MX389697B - Nuevos derivados de pirazolopirimidina. - Google Patents

Nuevos derivados de pirazolopirimidina.

Info

Publication number
MX389697B
MX389697B MX2018012544A MX2018012544A MX389697B MX 389697 B MX389697 B MX 389697B MX 2018012544 A MX2018012544 A MX 2018012544A MX 2018012544 A MX2018012544 A MX 2018012544A MX 389697 B MX389697 B MX 389697B
Authority
MX
Mexico
Prior art keywords
sup
compounds
pyrazolopyrimidine derivatives
preparing
pharmaceutical compositions
Prior art date
Application number
MX2018012544A
Other languages
English (en)
Other versions
MX2018012544A (es
Inventor
Adeline Köhler
Claudia Böhm
Claudia Welz
Daniel Kulke
Dirk Nennstiel
Hans-Georg Schwarz
Johannes Köbberling
Kirsten Börngen
Klaus Raming
Maike Hink
Martin Adamczewski
Nils Griebenow
Thomas Ilg
Ulrich Ebbinghaus-Kintscher
Ulrich Görgens
Walter Hübsch
Wei Zhuang
Original Assignee
Elanco Animal Health Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elanco Animal Health Gmbh filed Critical Elanco Animal Health Gmbh
Publication of MX2018012544A publication Critical patent/MX2018012544A/es
Publication of MX389697B publication Critical patent/MX389697B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)

Abstract

La presente invención abarca compuestos pirazolopirimidina de fórmula general (I): (ver Fórmula) en donde n, o, X, Y, R, Q, R1, R2, R3 y R4 son como se definen en la presente, métodos para preparar dichos compuestos, compuestos intermediarios útiles para preparar dichos compuestos, composiciones farmacéuticas y combinaciones que comprenden dichos compuestos y el uso de dichos compuestos para la fabricación de composiciones farmacéuticas para el tratamiento, control y/o prevención de enfermedades, en particular de infecciones helmínticas, como agente único o en combinación con otros ingredientes activos.
MX2018012544A 2016-04-15 2017-04-10 Nuevos derivados de pirazolopirimidina. MX389697B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16165572 2016-04-15
PCT/EP2017/058519 WO2017178416A1 (en) 2016-04-15 2017-04-10 Pyrazolopyrimidine derivatives

Publications (2)

Publication Number Publication Date
MX2018012544A MX2018012544A (es) 2019-01-31
MX389697B true MX389697B (es) 2025-03-20

Family

ID=55755480

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018012544A MX389697B (es) 2016-04-15 2017-04-10 Nuevos derivados de pirazolopirimidina.

Country Status (22)

Country Link
US (3) US10604525B2 (es)
EP (1) EP3442974B8 (es)
JP (1) JP7051703B2 (es)
KR (1) KR102467347B1 (es)
CN (1) CN109071545B (es)
AR (1) AR108130A1 (es)
AU (1) AU2017251155B2 (es)
CA (1) CA3020793C (es)
CL (1) CL2018002920A1 (es)
CO (1) CO2018010966A2 (es)
DO (1) DOP2018000226A (es)
ES (1) ES2953467T3 (es)
IL (1) IL261885A (es)
MX (1) MX389697B (es)
PH (1) PH12018550173A1 (es)
PL (1) PL3442974T3 (es)
RU (1) RU2769448C2 (es)
SG (1) SG11201808214TA (es)
TW (1) TWI742067B (es)
UY (1) UY37201A (es)
WO (1) WO2017178416A1 (es)
ZA (1) ZA201807656B (es)

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TW202237600A (zh) 2020-12-04 2022-10-01 瑞士商禮藍動物保健股份有限公司 雙環衍生物
US20240043446A1 (en) * 2020-12-11 2024-02-08 Intervet Inc. Anthelmintic compounds comprising a thienopyridine structure
CN113252824B (zh) * 2021-06-17 2022-04-19 湖南农业大学 测定水体中三氟苯嘧啶含量的气相色谱-电子捕获检测器法
KR102660894B1 (ko) * 2021-09-17 2024-04-26 기초과학연구원 피리미딘-2-아민 화합물의 제조방법
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Also Published As

Publication number Publication date
DOP2018000226A (es) 2018-11-15
US20200239482A1 (en) 2020-07-30
CL2018002920A1 (es) 2019-02-01
ZA201807656B (en) 2024-06-26
KR20180134966A (ko) 2018-12-19
RU2018140092A (ru) 2020-05-15
SG11201808214TA (en) 2018-10-30
US11001590B2 (en) 2021-05-11
EP3442974C0 (en) 2023-06-07
AR108130A1 (es) 2018-07-18
AU2017251155B2 (en) 2021-08-05
AU2017251155A1 (en) 2018-10-11
TW201803874A (zh) 2018-02-01
EP3442974B1 (en) 2023-06-07
US10934301B2 (en) 2021-03-02
EP3442974B8 (en) 2023-07-12
JP7051703B2 (ja) 2022-04-11
EP3442974A1 (en) 2019-02-20
RU2769448C2 (ru) 2022-03-31
PH12018550173A1 (en) 2019-07-15
CA3020793A1 (en) 2017-10-19
CN109071545B (zh) 2021-08-03
IL261885A (en) 2018-10-31
KR102467347B1 (ko) 2022-11-14
PL3442974T3 (pl) 2023-12-04
US10604525B2 (en) 2020-03-31
NZ747056A (en) 2025-05-30
CO2018010966A2 (es) 2018-10-22
US20190071447A1 (en) 2019-03-07
CA3020793C (en) 2024-05-21
JP2019513776A (ja) 2019-05-30
TWI742067B (zh) 2021-10-11
RU2018140092A3 (es) 2020-06-25
WO2017178416A1 (en) 2017-10-19
UY37201A (es) 2017-11-30
US20200299299A1 (en) 2020-09-24
CN109071545A (zh) 2018-12-21
MX2018012544A (es) 2019-01-31
ES2953467T3 (es) 2023-11-13

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