JP7108551B2 - リンパ球に形質導入を行うための方法及び組成物、並びにその制御された増加 - Google Patents

リンパ球に形質導入を行うための方法及び組成物、並びにその制御された増加 Download PDF

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JP7108551B2
JP7108551B2 JP2018568183A JP2018568183A JP7108551B2 JP 7108551 B2 JP7108551 B2 JP 7108551B2 JP 2018568183 A JP2018568183 A JP 2018568183A JP 2018568183 A JP2018568183 A JP 2018568183A JP 7108551 B2 JP7108551 B2 JP 7108551B2
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cells
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recombinant retrovirus
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イアン フロスト グレゴリー
ジョセフ オナッファー ジェイムズ
エイチ.グイビンガ ギアベ
クンドゥ アニルバン
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エクスマ バイオテック コーポレイション
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Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8450112B2 (en) 2008-04-09 2013-05-28 Maxcyte, Inc. Engineering and delivery of therapeutic compositions of freshly isolated cells
EP4282419A1 (en) 2012-12-20 2023-11-29 Purdue Research Foundation Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
BR112017001183A2 (pt) 2014-07-21 2017-11-28 Novartis Ag tratamento de câncer usando receptor de antígeno quimérico anti-bcma humanizado
EP3365453A2 (en) 2015-10-22 2018-08-29 Juno Therapeutics GmbH Methods, kits, agents and apparatuses for transduction
WO2020047527A2 (en) 2018-09-02 2020-03-05 F1 Bioventures, Llc Methods and compositions for genetically modifying lymphocytes in blood or in enriched pbmcs
US11111505B2 (en) 2016-03-19 2021-09-07 Exuma Biotech, Corp. Methods and compositions for transducing lymphocytes and regulating the activity thereof
US11325948B2 (en) 2016-03-19 2022-05-10 Exuma Biotech Corp. Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL
US12590321B2 (en) 2016-03-19 2026-03-31 Exuma Biotech Corp. Methods and compositions for genetically modifying and expanding lymphocytes and regulating the activity thereof
EP3439675A4 (en) 2016-04-08 2019-12-18 Purdue Research Foundation METHOD AND COMPOSITIONS FOR CAR-T CELL THERAPY
US11446398B2 (en) 2016-04-11 2022-09-20 Obsidian Therapeutics, Inc. Regulated biocircuit systems
EP4628587A3 (en) 2016-04-15 2026-02-25 Memorial Sloan Kettering Cancer Center Transgenic t cell and chimeric antigen receptor t cell compositions and related methods
SMT202600033T1 (it) 2016-04-15 2026-03-09 Bioatla Inc Anticorpi anti-axl, frammenti di anticorpo e loro immunoconiugati e loro utilizzi
EP3235908A1 (en) * 2016-04-21 2017-10-25 Ecole Normale Superieure De Lyon Methods for selectively modulating the activity of distinct subtypes of cells
GB201614093D0 (en) * 2016-08-17 2016-09-28 Autolus Ltd Vector
KR20230167769A (ko) 2016-08-26 2023-12-11 베이롤 칼리지 오브 메드신 세포 치료요법을 위한 항상성 활성 사이토킨 수용체
US11332713B2 (en) 2016-11-16 2022-05-17 KSQ Therapeutics, Inc. Gene-regulating compositions and methods for improved immunotherapy
KR20190098747A (ko) * 2016-12-05 2019-08-22 주노 쎄러퓨티크스 인코퍼레이티드 입양 세포 치료법을 위한 조작된 세포의 제조방법
US20190367876A1 (en) 2017-01-18 2019-12-05 F1 Oncology, Inc. Methods of transducing and expanding immune cells and uses thereof
US11649288B2 (en) 2017-02-07 2023-05-16 Seattle Children's Hospital Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents
WO2018160622A1 (en) 2017-02-28 2018-09-07 Endocyte, Inc. Compositions and methods for car t cell therapy
WO2018161026A1 (en) * 2017-03-03 2018-09-07 Obsidian Therapeutics, Inc. Il15 compositions and methods for immunotherapy
KR102879522B1 (ko) * 2017-03-03 2025-11-04 엑수마 바이오테크, 코포레이션 림프구를 형질도입 및 팽창시키고 이들의 활성을 조절하기 위한 방법 및 조성물
US11629340B2 (en) 2017-03-03 2023-04-18 Obsidian Therapeutics, Inc. DHFR tunable protein regulation
US10960071B2 (en) 2017-08-07 2021-03-30 The Regents Of The University Of California Platform for generating safe cell therapeutics
WO2019032628A1 (en) 2017-08-07 2019-02-14 The Regents Of The University Of California GENERATING PLATFORM FOR SAFE CELLULAR THERAPEUTIC AGENTS
EP3735460A4 (en) * 2017-09-18 2021-08-11 Exuma Biotech Corp. METHODS AND COMPOSITIONS FOR THE GENETIC MODIFICATION AND EXPANSION OF LYMPHOCYTES AND THE REGULATION OF THE ACTIVITY OF THE LATTER
WO2019090355A1 (en) * 2017-11-06 2019-05-09 Children's National Medical Center Cells expressing antibodies and methods of treatment using the same
CA3084551A1 (en) * 2017-12-14 2019-06-20 Bluebird Bio, Inc. Daric interleukin receptors
EP3735255A4 (en) * 2018-01-05 2021-09-22 Maxcyte, Inc. CHRONIC CANCER TREATMENT BY CARS
US11311576B2 (en) 2018-01-22 2022-04-26 Seattle Children's Hospital Methods of use for CAR T cells
US12312416B2 (en) 2018-02-06 2025-05-27 Seattle Children's Hospital Fluorescein-specific cars exhibiting optimal t cell function against FL-PLE labelled tumors
AU2019222560B2 (en) * 2018-02-17 2025-07-03 Flagship Pioneering Innovations V, Inc. Compositions and methods for membrane protein delivery
AU2019225174B2 (en) 2018-02-23 2025-11-20 Endocyte, Inc. Sequencing method for CAR T cell therapy
CN112040986A (zh) 2018-03-15 2020-12-04 Ksq治疗公司 用于改进的免疫疗法的基因调控组合物和方法
CA3096458A1 (en) 2018-04-12 2019-10-17 Umoja Biopharma, Inc. Viral vectors and packaging cell lines
AU2019250692A1 (en) 2018-04-13 2020-11-05 Sangamo Therapeutics France Chimeric antigen receptor specific for Interleukin-23 receptor
CN110499291B (zh) * 2018-05-16 2023-11-24 上海赛比曼生物科技有限公司 无血清培养制备嵌合抗原受体t细胞的方法
JP2021525518A (ja) * 2018-05-31 2021-09-27 ワシントン・ユニバーシティWashington University 細胞をゲノム編集及び活性化するための方法
TWI890660B (zh) 2018-06-13 2025-07-21 瑞士商諾華公司 Bcma 嵌合抗原受體及其用途
CN112955174A (zh) 2018-07-09 2021-06-11 旗舰先锋创新V股份有限公司 融合剂脂质体组合物和其用途
EP4635978A2 (en) * 2018-08-31 2025-10-22 Novartis AG Methods of making chimeric antigen receptor-expressing cells
CN113840911A (zh) * 2018-09-02 2021-12-24 埃克苏马生物技术公司 用于在血液中或在富集pbmc中基因修饰淋巴细胞的方法和组合物
EP3864199A4 (en) 2018-10-08 2023-05-03 Amberstone Biosciences, Inc. COMPARTMENTAL TESTING FOR BISPECIFIC AND MULTISPECIFIC BIOLOGICALS
WO2020092696A1 (en) * 2018-10-31 2020-05-07 Musc Foundation For Research Development Ex vivo activation and expansion of t cells for adoptive cell transfer therapy
AU2019378883A1 (en) * 2018-11-14 2021-06-03 Flagship Pioneering Innovations V, Inc. Fusosome compositions for T cell delivery
CN113631718A (zh) * 2018-11-14 2021-11-09 旗舰先锋创新V股份有限公司 用于特定隔室货物递送的组合物和方法
CA3120563A1 (en) 2018-11-26 2020-06-04 Nkarta, Inc. Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy
CN111378046B (zh) * 2018-12-27 2024-03-15 上海细胞治疗集团有限公司 一种免疫效应细胞转换受体
US20220136004A1 (en) * 2019-01-11 2022-05-05 Chan Zuckerberg Biohub, Inc. Targeted In Vivo Genome Modification
EP3773918A4 (en) 2019-03-05 2022-01-05 Nkarta, Inc. CD19 DIRECTED CHIMERIC ANTIGEN RECEPTORS AND THEIR USES IN IMMUNOTHERAPY
WO2020197984A1 (en) 2019-03-22 2020-10-01 Albany Medical College Methods for improving cognitive function
EP3963076A1 (en) * 2019-05-02 2022-03-09 Celyad Cells with multiplexed inhibitory rna
US12552855B2 (en) * 2019-05-08 2026-02-17 Regeneron Pharmaceuticals, Inc. CD33 targeted immunotherapies
US20220340927A1 (en) * 2019-09-01 2022-10-27 Exuma Biotech Corp. Methods and compositions for the modification and delivery of lymphocytes
WO2021046451A1 (en) 2019-09-06 2021-03-11 Obsidian Therapeutics, Inc. Compositions and methods for dhfr tunable protein regulation
WO2021044439A1 (en) * 2019-09-08 2021-03-11 Immunoadaptive Cell Therapy Pvt Ltd. Inducible cytokine signals & methods for immunotherapy
CA3154281A1 (en) * 2019-10-16 2021-04-22 Andrew Scharenberg Retroviral vector for universal receptor therapy
CN112779223B (zh) * 2019-11-08 2024-06-11 浙江煦顼技术有限公司 偶联嵌合抗原受体细胞及其用途
EP4065157A1 (en) 2019-11-26 2022-10-05 Novartis AG Cd19 and cd22 chimeric antigen receptors and uses thereof
AU2020395113A1 (en) * 2019-12-02 2022-06-09 Shape Therapeutics Inc. Therapeutic editing
JP2023504884A (ja) * 2019-12-05 2023-02-07 ヴィセリックス・インコーポレーティッド ユニバーサル細胞療法のための免疫逃避機構のモジュレーター
WO2021142376A1 (en) * 2020-01-08 2021-07-15 Obsidian Therapeutics, Inc. Compositions and methods for tunable regulation of transcription
AU2021213735A1 (en) 2020-01-30 2022-09-22 Umoja Biopharma, Inc. Bispecific transduction enhancer
CN115210252A (zh) 2020-02-04 2022-10-18 西雅图儿童医院(Dba西雅图儿童研究所) 抗二硝基苯酚的嵌合抗原受体
CN115243713A (zh) * 2020-03-05 2022-10-25 埃克苏马生物技术公司 用于递送修饰的淋巴细胞聚集体的方法和组合物
KR20230010231A (ko) * 2020-05-11 2023-01-18 아빈투스 바이오, 인코포레이티드 생체내 형질도입을 위한 벡터 및 방법
CN112592408B (zh) * 2020-07-20 2021-08-17 北京鼎成肽源生物技术有限公司 一种靶向c-Met的单链抗体、嵌合抗原受体、重组载体、CAR-T细胞及应用
US12012441B2 (en) 2020-10-26 2024-06-18 Neptune Biosciences Llc Engineered human IL-21 cytokines and methods for using the same
CN118064467A (zh) * 2020-11-02 2024-05-24 上海医药集团生物治疗技术有限公司 两个或多个靶点嵌合抗原受体基因工程载体及其应用
AU2022212952A1 (en) 2021-01-27 2023-08-10 Umoja Biopharma, Inc. Lentivirus for generating cells expressing anti-cd19 chimeric antigen receptor
AU2022212090A1 (en) 2021-01-28 2023-07-06 Allogene Therapeutics, Inc. Methods for transducing immune cells
WO2022187289A1 (en) 2021-03-01 2022-09-09 Exuma Biotech Corp. Methods and compositions for the delivery of retroviral particles
WO2022216906A1 (en) * 2021-04-08 2022-10-13 The Scripps Research Institute Novel therapies with engineered effector cells
KR20240028975A (ko) 2021-04-08 2024-03-05 사나 바이오테크놀로지, 인크. Cd8-특이적 항체 구조체들 및 이의 조성물
TW202307210A (zh) 2021-06-01 2023-02-16 瑞士商諾華公司 Cd19和cd22嵌合抗原受體及其用途
CN117813378A (zh) * 2021-07-26 2024-04-02 乔治亚技术研究公司 用于通过免疫细胞展示进行体内蛋白酶谱分析的组合物和方法
CN116143944B (zh) * 2021-11-17 2026-03-20 上海君赛生物股份有限公司 含gpi锚定区的膜表面蛋白
JP2024546145A (ja) * 2021-12-22 2024-12-17 クレ.エーアイ,インク. 迅速t-細胞製造
EP4469586A1 (en) 2022-03-01 2024-12-04 Exuma Biotech Corp. Viral particles with membrane-bound hyaluronidase
CA3254198A1 (en) * 2022-05-27 2023-11-30 Kite Pharma, Inc. Compositions and methods for preparing engineered lymphocytes for cell therapy
WO2024050138A2 (en) * 2022-09-02 2024-03-07 Myeloid Therapeutics, Inc. Compositions for cell-specific expression and uses thereof
IL319793A (en) * 2022-09-22 2025-05-01 Myeloid Therapeutics Inc Engineered chimeric fusion protein compositions and methods for using them
CN115807020A (zh) * 2022-09-23 2023-03-17 卡瑞济(北京)生命科技有限公司 白介素15受体α装甲CAR-T细胞在降低白介素15诱导的细胞毒性中的用途
CN116731974B (zh) * 2023-05-23 2024-11-29 杭州荣谷生物科技有限公司 病毒的制备方法和应用
WO2024259051A1 (en) * 2023-06-14 2024-12-19 The Children's Medical Center Corporation Systems and methods for modifying a polynucleotide

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014138306A1 (en) 2013-03-05 2014-09-12 Baylor College Of Medicine Engager cells for immunotherapy
JP2015503907A (ja) 2011-12-22 2015-02-05 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 真核細胞のための全長抗体提示システムおよびその使用
WO2015066042A1 (en) 2013-10-28 2015-05-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Oncolytic hsv vector
JP2015513394A (ja) 2012-02-13 2015-05-14 シアトル チルドレンズ ホスピタル ドゥーイング ビジネ 二重特異性キメラ抗原受容体およびその治療的使用
WO2016016344A1 (en) 2014-07-29 2016-02-04 Cellectis Ror1(ntrkr1)specific chimeric antigen receptors for cancer immunotherapy

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5677425A (en) 1987-09-04 1997-10-14 Celltech Therapeutics Limited Recombinant antibody
US5585362A (en) 1989-08-22 1996-12-17 The Regents Of The University Of Michigan Adenovirus vectors for gene therapy
DE69233013T2 (de) 1991-08-20 2004-03-04 The Government Of The United States Of America As Represented By The Secretary Of National Institute Of Health, Office Of Technology Transfer Adenovirus vermittelter gentransfer in den gastrointestinaltrakt
US5252479A (en) 1991-11-08 1993-10-12 Research Corporation Technologies, Inc. Safe vector for gene therapy
FR2688514A1 (fr) 1992-03-16 1993-09-17 Centre Nat Rech Scient Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant.
EP1024198A3 (en) 1992-12-03 2002-05-29 Genzyme Corporation Pseudo-adenoviral vectors for the gene therapy of haemophiliae
EP0705344B8 (en) 1993-06-24 2006-05-10 Advec Inc. Adenovirus vectors for gene therapy
AU687117B2 (en) 1993-10-25 1998-02-19 Canji, Inc. Recombinant adenoviral vector and methods of use
FR2713657B1 (fr) * 1993-12-13 1996-03-01 Transgene Sa Nouveaux vecteurs pour le traitement du sida.
KR100551104B1 (ko) 1994-12-09 2006-02-09 임페리얼 컬리지 이노베이션스 리미티드 유전자의 동정
AUPR074500A0 (en) * 2000-10-13 2000-11-09 Monash University Treatment of t cell disorders
GB0105924D0 (en) 2001-03-09 2001-04-25 Microscience Ltd Promoter
EP1769078A1 (en) * 2004-07-01 2007-04-04 VIRxSYS Corporation Vector packaging cell line
AU2005306801B2 (en) 2004-11-08 2012-05-17 The Regents Of The University Of Colorado Structure-based compound design involving riboswitches
EP2164996A4 (en) * 2007-05-29 2010-07-14 Univ Yale RIBOSWITCHES AND METHOD AND COMPOSITIONS FOR USE AND WITH RIBOSWITCHES
CN102369296A (zh) 2009-03-09 2012-03-07 生物蛋白有限公司 Mirac蛋白
TR201904484T4 (tr) 2009-11-03 2019-05-21 Hope City Transdüse T hücre seçimine yönelik kesik epiderimal büyüme faktörü reseptörü (EGFRt).
CA2832569A1 (en) * 2011-04-08 2012-10-11 Baylor College Of Medicine Reversing the effects of the tumor microenvironment using chimeric cytokine receptors
GB201107768D0 (en) * 2011-05-10 2011-06-22 Univ Manchester Riboswitches
EP2820138B1 (en) * 2012-02-29 2020-10-28 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Retroviral transduction using poloxamers
EP3783098A1 (en) * 2013-05-14 2021-02-24 Board Of Regents, The University Of Texas System Human application of engineered chimeric antigen receptor (car) t-cells
KR20160010493A (ko) * 2013-05-14 2016-01-27 쓰리엠 이노베이티브 프로퍼티즈 컴파니 접착제 조성물
DK4074735T3 (da) * 2014-08-28 2025-07-14 Bioatla Inc Betinget aktive kimæriske antigenreceptorer til modificerede t-celler
GB201503500D0 (en) * 2015-03-02 2015-04-15 Ucl Business Plc Cell
HK1255161A1 (zh) * 2015-07-15 2019-08-09 Juno Therapeutics, Inc. 用於过继性细胞治疗的工程细胞
CA3030003A1 (en) * 2016-07-08 2018-01-11 F1 Oncology, Inc. Methods and compositions for transducing lymphocytes and regulating the activity thereof
KR102879522B1 (ko) * 2017-03-03 2025-11-04 엑수마 바이오테크, 코포레이션 림프구를 형질도입 및 팽창시키고 이들의 활성을 조절하기 위한 방법 및 조성물

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015503907A (ja) 2011-12-22 2015-02-05 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 真核細胞のための全長抗体提示システムおよびその使用
JP2015513394A (ja) 2012-02-13 2015-05-14 シアトル チルドレンズ ホスピタル ドゥーイング ビジネ 二重特異性キメラ抗原受容体およびその治療的使用
WO2014138306A1 (en) 2013-03-05 2014-09-12 Baylor College Of Medicine Engager cells for immunotherapy
WO2015066042A1 (en) 2013-10-28 2015-05-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Oncolytic hsv vector
WO2016016344A1 (en) 2014-07-29 2016-02-04 Cellectis Ror1(ntrkr1)specific chimeric antigen receptors for cancer immunotherapy

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Chen Shochat,Gain-of-function mutations in interleukin-7 receptor-α (IL7R) in childhood acute lymphoblastic leukemias,J Exp Med.,2011年,208(5),901-908
Chen Shochat,J Exp Med.,2011年,208(5),901-908
SHARMA S,EFFICIENT INFECTION OF A HUMAN T-CELL LINE AND OF HUMAN PRIMARY PERIPHERAL BLOOD LEUKOCYTES 以下備考,PROCEEDINGS NATIONAL ACADEMY OF SCIENCES,米国,NATIONAL ACADEMY OF SCIENCES,1996年,VOL:93, NR:21,,PAGE(S):11842 - 11847,http://dx.doi.org/10.1073/pnas.93.21.11842,WITH A PSEUDOTYPED RETROVIRUS VECTOR
SHARMA S,PROCEEDINGS NATIONAL ACADEMY OF SCIENCES,NATIONAL ACADEMY OF SCIENCES,1996年,VOL:93, NR:21,PAGE(S):11842 - 11847,http://dx.doi.org/10.1073/pnas.93.21.11842

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