JP7178355B2 - Car t細胞療法のための組成物および方法 - Google Patents
Car t細胞療法のための組成物および方法 Download PDFInfo
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- JP7178355B2 JP7178355B2 JP2019547107A JP2019547107A JP7178355B2 JP 7178355 B2 JP7178355 B2 JP 7178355B2 JP 2019547107 A JP2019547107 A JP 2019547107A JP 2019547107 A JP2019547107 A JP 2019547107A JP 7178355 B2 JP7178355 B2 JP 7178355B2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
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- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4274—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; Prostatic acid phosphatase [PAP]; Prostate-specific G-protein-coupled receptor [PSGR]
- A61K40/4276—Prostate specific membrane antigen [PSMA]
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
- A61K47/551—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug one of the codrug's components being a vitamin, e.g. niacinamide, vitamin B3, cobalamin, vitamin B12, folate, vitamin A or retinoic acid
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- A—HUMAN NECESSITIES
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
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- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/49—Breast
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/033—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the internal surface of the plasma membrane, e.g. containing a myristoylation motif
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022181982A JP7585280B2 (ja) | 2017-02-28 | 2022-11-14 | Car t細胞療法のための組成物および方法 |
| JP2024194196A JP2025024006A (ja) | 2017-02-28 | 2024-11-06 | Car t細胞療法のための組成物および方法 |
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762464792P | 2017-02-28 | 2017-02-28 | |
| US62/464,792 | 2017-02-28 | ||
| US201762480627P | 2017-04-03 | 2017-04-03 | |
| US62/480,627 | 2017-04-03 | ||
| US201762554421P | 2017-09-05 | 2017-09-05 | |
| US62/554,421 | 2017-09-05 | ||
| US201862620384P | 2018-01-22 | 2018-01-22 | |
| US201862620423P | 2018-01-22 | 2018-01-22 | |
| US62/620,423 | 2018-01-22 | ||
| US62/620,384 | 2018-01-22 | ||
| US201862620701P | 2018-01-23 | 2018-01-23 | |
| US62/620,701 | 2018-01-23 | ||
| US201862634595P | 2018-02-23 | 2018-02-23 | |
| US62/634,595 | 2018-02-23 | ||
| PCT/US2018/020095 WO2018160622A1 (en) | 2017-02-28 | 2018-02-28 | Compositions and methods for car t cell therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022181982A Division JP7585280B2 (ja) | 2017-02-28 | 2022-11-14 | Car t細胞療法のための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020510662A JP2020510662A (ja) | 2020-04-09 |
| JP2020510662A5 JP2020510662A5 (enExample) | 2021-05-06 |
| JP7178355B2 true JP7178355B2 (ja) | 2022-11-25 |
Family
ID=63370158
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019547107A Active JP7178355B2 (ja) | 2017-02-28 | 2018-02-28 | Car t細胞療法のための組成物および方法 |
| JP2022181982A Active JP7585280B2 (ja) | 2017-02-28 | 2022-11-14 | Car t細胞療法のための組成物および方法 |
| JP2024194196A Pending JP2025024006A (ja) | 2017-02-28 | 2024-11-06 | Car t細胞療法のための組成物および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022181982A Active JP7585280B2 (ja) | 2017-02-28 | 2022-11-14 | Car t細胞療法のための組成物および方法 |
| JP2024194196A Pending JP2025024006A (ja) | 2017-02-28 | 2024-11-06 | Car t細胞療法のための組成物および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US11850262B2 (enExample) |
| EP (2) | EP3589295B1 (enExample) |
| JP (3) | JP7178355B2 (enExample) |
| CN (1) | CN110582288B (enExample) |
| ES (1) | ES3010559T3 (enExample) |
| TW (2) | TWI831740B (enExample) |
| WO (1) | WO2018160622A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2934532B1 (en) | 2012-12-20 | 2019-10-23 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| CN108697798A (zh) | 2016-02-16 | 2018-10-23 | 达纳-法伯癌症研究所有限公司 | 免疫疗法组合物及方法 |
| CA3019835A1 (en) * | 2016-04-08 | 2017-10-12 | Purdue Research Foundation | Methods and compositions for car t cell therapy |
| AU2018219226B2 (en) | 2017-02-07 | 2024-12-19 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents |
| CN110582288B (zh) | 2017-02-28 | 2024-09-20 | 恩多塞特公司 | 用于car t细胞疗法的组合物和方法 |
| ES3025461T3 (en) | 2017-08-22 | 2025-06-09 | Purdue Research Foundation | Fbsa-based therapeutic and radioimaging conjugates targeting carbonic anhydrase positive cancers |
| WO2019144095A1 (en) | 2018-01-22 | 2019-07-25 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Methods of use for car t cells |
| AU2019218729B2 (en) | 2018-02-06 | 2025-12-04 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Fluorescein-specific CARs exhibiting optimal T cell function against FL-PLE labelled tumors |
| JP7568224B2 (ja) | 2018-02-23 | 2024-10-16 | エンドサイト・インコーポレイテッド | Car t細胞療法のための配列決定法 |
| SG11202009975TA (en) | 2018-04-12 | 2020-11-27 | Umoja Biopharma Inc | Viral vectors and packaging cell lines |
| JP2021530444A (ja) | 2018-06-28 | 2021-11-11 | ダナ−ファーバー キャンサー インスティテュート,インコーポレイテッド | 固形および液体悪性病変における多重car t細胞での複数抗原の標的化 |
| AU2019317278B2 (en) | 2018-08-07 | 2025-05-22 | Purdue Research Foundation | Rejuvenation of CAR T cell |
| CA3140210A1 (en) * | 2019-03-13 | 2020-09-17 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Sodium fluorescein as a reversal agent for an anti-fluorescein car t cells and fluorescein-phospholipid-ethers or profluorescein-phospholipid-ethers |
| IL295063A (en) * | 2020-02-04 | 2022-09-01 | Seattle Childrens Hospital Dba Seattle Childrens Res Inst | Chimeric antigen receptors (car) against dinitrophenol |
| CN119137261A (zh) | 2021-12-17 | 2024-12-13 | 优莫佳生物制药股份有限公司 | 细胞毒性先天淋巴样细胞及其用途 |
| WO2023225569A1 (en) | 2022-05-17 | 2023-11-23 | Umoja Biopharma, Inc. | Manufacturing viral particles |
| EP4531862A2 (en) * | 2022-05-26 | 2025-04-09 | Purdue Research Foundation | Combination of small molecule drug conjugate and car-expressing cytotoxic lymphocytes and methods of use |
| US20250354118A1 (en) | 2022-06-09 | 2025-11-20 | Umoja Biopharma, Inc. | Compositions and methods for nk cell differentiation |
| KR20250022800A (ko) | 2022-06-10 | 2025-02-17 | 우모자 바이오파마 인코포레이티드 | 조작된 줄기 세포 및 그의 용도 |
| CN114835723B (zh) * | 2022-07-01 | 2022-09-16 | 戴格普瑞生物科技(苏州)有限公司 | Psma荧光分子探针、制备方法及试剂盒 |
| EP4562133A1 (en) | 2022-07-27 | 2025-06-04 | Umoja Biopharma, Inc. | Differentiation of stem cells in suspension culture |
| KR20250120449A (ko) | 2022-11-04 | 2025-08-08 | 우모자 바이오파마 인코포레이티드 | 폴리뉴클레오티드 구축물 및 관련 바이러스 벡터 및 방법 |
| US20260176651A1 (en) | 2022-11-04 | 2026-06-25 | Umoja Biopharma, Inc. | Particles displaying adhesion-molecule fusions |
| CN120882422A (zh) | 2022-12-09 | 2025-10-31 | 艾威赛尔欧洲有限公司 | 一种用于治疗血液癌症的试剂盒 |
| EP4382119A1 (en) | 2022-12-09 | 2024-06-12 | AvenCell Europe GmbH | A kit for use in the treatment of hematological cancer |
| IL328711A (en) | 2023-12-13 | 2026-07-01 | Umoja Biopharma Inc | Myeloid cells derived from engineered induced stem cells and methods for differentiating and using them |
| WO2025231174A1 (en) | 2024-04-30 | 2025-11-06 | Umoja Biopharma, Inc. | Manufacturing viral particles |
| WO2026123000A2 (en) | 2024-12-06 | 2026-06-11 | Umoja Biopharma, Inc. | Cytokine armored engineered innate lymphoid cells and related methods |
| WO2026123001A2 (en) | 2024-12-06 | 2026-06-11 | Umoja Biopharma, Inc. | Lineage-loci engineered cell therapy and related methods of producing and using same |
| WO2026143070A1 (en) | 2024-12-23 | 2026-07-02 | Umoja Biopharma, Inc. | Improved rapamycin activated synthetic receptor transgene constructs |
| WO2026143065A1 (en) | 2024-12-23 | 2026-07-02 | Umoja Biopharma, Inc. | Polynucleotide construct for chimeric antigen receptor expression and related viral vectors and methods |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014100615A1 (en) | 2012-12-20 | 2014-06-26 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| JP2015525765A (ja) | 2012-07-13 | 2015-09-07 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | Cart細胞を調節するための組成物および方法 |
| JP2016534995A (ja) | 2013-10-15 | 2016-11-10 | ザ カリフォルニア インスティテュート フォー バイオメディカル リサーチ | キメラ抗原受容体t細胞スイッチおよびその使用 |
| WO2017025638A1 (en) | 2015-08-12 | 2017-02-16 | Sigmoid Pharma Limited | Compositions |
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