CL2018002920A1 - Nuevos derivados de pirazolopirimidina - Google Patents
Nuevos derivados de pirazolopirimidinaInfo
- Publication number
- CL2018002920A1 CL2018002920A1 CL2018002920A CL2018002920A CL2018002920A1 CL 2018002920 A1 CL2018002920 A1 CL 2018002920A1 CL 2018002920 A CL2018002920 A CL 2018002920A CL 2018002920 A CL2018002920 A CL 2018002920A CL 2018002920 A1 CL2018002920 A1 CL 2018002920A1
- Authority
- CL
- Chile
- Prior art keywords
- compounds
- pyrazolopyrimidine derivatives
- influences
- pharmaceutical compositions
- new
- Prior art date
Links
- OGEBRHQLRGFBNV-RZDIXWSQSA-N chembl2036808 Chemical class C12=NC(NCCCC)=NC=C2C(C=2C=CC(F)=CC=2)=NN1C[C@H]1CC[C@H](N)CC1 OGEBRHQLRGFBNV-RZDIXWSQSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 238000003306 harvesting Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16165572 | 2016-04-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2018002920A1 true CL2018002920A1 (es) | 2019-02-01 |
Family
ID=55755480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2018002920A CL2018002920A1 (es) | 2016-04-15 | 2018-10-12 | Nuevos derivados de pirazolopirimidina |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US10604525B2 (enExample) |
| EP (1) | EP3442974B8 (enExample) |
| JP (1) | JP7051703B2 (enExample) |
| KR (1) | KR102467347B1 (enExample) |
| CN (1) | CN109071545B (enExample) |
| AR (1) | AR108130A1 (enExample) |
| AU (1) | AU2017251155B2 (enExample) |
| CA (1) | CA3020793C (enExample) |
| CL (1) | CL2018002920A1 (enExample) |
| CO (1) | CO2018010966A2 (enExample) |
| DO (1) | DOP2018000226A (enExample) |
| ES (1) | ES2953467T3 (enExample) |
| IL (1) | IL261885A (enExample) |
| MX (1) | MX389697B (enExample) |
| PH (1) | PH12018550173A1 (enExample) |
| PL (1) | PL3442974T3 (enExample) |
| RU (1) | RU2769448C2 (enExample) |
| SG (1) | SG11201808214TA (enExample) |
| TW (1) | TWI742067B (enExample) |
| UY (1) | UY37201A (enExample) |
| WO (1) | WO2017178416A1 (enExample) |
| ZA (1) | ZA201807656B (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12312356B2 (en) | 2020-05-29 | 2025-05-27 | Boehringer Ingelheim Vetmedica Gmbh | Anthelmintic heterocyclic compounds |
| US12435068B2 (en) | 2018-10-24 | 2025-10-07 | Elanco Animal Health Gmbh | Anthelmintic compounds |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170232024A1 (en) | 2014-08-04 | 2017-08-17 | Jerry Tan Eye Surgery Pte Ltd | Pharmaceutical compositions for demodex related blepharitis and eyelid crusting |
| ES2953467T3 (es) * | 2016-04-15 | 2023-11-13 | Elanco Animal Health Gmbh | Derivados de pirazolopirimidina |
| AU2017251537B2 (en) | 2016-04-15 | 2020-10-08 | Abbvie Inc. | Bromodomain inhibitors |
| WO2018195450A1 (en) | 2017-04-21 | 2018-10-25 | Epizyme, Inc. | Combination therapies with ehmt2 inhibitors |
| WO2018197401A1 (en) * | 2017-04-27 | 2018-11-01 | Bayer Animal Health Gmbh | New bicyclic pyrazole derivatives |
| US10738056B2 (en) | 2017-09-15 | 2020-08-11 | Aduro Biotech Inc. | Pyrazolopyrimidinone compounds and uses thereof |
| CN119157876A (zh) | 2017-12-15 | 2024-12-20 | 塔苏斯制药有限公司 | 用于治疗睑炎的异恶唑啉驱虫剂制剂和方法 |
| CN112074514B (zh) | 2018-05-09 | 2024-10-29 | 礼蓝动物保健有限公司 | 新的喹啉衍生物 |
| MX2021000293A (es) * | 2018-07-09 | 2021-07-15 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos heterociclicos antihelminticos. |
| US20220064159A1 (en) | 2018-12-18 | 2022-03-03 | Elanco Tiergesundheit Ag | Bicyclic derivatives |
| NZ777370A (en) * | 2018-12-18 | 2024-11-29 | Elanco Tiergesundheit Ag | Bicyclic derivatives |
| KR20220002890A (ko) * | 2019-03-19 | 2022-01-07 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 구충성 아자-벤조티오펜 및 아자-벤조푸란 화합물 |
| US12502377B2 (en) | 2019-04-04 | 2025-12-23 | Tarsus Pharmaceuticals, Inc. | Method of eradicating ticks that attach to humans using lotilaner formulations |
| US20200385398A1 (en) | 2019-06-07 | 2020-12-10 | Elanco Tiergesundheit Ag | New bicyclic derivatives |
| TWI865563B (zh) | 2019-07-30 | 2024-12-11 | 德商拜耳動物保健有限公司 | 新穎異喹啉衍生物 |
| JP2023507173A (ja) * | 2019-12-18 | 2023-02-21 | インターベット インターナショナル ベー． フェー． | キノリン構造を含む駆虫剤化合物 |
| MX2022007671A (es) | 2019-12-18 | 2022-07-19 | Intervet Int Bv | Compuestos antihelminticos que comprenden una estructura de azaindoles. |
| CN116685584A (zh) * | 2020-11-18 | 2023-09-01 | 礼蓝动物保健有限公司 | 用于治疗心丝虫感染的n-(2,3-二氢-1,4-苯并噁嗪-4-基)-3-异丙基-7-(2,3,5-三氟苯基)苯并噻吩-2-甲酰胺衍生物和类似化合物 |
| US20240059680A1 (en) | 2020-11-18 | 2024-02-22 | Elanco Tiergesundheit Ag | N-(2,3-dihydro-1,4-benzoxazin-4-yl)-3-isopropyl-7-(2,3,5-trifluorophenyl)benzo-thiophene-2-carboxamide derivatives and similar compounds for the treatment of heartworm infections |
| TW202237600A (zh) | 2020-12-04 | 2022-10-01 | 瑞士商禮藍動物保健股份有限公司 | 雙環衍生物 |
| WO2022122988A1 (en) | 2020-12-11 | 2022-06-16 | Intervet International B.V. | Anthelmintic compounds comprising a thienopyridine structure |
| CN113252824B (zh) * | 2021-06-17 | 2022-04-19 | 湖南农业大学 | 测定水体中三氟苯嘧啶含量的气相色谱-电子捕获检测器法 |
| KR102660894B1 (ko) * | 2021-09-17 | 2024-04-26 | 기초과학연구원 | 피리미딘-2-아민 화합물의 제조방법 |
| WO2023073641A1 (en) | 2021-11-01 | 2023-05-04 | Boehringer Ingelheim Vetmedica Gmbh | Anthelmintic pyrrolopyridazine compounds |
| EP4694887A1 (en) | 2023-04-14 | 2026-02-18 | Elanco Animal Health GmbH | Long-term prevention and/or treatment of a disease by slo-1 inhibitors |
| CN121620507A (zh) | 2023-08-02 | 2026-03-06 | 英特维特国际股份有限公司 | 具有驱虫活性的甲酰胺-4-喹啉化合物 |
| CN119139315B (zh) * | 2024-09-23 | 2026-03-10 | 大连大学 | D724-0491在制备治疗乳腺癌药物中的应用 |
| WO2026078157A2 (en) | 2024-10-10 | 2026-04-16 | Elanco Animal Health Gmbh | Slo-1 modulators for prevention and/or treatment of a disease |
| WO2026115027A1 (en) | 2024-11-28 | 2026-06-04 | Intervet International B.V. | Carboxamide-4-quinoline compounds with anthelmintic activity |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY125533A (en) | 1999-12-06 | 2006-08-30 | Bristol Myers Squibb Co | Heterocyclic dihydropyrimidine compounds |
| RU15525U1 (ru) | 2000-07-04 | 2000-10-20 | Федеральный научно-производственный центр закрытое акционерное общество "Научно-производственный концерн (объединение) "ЭНЕРГИЯ" | Электродвигатель постоянного тока |
| CA2483306A1 (en) * | 2002-04-23 | 2003-11-06 | Shionogi & Co., Ltd. | Pyrazolo[1,5-a]pyrimidine derivative and nad(p)h oxidase inhibitor containing the same |
| GB0213715D0 (en) | 2002-06-14 | 2002-07-24 | Syngenta Ltd | Chemical compounds |
| TWI312272B (en) | 2003-05-12 | 2009-07-21 | Sumitomo Chemical Co | Pyrimidine compound and pests controlling composition containing the same |
| EA009517B1 (ru) * | 2003-06-27 | 2008-02-28 | Байер Кропсайенс Аг | Пиразолопиримидины |
| ATE388138T1 (de) | 2003-06-27 | 2008-03-15 | Bayer Cropscience Ag | Pyrazolopyrimidine |
| GB0414438D0 (en) | 2004-06-28 | 2004-07-28 | Syngenta Participations Ag | Chemical compounds |
| KR101310073B1 (ko) | 2004-10-20 | 2013-09-24 | 이하라케미칼 고교가부시키가이샤 | 3-트리아졸릴페닐설파이드 유도체 및 그것을유효성분으로서 함유하는 살충·살진드기·살선충제 |
| EP1932844B1 (en) | 2005-10-06 | 2015-09-02 | Nippon Soda Co., Ltd. | Cross-linked cyclic amine compounds and agents for pest control |
| EP1918291A1 (en) | 2006-10-30 | 2008-05-07 | Novartis AG | 3-Aminocarbonyl-substituted fused pyrazolo-derivatives as protein kinase modulators |
| US20080176870A1 (en) * | 2006-11-20 | 2008-07-24 | Bert Nolte | Heterobicyclic metalloprotease inhibitors |
| KR20100087298A (ko) | 2007-09-28 | 2010-08-04 | 교와 핫꼬 기린 가부시키가이샤 | 피부 질환의 예방 및/또는 치료제 |
| JP5268461B2 (ja) | 2008-07-14 | 2013-08-21 | Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 | Ｐｆ１３６４物質、その製造方法、生産菌株、及び、それを有効成分とする農園芸用殺虫剤 |
| CN101337940B (zh) | 2008-08-12 | 2012-05-02 | 国家农药创制工程技术研究中心 | 具杀虫活性的含氮杂环二氯烯丙醚类化合物 |
| CN101337937B (zh) | 2008-08-12 | 2010-12-22 | 国家农药创制工程技术研究中心 | 具有杀虫活性的n-苯基-5-取代氨基吡唑类化合物 |
| CN101715774A (zh) | 2008-10-09 | 2010-06-02 | 浙江化工科技集团有限公司 | 一个具有杀虫活性化合物制备及用途 |
| EP2184273A1 (de) | 2008-11-05 | 2010-05-12 | Bayer CropScience AG | Halogen-substituierte Verbindungen als Pestizide |
| GB0820344D0 (en) | 2008-11-06 | 2008-12-17 | Syngenta Ltd | Herbicidal compositions |
| US8007468B2 (en) | 2009-07-13 | 2011-08-30 | Navilyst Medical, Inc. | Method to secure an elastic component in a valve |
| WO2011085575A1 (zh) | 2010-01-15 | 2011-07-21 | 江苏省农药研究所股份有限公司 | 邻杂环甲酰苯胺类化合物及其合成方法和应用 |
| AU2011297160B2 (en) | 2010-08-31 | 2014-11-20 | Mitsui Chemicals Crop & Life Solutions, Inc. | Noxious organism control agent |
| CN101967139B (zh) | 2010-09-14 | 2013-06-05 | 中化蓝天集团有限公司 | 一种含一氟甲氧基吡唑的邻甲酰氨基苯甲酰胺类化合物、其合成方法及应用 |
| EP2675440B1 (en) | 2011-02-14 | 2020-03-25 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
| WO2013050317A1 (en) | 2011-10-03 | 2013-04-11 | Syngenta Limited | Polymorphs of an isoxazoline derivative |
| CN102391261A (zh) | 2011-10-14 | 2012-03-28 | 上海交通大学 | 一种n-取代噁二嗪类化合物及其制备方法和应用 |
| CN104202981B (zh) | 2012-03-30 | 2018-01-30 | 巴斯夫欧洲公司 | 防治动物害虫的n‑取代的吡啶亚基化合物和衍生物 |
| EP2647626A1 (en) | 2012-04-03 | 2013-10-09 | Syngenta Participations AG. | 1-Aza-spiro[4.5]dec-3-ene and 1,8-diaza-spiro[4.5]dec-3-ene derivatives as pesticides |
| US9282739B2 (en) | 2012-04-27 | 2016-03-15 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
| CA2870090A1 (en) | 2012-04-27 | 2013-10-31 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
| US9284310B2 (en) | 2012-11-03 | 2016-03-15 | Boehringer Ingelheim International Gmbh | Inhibitors of cytomegalovirus |
| CN103109816B (zh) | 2013-01-25 | 2014-09-10 | 青岛科技大学 | 硫代苯甲酰胺类化合物及其应用 |
| CN103232431B (zh) | 2013-01-25 | 2014-11-05 | 青岛科技大学 | 一种二卤代吡唑酰胺类化合物及其应用 |
| US20140275503A1 (en) | 2013-03-13 | 2014-09-18 | Dow Agrosciences Llc | Process for the preparation of certain triaryl rhamnose carbamates |
| CN103265527B (zh) | 2013-06-07 | 2014-08-13 | 江苏省农用激素工程技术研究中心有限公司 | 邻氨基苯甲酰胺化合物及其制备方法和应用 |
| CN103524422B (zh) | 2013-10-11 | 2015-05-27 | 中国农业科学院植物保护研究所 | 苯并咪唑衍生物及其制备方法和用途 |
| KR20160072155A (ko) | 2013-10-17 | 2016-06-22 | 다우 아그로사이언시즈 엘엘씨 | 살충성 화합물의 제조 방법 |
| CN105636441B (zh) | 2013-10-17 | 2018-06-15 | 美国陶氏益农公司 | 制备杀虫化合物的方法 |
| UY36196A (es) * | 2014-07-25 | 2016-02-29 | Bayer Animal Health Gmbh | Compuestos para usar en el tratamiento antihelmíntico |
| ES2953467T3 (es) | 2016-04-15 | 2023-11-13 | Elanco Animal Health Gmbh | Derivados de pirazolopirimidina |
-
2017
- 2017-04-10 ES ES17715204T patent/ES2953467T3/es active Active
- 2017-04-10 PL PL17715204.8T patent/PL3442974T3/pl unknown
- 2017-04-10 JP JP2018553486A patent/JP7051703B2/ja active Active
- 2017-04-10 SG SG11201808214TA patent/SG11201808214TA/en unknown
- 2017-04-10 WO PCT/EP2017/058519 patent/WO2017178416A1/en not_active Ceased
- 2017-04-10 US US16/093,565 patent/US10604525B2/en active Active
- 2017-04-10 KR KR1020187032684A patent/KR102467347B1/ko active Active
- 2017-04-10 CN CN201780023855.8A patent/CN109071545B/zh active Active
- 2017-04-10 CA CA3020793A patent/CA3020793C/en active Active
- 2017-04-10 EP EP17715204.8A patent/EP3442974B8/en active Active
- 2017-04-10 MX MX2018012544A patent/MX389697B/es unknown
- 2017-04-10 RU RU2018140092A patent/RU2769448C2/ru active
- 2017-04-10 AU AU2017251155A patent/AU2017251155B2/en active Active
- 2017-04-12 AR ARP170100939A patent/AR108130A1/es active IP Right Grant
- 2017-04-13 TW TW106112313A patent/TWI742067B/zh active
- 2017-04-18 UY UY0001037201A patent/UY37201A/es not_active Application Discontinuation
-
2018
- 2018-09-20 IL IL261885A patent/IL261885A/en unknown
- 2018-10-12 DO DO2018000226A patent/DOP2018000226A/es unknown
- 2018-10-12 CL CL2018002920A patent/CL2018002920A1/es unknown
- 2018-10-12 CO CONC2018/0010966A patent/CO2018010966A2/es unknown
- 2018-10-15 PH PH12018550173A patent/PH12018550173A1/en unknown
- 2018-11-14 ZA ZA2018/07656A patent/ZA201807656B/en unknown
-
2020
- 2020-01-29 US US16/776,374 patent/US11001590B2/en active Active
- 2020-01-29 US US16/776,377 patent/US10934301B2/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12435068B2 (en) | 2018-10-24 | 2025-10-07 | Elanco Animal Health Gmbh | Anthelmintic compounds |
| US12312356B2 (en) | 2020-05-29 | 2025-05-27 | Boehringer Ingelheim Vetmedica Gmbh | Anthelmintic heterocyclic compounds |
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