CA3020793C - Pyrazolopyrimidine derivatives - Google Patents

Pyrazolopyrimidine derivatives Download PDF

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Publication number
CA3020793C
CA3020793C CA3020793A CA3020793A CA3020793C CA 3020793 C CA3020793 C CA 3020793C CA 3020793 A CA3020793 A CA 3020793A CA 3020793 A CA3020793 A CA 3020793A CA 3020793 C CA3020793 C CA 3020793C
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CA
Canada
Prior art keywords
alkyl
group
hydrogen
methyl
halogenoalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3020793A
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English (en)
French (fr)
Other versions
CA3020793A1 (en
Inventor
Adeline Kohler
Claudia WELZ
Kirsten Borngen
Daniel Kulke
Thomas Ilg
Johannes Kobberling
Walter Hubsch
Hans-Georg Schwarz
Ulrich Gorgens
Ulrich Ebbinghaus-Kintscher
Maike HINK
Dirk Nennstiel
Klaus Raming
Martin Adamczewski
Claudia Bohm
Nils Griebenow
Wei Zhuang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elanco Animal Health GmbH
Original Assignee
Bayer Animal Health GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Animal Health GmbH filed Critical Bayer Animal Health GmbH
Publication of CA3020793A1 publication Critical patent/CA3020793A1/en
Application granted granted Critical
Publication of CA3020793C publication Critical patent/CA3020793C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
CA3020793A 2016-04-15 2017-04-10 Pyrazolopyrimidine derivatives Active CA3020793C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16165572 2016-04-15
EP16165572.5 2016-04-15
PCT/EP2017/058519 WO2017178416A1 (en) 2016-04-15 2017-04-10 Pyrazolopyrimidine derivatives

Publications (2)

Publication Number Publication Date
CA3020793A1 CA3020793A1 (en) 2017-10-19
CA3020793C true CA3020793C (en) 2024-05-21

Family

ID=55755480

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3020793A Active CA3020793C (en) 2016-04-15 2017-04-10 Pyrazolopyrimidine derivatives

Country Status (22)

Country Link
US (3) US10604525B2 (enExample)
EP (1) EP3442974B8 (enExample)
JP (1) JP7051703B2 (enExample)
KR (1) KR102467347B1 (enExample)
CN (1) CN109071545B (enExample)
AR (1) AR108130A1 (enExample)
AU (1) AU2017251155B2 (enExample)
CA (1) CA3020793C (enExample)
CL (1) CL2018002920A1 (enExample)
CO (1) CO2018010966A2 (enExample)
DO (1) DOP2018000226A (enExample)
ES (1) ES2953467T3 (enExample)
IL (1) IL261885A (enExample)
MX (1) MX389697B (enExample)
PH (1) PH12018550173A1 (enExample)
PL (1) PL3442974T3 (enExample)
RU (1) RU2769448C2 (enExample)
SG (1) SG11201808214TA (enExample)
TW (1) TWI742067B (enExample)
UY (1) UY37201A (enExample)
WO (1) WO2017178416A1 (enExample)
ZA (1) ZA201807656B (enExample)

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CN116685584A (zh) * 2020-11-18 2023-09-01 礼蓝动物保健有限公司 用于治疗心丝虫感染的n-(2,3-二氢-1,4-苯并噁嗪-4-基)-3-异丙基-7-(2,3,5-三氟苯基)苯并噻吩-2-甲酰胺衍生物和类似化合物
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TW202237600A (zh) 2020-12-04 2022-10-01 瑞士商禮藍動物保健股份有限公司 雙環衍生物
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CN113252824B (zh) * 2021-06-17 2022-04-19 湖南农业大学 测定水体中三氟苯嘧啶含量的气相色谱-电子捕获检测器法
KR102660894B1 (ko) * 2021-09-17 2024-04-26 기초과학연구원 피리미딘-2-아민 화합물의 제조방법
AR127495A1 (es) 2021-11-01 2024-01-31 Boehringer Ingelheim Vetmedica Gmbh Compuestos de pirrolopiridazina como antihelmínticos
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Also Published As

Publication number Publication date
US10604525B2 (en) 2020-03-31
JP2019513776A (ja) 2019-05-30
ES2953467T3 (es) 2023-11-13
AU2017251155A1 (en) 2018-10-11
KR102467347B1 (ko) 2022-11-14
JP7051703B2 (ja) 2022-04-11
CL2018002920A1 (es) 2019-02-01
NZ747056A (en) 2025-05-30
PH12018550173A1 (en) 2019-07-15
RU2018140092A (ru) 2020-05-15
TW201803874A (zh) 2018-02-01
US20200239482A1 (en) 2020-07-30
US11001590B2 (en) 2021-05-11
CN109071545A (zh) 2018-12-21
PL3442974T3 (pl) 2023-12-04
US20190071447A1 (en) 2019-03-07
TWI742067B (zh) 2021-10-11
EP3442974B1 (en) 2023-06-07
RU2769448C2 (ru) 2022-03-31
KR20180134966A (ko) 2018-12-19
AR108130A1 (es) 2018-07-18
EP3442974B8 (en) 2023-07-12
MX389697B (es) 2025-03-20
WO2017178416A1 (en) 2017-10-19
RU2018140092A3 (enExample) 2020-06-25
IL261885A (en) 2018-10-31
DOP2018000226A (es) 2018-11-15
CO2018010966A2 (es) 2018-10-22
CA3020793A1 (en) 2017-10-19
ZA201807656B (en) 2024-06-26
EP3442974A1 (en) 2019-02-20
UY37201A (es) 2017-11-30
US10934301B2 (en) 2021-03-02
MX2018012544A (es) 2019-01-31
SG11201808214TA (en) 2018-10-30
US20200299299A1 (en) 2020-09-24
CN109071545B (zh) 2021-08-03
EP3442974C0 (en) 2023-06-07
AU2017251155B2 (en) 2021-08-05

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