|
2010-07-19 |
2011-11-30 |
大邦(湖南)生物制药有限公司 |
一种毒三素链霉菌发酵液中分离提取利普司他汀的工艺
|
|
US9616097B2
(en)
|
2010-09-15 |
2017-04-11 |
Synergy Pharmaceuticals, Inc. |
Formulations of guanylate cyclase C agonists and methods of use
|
|
CN101948450B
(zh)
*
|
2010-10-13 |
2013-04-24 |
鲁南制药集团股份有限公司 |
一种生产制备奥利司他的方法
|
|
US9149959B2
(en)
|
2010-10-22 |
2015-10-06 |
Monosol Rx, Llc |
Manufacturing of small film strips
|
|
BR112013010157B1
(pt)
|
2010-11-04 |
2020-02-04 |
Albireo Ab |
iinibidores do ibat, seus usos, e composição e combinações farmacêuticas
|
|
US20130236541A1
(en)
|
2010-11-08 |
2013-09-12 |
Albireo Ab |
Pharmaceutical combination comprising an ibat inhibitor and a bile acid binder
|
|
CN103476258B
(zh)
|
2011-02-25 |
2017-04-26 |
默沙东公司 |
用作抗糖尿病药剂的新的环状氮杂苯并咪唑衍生物
|
|
US20130345392A1
(en)
|
2011-03-04 |
2013-12-26 |
Pfizer Inc |
Edn3-like peptides and uses thereof
|
|
CN102304105B
(zh)
*
|
2011-07-15 |
2013-07-10 |
鲁南新时代生物技术有限公司 |
一种制备高纯度奥利司他的方法
|
|
UY34194A
(es)
|
2011-07-15 |
2013-02-28 |
Astrazeneca Ab |
?(3-(4-(espiroheterocíclico)metil)fenoxi)azetidin-1-il)(5-(fenil)-1,3,4-oxadiazol-2-il)metanona en el tratamiento de la obesidad?
|
|
CN103030613B
(zh)
*
|
2011-09-29 |
2014-11-12 |
北大方正集团有限公司 |
一种利普司他汀的提纯方法
|
|
JP2013249293A
(ja)
*
|
2012-06-04 |
2013-12-12 |
Kao Corp |
リパーゼ活性阻害剤、抗真菌剤、及びフケ抑制剤
|
|
US20140045746A1
(en)
|
2012-08-02 |
2014-02-13 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
|
WO2014060445A1
(en)
|
2012-10-19 |
2014-04-24 |
Akzo Nobel Chemicals International B.V. |
Method for preparing high purity orlistat
|
|
CN102936234B
(zh)
*
|
2012-11-15 |
2015-04-01 |
江苏阿尔法药业有限公司 |
一种制备脂肪酶抑制剂奥利司他的方法
|
|
CN102993134B
(zh)
*
|
2012-12-31 |
2015-08-05 |
鲁南新时代生物技术有限公司 |
一种利普司他汀的提纯方法
|
|
EP2958562B1
(en)
|
2013-02-22 |
2025-09-10 |
Merck Sharp & Dohme LLC |
Antidiabetic bicyclic compounds
|
|
EP2970119B1
(en)
|
2013-03-14 |
2021-11-03 |
Merck Sharp & Dohme Corp. |
Novel indole derivatives useful as anti-diabetic agents
|
|
CA2905435A1
(en)
|
2013-03-15 |
2014-09-25 |
Synergy Pharmaceuticals Inc. |
Compositions useful for the treatment of gastrointestinal disorders
|
|
US9708367B2
(en)
|
2013-03-15 |
2017-07-18 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase and their uses
|
|
BR112015026513A2
(pt)
|
2013-04-17 |
2017-07-25 |
Pfizer |
derivados de n-piperidin-3-ilbenzamida para tratar as doenças cardiovasculares
|
|
RS65632B1
(sr)
|
2013-06-05 |
2024-07-31 |
Bausch Health Ireland Ltd |
Ultra-prečišćeni agonisti guanilat-ciklaze c, postupak njihove pripreme i upotrebe
|
|
WO2015051496A1
(en)
|
2013-10-08 |
2015-04-16 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
|
CN113121450A
(zh)
|
2014-08-29 |
2021-07-16 |
Tes制药有限责任公司 |
α-氨基-β-羧基粘康酸半醛脱羧酶抑制剂
|
|
US10743813B2
(en)
|
2014-09-11 |
2020-08-18 |
Rattan Nath |
Diabetes control using postprandial feedback
|
|
WO2016055901A1
(en)
|
2014-10-08 |
2016-04-14 |
Pfizer Inc. |
Substituted amide compounds
|
|
KR20230137362A
(ko)
|
2016-05-05 |
2023-10-04 |
어퀘스티브 테라퓨틱스, 아이엔씨. |
강화된 전달 에프네프린 조성물
|
|
US12433850B2
(en)
|
2016-05-05 |
2025-10-07 |
Aquestive Therapeutics, Inc. |
Enhanced delivery epinephrine and prodrug compositions
|
|
US12427121B2
(en)
|
2016-05-05 |
2025-09-30 |
Aquestive Therapeutics, Inc. |
Enhanced delivery epinephrine compositions
|
|
US11273131B2
(en)
|
2016-05-05 |
2022-03-15 |
Aquestive Therapeutics, Inc. |
Pharmaceutical compositions with enhanced permeation
|
|
US20180134667A1
(en)
|
2016-10-14 |
2018-05-17 |
TES Pharma S.r.I. |
Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
|
|
WO2018106518A1
(en)
|
2016-12-06 |
2018-06-14 |
Merck Sharp & Dohme Corp. |
Antidiabetic heterocyclic compounds
|
|
WO2018118670A1
(en)
|
2016-12-20 |
2018-06-28 |
Merck Sharp & Dohme Corp. |
Antidiabetic spirochroman compounds
|
|
IL283182B2
(en)
|
2018-11-20 |
2025-10-01 |
Tes Pharma S R L |
Alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase inhibitors
|
|
MA54261B1
(fr)
|
2019-01-18 |
2025-03-28 |
Astrazeneca Ab |
Inhibiteurs de pcsk9 et leurs procédés d'utilisation
|
|
NL2022615B1
(en)
|
2019-02-21 |
2020-08-31 |
Patrick Alexander Unger |
Pharmaceutical composition comprising tetrahydrocannabivarin for the prevention and treatment of overweight
|
|
JP7722195B2
(ja)
|
2020-02-05 |
2025-08-13 |
日油株式会社 |
膵液瘻の予防または治療剤
|
|
US12465564B2
(en)
|
2021-10-25 |
2025-11-11 |
Aquestive Therapeutics, Inc. |
Oral and nasal compositions and methods of treatment
|