BR112018069075A2 - métodos e composições para transduzir linfócitos e expansão regulada dos mesmos - Google Patents
métodos e composições para transduzir linfócitos e expansão regulada dos mesmosInfo
- Publication number
- BR112018069075A2 BR112018069075A2 BR112018069075A BR112018069075A BR112018069075A2 BR 112018069075 A2 BR112018069075 A2 BR 112018069075A2 BR 112018069075 A BR112018069075 A BR 112018069075A BR 112018069075 A BR112018069075 A BR 112018069075A BR 112018069075 A2 BR112018069075 A2 BR 112018069075A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- cells
- producing
- compositions
- genetically modified
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 6
- 210000004698 lymphocyte Anatomy 0.000 title abstract 2
- 230000002463 transducing effect Effects 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 230000001105 regulatory effect Effects 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 230000011664 signaling Effects 0.000 abstract 2
- 239000013598 vector Substances 0.000 abstract 2
- 108020004422 Riboswitch Proteins 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 238000011467 adoptive cell therapy Methods 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000001589 lymphoproliferative effect Effects 0.000 abstract 1
- 210000000822 natural killer cell Anatomy 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
- 238000004806 packaging method and process Methods 0.000 abstract 1
- 230000001177 retroviral effect Effects 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 241001430294 unidentified retrovirus Species 0.000 abstract 1
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Abstract
a presente revelação fornece métodos para modificar geneticamente linfócitos e métodos para realizar terapia celular adotiva que incluem transduzir células t e/ou células nk sem estimulação ex vivo anterior. os métodos incluem tipicamente polipeptídeos de sinalização geneticamente modificados que podem incluir um elemento linfoproliferativo e/ou um receptor de antígeno quimérico (car), por exemplo, car restrito a microambiente. exemplos adicionais de tais polipeptídeos de sinalização geneticamente modificados são fornecidos no presente documento, assim como vetores, tais como vetores retrovirais, linhagens de células de empacotamento e métodos para produzir os mesmos. ademais, retrovírus recombinantes e métodos para produzir os mesmos são fornecidos. inúmeros controles são fornecidos, incluindo riboswitches que são controlados, por exemplo, in vivo, por análogos de nucleosídeo.
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PCT/US2017/023112 WO2017165245A2 (en) | 2016-03-19 | 2017-03-19 | Methods and compositions for transducing lymphocytes and regulated expansion thereof |
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EP (1) | EP3430136A2 (pt) |
JP (3) | JP7108551B2 (pt) |
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CN (2) | CN108884460B (pt) |
AU (2) | AU2017236796B2 (pt) |
BR (1) | BR112018069075A2 (pt) |
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MA42895A (fr) * | 2015-07-15 | 2018-05-23 | Juno Therapeutics Inc | Cellules modifiées pour thérapie cellulaire adoptive |
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KR102457098B1 (ko) | 2022-10-21 |
AU2017236796A1 (en) | 2018-09-13 |
CN116426490A (zh) | 2023-07-14 |
JP7108551B2 (ja) | 2022-07-28 |
SG11201807286WA (en) | 2018-10-30 |
AU2021250935A1 (en) | 2021-11-11 |
US20170296678A1 (en) | 2017-10-19 |
US10596274B2 (en) | 2020-03-24 |
JP2022093363A (ja) | 2022-06-23 |
IL261713B1 (en) | 2023-05-01 |
KR20180127638A (ko) | 2018-11-29 |
CA3017378A1 (en) | 2017-09-28 |
JP2024086884A (ja) | 2024-06-28 |
JP7474281B2 (ja) | 2024-04-24 |
WO2017165245A2 (en) | 2017-09-28 |
SG10202104509PA (en) | 2021-06-29 |
CU20180109A7 (es) | 2019-05-03 |
EP3430136A2 (en) | 2019-01-23 |
CN108884460A (zh) | 2018-11-23 |
RU2018136607A3 (pt) | 2020-12-14 |
RU2018136607A (ru) | 2020-04-20 |
RU2755059C2 (ru) | 2021-09-13 |
AU2017236796B2 (en) | 2021-07-15 |
IL261713B2 (en) | 2023-09-01 |
CU24649B1 (es) | 2023-02-13 |
MX2018011345A (es) | 2019-05-27 |
IL261713A (en) | 2018-10-31 |
CN108884460B (zh) | 2023-04-28 |
JP2019509063A (ja) | 2019-04-04 |
WO2017165245A3 (en) | 2017-11-02 |
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