MX389697B - Nuevos derivados de pirazolopirimidina. - Google Patents

Nuevos derivados de pirazolopirimidina.

Info

Publication number
MX389697B
MX389697B MX2018012544A MX2018012544A MX389697B MX 389697 B MX389697 B MX 389697B MX 2018012544 A MX2018012544 A MX 2018012544A MX 2018012544 A MX2018012544 A MX 2018012544A MX 389697 B MX389697 B MX 389697B
Authority
MX
Mexico
Prior art keywords
sup
compounds
pyrazolopyrimidine derivatives
preparing
pharmaceutical compositions
Prior art date
Application number
MX2018012544A
Other languages
English (en)
Other versions
MX2018012544A (es
Inventor
Adeline Köhler
Claudia Böhm
Claudia Welz
Daniel Kulke
Dirk Nennstiel
Hans-Georg Schwarz
Johannes Köbberling
Kirsten Börngen
Klaus Raming
Maike Hink
Martin Adamczewski
Nils Griebenow
Thomas Ilg
Ulrich Ebbinghaus-Kintscher
Ulrich Görgens
Walter Hübsch
Wei Zhuang
Original Assignee
Elanco Animal Health Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elanco Animal Health Gmbh filed Critical Elanco Animal Health Gmbh
Publication of MX2018012544A publication Critical patent/MX2018012544A/es
Publication of MX389697B publication Critical patent/MX389697B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)

Abstract

La presente invención abarca compuestos pirazolopirimidina de fórmula general (I): (ver Fórmula) en donde n, o, X, Y, R, Q, R1, R2, R3 y R4 son como se definen en la presente, métodos para preparar dichos compuestos, compuestos intermediarios útiles para preparar dichos compuestos, composiciones farmacéuticas y combinaciones que comprenden dichos compuestos y el uso de dichos compuestos para la fabricación de composiciones farmacéuticas para el tratamiento, control y/o prevención de enfermedades, en particular de infecciones helmínticas, como agente único o en combinación con otros ingredientes activos.
MX2018012544A 2016-04-15 2017-04-10 Nuevos derivados de pirazolopirimidina. MX389697B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16165572 2016-04-15
PCT/EP2017/058519 WO2017178416A1 (en) 2016-04-15 2017-04-10 Pyrazolopyrimidine derivatives

Publications (2)

Publication Number Publication Date
MX2018012544A MX2018012544A (es) 2019-01-31
MX389697B true MX389697B (es) 2025-03-20

Family

ID=55755480

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018012544A MX389697B (es) 2016-04-15 2017-04-10 Nuevos derivados de pirazolopirimidina.

Country Status (22)

Country Link
US (3) US10604525B2 (es)
EP (1) EP3442974B8 (es)
JP (1) JP7051703B2 (es)
KR (1) KR102467347B1 (es)
CN (1) CN109071545B (es)
AR (1) AR108130A1 (es)
AU (1) AU2017251155B2 (es)
CA (1) CA3020793C (es)
CL (1) CL2018002920A1 (es)
CO (1) CO2018010966A2 (es)
DO (1) DOP2018000226A (es)
ES (1) ES2953467T3 (es)
IL (1) IL261885A (es)
MX (1) MX389697B (es)
PH (1) PH12018550173A1 (es)
PL (1) PL3442974T3 (es)
RU (1) RU2769448C2 (es)
SG (1) SG11201808214TA (es)
TW (1) TWI742067B (es)
UY (1) UY37201A (es)
WO (1) WO2017178416A1 (es)
ZA (1) ZA201807656B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016022066A1 (en) 2014-08-04 2016-02-11 Jerry Tan Eye Surgery Pte Ltd Pharmaceutical compositions for demodex related blepharitis and eyelid crusting
RS60302B1 (sr) 2016-04-15 2020-07-31 Abbvie Inc Inhibitori bromodomena
PL3442974T3 (pl) * 2016-04-15 2023-12-04 Elanco Animal Health Gmbh Pochodne pirazolopirymidyny
CN118021814A (zh) 2017-04-21 2024-05-14 Epizyme股份有限公司 用ehmt2抑制剂进行的组合疗法
CA3061406A1 (en) * 2017-04-27 2018-11-01 Bayer Animal Health Gmbh New bicyclic pyrazole derivatives
MX2020002869A (es) 2017-09-15 2020-07-24 Aduro Biotech Inc Compuestos de pirazolopirimidinona y usos de los mismos.
KR20250057155A (ko) 2017-12-15 2025-04-28 타르서스 파마수티칼스, 아이엔씨. 안검염을 치료하기 위한 이속사졸린 구충제 제제 및 방법
CA3099610A1 (en) 2018-05-09 2019-11-14 Bayer Animal Health Gmbh New quinoline derivatives
MX2021000293A (es) 2018-07-09 2021-07-15 Boehringer Ingelheim Animal Health Usa Inc Compuestos heterociclicos antihelminticos.
EP3643711A1 (en) 2018-10-24 2020-04-29 Bayer Animal Health GmbH New anthelmintic compounds
PL3897842T3 (pl) * 2018-12-18 2025-05-19 Elanco Tiergesundheit Ag Pochodne bicykliczne
US20220064160A1 (en) * 2018-12-18 2022-03-03 Elanco Tiergesundheit Ag Bicyclic derivatives
BR112021018631A2 (pt) * 2019-03-19 2021-11-23 Boehringer Ingelheim Animal Health Usa Inc Compostos anti-helmínticos de aza-benzotiofeno e aza-benzofurano
US12502377B2 (en) 2019-04-04 2025-12-23 Tarsus Pharmaceuticals, Inc. Method of eradicating ticks that attach to humans using lotilaner formulations
CN114206860B (zh) * 2019-06-07 2025-02-18 礼蓝动物保健有限公司 用于治疗体内寄生虫的双环衍生物
TWI865563B (zh) 2019-07-30 2024-12-11 德商拜耳動物保健有限公司 新穎異喹啉衍生物
WO2021122911A1 (en) 2019-12-18 2021-06-24 Intervet International B.V. Anthelmintic compounds comprising a quinoline structure
MX2022007671A (es) * 2019-12-18 2022-07-19 Intervet Int Bv Compuestos antihelminticos que comprenden una estructura de azaindoles.
WO2021242581A1 (en) * 2020-05-29 2021-12-02 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic heterocyclic compounds
CN116685584A (zh) * 2020-11-18 2023-09-01 礼蓝动物保健有限公司 用于治疗心丝虫感染的n-(2,3-二氢-1,4-苯并噁嗪-4-基)-3-异丙基-7-(2,3,5-三氟苯基)苯并噻吩-2-甲酰胺衍生物和类似化合物
WO2022106469A2 (en) 2020-11-18 2022-05-27 Elanco Tiergesundheit Ag N-(2,3-dihydro-1,4-benzoxazin-4-yl)-3-isopropyl-7-(2,3,5-trifluorophenyl)benzo-thiophene-2-carboxamide derivatives and similar compounds for the treatment of heartworm infections
TW202237600A (zh) 2020-12-04 2022-10-01 瑞士商禮藍動物保健股份有限公司 雙環衍生物
AU2021395477A1 (en) * 2020-12-11 2023-06-22 Intervet International B.V. Anthelmintic compounds comprising a thienopyridine structure
CN113252824B (zh) * 2021-06-17 2022-04-19 湖南农业大学 测定水体中三氟苯嘧啶含量的气相色谱-电子捕获检测器法
KR102660894B1 (ko) * 2021-09-17 2024-04-26 기초과학연구원 피리미딘-2-아민 화합물의 제조방법
UY39995A (es) 2021-11-01 2023-05-15 Boehringer Ingelheim Vetmedica GmbH Compuestos de pirrolopiridazina como antihelmínticos
WO2024213752A1 (en) 2023-04-14 2024-10-17 Elanco Animal Health Gmbh Long-term prevention and/or treatment of a disease by slo-1 inhibitors
CN121620507A (zh) 2023-08-02 2026-03-06 英特维特国际股份有限公司 具有驱虫活性的甲酰胺-4-喹啉化合物
CN119139315B (zh) * 2024-09-23 2026-03-10 大连大学 D724-0491在制备治疗乳腺癌药物中的应用

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY125533A (en) 1999-12-06 2006-08-30 Bristol Myers Squibb Co Heterocyclic dihydropyrimidine compounds
RU15525U1 (ru) 2000-07-04 2000-10-20 Федеральный научно-производственный центр закрытое акционерное общество "Научно-производственный концерн (объединение) "ЭНЕРГИЯ" Электродвигатель постоянного тока
US7662826B2 (en) * 2002-04-23 2010-02-16 Shionogi & Co., Ltd. Pyrazolo [1,5-a] pyrimidine derivative and nad (p) h oxidase inhibitor containing the same
GB0213715D0 (en) 2002-06-14 2002-07-24 Syngenta Ltd Chemical compounds
TWI312272B (en) 2003-05-12 2009-07-21 Sumitomo Chemical Co Pyrimidine compound and pests controlling composition containing the same
EA009517B1 (ru) * 2003-06-27 2008-02-28 Байер Кропсайенс Аг Пиразолопиримидины
CA2530378A1 (en) 2003-06-27 2005-01-06 Bayer Cropscience Ag Pyrazolopyrimidines
GB0414438D0 (en) 2004-06-28 2004-07-28 Syngenta Participations Ag Chemical compounds
RU2394819C2 (ru) 2004-10-20 2010-07-20 Кумиай Кемикал Индастри Ко., Лтд. Инсектицид, акарицид и нематоцид, содержащие в качестве активного компонента производное 3-триазолилфенилсульфида
BRPI0616667B1 (pt) 2005-10-06 2017-07-18 Nippon Soda Co. , Ltd. Compounds of cyclical amine or salts thereof or non-oxides thereof, and agents for control of fever
EP1918291A1 (en) * 2006-10-30 2008-05-07 Novartis AG 3-Aminocarbonyl-substituted fused pyrazolo-derivatives as protein kinase modulators
CA2670083A1 (en) * 2006-11-20 2008-05-29 Alantos Pharmaceuticals Holding, Inc. Heterobicyclic metalloprotease inhibitors
US8729264B2 (en) 2007-09-28 2014-05-20 Kyowa Hakko Kirin Co., Ltd. Agent for prevention and/or treatment of skin diseases
JP5268461B2 (ja) 2008-07-14 2013-08-21 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 Ｐｆ１３６４物質、その製造方法、生産菌株、及び、それを有効成分とする農園芸用殺虫剤
CN101337937B (zh) 2008-08-12 2010-12-22 国家农药创制工程技术研究中心 具有杀虫活性的n-苯基-5-取代氨基吡唑类化合物
CN101337940B (zh) 2008-08-12 2012-05-02 国家农药创制工程技术研究中心 具杀虫活性的含氮杂环二氯烯丙醚类化合物
CN101715774A (zh) 2008-10-09 2010-06-02 浙江化工科技集团有限公司 一个具有杀虫活性化合物制备及用途
EP2184273A1 (de) 2008-11-05 2010-05-12 Bayer CropScience AG Halogen-substituierte Verbindungen als Pestizide
GB0820344D0 (en) 2008-11-06 2008-12-17 Syngenta Ltd Herbicidal compositions
US8007468B2 (en) 2009-07-13 2011-08-30 Navilyst Medical, Inc. Method to secure an elastic component in a valve
WO2011085575A1 (zh) 2010-01-15 2011-07-21 江苏省农药研究所股份有限公司 邻杂环甲酰苯胺类化合物及其合成方法和应用
PE20131380A1 (es) 2010-08-31 2014-01-05 Meiji Seika Pharma Co Ltd Agente de control de plagas
CN101967139B (zh) 2010-09-14 2013-06-05 中化蓝天集团有限公司 一种含一氟甲氧基吡唑的邻甲酰氨基苯甲酰胺类化合物、其合成方法及应用
WO2012112363A1 (en) 2011-02-14 2012-08-23 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
WO2013050317A1 (en) 2011-10-03 2013-04-11 Syngenta Limited Polymorphs of an isoxazoline derivative
CN102391261A (zh) 2011-10-14 2012-03-28 上海交通大学 一种n-取代噁二嗪类化合物及其制备方法和应用
US9334238B2 (en) 2012-03-30 2016-05-10 Basf Se N-substituted pyridinylidenes for combating animal pests
EP2647626A1 (en) 2012-04-03 2013-10-09 Syngenta Participations AG. 1-Aza-spiro[4.5]dec-3-ene and 1,8-diaza-spiro[4.5]dec-3-ene derivatives as pesticides
NZ700595A (en) 2012-04-27 2016-04-29 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
US9282739B2 (en) 2012-04-27 2016-03-15 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
WO2014070978A1 (en) 2012-11-03 2014-05-08 Boehringer Ingelheim International Gmbh Inhibitors of cytomegalovirus
CN103232431B (zh) 2013-01-25 2014-11-05 青岛科技大学 一种二卤代吡唑酰胺类化合物及其应用
CN103109816B (zh) 2013-01-25 2014-09-10 青岛科技大学 硫代苯甲酰胺类化合物及其应用
US20140275503A1 (en) 2013-03-13 2014-09-18 Dow Agrosciences Llc Process for the preparation of certain triaryl rhamnose carbamates
CN103265527B (zh) 2013-06-07 2014-08-13 江苏省农用激素工程技术研究中心有限公司 邻氨基苯甲酰胺化合物及其制备方法和应用
CN103524422B (zh) 2013-10-11 2015-05-27 中国农业科学院植物保护研究所 苯并咪唑衍生物及其制备方法和用途
CA2925873A1 (en) 2013-10-17 2015-04-23 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
MX2016004942A (es) 2013-10-17 2016-06-28 Dow Agrosciences Llc Procesos para la preparacion de compuestos plaguicidas.
UY36196A (es) * 2014-07-25 2016-02-29 Bayer Animal Health Gmbh Compuestos para usar en el tratamiento antihelmíntico
PL3442974T3 (pl) 2016-04-15 2023-12-04 Elanco Animal Health Gmbh Pochodne pirazolopirymidyny

Also Published As

Publication number Publication date
NZ747056A (en) 2025-05-30
UY37201A (es) 2017-11-30
TW201803874A (zh) 2018-02-01
JP2019513776A (ja) 2019-05-30
US20200299299A1 (en) 2020-09-24
CL2018002920A1 (es) 2019-02-01
EP3442974C0 (en) 2023-06-07
AU2017251155B2 (en) 2021-08-05
KR102467347B1 (ko) 2022-11-14
CA3020793C (en) 2024-05-21
US11001590B2 (en) 2021-05-11
KR20180134966A (ko) 2018-12-19
PL3442974T3 (pl) 2023-12-04
ES2953467T3 (es) 2023-11-13
CA3020793A1 (en) 2017-10-19
CN109071545B (zh) 2021-08-03
IL261885A (en) 2018-10-31
TWI742067B (zh) 2021-10-11
RU2018140092A (ru) 2020-05-15
CO2018010966A2 (es) 2018-10-22
WO2017178416A1 (en) 2017-10-19
CN109071545A (zh) 2018-12-21
US10934301B2 (en) 2021-03-02
EP3442974B1 (en) 2023-06-07
SG11201808214TA (en) 2018-10-30
RU2018140092A3 (es) 2020-06-25
US20200239482A1 (en) 2020-07-30
US10604525B2 (en) 2020-03-31
MX2018012544A (es) 2019-01-31
ZA201807656B (en) 2024-06-26
US20190071447A1 (en) 2019-03-07
DOP2018000226A (es) 2018-11-15
PH12018550173A1 (en) 2019-07-15
JP7051703B2 (ja) 2022-04-11
EP3442974B8 (en) 2023-07-12
RU2769448C2 (ru) 2022-03-31
EP3442974A1 (en) 2019-02-20
AU2017251155A1 (en) 2018-10-11
AR108130A1 (es) 2018-07-18

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