MX2019010445A - Metodos y composiciones para transducir y expandir linfocitos y regular la actividad de los mismos. - Google Patents

Metodos y composiciones para transducir y expandir linfocitos y regular la actividad de los mismos.

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Publication number
MX2019010445A
MX2019010445A MX2019010445A MX2019010445A MX2019010445A MX 2019010445 A MX2019010445 A MX 2019010445A MX 2019010445 A MX2019010445 A MX 2019010445A MX 2019010445 A MX2019010445 A MX 2019010445A MX 2019010445 A MX2019010445 A MX 2019010445A
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Mexico
Prior art keywords
methods
cells
car
regulating
transducing
Prior art date
Application number
MX2019010445A
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English (en)
Inventor
Joseph Onuffer James
H Guibinga Ghiabe
Ian Frost Gregory
Haerizadeh Farzad
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F1 Oncology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from PCT/US2017/023112 external-priority patent/WO2017165245A2/en
Priority claimed from PCT/US2017/041277 external-priority patent/WO2018009923A1/en
Priority claimed from US15/644,778 external-priority patent/US11111505B2/en
Application filed by F1 Oncology Inc filed Critical F1 Oncology Inc
Publication of MX2019010445A publication Critical patent/MX2019010445A/es

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Abstract

La presente invención se refiere a métodos para modificar genéticamente linfocitos y métodos para realizar terapia celular adoptiva que incluyen transducir células T y/o células NK. Los métodos pueden incluir molécula de ARN inhibidora(s) y/o polipéptidos de señalización diseñados por ingeniería que pueden incluir un elemento linfoproliferativo, y/o un receptor de antígeno quimérico (CAR), por ejemplo, un CAR biológico de microambiente restringido (MRB-CAR). Elementos adicionales de tales polipéptidos de señalización diseñados por ingeniería son proporcionados en la presente, tales como aquellos que conducen la proliferación y elementos reguladores de los mismos, así como también partículas retrovirales recombinantes incompetentes de replicación y líneas de células de empaquetamiento y métodos para elaborar los mismos. Numerosos elementos y métodos para regular células T y/o células NK transducidas y/o genéticamente modificadas son proporcionados, tales como, por ejemplo, aquellos que incluyen riboswitches, MRB-CARs, dominios de reconocimiento, y/o agentes moduladores de pH.
MX2019010445A 2017-03-03 2018-03-03 Metodos y composiciones para transducir y expandir linfocitos y regular la actividad de los mismos. MX2019010445A (es)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201762467039P 2017-03-03 2017-03-03
PCT/US2017/023112 WO2017165245A2 (en) 2016-03-19 2017-03-19 Methods and compositions for transducing lymphocytes and regulated expansion thereof
US15/462,855 US10596274B2 (en) 2016-03-19 2017-03-19 Methods and compositions for transducing lymphocytes and regulated expansion thereof
PCT/US2017/041277 WO2018009923A1 (en) 2016-07-08 2017-07-08 Methods and compositions for transducing lymphocytes and regulating the activity thereof
US15/644,778 US11111505B2 (en) 2016-03-19 2017-07-08 Methods and compositions for transducing lymphocytes and regulating the activity thereof
US201762560176P 2017-09-18 2017-09-18
US201762564253P 2017-09-27 2017-09-27
US201762564991P 2017-09-28 2017-09-28
PCT/US2018/020818 WO2018161064A1 (en) 2017-03-03 2018-03-03 Methods and compositions for transducing and expanding lymphocytes and regulating the activity thereof

Publications (1)

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MX2019010445A true MX2019010445A (es) 2019-10-24

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EP (1) EP3589733A1 (es)
KR (1) KR20200003370A (es)
CN (1) CN110892070A (es)
AU (1) AU2018226884A1 (es)
BR (1) BR112019018288A2 (es)
CA (1) CA3054064A1 (es)
CU (1) CU24645B1 (es)
IL (1) IL268739B1 (es)
MX (1) MX2019010445A (es)
SG (2) SG10202109571PA (es)
TW (1) TW201839127A (es)
WO (1) WO2018161064A1 (es)

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