JPH02292282A - キナゾリン誘導体及びその製造方法 - Google Patents

キナゾリン誘導体及びその製造方法

Info

Publication number
JPH02292282A
JPH02292282A JP2103239A JP10323990A JPH02292282A JP H02292282 A JPH02292282 A JP H02292282A JP 2103239 A JP2103239 A JP 2103239A JP 10323990 A JP10323990 A JP 10323990A JP H02292282 A JPH02292282 A JP H02292282A
Authority
JP
Japan
Prior art keywords
general formula
compound represented
reaction
manufacturing
carried out
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2103239A
Other languages
English (en)
Japanese (ja)
Inventor
Jozsef Reiter
レイテル ヨージェフ
Laszlo Pongo
ポンゴー ラースロー
Frigyes Goergenyi
フリジェシュ　ゲルジェーニ
Marton Fekete
フェケテ マールトン
Margit Csoergoe
マルギト　チェルゲー
Ilona Sztuhar
イロナ　スツハール
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egyt Gyogyszervegyeszeti Gyar
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU193089A external-priority patent/HU203333B/hu
Priority claimed from HU193189A external-priority patent/HU203342B/hu
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of JPH02292282A publication Critical patent/JPH02292282A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP2103239A 1989-04-21 1990-04-20 キナゾリン誘導体及びその製造方法 Pending JPH02292282A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HU2251-1931/89 1989-04-21
HU2251-1930/89 1989-04-21
HU193089A HU203333B (en) 1989-04-21 1989-04-21 Process for producing n-cyano-carboxamidine derivatives
HU193189A HU203342B (en) 1989-04-21 1989-04-21 Process for producing quinazoline deivatives

Publications (1)

Publication Number Publication Date
JPH02292282A true JPH02292282A (ja) 1990-12-03

Family

ID=26317437

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2103239A Pending JPH02292282A (ja) 1989-04-21 1990-04-20 キナゾリン誘導体及びその製造方法

Country Status (16)

Country Link
JP (1) JPH02292282A (en, 2012)
KR (1) KR900016194A (en, 2012)
AT (1) AT398075B (en, 2012)
BG (1) BG91821A (en, 2012)
CA (2) CA2028953A1 (en, 2012)
CH (1) CH681300A5 (en, 2012)
DK (1) DK99090A (en, 2012)
ES (1) ES2019826A6 (en, 2012)
FI (1) FI902002A7 (en, 2012)
GB (1) GB2231571B (en, 2012)
GR (1) GR900100294A (en, 2012)
IT (1) IT1241128B (en, 2012)
PL (1) PL162976B1 (en, 2012)
RU (1) RU1838309C (en, 2012)
SE (1) SE9001402L (en, 2012)
YU (1) YU70890A (en, 2012)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2077252C (en) * 1992-08-31 2001-04-10 Khashayar Karimian Methods of making ureas and guanidines, and intermediates therefor
ES2096518B1 (es) * 1994-03-28 1997-12-01 Grupo Farmaceutico Almirall S Nuevas anilinas.
WO2008015525A2 (en) * 2006-07-31 2008-02-07 Orchid Chemicals & Pharmaceuticals Limited An improved process for the preparation of alfuzosin hydrochloride
US20100174073A1 (en) 2007-05-04 2010-07-08 Actavis Group Ptc Ehf Process for the preparation of alfuzosin and salts thereof
US8716476B2 (en) 2007-08-02 2014-05-06 Cipla Limited Process for the preparation of alfuzosin hydrochloride

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4026894A (en) * 1975-10-14 1977-05-31 Abbott Laboratories Antihypertensive agents
US4044135A (en) * 1975-10-14 1977-08-23 Abbott Laboratories Antihypertensive agents
GB1591490A (en) * 1977-08-04 1981-06-24 Abbott Lab 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate
US4138561A (en) * 1977-09-30 1979-02-06 Bristol-Myers Company Cyanocarboxamidines and quinazoline process
FI57751C (fi) * 1977-10-25 1980-10-10 Fermion Oy Foerfarande foer framstaellning av 6,7-dimetoxi- eller 6,7,8-trimetoxi-4-amino-2-(4-substituerade-piperazin-1-yl)-kinazoliner med blodtryckssaenkande verkan
FI56836C (fi) * 1977-10-25 1980-04-10 Fermion Oy 4-substituerade piperazin-1-(n-aryl-n'-cyano)-karboximidamider som aer mellanprodukter vid framstaellningen av farmakologiskt vaerdefulla 6,7-dimetoxi- eller 6,7,8-trimetoxi-4-amino-2-(4-substituerade-piperazin-1-yl)-kinazoliner
FR2421888A1 (fr) * 1978-02-06 1979-11-02 Synthelabo Amides d'alkylene-diamines et leur application en therapeutique
FI59800C (fi) * 1979-01-10 1981-10-12 Fermion Oy Foerfarande foer framstaellning av 6,7-dimetoxi-4-amino-2-(4-(furo-2-yl)-piperazin-1-yl)-kinazolin
FI67699C (fi) * 1979-01-31 1985-05-10 Orion Yhtymae Oy Foerfarande foer framstaellning av 6,7-dimetoxi-4-amino-2-(4-(2-furoyl)-1-piperazinyl)kinazolinhydroklorid med blodtryckssaenkande verkan
ATE32074T1 (de) * 1983-11-22 1988-02-15 Heumann Ludwig & Co Gmbh Verfahren zur herstellung von 4-amino-6,7dimethoxy-2-(4-(furo-2-yl)-piperazin-1-yl)chinazolin und dessen physiologisch annehmbarer salze.

Also Published As

Publication number Publication date
RU1838309C (ru) 1993-08-30
PL162976B1 (pl) 1994-01-31
GB9008941D0 (en) 1990-06-20
IT9020092A0 (it) 1990-04-20
YU70890A (en) 1992-05-28
ES2019826A6 (es) 1991-07-01
BG91821A (bg) 1993-12-24
CA2015066A1 (en) 1990-10-21
PL284860A1 (en) 1991-03-11
IT1241128B (it) 1993-12-29
GB2231571B (en) 1992-09-16
FI902002A7 (fi) 1990-10-22
CA2028953A1 (en) 1990-10-22
IT9020092A1 (it) 1991-10-20
KR900016194A (ko) 1990-11-12
GB2231571A (en) 1990-11-21
ATA93190A (de) 1994-01-15
AT398075B (de) 1994-09-26
GR900100294A (el) 1991-09-27
DK99090A (da) 1990-10-22
CH681300A5 (en, 2012) 1993-02-26
DK99090D0 (da) 1990-04-20
SE9001402D0 (sv) 1990-04-20
SE9001402L (sv) 1990-10-22
FI902002A0 (fi) 1990-04-20

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