MX2018011345A - Métodos y composiciones para transducir linfocitos y expansión regulada de los mismos. - Google Patents
Métodos y composiciones para transducir linfocitos y expansión regulada de los mismos.Info
- Publication number
- MX2018011345A MX2018011345A MX2018011345A MX2018011345A MX2018011345A MX 2018011345 A MX2018011345 A MX 2018011345A MX 2018011345 A MX2018011345 A MX 2018011345A MX 2018011345 A MX2018011345 A MX 2018011345A MX 2018011345 A MX2018011345 A MX 2018011345A
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- Mexico
- Prior art keywords
- methods
- cells
- making
- compositions
- car
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 6
- 210000004698 lymphocyte Anatomy 0.000 title abstract 2
- 230000002463 transducing effect Effects 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 230000001105 regulatory effect Effects 0.000 title 1
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 230000011664 signaling Effects 0.000 abstract 2
- 239000013598 vector Substances 0.000 abstract 2
- 108020004422 Riboswitch Proteins 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000002659 cell therapy Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000001589 lymphoproliferative effect Effects 0.000 abstract 1
- 210000000822 natural killer cell Anatomy 0.000 abstract 1
- 229940127073 nucleoside analogue Drugs 0.000 abstract 1
- 238000004806 packaging method and process Methods 0.000 abstract 1
- 230000001177 retroviral effect Effects 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 241001430294 unidentified retrovirus Species 0.000 abstract 1
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Abstract
La presente invención se refiere a métodos para modificar linfocitos genéticamente y métodos para realizar terapia celular adoptiva que incluyen transducir células T y/o células NK sin estimulación ex vivo previa. Los métodos típicamente incluyen polipéptidos de señalización diseñados por ingeniería genética que pueden incluir un elemento linfoproliferativo, y/o un receptor de antígeno quimérico (CAR), por ejemplo un CAR de microambiente restringido. Elementos adicionales de tales polipéptidos de señalización diseñados por ingeniería genética se proporcionan en la presente, asi como también vectores, tales como vectores retrovirales, líneas de células de empaquetamiento y métodos para elaborar los mismos. Además. se proporcionan retrovirus recombinante y métodos para elaborar los mismos. Se proporcionan numerosos controles. que incluyen los riboswitch o riboconmutadores que son controlados, por ejemplo in vivo, por análogos de nucleósido.
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Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5779090B2 (ja) | 2008-04-09 | 2015-09-16 | マックスサイト インコーポレーティッド | 新規に単離された細胞の治療組成物の操作および送達 |
JP7195141B2 (ja) | 2015-10-22 | 2022-12-23 | ジュノ セラピューティクス ゲーエムベーハー | 形質導入のための方法、キット、作用物質および装置 |
US11325948B2 (en) | 2016-03-19 | 2022-05-10 | Exuma Biotech Corp. | Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL |
WO2021178701A1 (en) * | 2020-03-05 | 2021-09-10 | Exuma Biotech Corp. | Methods and compositions for the delivery of modified lymphocyte aggregates |
WO2020047527A2 (en) | 2018-09-02 | 2020-03-05 | F1 Bioventures, Llc | Methods and compositions for genetically modifying lymphocytes in blood or in enriched pbmcs |
US11111505B2 (en) | 2016-03-19 | 2021-09-07 | Exuma Biotech, Corp. | Methods and compositions for transducing lymphocytes and regulating the activity thereof |
US11446398B2 (en) | 2016-04-11 | 2022-09-20 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
KR102437015B1 (ko) | 2016-04-15 | 2022-08-29 | 메모리얼 슬로안 케터링 캔서 센터 | 유전자이식 t 세포 및 키메라 항원 수용체 t 세포 조성물 및 관련 방법 |
WO2017180842A1 (en) | 2016-04-15 | 2017-10-19 | Bioatla, Llc | Anti-axl antibodies, antibody fragments and their immunoconjugates and uses thereof |
EP3235908A1 (en) * | 2016-04-21 | 2017-10-25 | Ecole Normale Superieure De Lyon | Methods for selectively modulating the activity of distinct subtypes of cells |
GB201614093D0 (en) * | 2016-08-17 | 2016-09-28 | Autolus Ltd | Vector |
US11261428B2 (en) | 2018-03-15 | 2022-03-01 | KSQ Therapeutics, Inc. | Gene-regulating compositions and methods for improved immunotherapy |
US11332713B2 (en) | 2016-11-16 | 2022-05-17 | KSQ Therapeutics, Inc. | Gene-regulating compositions and methods for improved immunotherapy |
KR20190098747A (ko) * | 2016-12-05 | 2019-08-22 | 주노 쎄러퓨티크스 인코퍼레이티드 | 입양 세포 치료법을 위한 조작된 세포의 제조방법 |
US20190367876A1 (en) | 2017-01-18 | 2019-12-05 | F1 Oncology, Inc. | Methods of transducing and expanding immune cells and uses thereof |
WO2018148224A1 (en) | 2017-02-07 | 2018-08-16 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Phospholipid ether (ple) car t cell tumor targeting (ctct) agents |
JP7178355B2 (ja) | 2017-02-28 | 2022-11-25 | エンドサイト・インコーポレイテッド | Car t細胞療法のための組成物および方法 |
WO2018161026A1 (en) * | 2017-03-03 | 2018-09-07 | Obsidian Therapeutics, Inc. | Il15 compositions and methods for immunotherapy |
KR20200003370A (ko) * | 2017-03-03 | 2020-01-09 | 에프1 온콜로지, 인코포레이티드 | 림프구를 형질도입 및 팽창시키고 이들의 활성을 조절하기 위한 방법 및 조성물 |
US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
GB2578394A (en) | 2017-08-07 | 2020-05-06 | Univ California | Platform for generating safe cell therapeutics |
US10960071B2 (en) | 2017-08-07 | 2021-03-30 | The Regents Of The University Of California | Platform for generating safe cell therapeutics |
EP3735460A4 (en) * | 2017-09-18 | 2021-08-11 | Exuma Biotech Corp. | METHODS AND COMPOSITIONS FOR THE GENETIC MODIFICATION AND EXPANSION OF LYMPHOCYTES AND THE REGULATION OF THE ACTIVITY OF THE LATTER |
WO2019090355A1 (en) * | 2017-11-06 | 2019-05-09 | Children's National Medical Center | Cells expressing antibodies and methods of treatment using the same |
CA3084551A1 (en) * | 2017-12-14 | 2019-06-20 | Bluebird Bio, Inc. | Daric interleukin receptors |
US20190211109A1 (en) * | 2018-01-05 | 2019-07-11 | Maxcyte, Inc. | Chronic car treatment for cancer |
CN112055595A (zh) | 2018-01-22 | 2020-12-08 | 恩多塞特公司 | Car t细胞的使用方法 |
US20210147871A1 (en) * | 2018-04-12 | 2021-05-20 | Umoja Biopharma, Inc. | Viral vectors and packaging cell lines |
WO2019197678A1 (en) | 2018-04-13 | 2019-10-17 | Sangamo Therapeutics France | Chimeric antigen receptor specific for interleukin-23 receptor |
CN110499291B (zh) * | 2018-05-16 | 2023-11-24 | 上海赛比曼生物科技有限公司 | 无血清培养制备嵌合抗原受体t细胞的方法 |
EP3801574A4 (en) * | 2018-05-31 | 2022-03-16 | Washington University | METHODS OF GENOME EDITING AND ACTIVATION OF CELLS |
JP7438988B2 (ja) | 2018-06-13 | 2024-02-27 | ノバルティス アーゲー | Bcmaキメラ抗原受容体及びその使用 |
SG11202101825QA (en) * | 2018-08-31 | 2021-03-30 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
AU2019333324A1 (en) * | 2018-09-02 | 2021-05-06 | Exuma Biotech, Corp | Methods and compositions for genetically modifying lymphocytes in blood or in enriched PBMCs |
EP3864199A4 (en) * | 2018-10-08 | 2023-05-03 | Amberstone Biosciences, Inc. | COMPARTMENTAL DOSAGE OF BISPECIFIC AND MULTISPECIFIC BIOLOGICAL PRODUCTS |
WO2020092696A1 (en) * | 2018-10-31 | 2020-05-07 | Musc Foundation For Research Development | Ex vivo activation and expansion of t cells for adoptive cell transfer therapy |
EP3880831A1 (en) * | 2018-11-14 | 2021-09-22 | Flagship Pioneering Innovations V, Inc. | Compositions and methods for compartment-specific cargo delivery |
WO2020102503A2 (en) * | 2018-11-14 | 2020-05-22 | Flagship Pioneering Innovations V, Inc. | Fusosome compositions for t cell delivery |
AU2019385873A1 (en) * | 2018-11-26 | 2021-06-03 | Nkarta, Inc. | Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy |
CN111378046B (zh) * | 2018-12-27 | 2024-03-15 | 上海细胞治疗集团有限公司 | 一种免疫效应细胞转换受体 |
WO2020146899A1 (en) * | 2019-01-11 | 2020-07-16 | Chan Zuckerberg Biohub, Inc. | Targeted in vivo genome modification |
AU2020232691B2 (en) | 2019-03-05 | 2023-06-29 | Nkarta, Inc. | CD19-directed chimeric antigen receptors and uses thereof in immunotherapy |
AU2020336230A1 (en) * | 2019-09-01 | 2022-03-31 | Exuma Biotech Corp. | Methods and compositions for the modification and delivery of lymphocytes |
WO2021044439A1 (en) * | 2019-09-08 | 2021-03-11 | Immunoadaptive Cell Therapy Pvt Ltd. | Inducible cytokine signals & methods for immunotherapy |
CN114981441A (zh) * | 2019-10-16 | 2022-08-30 | 优莫佳生物制药股份有限公司 | 用于通用受体疗法的逆转录病毒载体 |
CN112779223B (zh) * | 2019-11-08 | 2024-06-11 | 浙江煦顼技术有限公司 | 偶联嵌合抗原受体细胞及其用途 |
MX2022006365A (es) | 2019-11-26 | 2022-06-22 | Novartis Ag | Receptores de antigeno quimerico cd19 y cd22 y usos de los mismos. |
CN115551887A (zh) * | 2019-12-05 | 2022-12-30 | 维萨列克斯股份有限公司 | 通用细胞疗法的免疫逃逸机制的调节剂 |
JP2023512071A (ja) | 2020-01-30 | 2023-03-23 | ウモジャ バイオファーマ, インコーポレイテッド | 二特異性形質導入エンハンサー |
EP4149495A4 (en) * | 2020-05-11 | 2024-06-26 | Abintus Bio, Inc. | IN VIVO TRANSDUCTION VECTORS AND METHODS |
CN111848797B (zh) * | 2020-07-20 | 2021-02-09 | 北京鼎成肽源生物技术有限公司 | 一种靶向c-Met的单链抗体、嵌合抗原受体、重组载体、CAR-T细胞及应用 |
US12012441B2 (en) | 2020-10-26 | 2024-06-18 | Neptune Biosciences Llc | Engineered human IL-21 cytokines and methods for using the same |
CN118064467A (zh) * | 2020-11-02 | 2024-05-24 | 上海医药集团生物治疗技术有限公司 | 两个或多个靶点嵌合抗原受体基因工程载体及其应用 |
AU2022212952A1 (en) | 2021-01-27 | 2023-08-10 | Umoja Biopharma, Inc. | Lentivirus for generating cells expressing anti-cd19 chimeric antigen receptor |
WO2022187289A1 (en) | 2021-03-01 | 2022-09-09 | Exuma Biotech Corp. | Methods and compositions for the delivery of retroviral particles |
KR20240028975A (ko) | 2021-04-08 | 2024-03-05 | 사나 바이오테크놀로지, 인크. | Cd8-특이적 항체 구조체들 및 이의 조성물 |
EP4319812A1 (en) * | 2021-04-08 | 2024-02-14 | The Scripps Research Institute | Novel therapies with engineered effector cells |
TW202307210A (zh) | 2021-06-01 | 2023-02-16 | 瑞士商諾華公司 | Cd19和cd22嵌合抗原受體及其用途 |
WO2023009985A1 (en) * | 2021-07-26 | 2023-02-02 | Georgia Tech Research Corporation | Compositions and methods for in vivo protease profiling by immune cell display |
KR20240123837A (ko) * | 2021-12-22 | 2024-08-14 | 큐어.에이아이, 인코포레이티드 | 신속한 t 세포 제조 |
WO2023168305A1 (en) | 2022-03-01 | 2023-09-07 | Exuma Biotech Corp. | Viral particles with membrane-bound hyaluronidase |
WO2024050138A2 (en) * | 2022-09-02 | 2024-03-07 | Myeloid Therapeutics, Inc. | Compositions for cell-specific expression and uses thereof |
WO2024064366A2 (en) * | 2022-09-22 | 2024-03-28 | Myeloid Therapeutics, Inc. | Engineered chimeric fusion protein compositions and methods of use thereof |
CN116731974A (zh) * | 2023-05-23 | 2023-09-12 | 杭州荣谷生物科技有限公司 | 病毒的制备方法和应用 |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5677425A (en) | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
ES2197145T3 (es) | 1991-08-20 | 2004-01-01 | The Government Of The Usa As Represented By The Secretary Of The Deptm. Of Health And Human Services | Transferencia de genes mediada por adenovirus al gastrointestinal. |
US5252479A (en) | 1991-11-08 | 1993-10-12 | Research Corporation Technologies, Inc. | Safe vector for gene therapy |
FR2688514A1 (fr) | 1992-03-16 | 1993-09-17 | Centre Nat Rech Scient | Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant. |
EP0905253A3 (en) | 1992-12-03 | 2000-11-02 | Genzyme Corporation | Adenoviral vector deleted of all E4-ORF except ORF6 |
AU687829B2 (en) | 1993-06-24 | 1998-03-05 | Advec, Inc. | Adenovirus vectors for gene therapy |
ATE314482T1 (de) | 1993-10-25 | 2006-01-15 | Canji Inc | Rekombinante adenoviren-vektor und verfahren zur verwendung |
FR2713657B1 (fr) * | 1993-12-13 | 1996-03-01 | Transgene Sa | Nouveaux vecteurs pour le traitement du sida. |
KR100445103B1 (ko) | 1994-12-09 | 2004-12-04 | 임페리얼 컬리지 이노베이션스 리미티드 | 유전자의동정 |
AUPR074500A0 (en) * | 2000-10-13 | 2000-11-09 | Monash University | Treatment of t cell disorders |
GB0105924D0 (en) | 2001-03-09 | 2001-04-25 | Microscience Ltd | Promoter |
CA2586998A1 (en) | 2004-11-08 | 2006-05-26 | Yale University | Structure-based compound design involving riboswitches |
WO2008156987A2 (en) * | 2007-05-29 | 2008-12-24 | Yale University | Riboswitches and methods and compositions for use of and with riboswitches |
PT2406399T (pt) | 2009-03-09 | 2018-03-05 | Bioatla Llc | Proteínas mirac |
TR201904484T4 (tr) | 2009-11-03 | 2019-05-21 | Hope City | Transdüse T hücre seçimine yönelik kesik epiderimal büyüme faktörü reseptörü (EGFRt). |
GB201107768D0 (en) * | 2011-05-10 | 2011-06-22 | Univ Manchester | Riboswitches |
SG11201403445YA (en) | 2011-12-22 | 2014-07-30 | Hoffmann La Roche | Full length antibody display system for eukaryotic cells and its use |
AU2013221672B2 (en) | 2012-02-13 | 2017-11-09 | Seattle Children's Hospital D/B/A Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
WO2013127964A1 (en) * | 2012-02-29 | 2013-09-06 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Retroviral transduction using poloxamers |
JP6420776B2 (ja) | 2013-03-05 | 2018-11-07 | ベイラー カレッジ オブ メディスンBaylor College Of Medicine | 免疫療法のためのエンゲージャー細胞 |
US10208232B2 (en) * | 2013-05-14 | 2019-02-19 | 3M Innovative Properties Company | Adhesive composition |
JP6463577B2 (ja) * | 2013-05-14 | 2019-02-06 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | 改変キメラ抗原受容体(car)t細胞のヒト応用 |
KR102330183B1 (ko) | 2013-10-28 | 2021-11-23 | 유니버시티 오브 피츠버그-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | 종양분해성 hsv 벡터 |
MX367787B (es) | 2014-07-29 | 2019-09-06 | Cellectis | Receptores de antígenos quimericos ror1 (ntrkr1) específicos para inmunoterapia del cáncer. |
AU2015308818B2 (en) * | 2014-08-28 | 2021-02-25 | Bioatla Llc | Conditionally active chimeric antigen receptors for modified T-cells |
GB201503500D0 (en) * | 2015-03-02 | 2015-04-15 | Ucl Business Plc | Cell |
MA42895A (fr) * | 2015-07-15 | 2018-05-23 | Juno Therapeutics Inc | Cellules modifiées pour thérapie cellulaire adoptive |
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AU2017236796B2 (en) | 2021-07-15 |
JP2022093363A (ja) | 2022-06-23 |
SG11201807286WA (en) | 2018-10-30 |
CA3017378A1 (en) | 2017-09-28 |
EP3430136A2 (en) | 2019-01-23 |
CN108884460A (zh) | 2018-11-23 |
JP7474281B2 (ja) | 2024-04-24 |
AU2017236796A1 (en) | 2018-09-13 |
CU24649B1 (es) | 2023-02-13 |
RU2018136607A3 (es) | 2020-12-14 |
CU20180109A7 (es) | 2019-05-03 |
WO2017165245A3 (en) | 2017-11-02 |
AU2021250935A1 (en) | 2021-11-11 |
RU2018136607A (ru) | 2020-04-20 |
BR112018069075A2 (pt) | 2019-01-29 |
SG10202104509PA (en) | 2021-06-29 |
WO2017165245A2 (en) | 2017-09-28 |
RU2755059C2 (ru) | 2021-09-13 |
CN108884460B (zh) | 2023-04-28 |
CN116426490A (zh) | 2023-07-14 |
US20170296678A1 (en) | 2017-10-19 |
IL261713B2 (en) | 2023-09-01 |
IL261713B1 (en) | 2023-05-01 |
KR20180127638A (ko) | 2018-11-29 |
KR102457098B1 (ko) | 2022-10-21 |
JP2024086884A (ja) | 2024-06-28 |
US10596274B2 (en) | 2020-03-24 |
JP2019509063A (ja) | 2019-04-04 |
IL261713A (en) | 2018-10-31 |
JP7108551B2 (ja) | 2022-07-28 |
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