JP7051703B2 - ピラゾロピリミジン誘導体 - Google Patents

ピラゾロピリミジン誘導体 Download PDF

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Publication number
JP7051703B2
JP7051703B2 JP2018553486A JP2018553486A JP7051703B2 JP 7051703 B2 JP7051703 B2 JP 7051703B2 JP 2018553486 A JP2018553486 A JP 2018553486A JP 2018553486 A JP2018553486 A JP 2018553486A JP 7051703 B2 JP7051703 B2 JP 7051703B2
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JP
Japan
Prior art keywords
alkyl
group
hydrogen
alkoxy
methyl
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Active
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JP2018553486A
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English (en)
Japanese (ja)
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JP2019513776A (ja
JP2019513776A5 (enExample
Inventor
コーラー，アドリーヌ
ヴェルツ，クラウディア
ベルンゲン，キルステン
クルケ，ダニエル
イルク，トマス
ケーベルリング，ヨハネス
ヒュプシュ，ヴァルター
シュヴアルツ，ハンス－ゲオルク
ゲルゲンス，ウルリッヒ
エビングハウス－キンツシェール，ウルリッヒ
ヒンク，マイケ
ネンシュティール，ダーク
ローミング，クラウス
アダムクゼウスキー，マルティン
ベーム，クラウディア
グリーベナウ，ニルス
チュアン，ウェイ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elanco Animal Health GmbH
Original Assignee
Bayer Animal Health GmbH
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Publication of JP2019513776A publication Critical patent/JP2019513776A/ja
Publication of JP2019513776A5 publication Critical patent/JP2019513776A5/ja
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
JP2018553486A 2016-04-15 2017-04-10 ピラゾロピリミジン誘導体 Active JP7051703B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16165572.5 2016-04-15
EP16165572 2016-04-15
PCT/EP2017/058519 WO2017178416A1 (en) 2016-04-15 2017-04-10 Pyrazolopyrimidine derivatives

Publications (3)

Publication Number Publication Date
JP2019513776A JP2019513776A (ja) 2019-05-30
JP2019513776A5 JP2019513776A5 (enExample) 2020-05-21
JP7051703B2 true JP7051703B2 (ja) 2022-04-11

Family

ID=55755480

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018553486A Active JP7051703B2 (ja) 2016-04-15 2017-04-10 ピラゾロピリミジン誘導体

Country Status (22)

Country Link
US (3) US10604525B2 (enExample)
EP (1) EP3442974B8 (enExample)
JP (1) JP7051703B2 (enExample)
KR (1) KR102467347B1 (enExample)
CN (1) CN109071545B (enExample)
AR (1) AR108130A1 (enExample)
AU (1) AU2017251155B2 (enExample)
CA (1) CA3020793C (enExample)
CL (1) CL2018002920A1 (enExample)
CO (1) CO2018010966A2 (enExample)
DO (1) DOP2018000226A (enExample)
ES (1) ES2953467T3 (enExample)
IL (1) IL261885A (enExample)
MX (1) MX389697B (enExample)
PH (1) PH12018550173A1 (enExample)
PL (1) PL3442974T3 (enExample)
RU (1) RU2769448C2 (enExample)
SG (1) SG11201808214TA (enExample)
TW (1) TWI742067B (enExample)
UY (1) UY37201A (enExample)
WO (1) WO2017178416A1 (enExample)
ZA (1) ZA201807656B (enExample)

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TWI865563B (zh) 2019-07-30 2024-12-11 德商拜耳動物保健有限公司 新穎異喹啉衍生物
JP2023507173A (ja) * 2019-12-18 2023-02-21 インターベット インターナショナル ベー． フェー． キノリン構造を含む駆虫剤化合物
MX2022007671A (es) 2019-12-18 2022-07-19 Intervet Int Bv Compuestos antihelminticos que comprenden una estructura de azaindoles.
BR112022024156A2 (pt) 2020-05-29 2023-02-14 Boehringer Ingelheim Animal Health Usa Inc Compostos heterocílicos antelmínticos
CN116685584A (zh) * 2020-11-18 2023-09-01 礼蓝动物保健有限公司 用于治疗心丝虫感染的n-(2,3-二氢-1,4-苯并噁嗪-4-基)-3-异丙基-7-(2,3,5-三氟苯基)苯并噻吩-2-甲酰胺衍生物和类似化合物
US20240059680A1 (en) 2020-11-18 2024-02-22 Elanco Tiergesundheit Ag N-(2,3-dihydro-1,4-benzoxazin-4-yl)-3-isopropyl-7-(2,3,5-trifluorophenyl)benzo-thiophene-2-carboxamide derivatives and similar compounds for the treatment of heartworm infections
TW202237600A (zh) 2020-12-04 2022-10-01 瑞士商禮藍動物保健股份有限公司 雙環衍生物
WO2022122988A1 (en) 2020-12-11 2022-06-16 Intervet International B.V. Anthelmintic compounds comprising a thienopyridine structure
CN113252824B (zh) * 2021-06-17 2022-04-19 湖南农业大学 测定水体中三氟苯嘧啶含量的气相色谱-电子捕获检测器法
KR102660894B1 (ko) * 2021-09-17 2024-04-26 기초과학연구원 피리미딘-2-아민 화합물의 제조방법
WO2023073641A1 (en) 2021-11-01 2023-05-04 Boehringer Ingelheim Vetmedica Gmbh Anthelmintic pyrrolopyridazine compounds
EP4694887A1 (en) 2023-04-14 2026-02-18 Elanco Animal Health GmbH Long-term prevention and/or treatment of a disease by slo-1 inhibitors
CN121620507A (zh) 2023-08-02 2026-03-06 英特维特国际股份有限公司 具有驱虫活性的甲酰胺-4-喹啉化合物
CN119139315B (zh) * 2024-09-23 2026-03-10 大连大学 D724-0491在制备治疗乳腺癌药物中的应用
WO2026078157A2 (en) 2024-10-10 2026-04-16 Elanco Animal Health Gmbh Slo-1 modulators for prevention and/or treatment of a disease
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Publication number Publication date
RU2018140092A (ru) 2020-05-15
EP3442974B8 (en) 2023-07-12
AU2017251155A1 (en) 2018-10-11
SG11201808214TA (en) 2018-10-30
CL2018002920A1 (es) 2019-02-01
US10934301B2 (en) 2021-03-02
UY37201A (es) 2017-11-30
AU2017251155B2 (en) 2021-08-05
RU2769448C2 (ru) 2022-03-31
MX389697B (es) 2025-03-20
WO2017178416A1 (en) 2017-10-19
JP2019513776A (ja) 2019-05-30
EP3442974C0 (en) 2023-06-07
TWI742067B (zh) 2021-10-11
KR20180134966A (ko) 2018-12-19
CN109071545A (zh) 2018-12-21
ZA201807656B (en) 2024-06-26
US11001590B2 (en) 2021-05-11
PH12018550173A1 (en) 2019-07-15
US20200239482A1 (en) 2020-07-30
MX2018012544A (es) 2019-01-31
US20200299299A1 (en) 2020-09-24
NZ747056A (en) 2025-05-30
PL3442974T3 (pl) 2023-12-04
CO2018010966A2 (es) 2018-10-22
CA3020793C (en) 2024-05-21
DOP2018000226A (es) 2018-11-15
TW201803874A (zh) 2018-02-01
AR108130A1 (es) 2018-07-18
IL261885A (en) 2018-10-31
EP3442974A1 (en) 2019-02-20
KR102467347B1 (ko) 2022-11-14
RU2018140092A3 (enExample) 2020-06-25
ES2953467T3 (es) 2023-11-13
EP3442974B1 (en) 2023-06-07
US20190071447A1 (en) 2019-03-07
CA3020793A1 (en) 2017-10-19
CN109071545B (zh) 2021-08-03
US10604525B2 (en) 2020-03-31

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