JP7187437B2 - 化合物および組成物ならびにそれらの使用 - Google Patents

化合物および組成物ならびにそれらの使用 Download PDF

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JP7187437B2
JP7187437B2 JP2019504697A JP2019504697A JP7187437B2 JP 7187437 B2 JP7187437 B2 JP 7187437B2 JP 2019504697 A JP2019504697 A JP 2019504697A JP 2019504697 A JP2019504697 A JP 2019504697A JP 7187437 B2 JP7187437 B2 JP 7187437B2
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methyl
pharmaceutically acceptable
hydrogen
acceptable salt
disorder
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JP2019525939A5 (OSRAM
JP2019525939A (ja
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タリーン・ジー・ハナニア
ミシェル・エル・アール・ヘファーナン
フィリップ・グリン・ジョーンズ
リンホン・シエ
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Sunovion Pharmaceuticals Inc
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Sunovion Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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    • A—HUMAN NECESSITIES
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    • A61P25/32—Alcohol-abuse
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
JP2019504697A 2016-07-29 2017-07-28 化合物および組成物ならびにそれらの使用 Active JP7187437B2 (ja)

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JP2022128312A JP7402284B2 (ja) 2016-07-29 2022-08-10 化合物および組成物ならびにそれらの使用

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US201662368526P 2016-07-29 2016-07-29
US62/368,526 2016-07-29
PCT/US2017/044517 WO2018023072A2 (en) 2016-07-29 2017-07-28 Compounds and compositions and uses thereof

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JP2019525939A JP2019525939A (ja) 2019-09-12
JP2019525939A5 JP2019525939A5 (OSRAM) 2020-09-17
JP7187437B2 true JP7187437B2 (ja) 2022-12-12

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US (4) US10196403B2 (OSRAM)
EP (2) EP3494119B1 (OSRAM)
JP (2) JP7187437B2 (OSRAM)
KR (1) KR102811121B1 (OSRAM)
CN (3) CN110088107B (OSRAM)
AU (2) AU2017301769B2 (OSRAM)
BR (1) BR112019001439A8 (OSRAM)
CA (1) CA3032302A1 (OSRAM)
DK (1) DK3494119T3 (OSRAM)
EA (1) EA201990400A1 (OSRAM)
ES (1) ES2996835T3 (OSRAM)
FI (1) FI3494119T3 (OSRAM)
HR (1) HRP20241631T1 (OSRAM)
HU (1) HUE070203T2 (OSRAM)
IL (1) IL264446B2 (OSRAM)
LT (1) LT3494119T (OSRAM)
MA (1) MA45857A (OSRAM)
MX (2) MX391221B (OSRAM)
MY (1) MY199446A (OSRAM)
PH (1) PH12019500196A1 (OSRAM)
PL (1) PL3494119T3 (OSRAM)
PT (1) PT3494119T (OSRAM)
SG (2) SG11201900689RA (OSRAM)
SI (1) SI3494119T1 (OSRAM)
UA (1) UA125519C2 (OSRAM)
WO (1) WO2018023072A2 (OSRAM)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110087687A (zh) 2016-07-29 2019-08-02 赛诺维信制药公司 化合物、组合物及其用途
CA3032302A1 (en) 2016-07-29 2018-02-01 Taleen G. Hanania Compounds and compositions and uses thereof
CN111183138A (zh) 2017-08-02 2020-05-19 赛诺维信制药公司 异色满化合物以及用途
WO2020087031A1 (en) 2018-10-26 2020-04-30 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
CN109369597B (zh) * 2018-12-28 2022-11-29 陕西师范大学 一种异香豆素类化合物的合成方法
MX2021010880A (es) * 2019-03-14 2022-01-18 Sunovion Pharmaceuticals Inc Sales de un compuesto de isocromanilo y formas cristalinas, procesos de preparacion, usos terapeuticos y composiciones farmaceuticas de las mismas.
CN111122736B (zh) * 2019-12-30 2021-03-12 北京鑫开元医药科技有限公司海南分公司 一种用于检测布瓦西坦中间体中对映异构体的方法
US20240190835A1 (en) * 2021-04-08 2024-06-13 Sunovion Pharmaceuticals Inc. Isochroman derivatives and compositions and uses thereof
CN117177977A (zh) * 2021-04-10 2023-12-05 住友制药株式会社 二环吡啶衍生物
US20240228505A1 (en) * 2021-04-10 2024-07-11 Sumitomo Pharma Co., Ltd. Bicyclic pyridine derivative
US12077546B2 (en) 2021-04-10 2024-09-03 Sumitomo Pharma Co., Ltd. Bicyclic pyridine derivative
CN115677719B (zh) * 2022-10-27 2025-03-07 复旦大学 一种芳基并杂环化合物及其制备方法和用途
CN119263959B (zh) * 2024-12-10 2025-09-05 浙江九洲药业股份有限公司 一种格列齐特中间体1,2-环戊二甲醇的制备方法
CN120518681B (zh) * 2025-07-22 2025-09-12 成都施贝康生物医药科技有限公司 一种化合物及其应用

Citations (2)

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JP2007535548A (ja) 2004-04-29 2007-12-06 アベンティス・ファーマスーティカルズ・インコーポレイテツド ドーパミンアゴニストとしての３−ピペリジニルイソクロマン−５−オール
JP2013512926A (ja) 2009-12-04 2013-04-18 スノビオン プハルマセウトイカルス インコーポレイテッド 多環式化合物及びその使用方法

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