JP7237344B2 - インフルエンザウイルス血球凝集素タンパク質及びその使用 - Google Patents

インフルエンザウイルス血球凝集素タンパク質及びその使用 Download PDF

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JP7237344B2
JP7237344B2 JP2018565670A JP2018565670A JP7237344B2 JP 7237344 B2 JP7237344 B2 JP 7237344B2 JP 2018565670 A JP2018565670 A JP 2018565670A JP 2018565670 A JP2018565670 A JP 2018565670A JP 7237344 B2 JP7237344 B2 JP 7237344B2
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amino acid
virus
influenza
acid residues
yamagata
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JP2019521674A (ja
JP2019521674A5 (cg-RX-API-DMAC7.html
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パレセ ピーター
ガルシア‐サストレ アドルフォ
クラムメル フロリアン
エルムレル ミーガン
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アイカーン スクール オブ メディシン アット マウント サイナイ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
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    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16271—Demonstrated in vivo effect

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2018565670A 2016-06-15 2017-06-14 インフルエンザウイルス血球凝集素タンパク質及びその使用 Active JP7237344B2 (ja)

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US201662350701P 2016-06-15 2016-06-15
US62/350,701 2016-06-15
US201662355679P 2016-06-28 2016-06-28
US62/355,679 2016-06-28
PCT/US2017/037384 WO2017218624A1 (en) 2016-06-15 2017-06-14 Influenza virus hemagglutinin proteins and uses thereof

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CN102939103A (zh) 2010-03-30 2013-02-20 西奈山医学院 流感病毒疫苗及其应用
EP2758075B1 (en) 2011-09-20 2023-05-03 Icahn School of Medicine at Mount Sinai Influenza virus vaccines and uses thereof
SG11201504728RA (en) 2012-12-18 2015-07-30 Icahn School Med Mount Sinai Influenza virus vaccines and uses thereof
US9908930B2 (en) 2013-03-14 2018-03-06 Icahn School Of Medicine At Mount Sinai Antibodies against influenza virus hemagglutinin and uses thereof
JP2018504412A (ja) 2015-01-23 2018-02-15 アイカーン スクール オブ メディシン アット マウント サイナイ インフルエンザウイルスワクチン接種レジメン
CN109641041A (zh) 2016-06-15 2019-04-16 西奈山伊坎医学院 流感病毒血细胞凝集素蛋白及其用途
EP3606555A4 (en) 2017-04-07 2021-08-04 Icahn School of Medicine at Mount Sinai INFLUENZA VIRUS TYPE B ANTI-NEURAMINIDASE ANTIBODIES AND THEIR USES
KR101964044B1 (ko) 2018-03-14 2019-04-02 인제대학교 산학협력단 재조합 아데노바이러스를 이용한 다가형 인플루엔자 생백신 플랫폼
US12364746B2 (en) 2018-06-21 2025-07-22 Icahn School Of Medicine At Mount Sinai Mosaic influenza virus hemagglutinin polypeptides and uses thereof
US12496336B2 (en) 2019-05-16 2025-12-16 Vanderbilt University Peptide vaccine based on a new universal influenza a hemagglutinin head domain epitope and human monoclonal antibodies binding thereto
US20220249652A1 (en) * 2019-06-26 2022-08-11 Icahn School Of Medicine At Mount Sinai Influenza virus neuraminidase and uses thereof
JP7611908B2 (ja) * 2019-10-28 2025-01-10 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 抗血球凝集素抗体およびその使用方法
CN119452088A (zh) * 2022-05-31 2025-02-14 Vlp治疗日本公司 修饰疫苗设计开发
CN116284432A (zh) * 2022-09-09 2023-06-23 中山大学·深圳 一种乙型流感病毒重组蛋白疫苗及其制备方法
WO2025072921A1 (en) * 2023-09-29 2025-04-03 Icahn School Of Medicine At Mount Sinai Chimeric influenza virus hemagglutinin mrna-based vaccines and uses thereof
WO2025184346A1 (en) * 2024-02-29 2025-09-04 Icahn School Of Medicine At Mount Sinai Immunogenic compositions containing inactivated influenza b virus and cpg oligonucleotide adjuvant and uses thereof

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JP2014530003A (ja) 2011-09-20 2014-11-17 モウント シナイ スクール オフ メディシネ インフルエンザウイルスワクチン及びその使用
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