JP7114465B2 - 薬剤の細胞内送達のための化合物および組成物 - Google Patents
薬剤の細胞内送達のための化合物および組成物 Download PDFInfo
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- JP7114465B2 JP7114465B2 JP2018532573A JP2018532573A JP7114465B2 JP 7114465 B2 JP7114465 B2 JP 7114465B2 JP 2018532573 A JP2018532573 A JP 2018532573A JP 2018532573 A JP2018532573 A JP 2018532573A JP 7114465 B2 JP7114465 B2 JP 7114465B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1808—Epidermal growth factor [EGF] urogastrone
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K38/1816—Erythropoietin [EPO]
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
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- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
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- Biotechnology (AREA)
- Biochemistry (AREA)
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- Oil, Petroleum & Natural Gas (AREA)
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- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022119505A JP7367137B2 (ja) | 2015-12-22 | 2022-07-27 | 薬剤の細胞内送達のための化合物および組成物 |
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562271200P | 2015-12-22 | 2015-12-22 | |
| US201562271179P | 2015-12-22 | 2015-12-22 | |
| US201562271160P | 2015-12-22 | 2015-12-22 | |
| US201562271146P | 2015-12-22 | 2015-12-22 | |
| US201562271137P | 2015-12-22 | 2015-12-22 | |
| US62/271,179 | 2015-12-22 | ||
| US62/271,137 | 2015-12-22 | ||
| US62/271,160 | 2015-12-22 | ||
| US62/271,146 | 2015-12-22 | ||
| US62/271,200 | 2015-12-22 | ||
| US201662338474P | 2016-05-18 | 2016-05-18 | |
| US62/338,474 | 2016-05-18 | ||
| US201662413345P | 2016-10-26 | 2016-10-26 | |
| US62/413,345 | 2016-10-26 | ||
| PCT/US2016/068300 WO2017112865A1 (en) | 2015-12-22 | 2016-12-22 | Compounds and compositions for intracellular delivery of agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022119505A Division JP7367137B2 (ja) | 2015-12-22 | 2022-07-27 | 薬剤の細胞内送達のための化合物および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019508371A JP2019508371A (ja) | 2019-03-28 |
| JP2019508371A5 JP2019508371A5 (enExample) | 2020-02-06 |
| JP7114465B2 true JP7114465B2 (ja) | 2022-08-08 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018532573A Active JP7114465B2 (ja) | 2015-12-22 | 2016-12-22 | 薬剤の細胞内送達のための化合物および組成物 |
| JP2022119505A Active JP7367137B2 (ja) | 2015-12-22 | 2022-07-27 | 薬剤の細胞内送達のための化合物および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022119505A Active JP7367137B2 (ja) | 2015-12-22 | 2022-07-27 | 薬剤の細胞内送達のための化合物および組成物 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US10799463B2 (enExample) |
| EP (2) | EP3394030B2 (enExample) |
| JP (2) | JP7114465B2 (enExample) |
| AU (2) | AU2016377681B2 (enExample) |
| CA (1) | CA3007297A1 (enExample) |
| CY (1) | CY1125087T1 (enExample) |
| DK (1) | DK3394030T3 (enExample) |
| ES (1) | ES2913626T5 (enExample) |
| HR (1) | HRP20220268T1 (enExample) |
| HU (1) | HUE057877T2 (enExample) |
| LT (1) | LT3394030T (enExample) |
| PL (1) | PL3394030T3 (enExample) |
| RS (1) | RS63051B1 (enExample) |
| SI (1) | SI3394030T1 (enExample) |
| SM (1) | SMT202200252T1 (enExample) |
| WO (1) | WO2017112865A1 (enExample) |
Families Citing this family (163)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160067219A (ko) | 2013-10-03 | 2016-06-13 | 모더나 세라퓨틱스, 인코포레이티드 | 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드 |
| MA58292B1 (fr) | 2014-04-23 | 2025-01-31 | Modernatx, Inc. | Vaccins à base d'acide nucléique |
| WO2015199952A1 (en) | 2014-06-25 | 2015-12-30 | Acuitas Therapeutics Inc. | Novel lipids and lipid nanoparticle formulations for delivery of nucleic acids |
| HUE067372T2 (hu) | 2015-06-29 | 2024-10-28 | Acuitas Therapeutics Inc | Lipidek és nanoszemcsés lipid formulázások nukleinsavak beadására |
| EP3328394A4 (en) | 2015-07-30 | 2019-03-13 | ModernaTX, Inc. | CONCATEMEE peptide epitope RNAs |
| JP6948313B6 (ja) | 2015-09-17 | 2022-01-14 | モデルナティエックス インコーポレイテッド | 治療剤の細胞内送達のための化合物および組成物 |
| PL3718565T3 (pl) | 2015-10-22 | 2022-09-19 | Modernatx, Inc. | Szczepionki przeciwko wirusom układu oddechowego |
| IL286515B2 (en) | 2015-10-28 | 2024-02-01 | Acuitas Therapeutics Inc | Novel lipids and nanoparticle formulations of lipids for delivery of nucleic acids |
| EP3394030B2 (en) | 2015-12-22 | 2025-02-12 | ModernaTX, Inc. | Compounds and compositions for intracellular delivery of agents |
| EP4166666A1 (en) | 2016-09-14 | 2023-04-19 | ModernaTX, Inc. | High purity rna compositions and methods for preparation thereof |
| EP3538067A1 (en) | 2016-11-08 | 2019-09-18 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
| JP7738979B2 (ja) | 2016-11-10 | 2025-09-16 | トランスレイト バイオ, インコーポレイテッド | Mrna担持脂質ナノ粒子を調製する改善されたプロセス |
| WO2018089851A2 (en) | 2016-11-11 | 2018-05-17 | Modernatx, Inc. | Influenza vaccine |
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| SI3596042T1 (sl) | 2017-03-15 | 2022-04-29 | Modernatx, Inc. | Kristalne oblike amino lipidov |
| WO2018170336A1 (en) * | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Lipid nanoparticle formulation |
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| US11542225B2 (en) | 2017-08-17 | 2023-01-03 | Acuitas Therapeutics, Inc. | Lipids for use in lipid nanoparticle formulations |
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| EP3668979A4 (en) | 2017-08-18 | 2021-06-02 | Modernatx, Inc. | METHOD OF HPLC ANALYSIS |
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| MX2020002501A (es) * | 2017-09-08 | 2020-09-17 | Generation Bio Co | Formulaciones de nanoparticulas lipidas de vectores de adn libres de capsidos, no virales. |
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| EP3773702A2 (en) | 2018-04-05 | 2021-02-17 | CureVac AG | Novel yellow fever nucleic acid molecules for vaccination |
| CN112292395A (zh) | 2018-04-17 | 2021-01-29 | 库瑞瓦格股份公司 | 用于疫苗接种的新型rsv rna分子和组合物 |
| MA52709A (fr) * | 2018-05-23 | 2021-03-31 | Modernatx Inc | Administration d'adn |
| WO2020002525A1 (en) | 2018-06-27 | 2020-01-02 | Curevac Ag | Novel lassa virus rna molecules and compositions for vaccination |
| KR20210031932A (ko) | 2018-07-13 | 2021-03-23 | 젠맵 에이/에스 | Cd38 항체의 변이체 및 그의 용도 |
| US20240254252A1 (en) | 2018-07-13 | 2024-08-01 | Genmab A/S | Trogocytosis-mediated therapy using cd38 antibodies |
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